Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ART0_LEIMU

TriTrypDb:

LmxM.18.1460

Length:

906

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005858	axonemal dynein complex	4	1
GO:0005875	microtubule associated complex	2	2
GO:0005929	cilium	4	2
GO:0030286	dynein complex	3	2
GO:0030990	intraciliary transport particle	2	1
GO:0032991	protein-containing complex	1	2
GO:0036064	ciliary basal body	3	1
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2
GO:1902494	catalytic complex	2	2
GO:0005840	ribosome	5	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9ART0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ART0

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	1
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2
GO:0006810	transport	3	1
GO:0010970	transport along microtubule	4	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0042073	intraciliary transport	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0099111	microtubule-based transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045503	dynein light chain binding	3	2
GO:0045504	dynein heavy chain binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.554
CLV_C14_Caspase3-7	223	227	PF00656	0.727
CLV_C14_Caspase3-7	309	313	PF00656	0.647
CLV_C14_Caspase3-7	356	360	PF00656	0.673
CLV_C14_Caspase3-7	380	384	PF00656	0.715
CLV_C14_Caspase3-7	689	693	PF00656	0.646
CLV_NRD_NRD_1	121	123	PF00675	0.641
CLV_NRD_NRD_1	15	17	PF00675	0.494
CLV_NRD_NRD_1	189	191	PF00675	0.482
CLV_NRD_NRD_1	19	21	PF00675	0.500
CLV_NRD_NRD_1	198	200	PF00675	0.481
CLV_NRD_NRD_1	202	204	PF00675	0.472
CLV_NRD_NRD_1	264	266	PF00675	0.462
CLV_NRD_NRD_1	350	352	PF00675	0.591
CLV_NRD_NRD_1	605	607	PF00675	0.522
CLV_NRD_NRD_1	77	79	PF00675	0.523
CLV_NRD_NRD_1	8	10	PF00675	0.493
CLV_NRD_NRD_1	84	86	PF00675	0.536
CLV_NRD_NRD_1	840	842	PF00675	0.563
CLV_PCSK_KEX2_1	121	123	PF00082	0.620
CLV_PCSK_KEX2_1	14	16	PF00082	0.531
CLV_PCSK_KEX2_1	170	172	PF00082	0.550
CLV_PCSK_KEX2_1	191	193	PF00082	0.483
CLV_PCSK_KEX2_1	198	200	PF00082	0.420
CLV_PCSK_KEX2_1	202	204	PF00082	0.475
CLV_PCSK_KEX2_1	264	266	PF00082	0.462
CLV_PCSK_KEX2_1	349	351	PF00082	0.602
CLV_PCSK_KEX2_1	631	633	PF00082	0.539
CLV_PCSK_KEX2_1	77	79	PF00082	0.549
CLV_PCSK_KEX2_1	8	10	PF00082	0.516
CLV_PCSK_KEX2_1	83	85	PF00082	0.589
CLV_PCSK_KEX2_1	840	842	PF00082	0.563
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.581
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.618
