VASt domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ARU3_LEIMU

TriTrypDb:

LmxM.18.1590

Length:

213

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9ARU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARU3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	195	197	PF00675	0.426
CLV_PCSK_KEX2_1	14	16	PF00082	0.605
CLV_PCSK_KEX2_1	194	196	PF00082	0.441
CLV_PCSK_KEX2_1	39	41	PF00082	0.652
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.605
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.623
CLV_PCSK_SKI1_1	127	131	PF00082	0.539
CLV_PCSK_SKI1_1	196	200	PF00082	0.422
DOC_MAPK_gen_1	12	21	PF00069	0.338
DOC_MAPK_gen_1	39	47	PF00069	0.406
DOC_MAPK_gen_1	52	60	PF00069	0.290
DOC_PP1_RVXF_1	194	201	PF00149	0.624
DOC_PP4_FxxP_1	125	128	PF00568	0.374
DOC_USP7_MATH_1	153	157	PF00917	0.410
DOC_USP7_MATH_1	166	170	PF00917	0.463
DOC_USP7_MATH_1	75	79	PF00917	0.343
DOC_WW_Pin1_4	145	150	PF00397	0.425
LIG_14-3-3_CanoR_1	170	178	PF00244	0.277
LIG_14-3-3_CanoR_1	195	201	PF00244	0.623
LIG_14-3-3_CanoR_1	205	211	PF00244	0.635
LIG_ActinCP_TwfCPI_2	125	132	PF01115	0.269
LIG_BIR_III_2	146	150	PF00653	0.430
LIG_BRCT_BRCA1_1	56	60	PF00533	0.335
LIG_BRCT_BRCA1_2	56	62	PF00533	0.335
LIG_FHA_1	157	163	PF00498	0.482
LIG_FHA_1	61	67	PF00498	0.341
LIG_FHA_1	92	98	PF00498	0.396
LIG_FHA_2	104	110	PF00498	0.376
LIG_FHA_2	141	147	PF00498	0.398
LIG_LIR_Apic_2	122	128	PF02991	0.380
LIG_LIR_Gen_1	103	112	PF02991	0.317
LIG_LIR_Gen_1	179	188	PF02991	0.205
LIG_LIR_Gen_1	29	36	PF02991	0.229
LIG_LIR_Gen_1	78	87	PF02991	0.367
LIG_LIR_Nem_3	103	107	PF02991	0.306
LIG_LIR_Nem_3	179	184	PF02991	0.205
LIG_LIR_Nem_3	209	213	PF02991	0.693
LIG_LIR_Nem_3	29	35	PF02991	0.315
LIG_LIR_Nem_3	43	49	PF02991	0.292
LIG_LIR_Nem_3	61	67	PF02991	0.312
LIG_LIR_Nem_3	78	83	PF02991	0.325
LIG_PDZ_Class_1	208	213	PF00595	0.692
LIG_Pex14_2	125	129	PF04695	0.338
LIG_REV1ctd_RIR_1	127	136	PF16727	0.346
LIG_SH2_CRK	64	68	PF00017	0.297
LIG_SH2_CRK	86	90	PF00017	0.350
LIG_SH2_NCK_1	86	90	PF00017	0.380
LIG_SH2_PTP2	104	107	PF00017	0.308
LIG_SH2_STAT5	104	107	PF00017	0.310
LIG_TYR_ITIM	102	107	PF00017	0.304
LIG_Vh1_VBS_1	165	183	PF01044	0.198
MOD_CK1_1	148	154	PF00069	0.467
MOD_CK1_1	156	162	PF00069	0.456
MOD_CK1_1	169	175	PF00069	0.466
MOD_CK2_1	103	109	PF00069	0.312
MOD_CK2_1	158	164	PF00069	0.412
MOD_Cter_Amidation	12	15	PF01082	0.611
MOD_GlcNHglycan	172	175	PF01048	0.549
MOD_GlcNHglycan	201	204	PF01048	0.463
MOD_GSK3_1	165	172	PF00069	0.479
MOD_GSK3_1	199	206	PF00069	0.548
MOD_GSK3_1	54	61	PF00069	0.372
MOD_GSK3_1	91	98	PF00069	0.357
MOD_NEK2_1	165	170	PF00069	0.421
MOD_NEK2_1	28	33	PF00069	0.283
MOD_NEK2_1	60	65	PF00069	0.317
MOD_NEK2_1	7	12	PF00069	0.319
MOD_NEK2_2	203	208	PF00069	0.553
MOD_PK_1	54	60	PF00069	0.340
MOD_PKA_2	169	175	PF00069	0.445
MOD_PKB_1	194	202	PF00069	0.668
MOD_Plk_1	54	60	PF00069	0.340
MOD_Plk_2-3	103	109	PF00069	0.344
MOD_Plk_2-3	158	164	PF00069	0.396
MOD_Plk_4	176	182	PF00069	0.341
MOD_Plk_4	54	60	PF00069	0.340
MOD_Plk_4	75	81	PF00069	0.272
MOD_ProDKin_1	145	151	PF00069	0.429
TRG_DiLeu_BaEn_1	111	116	PF01217	0.326
TRG_ENDOCYTIC_2	104	107	PF00928	0.308
TRG_ENDOCYTIC_2	64	67	PF00928	0.297
TRG_ER_diArg_1	194	196	PF00400	0.699
TRG_ER_diArg_1	49	52	PF00400	0.295
TRG_NES_CRM1_1	43	55	PF08389	0.308
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I127	Leptomonas seymouri	61%	100%
A0A3S7WV60	Leishmania donovani	89%	100%
A4H9R0	Leishmania braziliensis	83%	100%
A4HY29	Leishmania infantum	89%	100%
Q4QDN0	Leishmania major	88%	100%