Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARS3_LEIMU

TriTrypDb:

LmxM.18.1390

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9ARS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARS3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	182	184	PF00675	0.654
CLV_NRD_NRD_1	40	42	PF00675	0.427
CLV_NRD_NRD_1	79	81	PF00675	0.370
CLV_PCSK_KEX2_1	182	184	PF00082	0.551
CLV_PCSK_KEX2_1	35	37	PF00082	0.397
CLV_PCSK_KEX2_1	40	42	PF00082	0.428
CLV_PCSK_KEX2_1	79	81	PF00082	0.370
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.385
CLV_PCSK_PC7_1	36	42	PF00082	0.431
CLV_PCSK_SKI1_1	74	78	PF00082	0.337
DEG_Nend_UBRbox_3	1	3	PF02207	0.600
DOC_MAPK_gen_1	40	48	PF00069	0.637
DOC_MAPK_gen_1	79	87	PF00069	0.562
DOC_MAPK_MEF2A_6	40	48	PF00069	0.647
DOC_MAPK_MEF2A_6	86	95	PF00069	0.516
DOC_PP1_RVXF_1	77	84	PF00149	0.551
DOC_PP2B_LxvP_1	69	72	PF13499	0.554
DOC_WW_Pin1_4	115	120	PF00397	0.332
DOC_WW_Pin1_4	185	190	PF00397	0.348
LIG_14-3-3_CanoR_1	133	140	PF00244	0.298
LIG_14-3-3_CanoR_1	36	44	PF00244	0.633
LIG_14-3-3_CanoR_1	59	69	PF00244	0.603
LIG_14-3-3_CanoR_1	74	83	PF00244	0.473
LIG_Clathr_ClatBox_1	4	8	PF01394	0.598
LIG_FHA_1	43	49	PF00498	0.608
LIG_LIR_Gen_1	124	132	PF02991	0.298
LIG_LIR_Gen_1	192	203	PF02991	0.316
LIG_LIR_Gen_1	239	249	PF02991	0.661
LIG_LIR_Gen_1	63	73	PF02991	0.555
LIG_LIR_Nem_3	192	198	PF02991	0.356
LIG_LIR_Nem_3	63	69	PF02991	0.513
LIG_SH2_CRK	66	70	PF00017	0.640
LIG_SH2_NCK_1	134	138	PF00017	0.311
LIG_SH2_STAP1	125	129	PF00017	0.355
LIG_SH2_STAP1	134	138	PF00017	0.275
LIG_SH2_STAP1	66	70	PF00017	0.550
LIG_SH2_STAT5	107	110	PF00017	0.445
LIG_SH2_STAT5	195	198	PF00017	0.361
LIG_SH2_STAT5	6	9	PF00017	0.607
LIG_SH3_1	183	189	PF00018	0.349
LIG_SH3_3	183	189	PF00018	0.395
LIG_SUMO_SIM_par_1	101	106	PF11976	0.348
LIG_SUMO_SIM_par_1	218	226	PF11976	0.612
LIG_SUMO_SIM_par_1	91	97	PF11976	0.442
LIG_TRAF2_1	189	192	PF00917	0.390
LIG_TRAF2_1	234	237	PF00917	0.613
LIG_TYR_ITIM	193	198	PF00017	0.315
LIG_UBA3_1	26	35	PF00899	0.562
LIG_ULM_U2AF65_1	79	84	PF00076	0.525
MOD_CK2_1	185	191	PF00069	0.350
MOD_CK2_1	231	237	PF00069	0.667
MOD_CK2_1	36	42	PF00069	0.555
MOD_GlcNHglycan	233	236	PF01048	0.507
MOD_GSK3_1	42	49	PF00069	0.595
MOD_N-GLC_1	36	41	PF02516	0.329
MOD_PIKK_1	250	256	PF00454	0.647
MOD_PIKK_1	60	66	PF00454	0.446
MOD_PKA_1	35	41	PF00069	0.593
MOD_PKA_2	132	138	PF00069	0.266
MOD_PKA_2	35	41	PF00069	0.688
MOD_Plk_4	103	109	PF00069	0.355
MOD_ProDKin_1	115	121	PF00069	0.326
MOD_ProDKin_1	185	191	PF00069	0.350
MOD_SUMO_for_1	145	148	PF00179	0.433
TRG_DiLeu_BaEn_3	236	242	PF01217	0.630
TRG_DiLeu_BaEn_4	191	197	PF01217	0.330
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.583
TRG_ENDOCYTIC_2	125	128	PF00928	0.351
TRG_ENDOCYTIC_2	134	137	PF00928	0.264
TRG_ENDOCYTIC_2	195	198	PF00928	0.320
TRG_ENDOCYTIC_2	200	203	PF00928	0.291
TRG_ENDOCYTIC_2	66	69	PF00928	0.513
TRG_ENDOCYTIC_2	70	73	PF00928	0.517
TRG_ER_diArg_1	181	183	PF00400	0.332
TRG_ER_diArg_1	79	82	PF00400	0.579
TRG_NES_CRM1_1	152	165	PF08389	0.328
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.345

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JNI9	Bodo saltans	30%	72%
A0A1X0P730	Trypanosomatidae	46%	73%
A0A3Q8IB53	Leishmania donovani	92%	100%
A4H9P2	Leishmania braziliensis	80%	100%
A4HY09	Leishmania infantum	92%	100%
D0A587	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	74%
Q4QDQ0	Leishmania major	92%	100%
V5BEH9	Trypanosoma cruzi	46%	91%