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.606
CLV_PCSK_PC1ET2_1	631	633	PF00082	0.539
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.594
CLV_PCSK_PC7_1	11	17	PF00082	0.618
CLV_PCSK_PC7_1	187	193	PF00082	0.484
CLV_PCSK_PC7_1	198	204	PF00082	0.441
CLV_PCSK_PC7_1	80	86	PF00082	0.639
CLV_PCSK_SKI1_1	122	126	PF00082	0.529
CLV_PCSK_SKI1_1	170	174	PF00082	0.391
CLV_PCSK_SKI1_1	198	202	PF00082	0.616
CLV_PCSK_SKI1_1	343	347	PF00082	0.597
CLV_PCSK_SKI1_1	350	354	PF00082	0.595
CLV_PCSK_SKI1_1	410	414	PF00082	0.458
CLV_PCSK_SKI1_1	468	472	PF00082	0.258
CLV_PCSK_SKI1_1	569	573	PF00082	0.395
CLV_PCSK_SKI1_1	668	672	PF00082	0.402
DEG_APCC_DBOX_1	229	237	PF00400	0.578
DEG_APCC_DBOX_1	467	475	PF00400	0.252
DEG_SCF_FBW7_1	39	46	PF00400	0.483
DEG_SPOP_SBC_1	452	456	PF00917	0.502
DEG_SPOP_SBC_1	52	56	PF00917	0.487
DOC_CKS1_1	514	519	PF01111	0.291
DOC_CYCLIN_RxL_1	348	356	PF00134	0.353
DOC_MAPK_gen_1	463	473	PF00069	0.391
DOC_MAPK_MEF2A_6	466	475	PF00069	0.383
DOC_PP1_RVXF_1	263	270	PF00149	0.556
DOC_USP7_MATH_1	34	38	PF00917	0.704
DOC_USP7_MATH_1	447	451	PF00917	0.552
DOC_USP7_MATH_1	452	456	PF00917	0.441
DOC_USP7_MATH_1	678	682	PF00917	0.614
DOC_USP7_MATH_1	709	713	PF00917	0.464
DOC_USP7_MATH_1	733	737	PF00917	0.373
DOC_WW_Pin1_4	108	113	PF00397	0.648
DOC_WW_Pin1_4	231	236	PF00397	0.658
DOC_WW_Pin1_4	35	40	PF00397	0.705
DOC_WW_Pin1_4	493	498	PF00397	0.444
DOC_WW_Pin1_4	513	518	PF00397	0.374
DOC_WW_Pin1_4	530	535	PF00397	0.354
DOC_WW_Pin1_4	638	643	PF00397	0.547
DOC_WW_Pin1_4	716	721	PF00397	0.470
DOC_WW_Pin1_4	731	736	PF00397	0.560
DOC_WW_Pin1_4	794	799	PF00397	0.444
LIG_14-3-3_CanoR_1	171	179	PF00244	0.550
LIG_14-3-3_CanoR_1	230	234	PF00244	0.450
LIG_14-3-3_CanoR_1	259	267	PF00244	0.448
LIG_14-3-3_CanoR_1	466	471	PF00244	0.227
LIG_14-3-3_CanoR_1	519	527	PF00244	0.440
LIG_14-3-3_CanoR_1	559	567	PF00244	0.361
LIG_14-3-3_CanoR_1	845	853	PF00244	0.505
LIG_14-3-3_CanoR_1	895	905	PF00244	0.531
LIG_Actin_WH2_2	341	357	PF00022	0.533
LIG_Actin_WH2_2	879	897	PF00022	0.522
LIG_AP2alpha_2	633	635	PF02296	0.426
LIG_BIR_III_4	226	230	PF00653	0.594
LIG_BRCT_BRCA1_1	160	164	PF00533	0.585
LIG_BRCT_BRCA1_1	449	453	PF00533	0.447
LIG_Clathr_ClatBox_1	614	618	PF01394	0.296
LIG_FHA_1	398	404	PF00498	0.603
LIG_FHA_1	411	417	PF00498	0.406
LIG_FHA_1	585	591	PF00498	0.507
LIG_FHA_1	598	604	PF00498	0.543
LIG_FHA_1	711	717	PF00498	0.463
LIG_FHA_1	760	766	PF00498	0.439
LIG_FHA_1	785	791	PF00498	0.432
LIG_FHA_1	795	801	PF00498	0.409
LIG_FHA_2	115	121	PF00498	0.468
LIG_FHA_2	235	241	PF00498	0.662
LIG_FHA_2	30	36	PF00498	0.764
LIG_FHA_2	313	319	PF00498	0.629
LIG_FHA_2	364	370	PF00498	0.539
LIG_FHA_2	513	519	PF00498	0.371
LIG_FHA_2	603	609	PF00498	0.583
LIG_FHA_2	71	77	PF00498	0.521
LIG_FHA_2	84	90	PF00498	0.503
LIG_FHA_2	849	855	PF00498	0.479
LIG_FHA_2	857	863	PF00498	0.329
LIG_LIR_Gen_1	500	508	PF02991	0.312
LIG_LIR_Gen_1	608	617	PF02991	0.575
LIG_LIR_Nem_3	283	288	PF02991	0.450
LIG_LIR_Nem_3	342	348	PF02991	0.598
LIG_LIR_Nem_3	500	505	PF02991	0.351
LIG_LIR_Nem_3	608	614	PF02991	0.613
LIG_LIR_Nem_3	775	781	PF02991	0.383
LIG_NRBOX	502	508	PF00104	0.360
LIG_PCNA_yPIPBox_3	463	474	PF02747	0.403
LIG_PDZ_Wminus1_1	904	906	PF00595	0.380
LIG_PTAP_UEV_1	58	63	PF05743	0.526
LIG_REV1ctd_RIR_1	343	354	PF16727	0.597
LIG_SH2_SRC	783	786	PF00017	0.355
LIG_SH2_STAP1	285	289	PF00017	0.430
LIG_SH2_STAP1	567	571	PF00017	0.475
LIG_SH2_STAP1	611	615	PF00017	0.466
LIG_SH2_STAT3	249	252	PF00017	0.437
LIG_SH2_STAT5	288	291	PF00017	0.449
LIG_SH2_STAT5	715	718	PF00017	0.209
LIG_SH2_STAT5	791	794	PF00017	0.388
LIG_SH3_3	299	305	PF00018	0.515
LIG_SH3_3	474	480	PF00018	0.404
LIG_SH3_3	511	517	PF00018	0.310
LIG_SH3_3	531	537	PF00018	0.327
LIG_SH3_3	56	62	PF00018	0.657
LIG_SH3_3	760	766	PF00018	0.466
LIG_SUMO_SIM_anti_2	415	420	PF11976	0.420
LIG_SUMO_SIM_anti_2	500	507	PF11976	0.317
LIG_SUMO_SIM_anti_2	859	865	PF11976	0.460
LIG_SUMO_SIM_par_1	504	510	PF11976	0.389
LIG_TRAF2_1	117	120	PF00917	0.631
LIG_TRAF2_1	183	186	PF00917	0.525
LIG_TRAF2_1	305	308	PF00917	0.522
LIG_TRAF2_1	337	340	PF00917	0.609
LIG_TRAF2_1	4	7	PF00917	0.454
LIG_TRAF2_1	73	76	PF00917	0.529
LIG_TRFH_1	657	661	PF08558	0.461
LIG_TYR_ITAM	608	628	PF00017	0.422
LIG_TYR_ITIM	769	774	PF00017	0.302
LIG_WRC_WIRS_1	236	241	PF05994	0.410
LIG_WRC_WIRS_1	499	504	PF05994	0.519
MOD_CDC14_SPxK_1	38	41	PF00782	0.618
MOD_CDC14_SPxK_1	533	536	PF00782	0.357
MOD_CDK_SPK_2	108	113	PF00069	0.519
MOD_CDK_SPxK_1	35	41	PF00069	0.623
MOD_CDK_SPxK_1	513	519	PF00069	0.363
MOD_CDK_SPxK_1	530	536	PF00069	0.238
MOD_CDK_SPxxK_3	108	115	PF00069	0.579
MOD_CK1_1	234	240	PF00069	0.615
MOD_CK1_1	37	43	PF00069	0.763
MOD_CK1_1	428	434	PF00069	0.578
MOD_CK1_1	44	50	PF00069	0.782
MOD_CK1_1	441	447	PF00069	0.515
MOD_CK1_1	455	461	PF00069	0.355
MOD_CK1_1	51	57	PF00069	0.584
MOD_CK1_1	525	531	PF00069	0.367
MOD_CK1_1	576	582	PF00069	0.369
MOD_CK1_1	602	608	PF00069	0.692
