Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARU0_LEIMU

TriTrypDb:

LmxM.18.1560

Length:

563

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARU0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.594
CLV_NRD_NRD_1	177	179	PF00675	0.591
CLV_NRD_NRD_1	298	300	PF00675	0.604
CLV_NRD_NRD_1	31	33	PF00675	0.547
CLV_NRD_NRD_1	385	387	PF00675	0.421
CLV_NRD_NRD_1	499	501	PF00675	0.567
CLV_NRD_NRD_1	505	507	PF00675	0.561
CLV_NRD_NRD_1	561	563	PF00675	0.740
CLV_PCSK_FUR_1	296	300	PF00082	0.403
CLV_PCSK_FUR_1	559	563	PF00082	0.705
CLV_PCSK_KEX2_1	150	152	PF00082	0.552
CLV_PCSK_KEX2_1	176	178	PF00082	0.601
CLV_PCSK_KEX2_1	23	25	PF00082	0.491
CLV_PCSK_KEX2_1	298	300	PF00082	0.611
CLV_PCSK_KEX2_1	31	33	PF00082	0.592
CLV_PCSK_KEX2_1	385	387	PF00082	0.421
CLV_PCSK_KEX2_1	499	501	PF00082	0.567
CLV_PCSK_KEX2_1	561	563	PF00082	0.693
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.491
CLV_PCSK_SKI1_1	178	182	PF00082	0.599
CLV_PCSK_SKI1_1	317	321	PF00082	0.450
CLV_PCSK_SKI1_1	386	390	PF00082	0.510
CLV_PCSK_SKI1_1	39	43	PF00082	0.547
CLV_PCSK_SKI1_1	506	510	PF00082	0.523
DEG_APCC_DBOX_1	444	452	PF00400	0.417
DEG_MDM2_SWIB_1	526	533	PF02201	0.353
DOC_ANK_TNKS_1	31	38	PF00023	0.579
DOC_CYCLIN_RxL_1	85	96	PF00134	0.598
DOC_CYCLIN_yCln2_LP_2	12	18	PF00134	0.510
DOC_CYCLIN_yCln2_LP_2	452	458	PF00134	0.514
DOC_MAPK_gen_1	120	129	PF00069	0.530
DOC_MAPK_gen_1	296	306	PF00069	0.541
DOC_MAPK_gen_1	439	448	PF00069	0.412
DOC_MAPK_HePTP_8	438	450	PF00069	0.489
DOC_MAPK_MEF2A_6	123	131	PF00069	0.516
DOC_MAPK_MEF2A_6	298	306	PF00069	0.553
DOC_MAPK_MEF2A_6	362	370	PF00069	0.508
DOC_MAPK_MEF2A_6	441	450	PF00069	0.454
DOC_MAPK_MEF2A_6	81	89	PF00069	0.427
DOC_MAPK_NFAT4_5	445	453	PF00069	0.486
DOC_PP2B_LxvP_1	440	443	PF13499	0.346
DOC_USP7_MATH_1	294	298	PF00917	0.588
DOC_USP7_MATH_1	7	11	PF00917	0.511
DOC_USP7_UBL2_3	412	416	PF12436	0.459
DOC_WW_Pin1_4	153	158	PF00397	0.507
DOC_WW_Pin1_4	298	303	PF00397	0.547
DOC_WW_Pin1_4	312	317	PF00397	0.434
DOC_WW_Pin1_4	451	456	PF00397	0.418
LIG_14-3-3_CanoR_1	112	122	PF00244	0.668
LIG_14-3-3_CanoR_1	150	154	PF00244	0.548
LIG_14-3-3_CanoR_1	177	187	PF00244	0.514
LIG_14-3-3_CterR_2	559	563	PF00244	0.673
LIG_APCC_ABBA_1	159	164	PF00400	0.539
LIG_Clathr_ClatBox_1	194	198	PF01394	0.466
LIG_deltaCOP1_diTrp_1	189	196	PF00928	0.477
LIG_FHA_1	126	132	PF00498	0.527
LIG_FHA_1	137	143	PF00498	0.466
LIG_FHA_1	198	204	PF00498	0.495
