Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARS0_LEIMU

TriTrypDb:

LmxM.18.1360

Length:

961

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARS0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.467
CLV_C14_Caspase3-7	288	292	PF00656	0.547
CLV_C14_Caspase3-7	310	314	PF00656	0.471
CLV_C14_Caspase3-7	437	441	PF00656	0.328
CLV_NRD_NRD_1	105	107	PF00675	0.515
CLV_NRD_NRD_1	208	210	PF00675	0.464
CLV_NRD_NRD_1	241	243	PF00675	0.507
CLV_NRD_NRD_1	650	652	PF00675	0.519
CLV_NRD_NRD_1	772	774	PF00675	0.545
CLV_NRD_NRD_1	788	790	PF00675	0.379
CLV_NRD_NRD_1	802	804	PF00675	0.465
CLV_NRD_NRD_1	824	826	PF00675	0.585
CLV_NRD_NRD_1	899	901	PF00675	0.632
CLV_PCSK_FUR_1	293	297	PF00082	0.487
CLV_PCSK_KEX2_1	105	107	PF00082	0.515
CLV_PCSK_KEX2_1	208	210	PF00082	0.466
CLV_PCSK_KEX2_1	241	243	PF00082	0.507
CLV_PCSK_KEX2_1	295	297	PF00082	0.511
CLV_PCSK_KEX2_1	650	652	PF00082	0.486
CLV_PCSK_KEX2_1	772	774	PF00082	0.513
CLV_PCSK_KEX2_1	788	790	PF00082	0.396
CLV_PCSK_KEX2_1	802	804	PF00082	0.465
CLV_PCSK_KEX2_1	824	826	PF00082	0.552
CLV_PCSK_KEX2_1	899	901	PF00082	0.632
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.511
CLV_PCSK_SKI1_1	105	109	PF00082	0.535
CLV_PCSK_SKI1_1	193	197	PF00082	0.472
CLV_PCSK_SKI1_1	208	212	PF00082	0.487
CLV_PCSK_SKI1_1	257	261	PF00082	0.560
CLV_PCSK_SKI1_1	5	9	PF00082	0.564
CLV_PCSK_SKI1_1	601	605	PF00082	0.659
CLV_PCSK_SKI1_1	676	680	PF00082	0.458
CLV_PCSK_SKI1_1	751	755	PF00082	0.611
CLV_PCSK_SKI1_1	789	793	PF00082	0.582
CLV_PCSK_SKI1_1	900	904	PF00082	0.581
CLV_Separin_Metazoa	799	803	PF03568	0.526
DEG_APCC_DBOX_1	546	554	PF00400	0.610
DEG_APCC_KENBOX_2	850	854	PF00400	0.618
DEG_SPOP_SBC_1	884	888	PF00917	0.785
DEG_SPOP_SBC_1	951	955	PF00917	0.629
DOC_ANK_TNKS_1	25	32	PF00023	0.470
DOC_CDC14_PxL_1	774	782	PF14671	0.437
DOC_CYCLIN_RxL_1	205	214	PF00134	0.403
DOC_CYCLIN_RxL_1	685	697	PF00134	0.296
DOC_MAPK_DCC_7	231	240	PF00069	0.633
DOC_MAPK_gen_1	187	196	PF00069	0.568
DOC_MAPK_gen_1	205	213	PF00069	0.599
DOC_MAPK_HePTP_8	228	240	PF00069	0.627
DOC_MAPK_MEF2A_6	231	240	PF00069	0.624
DOC_MIT_MIM_1	204	213	PF04212	0.490
DOC_MIT_MIM_1	768	777	PF04212	0.483
DOC_PP4_FxxP_1	20	23	PF00568	0.708
DOC_PP4_FxxP_1	8	11	PF00568	0.720
DOC_PP4_MxPP_1	76	79	PF00568	0.481