MOD_CK1_1	663	669	PF00069	0.498
MOD_CK1_1	710	716	PF00069	0.504
MOD_CK2_1	1	7	PF00069	0.524
MOD_CK2_1	114	120	PF00069	0.615
MOD_CK2_1	180	186	PF00069	0.557
MOD_CK2_1	29	35	PF00069	0.759
MOD_CK2_1	292	298	PF00069	0.567
MOD_CK2_1	312	318	PF00069	0.632
MOD_CK2_1	363	369	PF00069	0.680
MOD_CK2_1	512	518	PF00069	0.305
MOD_CK2_1	602	608	PF00069	0.647
MOD_CK2_1	70	76	PF00069	0.529
MOD_CK2_1	83	89	PF00069	0.500
MOD_CK2_1	862	868	PF00069	0.470
MOD_CMANNOS	820	823	PF00535	0.294
MOD_GlcNHglycan	16	19	PF01048	0.633
MOD_GlcNHglycan	182	185	PF01048	0.600
MOD_GlcNHglycan	222	225	PF01048	0.725
MOD_GlcNHglycan	270	274	PF01048	0.608
MOD_GlcNHglycan	282	285	PF01048	0.586
MOD_GlcNHglycan	294	297	PF01048	0.491
MOD_GlcNHglycan	32	35	PF01048	0.566
MOD_GlcNHglycan	355	358	PF01048	0.575
MOD_GlcNHglycan	430	433	PF01048	0.676
MOD_GlcNHglycan	50	53	PF01048	0.639
MOD_GlcNHglycan	524	527	PF01048	0.452
MOD_GlcNHglycan	55	58	PF01048	0.804
MOD_GlcNHglycan	562	565	PF01048	0.535
MOD_GlcNHglycan	62	65	PF01048	0.741
MOD_GlcNHglycan	672	675	PF01048	0.568
MOD_GlcNHglycan	697	700	PF01048	0.630
MOD_GlcNHglycan	814	817	PF01048	0.368
MOD_GlcNHglycan	826	830	PF01048	0.360
MOD_GSK3_1	154	161	PF00069	0.542
MOD_GSK3_1	231	238	PF00069	0.548
MOD_GSK3_1	30	37	PF00069	0.711
MOD_GSK3_1	39	46	PF00069	0.664
MOD_GSK3_1	410	417	PF00069	0.499
MOD_GSK3_1	428	435	PF00069	0.571
MOD_GSK3_1	438	445	PF00069	0.558
MOD_GSK3_1	447	454	PF00069	0.414
MOD_GSK3_1	462	469	PF00069	0.434
MOD_GSK3_1	48	55	PF00069	0.683
MOD_GSK3_1	572	579	PF00069	0.192
MOD_GSK3_1	598	605	PF00069	0.551
MOD_GSK3_1	613	620	PF00069	0.265
MOD_GSK3_1	695	702	PF00069	0.655
MOD_GSK3_1	738	745	PF00069	0.574
MOD_GSK3_1	754	761	PF00069	0.584
MOD_GSK3_1	769	776	PF00069	0.307
MOD_GSK3_1	794	801	PF00069	0.385
MOD_GSK3_1	844	851	PF00069	0.415
MOD_GSK3_1	852	859	PF00069	0.347
MOD_N-GLC_1	425	430	PF02516	0.556
MOD_N-GLC_1	466	471	PF02516	0.245
MOD_N-GLC_1	598	603	PF02516	0.607
MOD_N-GLC_2	548	550	PF02516	0.427
MOD_NEK2_1	269	274	PF00069	0.647
MOD_NEK2_1	292	297	PF00069	0.490
MOD_NEK2_1	353	358	PF00069	0.585
MOD_NEK2_1	412	417	PF00069	0.445
MOD_NEK2_1	453	458	PF00069	0.345
MOD_NEK2_1	507	512	PF00069	0.383
MOD_NEK2_1	560	565	PF00069	0.420
MOD_NEK2_1	572	577	PF00069	0.293
MOD_NEK2_1	617	622	PF00069	0.424
MOD_OFUCOSY	524	529	PF10250	0.384
MOD_PIKK_1	312	318	PF00454	0.632
MOD_PIKK_1	41	47	PF00454	0.631
MOD_PIKK_1	710	716	PF00454	0.478
MOD_PIKK_1	83	89	PF00454	0.385
