BTB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ART9_LEIMU

TriTrypDb:

LmxM.18.1550

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ART9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ART9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.527
CLV_C14_Caspase3-7	19	23	PF00656	0.585
CLV_NRD_NRD_1	178	180	PF00675	0.545
CLV_NRD_NRD_1	204	206	PF00675	0.530
CLV_NRD_NRD_1	207	209	PF00675	0.518
CLV_NRD_NRD_1	250	252	PF00675	0.686
CLV_NRD_NRD_1	286	288	PF00675	0.488
CLV_NRD_NRD_1	345	347	PF00675	0.443
CLV_NRD_NRD_1	391	393	PF00675	0.663
CLV_NRD_NRD_1	9	11	PF00675	0.513
CLV_PCSK_FUR_1	205	209	PF00082	0.515
CLV_PCSK_KEX2_1	178	180	PF00082	0.545
CLV_PCSK_KEX2_1	204	206	PF00082	0.530
CLV_PCSK_KEX2_1	207	209	PF00082	0.518
CLV_PCSK_KEX2_1	250	252	PF00082	0.686
CLV_PCSK_KEX2_1	286	288	PF00082	0.468
CLV_PCSK_KEX2_1	345	347	PF00082	0.443
CLV_PCSK_KEX2_1	43	45	PF00082	0.593
CLV_PCSK_KEX2_1	9	11	PF00082	0.513
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.593
CLV_PCSK_SKI1_1	125	129	PF00082	0.399
CLV_PCSK_SKI1_1	168	172	PF00082	0.577
CLV_PCSK_SKI1_1	250	254	PF00082	0.758
CLV_PCSK_SKI1_1	379	383	PF00082	0.660
CLV_PCSK_SKI1_1	392	396	PF00082	0.448
CLV_PCSK_SKI1_1	43	47	PF00082	0.598
CLV_PCSK_SKI1_1	80	84	PF00082	0.512
DEG_SCF_FBW7_1	260	266	PF00400	0.536
DEG_SPOP_SBC_1	225	229	PF00917	0.440
DEG_SPOP_SBC_1	364	368	PF00917	0.632
DOC_CDC14_PxL_1	210	218	PF14671	0.612
DOC_CKS1_1	194	199	PF01111	0.362
DOC_CKS1_1	260	265	PF01111	0.535
DOC_CYCLIN_RxL_1	248	255	PF00134	0.665
DOC_MAPK_gen_1	286	293	PF00069	0.457
DOC_USP7_MATH_1	199	203	PF00917	0.372
DOC_USP7_MATH_1	221	225	PF00917	0.520
DOC_USP7_MATH_1	263	267	PF00917	0.758
DOC_USP7_MATH_1	363	367	PF00917	0.683
DOC_USP7_MATH_1	370	374	PF00917	0.602
DOC_USP7_MATH_1	4	8	PF00917	0.700
DOC_USP7_MATH_1	45	49	PF00917	0.306
DOC_USP7_MATH_1	97	101	PF00917	0.597
DOC_WW_Pin1_4	193	198	PF00397	0.346
DOC_WW_Pin1_4	244	249	PF00397	0.626
DOC_WW_Pin1_4	252	257	PF00397	0.575
DOC_WW_Pin1_4	259	264	PF00397	0.557
LIG_14-3-3_CanoR_1	125	131	PF00244	0.375
LIG_14-3-3_CanoR_1	168	174	PF00244	0.500
LIG_14-3-3_CanoR_1	286	293	PF00244	0.672
LIG_14-3-3_CanoR_1	300	309	PF00244	0.396
LIG_14-3-3_CanoR_1	44	53	PF00244	0.393
LIG_Actin_WH2_2	330	347	PF00022	0.431
LIG_Actin_WH2_2	403	420	PF00022	0.564
LIG_BIR_II_1	1	5	PF00653	0.787
LIG_BIR_III_1	1	5	PF00653	0.710
LIG_BIR_III_3	1	5	PF00653	0.710
LIG_FHA_1	169	175	PF00498	0.488
LIG_FHA_1	27	33	PF00498	0.363
LIG_FHA_1	286	292	PF00498	0.595
LIG_FHA_1	73	79	PF00498	0.551
LIG_FHA_2	156	162	PF00498	0.486
LIG_FHA_2	372	378	PF00498	0.678
LIG_LIR_Gen_1	158	167	PF02991	0.569
LIG_LIR_Gen_1	215	225	PF02991	0.308
LIG_LIR_Nem_3	102	108	PF02991	0.437
LIG_LIR_Nem_3	158	163	PF02991	0.560
LIG_LIR_Nem_3	203	209	PF02991	0.525
LIG_LIR_Nem_3	211	216	PF02991	0.509
LIG_LYPXL_yS_3	213	216	PF13949	0.599
LIG_NRBOX	182	188	PF00104	0.561
LIG_PDZ_Class_2	417	422	PF00595	0.679
LIG_Pex14_1	206	210	PF04695	0.607
LIG_Pex14_2	53	57	PF04695	0.507
