Noc2-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Noc2p family, putative

Species:

Leishmania mexicana

UniProt:

E9ARU5_LEIMU

TriTrypDb:

LmxM.18.1610

Length:

654

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0030689	Noc complex	3	1
GO:0030690	Noc1p-Noc2p complex	4	1
GO:0030691	Noc2p-Noc3p complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9ARU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARU5

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0022613	ribonucleoprotein complex biogenesis	4	1
GO:0042273	ribosomal large subunit biogenesis	5	1
GO:0044085	cellular component biogenesis	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.606
CLV_C14_Caspase3-7	97	101	PF00656	0.558
CLV_NRD_NRD_1	136	138	PF00675	0.662
CLV_NRD_NRD_1	182	184	PF00675	0.472
CLV_NRD_NRD_1	25	27	PF00675	0.480
CLV_NRD_NRD_1	538	540	PF00675	0.365
CLV_NRD_NRD_1	651	653	PF00675	0.640
CLV_PCSK_KEX2_1	136	138	PF00082	0.629
CLV_PCSK_KEX2_1	226	228	PF00082	0.330
CLV_PCSK_KEX2_1	25	27	PF00082	0.481
CLV_PCSK_KEX2_1	571	573	PF00082	0.244
CLV_PCSK_KEX2_1	595	597	PF00082	0.145
CLV_PCSK_KEX2_1	644	646	PF00082	0.598
CLV_PCSK_KEX2_1	651	653	PF00082	0.589
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.424
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.303
CLV_PCSK_PC1ET2_1	595	597	PF00082	0.145
CLV_PCSK_PC1ET2_1	644	646	PF00082	0.610
CLV_PCSK_PC7_1	222	228	PF00082	0.343
CLV_PCSK_PC7_1	647	653	PF00082	0.708
CLV_PCSK_SKI1_1	192	196	PF00082	0.427
CLV_PCSK_SKI1_1	226	230	PF00082	0.369
CLV_PCSK_SKI1_1	264	268	PF00082	0.336
CLV_PCSK_SKI1_1	27	31	PF00082	0.421
CLV_PCSK_SKI1_1	313	317	PF00082	0.244
CLV_PCSK_SKI1_1	368	372	PF00082	0.244
CLV_PCSK_SKI1_1	45	49	PF00082	0.503
CLV_PCSK_SKI1_1	461	465	PF00082	0.259
CLV_PCSK_SKI1_1	596	600	PF00082	0.145
CLV_PCSK_SKI1_1	8	12	PF00082	0.469
DEG_APCC_DBOX_1	141	149	PF00400	0.455
DEG_APCC_DBOX_1	624	632	PF00400	0.575
DEG_Kelch_Keap1_1	116	121	PF01344	0.585
DOC_CDC14_PxL_1	453	461	PF14671	0.259
DOC_CYCLIN_RxL_1	220	233	PF00134	0.371
DOC_CYCLIN_yCln2_LP_2	451	457	PF00134	0.389
DOC_MAPK_gen_1	217	225	PF00069	0.414
DOC_MAPK_gen_1	226	232	PF00069	0.284
DOC_MAPK_gen_1	539	547	PF00069	0.243
DOC_MAPK_gen_1	593	601	PF00069	0.145
DOC_MAPK_MEF2A_6	268	277	PF00069	0.286
DOC_MAPK_MEF2A_6	429	437	PF00069	0.244
DOC_MAPK_MEF2A_6	447	455	PF00069	0.244
DOC_MAPK_MEF2A_6	461	470	PF00069	0.241
DOC_PP2B_LxvP_1	451	454	PF13499	0.389
DOC_PP4_FxxP_1	185	188	PF00568	0.432
DOC_PP4_FxxP_1	425	428	PF00568	0.244
DOC_USP7_MATH_1	194	198	PF00917	0.497
DOC_USP7_MATH_1	231	235	PF00917	0.515
DOC_USP7_MATH_1	281	285	PF00917	0.430
DOC_USP7_MATH_1	396	400	PF00917	0.292
DOC_USP7_MATH_1	519	523	PF00917	0.236
DOC_USP7_MATH_1	533	537	PF00917	0.260
DOC_USP7_UBL2_3	12	16	PF12436	0.452
DOC_USP7_UBL2_3	213	217	PF12436	0.398
DOC_USP7_UBL2_3	567	571	PF12436	0.303
DOC_USP7_UBL2_3	636	640	PF12436	0.533
DOC_USP7_UBL2_3	7	11	PF12436	0.470
DOC_WW_Pin1_4	424	429	PF00397	0.244
DOC_WW_Pin1_4	462	467	PF00397	0.259
DOC_WW_Pin1_4	475	480	PF00397	0.259
LIG_14-3-3_CanoR_1	178	185	PF00244	0.584