DOC_USP7_MATH_1	146	150	PF00917	0.501
DOC_USP7_MATH_1	24	28	PF00917	0.682
DOC_USP7_MATH_1	279	283	PF00917	0.633
DOC_USP7_MATH_1	325	329	PF00917	0.537
DOC_USP7_MATH_1	587	591	PF00917	0.615
DOC_USP7_MATH_1	665	669	PF00917	0.413
DOC_USP7_MATH_1	884	888	PF00917	0.697
DOC_USP7_MATH_1	909	913	PF00917	0.785
DOC_USP7_MATH_1	91	95	PF00917	0.647
DOC_USP7_MATH_1	951	955	PF00917	0.637
DOC_USP7_UBL2_3	685	689	PF12436	0.528
DOC_WW_Pin1_4	19	24	PF00397	0.592
DOC_WW_Pin1_4	39	44	PF00397	0.640
DOC_WW_Pin1_4	890	895	PF00397	0.708
DOC_WW_Pin1_4	907	912	PF00397	0.782
DOC_WW_Pin1_4	919	924	PF00397	0.637
DOC_WW_Pin1_4	952	957	PF00397	0.633
LIG_14-3-3_CanoR_1	153	159	PF00244	0.479
LIG_14-3-3_CanoR_1	257	263	PF00244	0.452
LIG_14-3-3_CanoR_1	26	30	PF00244	0.603
LIG_14-3-3_CanoR_1	280	284	PF00244	0.529
LIG_14-3-3_CanoR_1	354	362	PF00244	0.677
LIG_14-3-3_CanoR_1	676	681	PF00244	0.537
LIG_14-3-3_CanoR_1	717	725	PF00244	0.575
LIG_14-3-3_CanoR_1	868	876	PF00244	0.770
LIG_14-3-3_CanoR_1	913	919	PF00244	0.504
LIG_14-3-3_CanoR_1	950	956	PF00244	0.711
LIG_Actin_WH2_2	767	783	PF00022	0.444
LIG_BIR_III_2	14	18	PF00653	0.605
LIG_BRCT_BRCA1_1	57	61	PF00533	0.447
LIG_BRCT_BRCA1_1	953	957	PF00533	0.605
LIG_BRCT_BRCA1_1	99	103	PF00533	0.603
LIG_Clathr_ClatBox_1	210	214	PF01394	0.340
LIG_FAT_LD_1	255	263	PF03623	0.488
LIG_FHA_1	117	123	PF00498	0.545
LIG_FHA_1	235	241	PF00498	0.494
LIG_FHA_1	375	381	PF00498	0.488
LIG_FHA_1	431	437	PF00498	0.588
LIG_FHA_1	796	802	PF00498	0.449
LIG_FHA_2	154	160	PF00498	0.491
LIG_FHA_2	162	168	PF00498	0.441
LIG_FHA_2	258	264	PF00498	0.527
LIG_FHA_2	286	292	PF00498	0.441
LIG_FHA_2	373	379	PF00498	0.649
LIG_FHA_2	421	427	PF00498	0.582
LIG_FHA_2	435	441	PF00498	0.333
LIG_FHA_2	454	460	PF00498	0.434
LIG_FHA_2	475	481	PF00498	0.502
LIG_FHA_2	533	539	PF00498	0.659
LIG_FHA_2	625	631	PF00498	0.455
LIG_GBD_Chelix_1	254	262	PF00786	0.559
LIG_HCF-1_HBM_1	365	368	PF13415	0.605
LIG_LIR_Apic_2	6	11	PF02991	0.716
LIG_LIR_Apic_2	65	70	PF02991	0.592
LIG_LIR_Gen_1	332	340	PF02991	0.422
LIG_LIR_Gen_1	674	682	PF02991	0.550
LIG_LIR_Gen_1	734	742	PF02991	0.427
LIG_LIR_Gen_1	826	836	PF02991	0.561
LIG_LIR_Gen_1	854	865	PF02991	0.694
LIG_LIR_Nem_3	305	311	PF02991	0.556
LIG_LIR_Nem_3	332	337	PF02991	0.407
LIG_LIR_Nem_3	674	680	PF02991	0.554