LIG_REV1ctd_RIR_1	50	58	PF16727	0.450
LIG_SH2_CRK	160	164	PF00017	0.573
LIG_SH2_CRK	191	195	PF00017	0.411
LIG_SH2_STAP1	131	135	PF00017	0.439
LIG_SH2_STAP1	169	173	PF00017	0.492
LIG_SH2_STAT3	380	383	PF00017	0.636
LIG_SH2_STAT5	333	336	PF00017	0.473
LIG_SH2_STAT5	340	343	PF00017	0.487
LIG_SH2_STAT5	40	43	PF00017	0.461
LIG_SH2_STAT5	56	59	PF00017	0.294
LIG_SH3_3	191	197	PF00018	0.444
LIG_SH3_3	257	263	PF00018	0.661
LIG_WRC_WIRS_1	27	32	PF05994	0.307
MOD_CDC14_SPxK_1	247	250	PF00782	0.672
MOD_CDC14_SPxK_1	255	258	PF00782	0.684
MOD_CDK_SPxK_1	244	250	PF00069	0.677
MOD_CDK_SPxK_1	252	258	PF00069	0.664
MOD_CDK_SPxxK_3	244	251	PF00069	0.742
MOD_CK1_1	224	230	PF00069	0.592
MOD_CK1_1	265	271	PF00069	0.744
MOD_CK1_1	273	279	PF00069	0.546
MOD_CK1_1	72	78	PF00069	0.587
MOD_CK2_1	371	377	PF00069	0.678
MOD_GlcNHglycan	146	149	PF01048	0.512
MOD_GlcNHglycan	223	226	PF01048	0.619
MOD_GlcNHglycan	230	233	PF01048	0.538
MOD_GlcNHglycan	235	239	PF01048	0.485
MOD_GlcNHglycan	265	268	PF01048	0.766
MOD_GlcNHglycan	272	275	PF01048	0.669
MOD_GlcNHglycan	302	305	PF01048	0.633
MOD_GlcNHglycan	367	370	PF01048	0.632
MOD_GlcNHglycan	385	388	PF01048	0.468
MOD_GlcNHglycan	67	70	PF01048	0.660
MOD_GlcNHglycan	71	74	PF01048	0.638
MOD_GlcNHglycan	95	98	PF01048	0.505
MOD_GSK3_1	221	228	PF00069	0.527
MOD_GSK3_1	259	266	PF00069	0.766
MOD_GSK3_1	35	42	PF00069	0.380
MOD_GSK3_1	65	72	PF00069	0.690
MOD_GSK3_1	93	100	PF00069	0.480
MOD_LATS_1	142	148	PF00433	0.549
MOD_N-GLC_1	97	102	PF02516	0.368
MOD_NEK2_1	104	109	PF00069	0.399
MOD_NEK2_1	316	321	PF00069	0.501
MOD_NEK2_1	39	44	PF00069	0.468
MOD_NEK2_1	93	98	PF00069	0.508
MOD_NEK2_2	126	131	PF00069	0.541
MOD_NEK2_2	35	40	PF00069	0.443
MOD_NEK2_2	371	376	PF00069	0.554
MOD_NEK2_2	4	9	PF00069	0.491
MOD_PKA_1	392	398	PF00069	0.393
MOD_PKA_2	285	291	PF00069	0.671
MOD_PKA_2	383	389	PF00069	0.524
MOD_PKB_1	298	306	PF00069	0.633
MOD_Plk_1	4	10	PF00069	0.709
MOD_Plk_2-3	16	22	PF00069	0.600
MOD_Plk_4	126	132	PF00069	0.436
MOD_Plk_4	155	161	PF00069	0.474
MOD_Plk_4	16	22	PF00069	0.529
MOD_Plk_4	169	175	PF00069	0.484
MOD_Plk_4	26	32	PF00069	0.415
MOD_Plk_4	35	41	PF00069	0.444
MOD_Plk_4	73	79	PF00069	0.548
MOD_ProDKin_1	193	199	PF00069	0.355
MOD_ProDKin_1	244	250	PF00069	0.624
MOD_ProDKin_1	252	258	PF00069	0.579
MOD_ProDKin_1	259	265	PF00069	0.560
MOD_SUMO_for_1	135	138	PF00179	0.468
MOD_SUMO_rev_2	386	395	PF00179	0.663
TRG_ENDOCYTIC_2	160	163	PF00928	0.562
TRG_ENDOCYTIC_2	191	194	PF00928	0.517
TRG_ENDOCYTIC_2	213	216	PF00928	0.599
TRG_ER_diArg_1	204	206	PF00400	0.530
TRG_ER_diArg_1	207	209	PF00400	0.518
TRG_ER_diArg_1	249	251	PF00400	0.674
TRG_ER_diArg_1	285	287	PF00400	0.586
TRG_ER_diArg_1	297	300	PF00400	0.537
TRG_ER_diArg_1	344	346	PF00400	0.443
TRG_ER_diArg_1	8	10	PF00400	0.540
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZP2	Leptomonas seymouri	45%	100%
A0A3S7WV66	Leishmania donovani	86%	100%
A4H9Q7	Leishmania braziliensis	68%	100%
A4HY26	Leishmania infantum	86%	100%
Q4QDN4	Leishmania major	85%	99%