LeishMANIAdb
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Got1-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Got1-domain-containing protein
Gene product:
Got1/Sft2-like family, putative
Species:
Leishmania mexicana
UniProt:
E9ARU6_LEIMU
TriTrypDb:
LmxM.18.1620
Length:
143

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0000139 Golgi membrane 5 11
GO:0005829 cytosol 2 11
GO:0016020 membrane 2 11
GO:0031090 organelle membrane 3 11
GO:0098588 bounding membrane of organelle 4 11
GO:0110165 cellular anatomical entity 1 11
GO:0005794 Golgi apparatus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

E9ARU6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARU6

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 11
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 4 11
GO:0009987 cellular process 1 11
GO:0016192 vesicle-mediated transport 4 11
GO:0016197 endosomal transport 4 11
GO:0016482 cytosolic transport 4 11
GO:0042147 retrograde transport, endosome to Golgi 5 11
GO:0046907 intracellular transport 3 11
GO:0048193 Golgi vesicle transport 5 11
GO:0051179 localization 1 11
GO:0051234 establishment of localization 2 11
GO:0051641 cellular localization 2 11
GO:0051649 establishment of localization in cell 3 11
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 56 58 PF00675 0.225
CLV_PCSK_KEX2_1 56 58 PF00082 0.239
CLV_PCSK_SKI1_1 59 63 PF00082 0.262
DEG_Nend_UBRbox_2 1 3 PF02207 0.597
DOC_MAPK_MEF2A_6 82 90 PF00069 0.355
DOC_PP2B_LxvP_1 121 124 PF13499 0.358
LIG_14-3-3_CanoR_1 65 74 PF00244 0.489
LIG_Actin_WH2_2 125 143 PF00022 0.675
LIG_BRCT_BRCA1_1 68 72 PF00533 0.446
LIG_GBD_Chelix_1 29 37 PF00786 0.320
LIG_LIR_Nem_3 25 29 PF02991 0.370
LIG_Pex14_2 99 103 PF04695 0.231
LIG_PTB_Apo_2 39 46 PF02174 0.299
LIG_REV1ctd_RIR_1 59 69 PF16727 0.446
LIG_SH3_3 112 118 PF00018 0.366
LIG_SH3_3 49 55 PF00018 0.299
LIG_SUMO_SIM_par_1 117 122 PF11976 0.319
LIG_SUMO_SIM_par_1 28 35 PF11976 0.353
LIG_WRC_WIRS_1 23 28 PF05994 0.372
MOD_GlcNHglycan 111 114 PF01048 0.451
MOD_GlcNHglycan 121 124 PF01048 0.400
MOD_GlcNHglycan 68 71 PF01048 0.277
MOD_GSK3_1 32 39 PF00069 0.299
MOD_N-GLC_1 7 12 PF02516 0.327
MOD_NEK2_1 22 27 PF00069 0.366
MOD_NEK2_1 32 37 PF00069 0.289
MOD_PKA_2 66 72 PF00069 0.448
MOD_Plk_4 127 133 PF00069 0.616
MOD_Plk_4 32 38 PF00069 0.327
TRG_ER_diArg_1 55 57 PF00400 0.423

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1II89 Leptomonas seymouri 72% 100%
A0A0S4IR47 Bodo saltans 67% 100%
A0A1X0P7B1 Trypanosomatidae 71% 100%
A0A3S7WV78 Leishmania donovani 98% 100%
A0A422NPN7 Trypanosoma rangeli 67% 100%
A4H9R3 Leishmania braziliensis 87% 100%
A4HY32 Leishmania infantum 97% 100%
D0A553 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 100%
Q03554 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 41% 100%
Q20263 Caenorhabditis elegans 36% 100%
Q2NKV8 Bos taurus 42% 100%
Q2YDE3 Bos taurus 43% 100%
Q4QDM7 Leishmania major 98% 100%
Q54CL4 Dictyostelium discoideum 36% 100%
Q6NMM1 Arabidopsis thaliana 38% 100%
Q6ZVE7 Homo sapiens 39% 100%
Q9CR60 Mus musculus 44% 100%
Q9DCQ3 Mus musculus 43% 100%
Q9USJ2 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 39% 100%
Q9Y3E0 Homo sapiens 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS