Putative kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative kinesin

Gene product:

kinesin, putative

Species:

Leishmania mexicana

UniProt:

E9ARU4_LEIMU

TriTrypDb:

LmxM.18.1600

Length:

796

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	1
GO:0005874	microtubule	6	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARU4

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003774	cytoskeletal motor activity	1	11
GO:0003777	microtubule motor activity	2	11
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0005524	ATP binding	5	11
GO:0008017	microtubule binding	5	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0015631	tubulin binding	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	4
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	4
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	477	481	PF00656	0.502
CLV_C14_Caspase3-7	607	611	PF00656	0.669
CLV_NRD_NRD_1	151	153	PF00675	0.329
CLV_NRD_NRD_1	187	189	PF00675	0.311
CLV_NRD_NRD_1	31	33	PF00675	0.344
CLV_NRD_NRD_1	367	369	PF00675	0.589
CLV_NRD_NRD_1	4	6	PF00675	0.427
CLV_NRD_NRD_1	403	405	PF00675	0.662
CLV_NRD_NRD_1	409	411	PF00675	0.557
CLV_NRD_NRD_1	47	49	PF00675	0.424
CLV_NRD_NRD_1	566	568	PF00675	0.650
CLV_NRD_NRD_1	654	656	PF00675	0.576
CLV_NRD_NRD_1	717	719	PF00675	0.792
CLV_NRD_NRD_1	774	776	PF00675	0.718
CLV_PCSK_FUR_1	313	317	PF00082	0.384
CLV_PCSK_KEX2_1	150	152	PF00082	0.326
CLV_PCSK_KEX2_1	187	189	PF00082	0.311
CLV_PCSK_KEX2_1	31	33	PF00082	0.429
CLV_PCSK_KEX2_1	315	317	PF00082	0.354
CLV_PCSK_KEX2_1	366	368	PF00082	0.594
CLV_PCSK_KEX2_1	4	6	PF00082	0.427
CLV_PCSK_KEX2_1	403	405	PF00082	0.643
CLV_PCSK_KEX2_1	409	411	PF00082	0.542
CLV_PCSK_KEX2_1	47	49	PF00082	0.424
CLV_PCSK_KEX2_1	566	568	PF00082	0.650
CLV_PCSK_KEX2_1	654	656	PF00082	0.622
CLV_PCSK_KEX2_1	773	775	PF00082	0.705
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.384
CLV_PCSK_PC1ET2_1	773	775	PF00082	0.733
CLV_PCSK_PC7_1	147	153	PF00082	0.314
CLV_PCSK_SKI1_1	280	284	PF00082	0.422
CLV_PCSK_SKI1_1	31	35	PF00082	0.212
CLV_PCSK_SKI1_1	566	570	PF00082	0.568
CLV_PCSK_SKI1_1	63	67	PF00082	0.392
CLV_PCSK_SKI1_1	692	696	PF00082	0.615
CLV_PCSK_SKI1_1	75	79	PF00082	0.364
CLV_Separin_Metazoa	117	121	PF03568	0.422
DEG_SCF_FBW7_2	663	669	PF00400	0.688
DEG_SPOP_SBC_1	561	565	PF00917	0.564
DOC_ANK_TNKS_1	776	783	PF00023	0.714
DOC_CDC14_PxL_1	420	428	PF14671	0.529
DOC_CKS1_1	663	668	PF01111	0.688
DOC_MAPK_DCC_7	418	428	PF00069	0.530
DOC_MAPK_gen_1	208	216	PF00069	0.314
DOC_MAPK_gen_1	346	353	PF00069	0.549
DOC_MAPK_gen_1	4	12	PF00069	0.405
DOC_MAPK_MEF2A_6	120	129	PF00069	0.414
DOC_MAPK_MEF2A_6	208	216	PF00069	0.301
DOC_MAPK_MEF2A_6	270	278	PF00069	0.305
DOC_MAPK_MEF2A_6	4	12	PF00069	0.405
DOC_PP1_RVXF_1	211	217	PF00149	0.422
DOC_PP2B_PxIxI_1	157	163	PF00149	0.422
DOC_USP7_MATH_1	387	391	PF00917	0.659
DOC_USP7_MATH_1	450	454	PF00917	0.606
DOC_USP7_MATH_1	524	528	PF00917	0.606
DOC_USP7_MATH_1	636	640	PF00917	0.753
DOC_USP7_MATH_1	658	662	PF00917	0.643
DOC_USP7_MATH_1	707	711	PF00917	0.551
DOC_USP7_MATH_1	733	737	PF00917	0.740
DOC_USP7_MATH_2	191	197	PF00917	0.212
DOC_WW_Pin1_4	226	231	PF00397	0.311
DOC_WW_Pin1_4	391	396	PF00397	0.608
DOC_WW_Pin1_4	594	599	PF00397	0.666
DOC_WW_Pin1_4	662	667	PF00397	0.646
DOC_WW_Pin1_4	703	708	PF00397	0.670
DOC_WW_Pin1_4	745	750	PF00397	0.624
DOC_WW_Pin1_4	75	80	PF00397	0.422
LIG_14-3-3_CanoR_1	187	191	PF00244	0.303
LIG_14-3-3_CanoR_1	19	26	PF00244	0.452
LIG_14-3-3_CanoR_1	194	204	PF00244	0.292
LIG_14-3-3_CanoR_1	224	228	PF00244	0.303
LIG_14-3-3_CanoR_1	245	250	PF00244	0.311
LIG_14-3-3_CanoR_1	309	317	PF00244	0.311
LIG_14-3-3_CanoR_1	31	39	PF00244	0.437
LIG_14-3-3_CanoR_1	457	466	PF00244	0.510
LIG_14-3-3_CanoR_1	47	51	PF00244	0.399
LIG_14-3-3_CanoR_1	488	494	PF00244	0.628
LIG_14-3-3_CanoR_1	709	713	PF00244	0.738
LIG_Actin_WH2_2	301	317	PF00022	0.311
LIG_APCC_ABBA_1	130	135	PF00400	0.311
LIG_APCC_ABBA_1	664	669	PF00400	0.681
LIG_BIR_II_1	1	5	PF00653	0.630
LIG_BIR_III_2	764	768	PF00653	0.481
LIG_BIR_III_4	531	535	PF00653	0.626
LIG_DLG_GKlike_1	596	604	PF00625	0.618
LIG_eIF4E_1	50	56	PF01652	0.422
LIG_FHA_1	165	171	PF00498	0.335
LIG_FHA_1	271	277	PF00498	0.335
LIG_FHA_1	28	34	PF00498	0.422
LIG_FHA_1	286	292	PF00498	0.304
LIG_FHA_1	309	315	PF00498	0.311
LIG_FHA_1	356	362	PF00498	0.561
LIG_FHA_1	406	412	PF00498	0.573
LIG_FHA_1	506	512	PF00498	0.434
LIG_FHA_1	563	569	PF00498	0.636
LIG_FHA_1	595	601	PF00498	0.718
LIG_FHA_1	658	664	PF00498	0.689
LIG_FHA_1	96	102	PF00498	0.311
LIG_FHA_2	169	175	PF00498	0.366
LIG_FHA_2	246	252	PF00498	0.310
LIG_FHA_2	32	38	PF00498	0.272
LIG_FHA_2	320	326	PF00498	0.633
LIG_FHA_2	456	462	PF00498	0.650
LIG_FHA_2	514	520	PF00498	0.554
LIG_KLC1_Yacidic_2	131	135	PF13176	0.455
LIG_LIR_Apic_2	435	440	PF02991	0.554
LIG_LIR_Gen_1	174	184	PF02991	0.308
LIG_LIR_Gen_1	263	274	PF02991	0.289
LIG_LIR_Nem_3	174	179	PF02991	0.289
LIG_LIR_Nem_3	263	269	PF02991	0.289
LIG_LIR_Nem_3	326	332	PF02991	0.465
LIG_LIR_Nem_3	431	437	PF02991	0.489
LIG_LIR_Nem_3	516	520	PF02991	0.400
LIG_LIR_Nem_3	84	90	PF02991	0.311
LIG_NRBOX	273	279	PF00104	0.311
LIG_Pex14_2	434	438	PF04695	0.505
LIG_SH2_GRB2like	266	269	PF00017	0.311
LIG_SH2_NCK_1	99	103	PF00017	0.409
LIG_SH2_SRC	133	136	PF00017	0.444
LIG_SH2_STAP1	310	314	PF00017	0.311
LIG_SH2_STAP1	430	434	PF00017	0.581
LIG_SH2_STAT5	133	136	PF00017	0.407
LIG_SH2_STAT5	266	269	PF00017	0.303
LIG_SH2_STAT5	281	284	PF00017	0.268
LIG_SH2_STAT5	310	313	PF00017	0.320
LIG_SH2_STAT5	433	436	PF00017	0.469
LIG_SH2_STAT5	437	440	PF00017	0.474
LIG_SH2_STAT5	447	450	PF00017	0.448
LIG_SH2_STAT5	513	516	PF00017	0.545
LIG_SH2_STAT5	545	548	PF00017	0.661
LIG_SH2_STAT5	99	102	PF00017	0.422
LIG_SH3_3	224	230	PF00018	0.422
LIG_SH3_3	389	395	PF00018	0.615
LIG_SH3_3	547	553	PF00018	0.529
LIG_SH3_3	709	715	PF00018	0.742
LIG_SH3_3	756	762	PF00018	0.691
LIG_SH3_3	76	82	PF00018	0.356
LIG_SH3_5	296	300	PF00018	0.455
LIG_SUMO_SIM_anti_2	271	278	PF11976	0.311
LIG_SUMO_SIM_par_1	157	163	PF11976	0.358
LIG_TRAF2_1	104	107	PF00917	0.378
LIG_TRAF2_1	666	669	PF00917	0.680
LIG_TRAF2_1	683	686	PF00917	0.738
LIG_UBA3_1	204	208	PF00899	0.311
LIG_WRC_WIRS_1	287	292	PF05994	0.422
LIG_WRC_WIRS_1	514	519	PF05994	0.323
LIG_WW_3	713	717	PF00397	0.767
MOD_CDC14_SPxK_1	706	709	PF00782	0.658
MOD_CDC14_SPxK_1	748	751	PF00782	0.643
MOD_CDK_SPxK_1	703	709	PF00069	0.767
MOD_CDK_SPxK_1	745	751	PF00069	0.652
MOD_CDK_SPxxK_3	391	398	PF00069	0.460
MOD_CK1_1	169	175	PF00069	0.349
MOD_CK1_1	186	192	PF00069	0.345
MOD_CK1_1	196	202	PF00069	0.243
MOD_CK1_1	22	28	PF00069	0.339
MOD_CK1_1	244	250	PF00069	0.309
MOD_CK1_1	286	292	PF00069	0.339
MOD_CK1_1	492	498	PF00069	0.643
MOD_CK1_1	599	605	PF00069	0.700
MOD_CK1_1	632	638	PF00069	0.625
MOD_CK1_1	639	645	PF00069	0.674
MOD_CK1_1	680	686	PF00069	0.664
MOD_CK1_1	708	714	PF00069	0.688
MOD_CK1_1	753	759	PF00069	0.727
MOD_CK1_1	95	101	PF00069	0.295
MOD_CK2_1	101	107	PF00069	0.326
MOD_CK2_1	168	174	PF00069	0.287
MOD_CK2_1	245	251	PF00069	0.310
MOD_CK2_1	46	52	PF00069	0.335
MOD_CK2_1	513	519	PF00069	0.501
MOD_CK2_1	524	530	PF00069	0.408
MOD_CK2_1	625	631	PF00069	0.769
MOD_CK2_1	680	686	PF00069	0.751
MOD_Cter_Amidation	45	48	PF01082	0.455
MOD_DYRK1A_RPxSP_1	75	79	PF00069	0.378
MOD_GlcNHglycan	296	299	PF01048	0.427
MOD_GlcNHglycan	328	332	PF01048	0.525
MOD_GlcNHglycan	389	392	PF01048	0.652
MOD_GlcNHglycan	448	451	PF01048	0.568
MOD_GlcNHglycan	526	529	PF01048	0.602
MOD_GlcNHglycan	547	550	PF01048	0.603
MOD_GlcNHglycan	636	639	PF01048	0.721
MOD_GlcNHglycan	643	646	PF01048	0.564
MOD_GlcNHglycan	670	676	PF01048	0.680
MOD_GlcNHglycan	692	695	PF01048	0.783
MOD_GlcNHglycan	752	755	PF01048	0.737
MOD_GlcNHglycan	94	97	PF01048	0.326
MOD_GSK3_1	15	22	PF00069	0.468
MOD_GSK3_1	164	171	PF00069	0.307
MOD_GSK3_1	182	189	PF00069	0.338
MOD_GSK3_1	219	226	PF00069	0.303
MOD_GSK3_1	235	242	PF00069	0.275
MOD_GSK3_1	27	34	PF00069	0.403
MOD_GSK3_1	304	311	PF00069	0.311
MOD_GSK3_1	351	358	PF00069	0.630
MOD_GSK3_1	387	394	PF00069	0.660
MOD_GSK3_1	446	453	PF00069	0.588
MOD_GSK3_1	520	527	PF00069	0.592
MOD_GSK3_1	594	601	PF00069	0.676
MOD_GSK3_1	625	632	PF00069	0.713
MOD_GSK3_1	636	643	PF00069	0.561
MOD_GSK3_1	658	665	PF00069	0.549
MOD_GSK3_1	673	680	PF00069	0.724
MOD_GSK3_1	703	710	PF00069	0.596
MOD_GSK3_1	745	752	PF00069	0.627
MOD_GSK3_1	91	98	PF00069	0.336
MOD_N-GLC_1	239	244	PF02516	0.295
MOD_N-GLC_1	355	360	PF02516	0.578
MOD_N-GLC_1	625	630	PF02516	0.778
MOD_N-GLC_2	21	23	PF02516	0.455
MOD_NEK2_1	269	274	PF00069	0.326
MOD_NEK2_1	308	313	PF00069	0.315