LIG_14-3-3_CanoR_1	272	276	PF00244	0.267
LIG_14-3-3_CanoR_1	461	466	PF00244	0.244
LIG_14-3-3_CanoR_1	491	501	PF00244	0.233
LIG_14-3-3_CanoR_1	539	548	PF00244	0.276
LIG_14-3-3_CanoR_1	559	568	PF00244	0.231
LIG_14-3-3_CanoR_1	625	629	PF00244	0.526
LIG_Actin_WH2_2	256	274	PF00022	0.318
LIG_Actin_WH2_2	353	370	PF00022	0.259
LIG_BIR_II_1	1	5	PF00653	0.523
LIG_BIR_III_4	620	624	PF00653	0.599
LIG_BRCT_BRCA1_1	308	312	PF00533	0.244
LIG_FHA_1	219	225	PF00498	0.367
LIG_FHA_1	265	271	PF00498	0.345
LIG_FHA_1	487	493	PF00498	0.259
LIG_FHA_1	513	519	PF00498	0.295
LIG_FHA_2	101	107	PF00498	0.589
LIG_FHA_2	139	145	PF00498	0.437
LIG_FHA_2	345	351	PF00498	0.244
LIG_FHA_2	398	404	PF00498	0.338
LIG_FHA_2	65	71	PF00498	0.481
LIG_FHA_2	79	85	PF00498	0.528
LIG_GBD_Chelix_1	224	232	PF00786	0.416
LIG_GBD_Chelix_1	363	371	PF00786	0.244
LIG_LIR_Apic_2	182	188	PF02991	0.502
LIG_LIR_Apic_2	399	404	PF02991	0.303
LIG_LIR_Apic_2	423	428	PF02991	0.244
LIG_LIR_Gen_1	70	80	PF02991	0.472
LIG_LIR_Nem_3	309	315	PF02991	0.259
LIG_LIR_Nem_3	393	397	PF02991	0.327
LIG_LIR_Nem_3	449	455	PF02991	0.244
LIG_LIR_Nem_3	529	534	PF02991	0.244
LIG_LIR_Nem_3	68	74	PF02991	0.464
LIG_LIR_Nem_3	9	13	PF02991	0.472
LIG_LYPXL_SIV_4	352	360	PF13949	0.321
LIG_PCNA_PIPBox_1	338	347	PF02747	0.303
LIG_Pex14_2	312	316	PF04695	0.244
LIG_Pex14_2	527	531	PF04695	0.244
LIG_PTB_Apo_2	381	388	PF02174	0.244
LIG_PTB_Phospho_1	381	387	PF10480	0.244
LIG_SH2_CRK	290	294	PF00017	0.441
LIG_SH2_GRB2like	387	390	PF00017	0.244
LIG_SH2_NCK_1	401	405	PF00017	0.244
LIG_SH2_PTP2	452	455	PF00017	0.338
LIG_SH2_SRC	353	356	PF00017	0.262
LIG_SH2_SRC	387	390	PF00017	0.244
LIG_SH2_SRC	452	455	PF00017	0.338
LIG_SH2_STAT3	359	362	PF00017	0.244
LIG_SH2_STAT5	262	265	PF00017	0.385
LIG_SH2_STAT5	359	362	PF00017	0.244
LIG_SH2_STAT5	366	369	PF00017	0.244
LIG_SH2_STAT5	387	390	PF00017	0.244
LIG_SH2_STAT5	452	455	PF00017	0.263
LIG_SH2_STAT5	458	461	PF00017	0.225
LIG_SH2_STAT5	512	515	PF00017	0.244
LIG_SH2_STAT5	74	77	PF00017	0.467
LIG_SH3_3	252	258	PF00018	0.322
LIG_SH3_3	451	457	PF00018	0.255
LIG_SH3_3	522	528	PF00018	0.338
LIG_SH3_3	542	548	PF00018	0.123
LIG_SUMO_SIM_anti_2	482	489	PF11976	0.265
LIG_SUMO_SIM_anti_2	88	95	PF11976	0.657
LIG_TRAF2_1	141	144	PF00917	0.490
LIG_TRAF2_1	280	283	PF00917	0.357
LIG_TRAF2_1	51	54	PF00917	0.614
LIG_UBA3_1	486	494	PF00899	0.389
LIG_WRC_WIRS_1	206	211	PF05994	0.464
MOD_CDK_SPK_2	424	429	PF00069	0.244
MOD_CK1_1	150	156	PF00069	0.547
MOD_CK1_1	215	221	PF00069	0.459
MOD_CK1_1	295	301	PF00069	0.420
MOD_CK1_1	399	405	PF00069	0.237
MOD_CK1_1	638	644	PF00069	0.488
MOD_CK2_1	138	144	PF00069	0.463
MOD_CK2_1	150	156	PF00069	0.444
MOD_CK2_1	28	34	PF00069	0.481
MOD_CK2_1	344	350	PF00069	0.244
MOD_CK2_1	397	403	PF00069	0.338
MOD_CK2_1	443	449	PF00069	0.145
MOD_CK2_1	64	70	PF00069	0.470
MOD_CK2_1	78	84	PF00069	0.495
MOD_CK2_1	96	102	PF00069	0.495
MOD_Cter_Amidation	642	645	PF01082	0.704
MOD_GlcNHglycan	149	152	PF01048	0.533
MOD_GlcNHglycan	163	166	PF01048	0.294
MOD_GlcNHglycan	245	248	PF01048	0.436
MOD_GlcNHglycan	596	599	PF01048	0.319
MOD_GlcNHglycan	620	624	PF01048	0.602
MOD_GlcNHglycan	637	640	PF01048	0.679
MOD_GSK3_1	143	150	PF00069	0.563
MOD_GSK3_1	204	211	PF00069	0.417
MOD_GSK3_1	302	309	PF00069	0.386
MOD_GSK3_1	315	322	PF00069	0.316
MOD_GSK3_1	464	471	PF00069	0.309
MOD_GSK3_1	517	524	PF00069	0.257
MOD_GSK3_1	634	641	PF00069	0.479
MOD_GSK3_1	96	103	PF00069	0.603
MOD_LATS_1	176	182	PF00433	0.641
MOD_N-GLC_1	329	334	PF02516	0.280
MOD_N-GLC_2	276	278	PF02516	0.369
MOD_NEK2_1	230	235	PF00069	0.335
MOD_NEK2_1	245	250	PF00069	0.256
MOD_NEK2_1	271	276	PF00069	0.362
MOD_NEK2_1	306	311	PF00069	0.244
MOD_NEK2_1	319	324	PF00069	0.244
MOD_NEK2_1	486	491	PF00069	0.244
MOD_NEK2_2	212	217	PF00069	0.457
MOD_NEK2_2	281	286	PF00069	0.420
MOD_NEK2_2	302	307	PF00069	0.387
MOD_NEK2_2	602	607	PF00069	0.303
MOD_PIKK_1	143	149	PF00454	0.452
MOD_PIKK_1	372	378	PF00454	0.244
MOD_PIKK_1	492	498	PF00454	0.255
MOD_PIKK_1	540	546	PF00454	0.314
MOD_PIKK_1	562	568	PF00454	0.302
MOD_PKA_1	25	31	PF00069	0.486
MOD_PKA_2	138	144	PF00069	0.485
MOD_PKA_2	25	31	PF00069	0.486
MOD_PKA_2	271	277	PF00069	0.266
MOD_PKA_2	624	630	PF00069	0.523
MOD_Plk_1	143	149	PF00069	0.610
MOD_Plk_1	281	287	PF00069	0.341
MOD_Plk_1	329	335	PF00069	0.280
MOD_Plk_1	534	540	PF00069	0.244
MOD_Plk_2-3	100	106	PF00069	0.593
MOD_Plk_2-3	624	630	PF00069	0.538
MOD_Plk_2-3	70	76	PF00069	0.458
MOD_Plk_2-3	78	84	PF00069	0.480
MOD_Plk_4	205	211	PF00069	0.552
MOD_Plk_4	231	237	PF00069	0.350
MOD_Plk_4	245	251	PF00069	0.295
MOD_Plk_4	266	272	PF00069	0.322
MOD_Plk_4	315	321	PF00069	0.257
MOD_Plk_4	70	76	PF00069	0.416
MOD_Plk_4	78	84	PF00069	0.438
MOD_ProDKin_1	424	430	PF00069	0.244
MOD_ProDKin_1	462	468	PF00069	0.259
MOD_ProDKin_1	475	481	PF00069	0.259
MOD_SUMO_rev_2	34	44	PF00179	0.452
TRG_DiLeu_BaEn_1	186	191	PF01217	0.469
TRG_DiLeu_BaEn_1	509	514	PF01217	0.259
TRG_DiLeu_BaEn_1	78	83	PF01217	0.479
TRG_DiLeu_BaLyEn_6	224	229	PF01217	0.357
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.458
TRG_DiLeu_BaLyEn_6	406	411	PF01217	0.259
TRG_ENDOCYTIC_2	290	293	PF00928	0.289
TRG_ENDOCYTIC_2	452	455	PF00928	0.338
TRG_ENDOCYTIC_2	603	606	PF00928	0.280
TRG_ENDOCYTIC_2	72	75	PF00928	0.451
TRG_ER_diArg_1	135	137	PF00400	0.694
TRG_ER_diArg_1	24	26	PF00400	0.406
TRG_ER_diArg_1	645	648	PF00400	0.694
TRG_ER_diArg_1	650	652	PF00400	0.664
TRG_NLS_MonoExtC_3	643	648	PF00514	0.664
TRG_Pf-PMV_PEXEL_1	167	172	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	539	544	PF00026	0.365

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P383	Leptomonas seymouri	85%	100%
A0A0S4IWR5	Bodo saltans	61%	99%
A0A1X0P734	Trypanosomatidae	68%	100%
A0A3R7MKH6	Trypanosoma rangeli	67%	100%
A0A3S7WV72	Leishmania donovani	96%	100%
A4H9R2	Leishmania braziliensis	87%	100%
A4HY31	Leishmania infantum	96%	100%
D0A554	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
P39744	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	92%
Q0WVH0	Arabidopsis thaliana	22%	100%
Q4QDM8	Leishmania major	96%	100%
Q9P7G0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	93%
Q9WV70	Mus musculus	26%	88%
V5B4B0	Trypanosoma cruzi	66%	100%