EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EF-hand domain pair, putative

Species:

Leishmania mexicana

UniProt:

E9ARS8_LEIMU

TriTrypDb:

LmxM.18.1440

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARS8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005509	calcium ion binding	5	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	184	186	PF00675	0.400
CLV_NRD_NRD_1	192	194	PF00675	0.368
CLV_NRD_NRD_1	200	202	PF00675	0.270
CLV_NRD_NRD_1	60	62	PF00675	0.612
CLV_NRD_NRD_1	67	69	PF00675	0.632
CLV_NRD_NRD_1	87	89	PF00675	0.470
CLV_PCSK_KEX2_1	184	186	PF00082	0.342
CLV_PCSK_KEX2_1	192	194	PF00082	0.386
CLV_PCSK_KEX2_1	60	62	PF00082	0.539
CLV_PCSK_KEX2_1	67	69	PF00082	0.586
CLV_PCSK_KEX2_1	87	89	PF00082	0.560
CLV_PCSK_SKI1_1	125	129	PF00082	0.417
CLV_PCSK_SKI1_1	212	216	PF00082	0.314
CLV_PCSK_SKI1_1	32	36	PF00082	0.484
CLV_PCSK_SKI1_1	60	64	PF00082	0.448
DOC_CKS1_1	41	46	PF01111	0.423
DOC_MAPK_gen_1	192	200	PF00069	0.375
DOC_USP7_MATH_1	36	40	PF00917	0.528
DOC_WW_Pin1_4	40	45	PF00397	0.415
LIG_14-3-3_CanoR_1	20	28	PF00244	0.416
LIG_14-3-3_CanoR_1	212	221	PF00244	0.413
LIG_eIF4E_1	136	142	PF01652	0.377
LIG_FHA_1	136	142	PF00498	0.377
LIG_FHA_1	168	174	PF00498	0.306
LIG_FHA_1	41	47	PF00498	0.510
LIG_LIR_Gen_1	105	114	PF02991	0.364
LIG_LIR_Gen_1	140	149	PF02991	0.297
LIG_LIR_Gen_1	154	164	PF02991	0.300
LIG_LIR_Gen_1	73	83	PF02991	0.638
LIG_LIR_Nem_3	105	110	PF02991	0.386
LIG_LIR_Nem_3	12	16	PF02991	0.463
LIG_LIR_Nem_3	123	127	PF02991	0.362
LIG_LIR_Nem_3	139	145	PF02991	0.267
LIG_LIR_Nem_3	154	159	PF02991	0.292
LIG_LIR_Nem_3	215	221	PF02991	0.529
LIG_LIR_Nem_3	73	78	PF02991	0.631
LIG_LYPXL_yS_3	218	221	PF13949	0.526
LIG_Pex14_2	142	146	PF04695	0.279
LIG_SH2_SRC	50	53	PF00017	0.412
LIG_SH2_STAP1	107	111	PF00017	0.383
LIG_SH2_STAT5	143	146	PF00017	0.347
LIG_SH2_STAT5	172	175	PF00017	0.351
LIG_SH2_STAT5	205	208	PF00017	0.381
LIG_SH2_STAT5	50	53	PF00017	0.374
LIG_SH3_3	38	44	PF00018	0.518
LIG_TRAF2_1	98	101	PF00917	0.728
LIG_UBA3_1	194	202	PF00899	0.297
LIG_WRC_WIRS_1	121	126	PF05994	0.354
MOD_GlcNHglycan	38	41	PF01048	0.545
MOD_GSK3_1	36	43	PF00069	0.588
MOD_GSK3_1	70	77	PF00069	0.599
MOD_NEK2_1	28	33	PF00069	0.513
MOD_NEK2_1	78	83	PF00069	0.710
MOD_NEK2_2	120	125	PF00069	0.374
MOD_NMyristoyl	1	7	PF02799	0.633
MOD_PIKK_1	212	218	PF00454	0.390
MOD_PK_1	70	76	PF00069	0.406
MOD_PKA_2	19	25	PF00069	0.442
MOD_PKA_2	3	9	PF00069	0.672
MOD_PKB_1	68	76	PF00069	0.406
MOD_Plk_2-3	19	25	PF00069	0.491
MOD_Plk_4	70	76	PF00069	0.631
MOD_ProDKin_1	40	46	PF00069	0.413
MOD_SUMO_rev_2	158	165	PF00179	0.421
TRG_DiLeu_BaEn_1	190	195	PF01217	0.330
TRG_DiLeu_BaEn_1	209	214	PF01217	0.357
TRG_DiLeu_BaEn_3	23	29	PF01217	0.431
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.511
TRG_DiLeu_LyEn_5	209	214	PF01217	0.357
TRG_ENDOCYTIC_2	107	110	PF00928	0.375
TRG_ENDOCYTIC_2	13	16	PF00928	0.454
TRG_ENDOCYTIC_2	143	146	PF00928	0.374
TRG_ENDOCYTIC_2	205	208	PF00928	0.410
TRG_ENDOCYTIC_2	218	221	PF00928	0.526
TRG_ER_diArg_1	183	185	PF00400	0.423
TRG_ER_diArg_1	192	194	PF00400	0.400
TRG_ER_diArg_1	60	62	PF00400	0.594
TRG_ER_diArg_1	67	69	PF00400	0.614
TRG_ER_diLys_1	224	229	PF00400	0.389
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.305
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC76	Leptomonas seymouri	73%	100%
A0A0S4JR21	Bodo saltans	38%	89%
A0A1X0P714	Trypanosomatidae	56%	100%
A0A3Q8IEC5	Leishmania donovani	94%	98%
A0A422NIP8	Trypanosoma rangeli	57%	100%
A4H9P7	Leishmania braziliensis	83%	100%
A4HY14	Leishmania infantum	94%	98%
D0A578	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
Q4QDP5	Leishmania major	91%	100%