LIG_LIR_Nem_3	734	739	PF02991	0.425
LIG_LIR_Nem_3	826	832	PF02991	0.507
LIG_LIR_Nem_3	854	860	PF02991	0.689
LIG_NRP_CendR_1	958	961	PF00754	0.570
LIG_REV1ctd_RIR_1	274	284	PF16727	0.559
LIG_RPA_C_Fungi	275	287	PF08784	0.458
LIG_SH2_CRK	147	151	PF00017	0.600
LIG_SH2_CRK	677	681	PF00017	0.564
LIG_SH2_CRK	736	740	PF00017	0.535
LIG_SH2_SRC	67	70	PF00017	0.630
LIG_SH2_STAP1	154	158	PF00017	0.510
LIG_SH2_STAP1	482	486	PF00017	0.432
LIG_SH2_STAT5	147	150	PF00017	0.493
LIG_SH2_STAT5	368	371	PF00017	0.560
LIG_SH2_STAT5	95	98	PF00017	0.631
LIG_SH3_2	956	961	PF14604	0.623
LIG_SH3_3	888	894	PF00018	0.658
LIG_SH3_3	953	959	PF00018	0.580
LIG_SH3_CIN85_PxpxPR_1	894	899	PF14604	0.617
LIG_Sin3_3	464	471	PF02671	0.452
LIG_SUMO_SIM_anti_2	400	406	PF11976	0.313
LIG_SUMO_SIM_par_1	321	329	PF11976	0.472
LIG_SUMO_SIM_par_1	400	406	PF11976	0.313
LIG_TRAF2_1	170	173	PF00917	0.632
LIG_TRAF2_1	268	271	PF00917	0.468
LIG_TRAF2_1	362	365	PF00917	0.631
LIG_TRAF2_1	671	674	PF00917	0.542
LIG_TRAF2_1	794	797	PF00917	0.460
LIG_TRAF2_2	11	16	PF00917	0.562
LIG_UBA3_1	210	217	PF00899	0.353
LIG_UBA3_1	323	331	PF00899	0.384
LIG_WRPW_1	957	961	PF00400	0.612
LIG_WRPW_2	957	960	PF00400	0.605
MOD_CDC14_SPxK_1	42	45	PF00782	0.605
MOD_CDC14_SPxK_1	910	913	PF00782	0.715
MOD_CDC14_SPxK_1	922	925	PF00782	0.567
MOD_CDC14_SPxK_1	955	958	PF00782	0.650
MOD_CDK_SPxK_1	39	45	PF00069	0.616
MOD_CDK_SPxK_1	907	913	PF00069	0.749
MOD_CDK_SPxK_1	919	925	PF00069	0.541
MOD_CDK_SPxK_1	952	958	PF00069	0.657
MOD_CDK_SPxxK_3	19	26	PF00069	0.621
MOD_CK1_1	163	169	PF00069	0.576
MOD_CK1_1	261	267	PF00069	0.564
MOD_CK1_1	269	275	PF00069	0.496
MOD_CK1_1	282	288	PF00069	0.349
MOD_CK1_1	430	436	PF00069	0.581
MOD_CK1_1	582	588	PF00069	0.707
MOD_CK1_1	668	674	PF00069	0.601
MOD_CK1_1	94	100	PF00069	0.581
MOD_CK1_1	952	958	PF00069	0.668
MOD_CK2_1	153	159	PF00069	0.481
MOD_CK2_1	167	173	PF00069	0.516
MOD_CK2_1	257	263	PF00069	0.526
MOD_CK2_1	265	271	PF00069	0.545
MOD_CK2_1	372	378	PF00069	0.479
MOD_CK2_1	420	426	PF00069	0.556
MOD_CK2_1	445	451	PF00069	0.457
MOD_CK2_1	453	459	PF00069	0.488
MOD_CK2_1	532	538	PF00069	0.533
MOD_CK2_1	624	630	PF00069	0.459
MOD_CK2_1	668	674	PF00069	0.513
MOD_CK2_1	846	852	PF00069	0.680
MOD_GlcNHglycan	284	287	PF01048	0.475
MOD_GlcNHglycan	433	436	PF01048	0.572
MOD_GlcNHglycan	589	592	PF01048	0.656
MOD_GlcNHglycan	637	640	PF01048	0.642
MOD_GlcNHglycan	835	839	PF01048	0.564
MOD_GlcNHglycan	848	851	PF01048	0.535
MOD_GlcNHglycan	852	856	PF01048	0.482
MOD_GlcNHglycan	887	890	PF01048	0.791
MOD_GlcNHglycan	905	908	PF01048	0.687
MOD_GSK3_1	148	155	PF00069	0.515
MOD_GSK3_1	159	166	PF00069	0.568
MOD_GSK3_1	257	264	PF00069	0.521
MOD_GSK3_1	265	272	PF00069	0.494
MOD_GSK3_1	278	285	PF00069	0.420
MOD_GSK3_1	35	42	PF00069	0.676
MOD_GSK3_1	353	360	PF00069	0.642
MOD_GSK3_1	426	433	PF00069	0.630
MOD_GSK3_1	635	642	PF00069	0.669
MOD_GSK3_1	661	668	PF00069	0.385
MOD_GSK3_1	78	85	PF00069	0.659
MOD_GSK3_1	863	870	PF00069	0.594
MOD_GSK3_1	903	910	PF00069	0.668
MOD_GSK3_1	919	926	PF00069	0.737
MOD_NEK2_1	126	131	PF00069	0.479
MOD_NEK2_1	133	138	PF00069	0.498
MOD_NEK2_1	213	218	PF00069	0.680
MOD_NEK2_1	247	252	PF00069	0.542
MOD_NEK2_1	353	358	PF00069	0.635
MOD_NEK2_1	386	391	PF00069	0.560
MOD_NEK2_1	453	458	PF00069	0.570
MOD_NEK2_1	471	476	PF00069	0.531
MOD_NEK2_1	507	512	PF00069	0.474
MOD_NEK2_1	84	89	PF00069	0.686
MOD_NEK2_1	860	865	PF00069	0.687
MOD_NEK2_1	877	882	PF00069	0.682
MOD_PIKK_1	269	275	PF00454	0.507
MOD_PIKK_1	33	39	PF00454	0.769
MOD_PIKK_1	353	359	PF00454	0.577
MOD_PIKK_1	386	392	PF00454	0.514
MOD_PIKK_1	420	426	PF00454	0.563
MOD_PIKK_1	427	433	PF00454	0.535
MOD_PIKK_1	445	451	PF00454	0.534
MOD_PIKK_1	471	477	PF00454	0.586
MOD_PIKK_1	55	61	PF00454	0.584
MOD_PIKK_1	624	630	PF00454	0.484
MOD_PIKK_1	716	722	PF00454	0.584
MOD_PIKK_1	78	84	PF00454	0.589
MOD_PKA_2	116	122	PF00069	0.525
MOD_PKA_2	152	158	PF00069	0.565
MOD_PKA_2	25	31	PF00069	0.760
MOD_PKA_2	279	285	PF00069	0.563
MOD_PKA_2	316	322	PF00069	0.484
MOD_PKA_2	353	359	PF00069	0.585
MOD_PKA_2	579	585	PF00069	0.671
MOD_PKA_2	587	593	PF00069	0.699
MOD_PKA_2	716	722	PF00069	0.484
MOD_PKA_2	867	873	PF00069	0.713
MOD_PKA_2	949	955	PF00069	0.720
MOD_Plk_1	229	235	PF00069	0.516
MOD_Plk_1	24	30	PF00069	0.700
MOD_Plk_1	507	513	PF00069	0.443
MOD_Plk_1	601	607	PF00069	0.579
MOD_Plk_1	97	103	PF00069	0.614
MOD_Plk_2-3	167	173	PF00069	0.463
MOD_Plk_2-3	25	31	PF00069	0.467
MOD_Plk_4	279	285	PF00069	0.492
MOD_Plk_4	335	341	PF00069	0.501
MOD_Plk_4	388	394	PF00069	0.581
MOD_Plk_4	91	97	PF00069	0.450
