Putative pumilio protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio protein, putative

Species:

Leishmania mexicana

UniProt:

E9ARS6_LEIMU

TriTrypDb:

LmxM.18.1420

Length:

877

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARS6

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	442	446	PF00656	0.412
CLV_C14_Caspase3-7	7	11	PF00656	0.501
CLV_NRD_NRD_1	105	107	PF00675	0.711
CLV_NRD_NRD_1	45	47	PF00675	0.673
CLV_NRD_NRD_1	513	515	PF00675	0.496
CLV_NRD_NRD_1	763	765	PF00675	0.803
CLV_PCSK_KEX2_1	104	106	PF00082	0.717
CLV_PCSK_KEX2_1	45	47	PF00082	0.673
CLV_PCSK_KEX2_1	763	765	PF00082	0.803
CLV_PCSK_SKI1_1	257	261	PF00082	0.465
CLV_PCSK_SKI1_1	434	438	PF00082	0.412
CLV_PCSK_SKI1_1	449	453	PF00082	0.252
CLV_PCSK_SKI1_1	510	514	PF00082	0.546
DEG_APCC_DBOX_1	509	517	PF00400	0.497
DEG_SPOP_SBC_1	591	595	PF00917	0.624
DOC_CKS1_1	414	419	PF01111	0.456
DOC_CKS1_1	663	668	PF01111	0.687
DOC_CKS1_1	743	748	PF01111	0.670
DOC_CYCLIN_yCln2_LP_2	646	652	PF00134	0.521
DOC_MAPK_gen_1	408	415	PF00069	0.412
DOC_PP1_RVXF_1	306	313	PF00149	0.412
DOC_PP2B_LxvP_1	401	404	PF13499	0.412
DOC_PP2B_LxvP_1	751	754	PF13499	0.611
DOC_PP4_FxxP_1	720	723	PF00568	0.698
DOC_PP4_MxPP_1	98	101	PF00568	0.647
DOC_SPAK_OSR1_1	410	414	PF12202	0.412
DOC_USP7_MATH_1	120	124	PF00917	0.724
DOC_USP7_MATH_1	747	751	PF00917	0.606
DOC_USP7_MATH_1	832	836	PF00917	0.708
DOC_USP7_MATH_1	842	846	PF00917	0.751
DOC_USP7_UBL2_3	449	453	PF12436	0.362
DOC_WW_Pin1_4	413	418	PF00397	0.482
DOC_WW_Pin1_4	482	487	PF00397	0.362
DOC_WW_Pin1_4	662	667	PF00397	0.734
DOC_WW_Pin1_4	742	747	PF00397	0.755
DOC_WW_Pin1_4	766	771	PF00397	0.726
DOC_WW_Pin1_4	787	792	PF00397	0.715
LIG_14-3-3_CanoR_1	126	136	PF00244	0.575
LIG_14-3-3_CanoR_1	79	87	PF00244	0.701
LIG_APCC_ABBA_1	169	174	PF00400	0.497
LIG_APCC_ABBA_1	213	218	PF00400	0.412
LIG_BIR_II_1	1	5	PF00653	0.647
LIG_BRCT_BRCA1_1	792	796	PF00533	0.730
LIG_CtBP_PxDLS_1	404	408	PF00389	0.412
LIG_FHA_1	158	164	PF00498	0.659
LIG_FHA_1	264	270	PF00498	0.516
LIG_FHA_1	414	420	PF00498	0.489
LIG_FHA_1	523	529	PF00498	0.487
LIG_FHA_2	436	442	PF00498	0.422
LIG_FHA_2	485	491	PF00498	0.412
LIG_FHA_2	5	11	PF00498	0.541
LIG_FHA_2	841	847	PF00498	0.651
LIG_Integrin_isoDGR_2	581	583	PF01839	0.697
LIG_Integrin_RGD_1	764	766	PF01839	0.605
LIG_LIR_Apic_2	665	670	PF02991	0.678
LIG_LIR_Apic_2	734	740	PF02991	0.561
LIG_LIR_Gen_1	179	189	PF02991	0.495
LIG_LIR_Gen_1	214	223	PF02991	0.362
LIG_LIR_Gen_1	81	89	PF02991	0.655
LIG_LIR_Nem_3	179	185	PF02991	0.490
LIG_LIR_Nem_3	214	219	PF02991	0.394
LIG_LIR_Nem_3	221	226	PF02991	0.411
