UAA transporter family-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UAA transporter family, putative

Species:

Leishmania mexicana

UniProt:

E9ART8_LEIMU

TriTrypDb:

LmxM.18.1540

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9ART8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ART8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0009987	cellular process	1	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0055085	transmembrane transport	2	10
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0022857	transmembrane transporter activity	2	1
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.430
CLV_NRD_NRD_1	207	209	PF00675	0.227
CLV_NRD_NRD_1	298	300	PF00675	0.235
CLV_NRD_NRD_1	74	76	PF00675	0.295
CLV_PCSK_KEX2_1	131	133	PF00082	0.211
CLV_PCSK_KEX2_1	157	159	PF00082	0.467
CLV_PCSK_KEX2_1	207	209	PF00082	0.176
CLV_PCSK_KEX2_1	74	76	PF00082	0.304
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.224
CLV_PCSK_SKI1_1	131	135	PF00082	0.323
CLV_PCSK_SKI1_1	83	87	PF00082	0.332
DOC_CDC14_PxL_1	46	54	PF14671	0.380
DOC_CYCLIN_yCln2_LP_2	245	251	PF00134	0.317
DOC_MAPK_gen_1	74	80	PF00069	0.467
DOC_MAPK_gen_1	81	88	PF00069	0.482
DOC_MAPK_MEF2A_6	114	122	PF00069	0.235
DOC_MAPK_MEF2A_6	81	88	PF00069	0.500
DOC_MAPK_NFAT4_5	81	89	PF00069	0.445
DOC_PP4_FxxP_1	133	136	PF00568	0.504
DOC_PP4_FxxP_1	239	242	PF00568	0.360
DOC_PP4_FxxP_1	47	50	PF00568	0.297
DOC_PP4_FxxP_1	55	58	PF00568	0.393
DOC_PP4_FxxP_1	76	79	PF00568	0.335
DOC_SPAK_OSR1_1	75	79	PF12202	0.395
DOC_USP7_MATH_1	172	176	PF00917	0.245
DOC_USP7_MATH_1	218	222	PF00917	0.437
DOC_WW_Pin1_4	173	178	PF00397	0.317
DOC_WW_Pin1_4	26	31	PF00397	0.224
LIG_14-3-3_CanoR_1	114	119	PF00244	0.268
LIG_14-3-3_CanoR_1	132	136	PF00244	0.358
LIG_14-3-3_CanoR_1	250	258	PF00244	0.279
LIG_14-3-3_CanoR_1	299	305	PF00244	0.270
LIG_14-3-3_CanoR_1	315	323	PF00244	0.163
LIG_APCC_ABBA_1	198	203	PF00400	0.268
LIG_BIR_II_1	1	5	PF00653	0.499
LIG_BIR_III_1	1	5	PF00653	0.438
LIG_BIR_III_2	224	228	PF00653	0.445
LIG_BIR_III_3	1	5	PF00653	0.438
LIG_BRCT_BRCA1_1	235	239	PF00533	0.400
LIG_deltaCOP1_diTrp_1	72	76	PF00928	0.335
LIG_eIF4E_1	41	47	PF01652	0.328
LIG_FHA_1	193	199	PF00498	0.301
LIG_FHA_1	289	295	PF00498	0.191
LIG_FHA_1	46	52	PF00498	0.386
LIG_HCF-1_HBM_1	203	206	PF13415	0.504
LIG_LIR_Apic_2	236	242	PF02991	0.403
LIG_LIR_Gen_1	253	260	PF02991	0.229
LIG_LIR_Gen_1	321	330	PF02991	0.227
LIG_LIR_Nem_3	253	258	PF02991	0.249
LIG_LIR_Nem_3	32	36	PF02991	0.268
LIG_LIR_Nem_3	333	338	PF02991	0.326
LIG_LIR_Nem_3	72	76	PF02991	0.492
LIG_LYPXL_yS_3	335	338	PF13949	0.249
LIG_Pex14_2	129	133	PF04695	0.445
LIG_Pex14_2	235	239	PF04695	0.443
LIG_REV1ctd_RIR_1	125	135	PF16727	0.251
LIG_SH2_CRK	82	86	PF00017	0.297
LIG_SH2_PTP2	41	44	PF00017	0.249
LIG_SH2_STAT5	126	129	PF00017	0.213
LIG_SH2_STAT5	310	313	PF00017	0.235
LIG_SH2_STAT5	41	44	PF00017	0.255