LIG_FHA_1	264	270	PF00498	0.473
LIG_FHA_1	275	281	PF00498	0.313
LIG_FHA_1	478	484	PF00498	0.440
LIG_FHA_1	511	517	PF00498	0.347
LIG_FHA_1	542	548	PF00498	0.384
LIG_FHA_2	442	448	PF00498	0.469
LIG_FHA_2	65	71	PF00498	0.536
LIG_FHA_2	77	83	PF00498	0.482
LIG_LIR_Gen_1	189	197	PF02991	0.472
LIG_LIR_Gen_1	279	289	PF02991	0.232
LIG_LIR_Gen_1	434	443	PF02991	0.369
LIG_LIR_Gen_1	44	53	PF02991	0.442
LIG_LIR_Gen_1	520	531	PF02991	0.397
LIG_LIR_Nem_3	189	194	PF02991	0.587
LIG_LIR_Nem_3	254	258	PF02991	0.375
LIG_LIR_Nem_3	279	285	PF02991	0.225
LIG_LIR_Nem_3	336	342	PF02991	0.492
LIG_LIR_Nem_3	434	440	PF02991	0.363
LIG_LIR_Nem_3	44	48	PF02991	0.437
LIG_LIR_Nem_3	473	479	PF02991	0.282
LIG_LIR_Nem_3	520	526	PF02991	0.476
LIG_LYPXL_yS_3	255	258	PF13949	0.454
LIG_NBox_RRM_1	543	553	PF00076	0.465
LIG_NRBOX	239	245	PF00104	0.431
LIG_PCNA_yPIPBox_3	377	389	PF02747	0.538
LIG_Pex14_2	526	530	PF04695	0.349
LIG_Rb_pABgroove_1	462	470	PF01858	0.419
LIG_SH2_CRK	22	26	PF00017	0.398
LIG_SH2_CRK	27	31	PF00017	0.424
LIG_SH2_CRK	398	402	PF00017	0.503
LIG_SH2_SRC	52	55	PF00017	0.569
LIG_SH2_STAP1	512	516	PF00017	0.472
LIG_SH2_STAP1	523	527	PF00017	0.350
LIG_SH2_STAT5	214	217	PF00017	0.504
LIG_SH2_STAT5	232	235	PF00017	0.443
LIG_SH2_STAT5	321	324	PF00017	0.447
LIG_SH2_STAT5	341	344	PF00017	0.367
LIG_SH2_STAT5	364	367	PF00017	0.475
LIG_SH2_STAT5	512	515	PF00017	0.399
LIG_SH2_STAT5	52	55	PF00017	0.453
LIG_SH2_STAT5	528	531	PF00017	0.338
LIG_SH3_2	455	460	PF14604	0.555
LIG_SH3_3	155	161	PF00018	0.517
LIG_SH3_3	27	33	PF00018	0.492
LIG_SH3_3	407	413	PF00018	0.376
LIG_SH3_3	452	458	PF00018	0.546
LIG_SH3_3	68	74	PF00018	0.536
LIG_SH3_4	412	419	PF00018	0.238
LIG_SUMO_SIM_anti_2	444	450	PF11976	0.488
LIG_SUMO_SIM_par_1	126	133	PF11976	0.535
LIG_SUMO_SIM_par_1	163	171	PF11976	0.527
LIG_SUMO_SIM_par_1	264	273	PF11976	0.547
LIG_SUMO_SIM_par_1	428	434	PF11976	0.474
LIG_SUMO_SIM_par_1	447	454	PF11976	0.453
LIG_TRAF2_1	161	164	PF00917	0.534
LIG_TRAF2_1	216	219	PF00917	0.690
LIG_TRAF2_1	91	94	PF00917	0.527
LIG_TYR_ITIM	25	30	PF00017	0.489
LIG_UBA3_1	16	23	PF00899	0.427
LIG_WRC_WIRS_1	42	47	PF05994	0.558
MOD_CDK_SPK_2	312	317	PF00069	0.501
MOD_CK1_1	205	211	PF00069	0.460
MOD_CK1_1	44	50	PF00069	0.463
MOD_CK1_1	76	82	PF00069	0.450
MOD_CK2_1	157	163	PF00069	0.555
MOD_CK2_1	201	207	PF00069	0.396
MOD_CK2_1	281	287	PF00069	0.497
MOD_CK2_1	64	70	PF00069	0.463
MOD_CK2_1	76	82	PF00069	0.377