LIG_LIR_Nem_3	228	234	PF02991	0.281
LIG_LIR_Nem_3	470	475	PF02991	0.524
LIG_LIR_Nem_3	81	87	PF02991	0.653
LIG_PCNA_yPIPBox_3	233	245	PF02747	0.412
LIG_Pex14_2	176	180	PF04695	0.510
LIG_PTB_Apo_2	772	779	PF02174	0.723
LIG_PTB_Phospho_1	772	778	PF10480	0.724
LIG_Rb_pABgroove_1	234	242	PF01858	0.412
LIG_SH2_CRK	182	186	PF00017	0.493
LIG_SH2_CRK	654	658	PF00017	0.645
LIG_SH2_CRK	663	667	PF00017	0.691
LIG_SH2_CRK	684	688	PF00017	0.599
LIG_SH2_CRK	737	741	PF00017	0.646
LIG_SH2_CRK	84	88	PF00017	0.652
LIG_SH2_GRB2like	472	475	PF00017	0.412
LIG_SH2_GRB2like	575	578	PF00017	0.703
LIG_SH2_GRB2like	773	776	PF00017	0.728
LIG_SH2_SRC	773	776	PF00017	0.728
LIG_SH2_STAP1	472	476	PF00017	0.412
LIG_SH2_STAP1	733	737	PF00017	0.724
LIG_SH2_STAP1	80	84	PF00017	0.660
LIG_SH2_STAT3	234	237	PF00017	0.412
LIG_SH2_STAT3	276	279	PF00017	0.412
LIG_SH2_STAT3	394	397	PF00017	0.412
LIG_SH2_STAT3	475	478	PF00017	0.412
LIG_SH2_STAT3	696	699	PF00017	0.694
LIG_SH2_STAT3	702	705	PF00017	0.631
LIG_SH2_STAT3	865	868	PF00017	0.676
LIG_SH2_STAT5	172	175	PF00017	0.492
LIG_SH2_STAT5	234	237	PF00017	0.412
LIG_SH2_STAT5	394	397	PF00017	0.412
LIG_SH2_STAT5	463	466	PF00017	0.412
LIG_SH2_STAT5	475	478	PF00017	0.412
LIG_SH2_STAT5	702	705	PF00017	0.589
LIG_SH2_STAT5	773	776	PF00017	0.728
LIG_SH2_STAT5	80	83	PF00017	0.661
LIG_SH3_1	737	743	PF00018	0.522
LIG_SH3_3	531	537	PF00018	0.670
LIG_SH3_3	636	642	PF00018	0.714
LIG_SH3_3	674	680	PF00018	0.680
LIG_SH3_3	720	726	PF00018	0.570
LIG_SH3_3	737	743	PF00018	0.537
LIG_SH3_3	90	96	PF00018	0.668
LIG_SH3_5	178	182	PF00018	0.489
LIG_TRAF2_1	439	442	PF00917	0.412
LIG_TRAF2_1	74	77	PF00917	0.790
LIG_UBA3_1	261	268	PF00899	0.470
LIG_UBA3_1	301	308	PF00899	0.441
LIG_UBA3_1	447	453	PF00899	0.412
LIG_WRC_WIRS_1	173	178	PF05994	0.513
LIG_WRC_WIRS_1	189	194	PF05994	0.412
MOD_CDK_SPxxK_3	482	489	PF00069	0.362
MOD_CK1_1	128	134	PF00069	0.795
MOD_CK1_1	277	283	PF00069	0.449
MOD_CK1_1	790	796	PF00069	0.738
MOD_CK1_1	835	841	PF00069	0.709
MOD_CK2_1	435	441	PF00069	0.422
MOD_CK2_1	484	490	PF00069	0.412
MOD_CK2_1	532	538	PF00069	0.535
MOD_GlcNHglycan	122	125	PF01048	0.825
MOD_GlcNHglycan	21	24	PF01048	0.581
MOD_GlcNHglycan	330	333	PF01048	0.435
MOD_GlcNHglycan	533	537	PF01048	0.649
MOD_GlcNHglycan	549	552	PF01048	0.580
MOD_GlcNHglycan	555	558	PF01048	0.660
MOD_GlcNHglycan	586	589	PF01048	0.740
MOD_GlcNHglycan	594	597	PF01048	0.729
MOD_GlcNHglycan	601	604	PF01048	0.677
MOD_GlcNHglycan	623	626	PF01048	0.638
MOD_GlcNHglycan	720	723	PF01048	0.650
MOD_GlcNHglycan	792	795	PF01048	0.616
MOD_GlcNHglycan	824	827	PF01048	0.798