MOD_ProDKin_1	19	25	PF00069	0.593
MOD_ProDKin_1	39	45	PF00069	0.640
MOD_ProDKin_1	890	896	PF00069	0.706
MOD_ProDKin_1	907	913	PF00069	0.785
MOD_ProDKin_1	919	925	PF00069	0.641
MOD_ProDKin_1	952	958	PF00069	0.632
MOD_SUMO_for_1	122	125	PF00179	0.588
MOD_SUMO_for_1	794	797	PF00179	0.529
MOD_SUMO_rev_2	163	171	PF00179	0.559
MOD_SUMO_rev_2	214	224	PF00179	0.586
MOD_SUMO_rev_2	328	333	PF00179	0.476
MOD_SUMO_rev_2	349	353	PF00179	0.606
MOD_SUMO_rev_2	465	474	PF00179	0.583
MOD_SUMO_rev_2	696	701	PF00179	0.489
MOD_SUMO_rev_2	748	753	PF00179	0.517
MOD_SUMO_rev_2	813	821	PF00179	0.483
TRG_DiLeu_BaEn_1	400	405	PF01217	0.538
TRG_DiLeu_BaEn_1	589	594	PF01217	0.460
TRG_DiLeu_BaEn_1	658	663	PF01217	0.324
TRG_DiLeu_BaEn_1	734	739	PF01217	0.500
TRG_DiLeu_BaEn_1	796	801	PF01217	0.578
TRG_DiLeu_BaEn_2	317	323	PF01217	0.557
TRG_DiLeu_BaEn_4	559	565	PF01217	0.530
TRG_DiLeu_BaEn_4	608	614	PF01217	0.635
TRG_DiLeu_BaEn_4	696	702	PF01217	0.455
TRG_DiLeu_BaEn_4	748	754	PF01217	0.552
TRG_DiLeu_BaEn_4	796	802	PF01217	0.468
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.515
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.315
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.488
TRG_ENDOCYTIC_2	147	150	PF00928	0.594
TRG_ENDOCYTIC_2	677	680	PF00928	0.568
TRG_ENDOCYTIC_2	736	739	PF00928	0.406
TRG_ENDOCYTIC_2	857	860	PF00928	0.689
TRG_ER_diArg_1	105	107	PF00400	0.621
TRG_ER_diArg_1	208	210	PF00400	0.472
TRG_ER_diArg_1	240	242	PF00400	0.538
TRG_ER_diArg_1	701	704	PF00400	0.429
TRG_ER_diArg_1	772	775	PF00400	0.576
TRG_ER_diArg_1	801	803	PF00400	0.571
TRG_ER_diArg_1	898	900	PF00400	0.629
TRG_Pf-PMV_PEXEL_1	105	109	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	413	417	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	487	492	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	772	776	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKJ3	Leptomonas seymouri	62%	98%
A0A0S4JNT6	Bodo saltans	30%	100%
A0A1X0P823	Trypanosomatidae	37%	100%
A0A3Q8IJT0	Leishmania donovani	93%	100%
A0A422NIX4	Trypanosoma rangeli	33%	100%
A4H9N9	Leishmania braziliensis	82%	100%
A4HY07	Leishmania infantum	93%	100%
D0A592	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4QDQ3	Leishmania major	92%	100%
V5BJ58	Trypanosoma cruzi	32%	100%