Putative P-type H+-ATPase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

P-type H+-ATPase, putative

Species:

Leishmania mexicana

UniProt:

E9ART5_LEIMU

TriTrypDb:

LmxM.18.1510

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ART5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ART5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017076	purine nucleotide binding	4	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	403	407	PF00656	0.587
CLV_NRD_NRD_1	225	227	PF00675	0.477
CLV_NRD_NRD_1	302	304	PF00675	0.477
CLV_NRD_NRD_1	53	55	PF00675	0.477
CLV_PCSK_KEX2_1	216	218	PF00082	0.477
CLV_PCSK_KEX2_1	225	227	PF00082	0.365
CLV_PCSK_KEX2_1	302	304	PF00082	0.477
CLV_PCSK_KEX2_1	53	55	PF00082	0.477
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.477
CLV_PCSK_SKI1_1	184	188	PF00082	0.477
CLV_PCSK_SKI1_1	312	316	PF00082	0.477
CLV_PCSK_SKI1_1	346	350	PF00082	0.526
CLV_PCSK_SKI1_1	54	58	PF00082	0.477
CLV_PCSK_SKI1_1	83	87	PF00082	0.477
CLV_Separin_Metazoa	181	185	PF03568	0.677
DEG_APCC_DBOX_1	183	191	PF00400	0.677
DEG_SPOP_SBC_1	104	108	PF00917	0.677
DOC_ANK_TNKS_1	14	21	PF00023	0.677
DOC_CYCLIN_RxL_1	323	332	PF00134	0.677
DOC_MAPK_gen_1	302	311	PF00069	0.677
DOC_MAPK_MEF2A_6	235	244	PF00069	0.677
DOC_MAPK_MEF2A_6	305	313	PF00069	0.677
DOC_MAPK_MEF2A_6	346	355	PF00069	0.726
DOC_MAPK_MEF2A_6	422	430	PF00069	0.477
DOC_PP1_RVXF_1	51	58	PF00149	0.677
DOC_PP2B_LxvP_1	290	293	PF13499	0.677
DOC_PP4_FxxP_1	289	292	PF00568	0.677
DOC_USP7_MATH_1	110	114	PF00917	0.677
DOC_USP7_MATH_1	462	466	PF00917	0.853
DOC_USP7_MATH_1	487	491	PF00917	0.888
DOC_USP7_UBL2_3	114	118	PF12436	0.677
DOC_USP7_UBL2_3	274	278	PF12436	0.677
DOC_USP7_UBL2_3	485	489	PF12436	0.894
DOC_WW_Pin1_4	376	381	PF00397	0.760
DOC_WW_Pin1_4	513	518	PF00397	0.884
DOC_WW_Pin1_4	519	524	PF00397	0.811
LIG_14-3-3_CanoR_1	217	223	PF00244	0.677
LIG_14-3-3_CanoR_1	268	273	PF00244	0.677
LIG_14-3-3_CanoR_1	54	60	PF00244	0.677
LIG_Actin_WH2_2	38	55	PF00022	0.677
LIG_APCC_ABBA_1	468	473	PF00400	0.879
LIG_BRCT_BRCA1_1	26	30	PF00533	0.677
LIG_EH1_1	238	246	PF00400	0.677
LIG_EH1_1	87	95	PF00400	0.677
LIG_FHA_1	104	110	PF00498	0.677
LIG_FHA_1	141	147	PF00498	0.677
LIG_FHA_1	167	173	PF00498	0.677
LIG_FHA_1	187	193	PF00498	0.427
LIG_FHA_1	23	29	PF00498	0.677
LIG_FHA_1	32	38	PF00498	0.565
LIG_FHA_1	408	414	PF00498	0.547
LIG_FHA_2	157	163	PF00498	0.677
LIG_FHA_2	286	292	PF00498	0.677
LIG_FHA_2	416	422	PF00498	0.578
LIG_IRF3_LxIS_1	351	356	PF10401	0.723
LIG_LIR_Apic_2	288	292	PF02991	0.677
LIG_LIR_Gen_1	201	211	PF02991	0.677
LIG_LIR_Gen_1	349	360	PF02991	0.722
LIG_LIR_Nem_3	201	206	PF02991	0.677
LIG_LIR_Nem_3	349	355	PF02991	0.724
LIG_LIR_Nem_3	358	363	PF02991	0.619
LIG_LIR_Nem_3	454	459	PF02991	0.810
LIG_NBox_RRM_1	82	92	PF00076	0.677
LIG_PAM2_1	55	67	PF00658	0.677
LIG_PCNA_PIPBox_1	283	292	PF02747	0.677
LIG_PCNA_yPIPBox_3	344	354	PF02747	0.729
LIG_Pex14_1	427	431	PF04695	0.577
LIG_Pex14_2	360	364	PF04695	0.726
LIG_Pex14_2	78	82	PF04695	0.677