MOD_NEK2_1	372	377	PF00069	0.535
MOD_NEK2_1	474	479	PF00069	0.493
MOD_NEK2_1	489	494	PF00069	0.469
MOD_NEK2_1	600	605	PF00069	0.741
MOD_NEK2_2	203	208	PF00069	0.330
MOD_NEK2_2	513	518	PF00069	0.315
MOD_PIKK_1	308	314	PF00454	0.311
MOD_PIKK_1	505	511	PF00454	0.475
MOD_PIKK_1	734	740	PF00454	0.659
MOD_PKA_1	31	37	PF00069	0.164
MOD_PKA_2	186	192	PF00069	0.302
MOD_PKA_2	193	199	PF00069	0.291
MOD_PKA_2	223	229	PF00069	0.303
MOD_PKA_2	244	250	PF00069	0.321
MOD_PKA_2	269	275	PF00069	0.290
MOD_PKA_2	308	314	PF00069	0.311
MOD_PKA_2	31	37	PF00069	0.346
MOD_PKA_2	405	411	PF00069	0.612
MOD_PKA_2	46	52	PF00069	0.439
MOD_PKA_2	708	714	PF00069	0.789
MOD_PKA_2	750	756	PF00069	0.705
MOD_PKA_2	776	782	PF00069	0.698
MOD_PKB_1	11	19	PF00069	0.455
MOD_Plk_1	239	245	PF00069	0.295
MOD_Plk_1	270	276	PF00069	0.330
MOD_Plk_1	342	348	PF00069	0.575
MOD_Plk_1	372	378	PF00069	0.497
MOD_Plk_1	658	664	PF00069	0.568
MOD_Plk_2-3	629	635	PF00069	0.608
MOD_Plk_4	223	229	PF00069	0.418
MOD_Plk_4	245	251	PF00069	0.299
MOD_Plk_4	272	278	PF00069	0.333
MOD_Plk_4	286	292	PF00069	0.302
MOD_Plk_4	450	456	PF00069	0.623
MOD_Plk_4	474	480	PF00069	0.481
MOD_Plk_4	507	513	PF00069	0.336
MOD_Plk_4	553	559	PF00069	0.571
MOD_Plk_4	600	606	PF00069	0.666
MOD_ProDKin_1	226	232	PF00069	0.311
MOD_ProDKin_1	391	397	PF00069	0.607
MOD_ProDKin_1	594	600	PF00069	0.667
MOD_ProDKin_1	662	668	PF00069	0.648
MOD_ProDKin_1	703	709	PF00069	0.672
MOD_ProDKin_1	745	751	PF00069	0.624
MOD_ProDKin_1	75	81	PF00069	0.422
MOD_SUMO_for_1	568	571	PF00179	0.623
TRG_DiLeu_BaEn_1	336	341	PF01217	0.521
TRG_DiLeu_BaLyEn_6	547	552	PF01217	0.656
TRG_ENDOCYTIC_2	266	269	PF00928	0.311
TRG_ER_diArg_1	10	13	PF00400	0.321
TRG_ER_diArg_1	149	152	PF00400	0.322
TRG_ER_diArg_1	31	33	PF00400	0.183
TRG_ER_diArg_1	366	368	PF00400	0.596
TRG_ER_diArg_1	4	6	PF00400	0.447
TRG_ER_diArg_1	403	406	PF00400	0.581
TRG_ER_diArg_1	409	411	PF00400	0.543
TRG_ER_diArg_1	566	568	PF00400	0.650
TRG_ER_diArg_1	653	655	PF00400	0.620
TRG_ER_diArg_1	715	718	PF00400	0.744
TRG_ER_diArg_1	774	777	PF00400	0.803
TRG_NES_CRM1_1	342	355	PF08389	0.551
TRG_NLS_MonoExtC_3	772	777	PF00514	0.716
TRG_NLS_MonoExtN_4	313	319	PF00514	0.387
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	418	422	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	625	629	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	698	703	PF00026	0.697

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2F8	Leptomonas seymouri	58%	95%
A0A1X0P728	Trypanosomatidae	50%	90%
A0A3R7KGY3	Trypanosoma rangeli	49%	91%
A0A3S5H747	Leishmania donovani	91%	100%
A4H9R1	Leishmania braziliensis	79%	100%
A4HY30	Leishmania infantum	91%	100%
D0A556	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	92%
Q4QDM9	Leishmania major	90%	100%
Q9FZ06	Arabidopsis thaliana	25%	87%
V5D4P5	Trypanosoma cruzi	52%	100%