MOD_GlcNHglycan	835	838	PF01048	0.613
MOD_GSK3_1	125	132	PF00069	0.789
MOD_GSK3_1	157	164	PF00069	0.569
MOD_GSK3_1	184	191	PF00069	0.502
MOD_GSK3_1	422	429	PF00069	0.412
MOD_GSK3_1	499	506	PF00069	0.519
MOD_GSK3_1	52	59	PF00069	0.666
MOD_GSK3_1	522	529	PF00069	0.582
MOD_GSK3_1	553	560	PF00069	0.684
MOD_GSK3_1	741	748	PF00069	0.737
MOD_N-GLC_1	3	8	PF02516	0.693
MOD_N-GLC_1	503	508	PF02516	0.526
MOD_N-GLC_1	560	565	PF02516	0.672
MOD_N-GLC_1	584	589	PF02516	0.649
MOD_N-GLC_1	599	604	PF02516	0.668
MOD_N-GLC_1	731	736	PF02516	0.673
MOD_N-GLC_1	840	845	PF02516	0.668
MOD_N-GLC_1	853	858	PF02516	0.588
MOD_NEK2_1	119	124	PF00069	0.771
MOD_NEK2_1	274	279	PF00069	0.412
MOD_NEK2_1	28	33	PF00069	0.700
MOD_NEK2_1	422	427	PF00069	0.496
MOD_NEK2_1	468	473	PF00069	0.474
MOD_NEK2_1	52	57	PF00069	0.666
MOD_NEK2_1	522	527	PF00069	0.470
MOD_NEK2_1	812	817	PF00069	0.542
MOD_NEK2_1	87	92	PF00069	0.662
MOD_NEK2_2	172	177	PF00069	0.506
MOD_NEK2_2	731	736	PF00069	0.673
MOD_PIKK_1	162	168	PF00454	0.552
MOD_PIKK_1	484	490	PF00454	0.412
MOD_PIKK_1	526	532	PF00454	0.488
MOD_PIKK_1	745	751	PF00454	0.688
MOD_PIKK_1	796	802	PF00454	0.653
MOD_PKA_2	125	131	PF00069	0.618
MOD_PKA_2	263	269	PF00069	0.515
MOD_PKA_2	553	559	PF00069	0.768
MOD_PKA_2	78	84	PF00069	0.708
MOD_Plk_1	274	280	PF00069	0.412
MOD_Plk_1	384	390	PF00069	0.412
MOD_Plk_1	503	509	PF00069	0.520
MOD_Plk_1	731	737	PF00069	0.672
MOD_Plk_1	813	819	PF00069	0.700
MOD_Plk_4	211	217	PF00069	0.362
MOD_Plk_4	503	509	PF00069	0.520
MOD_Plk_4	52	58	PF00069	0.735
MOD_Plk_4	522	528	PF00069	0.323
MOD_Plk_4	633	639	PF00069	0.722
MOD_ProDKin_1	413	419	PF00069	0.475
MOD_ProDKin_1	482	488	PF00069	0.362
MOD_ProDKin_1	662	668	PF00069	0.735
MOD_ProDKin_1	742	748	PF00069	0.755
MOD_ProDKin_1	766	772	PF00069	0.725
MOD_ProDKin_1	787	793	PF00069	0.717
MOD_SUMO_for_1	244	247	PF00179	0.494
MOD_SUMO_rev_2	249	259	PF00179	0.489
MOD_SUMO_rev_2	304	310	PF00179	0.362
MOD_SUMO_rev_2	445	454	PF00179	0.412
TRG_DiLeu_BaEn_3	442	448	PF01217	0.412
TRG_DiLeu_BaEn_4	221	227	PF01217	0.412
TRG_DiLeu_BaLyEn_6	201	206	PF01217	0.412
TRG_ENDOCYTIC_2	182	185	PF00928	0.485
TRG_ENDOCYTIC_2	654	657	PF00928	0.710
TRG_ENDOCYTIC_2	84	87	PF00928	0.650
TRG_ER_diArg_1	104	106	PF00400	0.717
TRG_ER_diArg_1	407	410	PF00400	0.412
TRG_ER_diArg_1	44	46	PF00400	0.672
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	869	873	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H745	Leishmania donovani	88%	98%
A4H9P5	Leishmania braziliensis	79%	97%
A4HY12	Leishmania infantum	88%	98%
Q4QDP7	Leishmania major	91%	100%