LIG_REV1ctd_RIR_1	28	37	PF16727	0.677
LIG_SH2_CRK	203	207	PF00017	0.677
LIG_SH2_STAT5	24	27	PF00017	0.677
LIG_SH2_STAT5	352	355	PF00017	0.723
LIG_SH2_STAT5	431	434	PF00017	0.577
LIG_SH2_STAT5	527	530	PF00017	0.878
LIG_SH2_STAT5	73	76	PF00017	0.677
LIG_SH3_3	207	213	PF00018	0.677
LIG_SH3_3	289	295	PF00018	0.677
LIG_SH3_3	464	470	PF00018	0.867
LIG_SH3_3	480	486	PF00018	0.696
LIG_SH3_3	92	98	PF00018	0.677
LIG_SH3_4	485	492	PF00018	0.892
LIG_SUMO_SIM_anti_2	253	260	PF11976	0.677
LIG_SUMO_SIM_par_1	106	113	PF11976	0.477
LIG_SUMO_SIM_par_1	253	260	PF11976	0.677
LIG_SUMO_SIM_par_1	90	96	PF11976	0.677
LIG_SUMO_SIM_par_1	97	102	PF11976	0.590
LIG_TRAF2_1	159	162	PF00917	0.677
LIG_TRAF2_1	517	520	PF00917	0.883
LIG_UBA3_1	350	354	PF00899	0.645
LIG_WRC_WIRS_1	286	291	PF05994	0.577
LIG_WRC_WIRS_1	79	84	PF05994	0.577
LIG_WW_3	181	185	PF00397	0.577
LIG_WW_3	291	295	PF00397	0.577
MOD_CK1_1	140	146	PF00069	0.577
MOD_CK1_1	365	371	PF00069	0.675
MOD_CK1_1	40	46	PF00069	0.577
MOD_CK1_1	460	466	PF00069	0.818
MOD_CK1_1	498	504	PF00069	0.862
MOD_CK2_1	124	130	PF00069	0.661
MOD_CK2_1	156	162	PF00069	0.577
MOD_CK2_1	415	421	PF00069	0.718
MOD_CK2_1	513	519	PF00069	0.868
MOD_GlcNHglycan	126	129	PF01048	0.650
MOD_GlcNHglycan	132	135	PF01048	0.578
MOD_GlcNHglycan	461	465	PF01048	0.821
MOD_GlcNHglycan	500	503	PF01048	0.859
MOD_GSK3_1	110	117	PF00069	0.577
MOD_GSK3_1	140	147	PF00069	0.577
MOD_GSK3_1	18	25	PF00069	0.577
MOD_GSK3_1	211	218	PF00069	0.577
MOD_GSK3_1	268	275	PF00069	0.577
MOD_GSK3_1	297	304	PF00069	0.577
MOD_GSK3_1	355	362	PF00069	0.639
MOD_GSK3_1	386	393	PF00069	0.577
MOD_GSK3_1	487	494	PF00069	0.874
MOD_N-GLC_1	495	500	PF02516	0.871
MOD_NEK2_1	166	171	PF00069	0.577
MOD_NEK2_1	231	236	PF00069	0.577
MOD_NEK2_1	31	36	PF00069	0.577
MOD_NEK2_1	353	358	PF00069	0.626
MOD_NEK2_1	363	368	PF00069	0.482
MOD_NEK2_1	390	395	PF00069	0.577
MOD_NEK2_1	495	500	PF00069	0.871
MOD_NEK2_1	78	83	PF00069	0.577
MOD_NEK2_1	93	98	PF00069	0.315
MOD_NEK2_2	26	31	PF00069	0.577
MOD_PK_1	268	274	PF00069	0.577
MOD_PKA_2	224	230	PF00069	0.577
MOD_PKA_2	301	307	PF00069	0.577
MOD_Plk_1	491	497	PF00069	0.876
MOD_Plk_4	166	172	PF00069	0.577
MOD_Plk_4	186	192	PF00069	0.227
MOD_Plk_4	218	224	PF00069	0.577
MOD_Plk_4	26	32	PF00069	0.577
MOD_Plk_4	285	291	PF00069	0.577
MOD_Plk_4	346	352	PF00069	0.651
MOD_Plk_4	359	365	PF00069	0.419
MOD_Plk_4	395	401	PF00069	0.577
MOD_ProDKin_1	376	382	PF00069	0.688
MOD_ProDKin_1	513	519	PF00069	0.868
MOD_SUMO_rev_2	161	169	PF00179	0.577
MOD_SUMO_rev_2	291	300	PF00179	0.577
MOD_SUMO_rev_2	304	314	PF00179	0.350
TRG_DiLeu_BaEn_4	161	167	PF01217	0.577
TRG_DiLeu_BaLyEn_6	419	424	PF01217	0.692
TRG_ENDOCYTIC_2	203	206	PF00928	0.577
TRG_ENDOCYTIC_2	352	355	PF00928	0.641
TRG_ENDOCYTIC_2	431	434	PF00928	0.577
TRG_ENDOCYTIC_2	79	82	PF00928	0.577
TRG_ER_diArg_1	301	303	PF00400	0.577
TRG_ER_diArg_1	52	54	PF00400	0.577
TRG_Pf-PMV_PEXEL_1	327	332	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
P05425	Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R)	22%	72%