MOD_GlcNHglycan	398	401	PF01048	0.483
MOD_GlcNHglycan	427	430	PF01048	0.546
MOD_GlcNHglycan	533	536	PF01048	0.370
MOD_GlcNHglycan	9	12	PF01048	0.558
MOD_GlcNHglycan	93	99	PF01048	0.624
MOD_GSK3_1	136	143	PF00069	0.515
MOD_GSK3_1	145	152	PF00069	0.524
MOD_GSK3_1	153	160	PF00069	0.574
MOD_GSK3_1	197	204	PF00069	0.410
MOD_GSK3_1	281	288	PF00069	0.437
MOD_GSK3_1	294	301	PF00069	0.421
MOD_GSK3_1	321	328	PF00069	0.542
MOD_GSK3_1	364	371	PF00069	0.558
MOD_N-GLC_2	199	201	PF02516	0.497
MOD_NEK2_1	197	202	PF00069	0.447
MOD_NEK2_1	414	419	PF00069	0.311
MOD_PIKK_1	140	146	PF00454	0.540
MOD_PK_1	114	120	PF00069	0.592
MOD_PK_1	123	129	PF00069	0.397
MOD_PKA_1	343	349	PF00069	0.409
MOD_PKA_2	113	119	PF00069	0.717
MOD_PKA_2	149	155	PF00069	0.548
MOD_PKB_1	112	120	PF00069	0.714
MOD_PKB_1	176	184	PF00069	0.525
MOD_Plk_1	263	269	PF00069	0.546
MOD_Plk_2-3	345	351	PF00069	0.612
MOD_Plk_4	228	234	PF00069	0.541
MOD_Plk_4	281	287	PF00069	0.502
MOD_Plk_4	305	311	PF00069	0.488
MOD_Plk_4	368	374	PF00069	0.411
MOD_Plk_4	41	47	PF00069	0.488
MOD_Plk_4	73	79	PF00069	0.482
MOD_ProDKin_1	153	159	PF00069	0.504
MOD_ProDKin_1	298	304	PF00069	0.546
MOD_ProDKin_1	312	318	PF00069	0.434
MOD_ProDKin_1	451	457	PF00069	0.417
TRG_DiLeu_BaEn_1	207	212	PF01217	0.474
TRG_DiLeu_BaEn_1	254	259	PF01217	0.493
TRG_DiLeu_BaEn_1	82	87	PF01217	0.418
TRG_DiLeu_BaEn_2	191	197	PF01217	0.557
TRG_DiLeu_BaEn_4	333	339	PF01217	0.540
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.424
TRG_ENDOCYTIC_2	22	25	PF00928	0.401
TRG_ENDOCYTIC_2	255	258	PF00928	0.444
TRG_ENDOCYTIC_2	27	30	PF00928	0.403
TRG_ENDOCYTIC_2	339	342	PF00928	0.503
TRG_ENDOCYTIC_2	398	401	PF00928	0.453
TRG_ENDOCYTIC_2	523	526	PF00928	0.405
TRG_ER_diArg_1	149	151	PF00400	0.523
TRG_ER_diArg_1	176	178	PF00400	0.603
TRG_ER_diArg_1	296	299	PF00400	0.591
TRG_ER_diArg_1	30	32	PF00400	0.511
TRG_ER_diArg_1	384	386	PF00400	0.396
TRG_ER_diArg_1	498	500	PF00400	0.566
TRG_ER_diArg_1	559	562	PF00400	0.704
TRG_NES_CRM1_1	425	436	PF08389	0.525
TRG_Pf-PMV_PEXEL_1	298	303	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRD6	Leptomonas seymouri	56%	100%
A0A1X0P7Z6	Trypanosomatidae	30%	100%
A0A3R7M1T0	Trypanosoma rangeli	31%	100%
A0A3S7WV76	Leishmania donovani	93%	100%
D0A560	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AGQ6	Leishmania infantum	93%	100%
E9AI61	Leishmania braziliensis	78%	100%
Q4QDN3	Leishmania major	91%	100%
V5BDF3	Trypanosoma cruzi	31%	100%