MOD_PIKK_1	848	854	PF00454	0.398
MOD_PK_1	466	472	PF00069	0.226
MOD_PKA_1	14	20	PF00069	0.641
MOD_PKA_1	170	176	PF00069	0.452
MOD_PKA_1	83	89	PF00069	0.432
MOD_PKA_2	129	135	PF00069	0.706
MOD_PKA_2	14	20	PF00069	0.641
MOD_PKA_2	158	164	PF00069	0.496
MOD_PKA_2	170	176	PF00069	0.495
MOD_PKA_2	229	235	PF00069	0.448
MOD_PKA_2	258	264	PF00069	0.435
MOD_PKA_2	462	468	PF00069	0.396
MOD_PKA_2	724	730	PF00069	0.519
MOD_PKA_2	812	818	PF00069	0.312
MOD_PKA_2	83	89	PF00069	0.680
MOD_PKA_2	844	850	PF00069	0.494
MOD_PKB_1	178	186	PF00069	0.513
MOD_Plk_1	425	431	PF00069	0.592
MOD_Plk_1	466	472	PF00069	0.266
MOD_Plk_1	598	604	PF00069	0.566
MOD_Plk_1	710	716	PF00069	0.259
MOD_Plk_2-3	399	405	PF00069	0.423
MOD_Plk_4	414	420	PF00069	0.537
MOD_Plk_4	498	504	PF00069	0.353
MOD_Plk_4	679	685	PF00069	0.676
MOD_Plk_4	733	739	PF00069	0.400
MOD_Plk_4	769	775	PF00069	0.437
MOD_ProDKin_1	108	114	PF00069	0.645
MOD_ProDKin_1	231	237	PF00069	0.656
MOD_ProDKin_1	35	41	PF00069	0.707
MOD_ProDKin_1	493	499	PF00069	0.433
MOD_ProDKin_1	513	519	PF00069	0.370
MOD_ProDKin_1	530	536	PF00069	0.357
MOD_ProDKin_1	638	644	PF00069	0.545
MOD_ProDKin_1	716	722	PF00069	0.468
MOD_ProDKin_1	731	737	PF00069	0.556
MOD_ProDKin_1	794	800	PF00069	0.438
MOD_SUMO_rev_2	183	193	PF00179	0.397
MOD_SUMO_rev_2	63	73	PF00179	0.682
TRG_DiLeu_BaEn_1	196	201	PF01217	0.477
TRG_DiLeu_BaEn_2	341	347	PF01217	0.348
TRG_DiLeu_BaEn_4	196	202	PF01217	0.528
TRG_DiLeu_BaEn_4	5	11	PF01217	0.574
TRG_DiLeu_LyEn_5	196	201	PF01217	0.477
TRG_ENDOCYTIC_2	611	614	PF00928	0.482
TRG_ENDOCYTIC_2	625	628	PF00928	0.403
TRG_ENDOCYTIC_2	771	774	PF00928	0.308
TRG_ER_diArg_1	178	181	PF00400	0.574
TRG_ER_diArg_1	198	200	PF00400	0.321
TRG_ER_diArg_1	201	203	PF00400	0.472
TRG_ER_diArg_1	263	265	PF00400	0.449
TRG_ER_diArg_1	322	325	PF00400	0.572
TRG_ER_diArg_1	348	351	PF00400	0.600
TRG_ER_diArg_1	77	80	PF00400	0.524
TRG_ER_diArg_1	8	11	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	8	13	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PED2	Leptomonas seymouri	56%	100%
A0A0S4JR75	Bodo saltans	32%	100%
A0A1X0P8I2	Trypanosomatidae	41%	100%
A0A3Q8ID60	Leishmania donovani	88%	100%
A0A3R7KCG9	Trypanosoma rangeli	42%	100%
A4H9P9	Leishmania braziliensis	77%	100%
A4HY16	Leishmania infantum	88%	100%
D0A574	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	97%
Q4QDP3	Leishmania major	87%	99%
Q8C761	Mus musculus	23%	91%
Q8WVS4	Homo sapiens	24%	85%
V5BNK6	Trypanosoma cruzi	41%	100%