LIG_SH3_3	333	339	PF00018	0.252
LIG_SUMO_SIM_anti_2	140	145	PF11976	0.143
LIG_SUMO_SIM_par_1	147	152	PF11976	0.295
LIG_SUMO_SIM_par_1	290	295	PF11976	0.251
LIG_TRFH_1	244	248	PF08558	0.293
LIG_TYR_ITIM	80	85	PF00017	0.445
LIG_UBA3_1	148	155	PF00899	0.293
LIG_WRC_WIRS_1	301	306	PF05994	0.268
MOD_CK1_1	175	181	PF00069	0.288
MOD_CK1_1	288	294	PF00069	0.406
MOD_CK1_1	29	35	PF00069	0.230
MOD_CK1_1	352	358	PF00069	0.610
MOD_CK2_1	315	321	PF00069	0.237
MOD_Cter_Amidation	129	132	PF01082	0.245
MOD_GlcNHglycan	160	163	PF01048	0.489
MOD_GlcNHglycan	287	290	PF01048	0.211
MOD_GlcNHglycan	317	320	PF01048	0.241
MOD_GlcNHglycan	345	348	PF01048	0.443
MOD_GlcNHglycan	350	354	PF01048	0.444
MOD_GSK3_1	109	116	PF00069	0.236
MOD_GSK3_1	188	195	PF00069	0.249
MOD_GSK3_1	284	291	PF00069	0.406
MOD_GSK3_1	300	307	PF00069	0.245
MOD_LATS_1	313	319	PF00433	0.224
MOD_N-GLC_1	343	348	PF02516	0.328
MOD_NEK2_1	103	108	PF00069	0.269
MOD_NEK2_1	109	114	PF00069	0.347
MOD_NEK2_1	188	193	PF00069	0.246
MOD_NEK2_1	233	238	PF00069	0.249
MOD_NEK2_1	24	29	PF00069	0.311
MOD_NEK2_1	290	295	PF00069	0.253
MOD_NEK2_1	304	309	PF00069	0.207
MOD_NEK2_1	330	335	PF00069	0.383
MOD_NEK2_2	7	12	PF00069	0.328
MOD_PIKK_1	269	275	PF00454	0.218
MOD_PKA_1	131	137	PF00069	0.411
MOD_PKA_1	157	163	PF00069	0.306
MOD_PKA_2	113	119	PF00069	0.270
MOD_PKA_2	131	137	PF00069	0.358
MOD_PKA_2	156	162	PF00069	0.272
MOD_Plk_1	62	68	PF00069	0.491
MOD_Plk_4	114	120	PF00069	0.247
MOD_Plk_4	137	143	PF00069	0.257
MOD_Plk_4	175	181	PF00069	0.260
MOD_Plk_4	29	35	PF00069	0.203
MOD_Plk_4	300	306	PF00069	0.292
MOD_Plk_4	7	13	PF00069	0.328
MOD_ProDKin_1	173	179	PF00069	0.317
MOD_ProDKin_1	26	32	PF00069	0.224
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.335
TRG_ENDOCYTIC_2	126	129	PF00928	0.225
TRG_ENDOCYTIC_2	314	317	PF00928	0.211
TRG_ENDOCYTIC_2	33	36	PF00928	0.293
TRG_ENDOCYTIC_2	335	338	PF00928	0.235
TRG_ENDOCYTIC_2	41	44	PF00928	0.210
TRG_ENDOCYTIC_2	82	85	PF00928	0.297
TRG_ER_diArg_1	206	208	PF00400	0.393
TRG_ER_diArg_1	73	75	PF00400	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT61	Leptomonas seymouri	59%	96%
A0A0S4JTD4	Bodo saltans	33%	98%
A0A1X0P7E5	Trypanosomatidae	45%	92%
A0A3Q8IJU2	Leishmania donovani	90%	100%
A0A3R7KQ47	Trypanosoma rangeli	52%	100%
A4HY25	Leishmania infantum	90%	100%
D0A561	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
O74750	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
P40004	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q00974	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	28%	100%
Q4QDN5	Leishmania major	87%	100%
Q5R8M3	Pongo abelii	26%	100%
Q7ZW46	Danio rerio	25%	100%
Q869W7	Dictyostelium discoideum	25%	100%
Q8CIA5	Mus musculus	26%	100%
Q95KB4	Macaca fascicularis	25%	100%
Q969S0	Homo sapiens	26%	100%
Q9W429	Drosophila melanogaster	28%	100%
V5B4B4	Trypanosoma cruzi	52%	100%