Zinc finger protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Zinc finger protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARR9_LEIMU

TriTrypDb:

LmxM.18.1350

Length:

593

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARR9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.584
CLV_NRD_NRD_1	239	241	PF00675	0.678
CLV_NRD_NRD_1	419	421	PF00675	0.510
CLV_NRD_NRD_1	476	478	PF00675	0.636
CLV_PCSK_KEX2_1	239	241	PF00082	0.678
CLV_PCSK_KEX2_1	416	418	PF00082	0.465
CLV_PCSK_KEX2_1	421	423	PF00082	0.540
CLV_PCSK_KEX2_1	476	478	PF00082	0.627
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.465
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.540
CLV_PCSK_PC7_1	417	423	PF00082	0.508
CLV_PCSK_SKI1_1	286	290	PF00082	0.410
CLV_PCSK_SKI1_1	363	367	PF00082	0.552
CLV_PCSK_SKI1_1	556	560	PF00082	0.537
DEG_SCF_FBW7_1	542	547	PF00400	0.635
DOC_CKS1_1	7	12	PF01111	0.789
DOC_PP2B_LxvP_1	568	571	PF13499	0.485
DOC_USP7_MATH_1	158	162	PF00917	0.498
DOC_USP7_MATH_1	302	306	PF00917	0.492
DOC_USP7_MATH_1	358	362	PF00917	0.420
DOC_USP7_MATH_1	533	537	PF00917	0.594
DOC_WW_Pin1_4	142	147	PF00397	0.765
DOC_WW_Pin1_4	192	197	PF00397	0.656
DOC_WW_Pin1_4	204	209	PF00397	0.560
DOC_WW_Pin1_4	214	219	PF00397	0.718
DOC_WW_Pin1_4	464	469	PF00397	0.675
DOC_WW_Pin1_4	478	483	PF00397	0.622
DOC_WW_Pin1_4	504	509	PF00397	0.628
DOC_WW_Pin1_4	540	545	PF00397	0.652
DOC_WW_Pin1_4	548	553	PF00397	0.636
DOC_WW_Pin1_4	6	11	PF00397	0.788
LIG_14-3-3_CanoR_1	37	41	PF00244	0.718
LIG_14-3-3_CanoR_1	398	402	PF00244	0.278
LIG_14-3-3_CanoR_1	572	580	PF00244	0.480
LIG_BIR_III_4	29	33	PF00653	0.574
LIG_BRCT_BRCA1_1	305	309	PF00533	0.465
LIG_FHA_1	137	143	PF00498	0.652
LIG_FHA_1	172	178	PF00498	0.603
LIG_FHA_1	253	259	PF00498	0.445
LIG_FHA_1	269	275	PF00498	0.347
LIG_FHA_1	283	289	PF00498	0.323
LIG_FHA_1	431	437	PF00498	0.491
LIG_FHA_1	559	565	PF00498	0.408
LIG_FHA_2	236	242	PF00498	0.630
LIG_FHA_2	243	249	PF00498	0.490
LIG_FHA_2	252	258	PF00498	0.352
LIG_FHA_2	380	386	PF00498	0.416
LIG_FHA_2	507	513	PF00498	0.615
LIG_LIR_Apic_2	195	200	PF02991	0.533
LIG_LIR_Gen_1	23	33	PF02991	0.581
LIG_LIR_Gen_1	313	324	PF02991	0.380
LIG_LIR_Nem_3	164	170	PF02991	0.547
LIG_LIR_Nem_3	23	28	PF02991	0.586
LIG_LIR_Nem_3	260	266	PF02991	0.399
LIG_LIR_Nem_3	313	319	PF02991	0.387
LIG_LYPXL_yS_3	338	341	PF13949	0.421
LIG_NRBOX	563	569	PF00104	0.528
LIG_PCNA_yPIPBox_3	239	250	PF02747	0.553
LIG_Pex14_2	259	263	PF04695	0.374
LIG_SH2_CRK	197	201	PF00017	0.540
LIG_SH2_CRK	267	271	PF00017	0.356
LIG_SH2_GRB2like	387	390	PF00017	0.399
LIG_SH2_NCK_1	170	174	PF00017	0.599
LIG_SH2_NCK_1	197	201	PF00017	0.540
LIG_SH2_NCK_1	25	29	PF00017	0.664
LIG_SH2_NCK_1	267	271	PF00017	0.356
LIG_SH2_SRC	197	200	PF00017	0.539
LIG_SH2_SRC	387	390	PF00017	0.361
LIG_SH2_STAP1	63	67	PF00017	0.683
LIG_SH2_STAT5	131	134	PF00017	0.631
LIG_SH2_STAT5	170	173	PF00017	0.464
LIG_SH2_STAT5	328	331	PF00017	0.369
LIG_SH2_STAT5	569	572	PF00017	0.468
LIG_SH2_STAT5	97	100	PF00017	0.570
LIG_SH3_3	255	261	PF00018	0.376
LIG_SH3_3	272	278	PF00018	0.380
LIG_SH3_3	292	298	PF00018	0.277
LIG_SH3_3	336	342	PF00018	0.430
LIG_SH3_3	346	352	PF00018	0.462
LIG_SH3_3	4	10	PF00018	0.837
LIG_SH3_3	576	582	PF00018	0.478
LIG_SUMO_SIM_anti_2	345	351	PF11976	0.617
LIG_SUMO_SIM_par_1	254	260	PF11976	0.522
LIG_TYR_ITSM	21	28	PF00017	0.665
MOD_CDK_SPK_2	204	209	PF00069	0.638
MOD_CDK_SPxxK_3	204	211	PF00069	0.609
MOD_CK1_1	135	141	PF00069	0.814
MOD_CK1_1	161	167	PF00069	0.565
MOD_CK1_1	204	210	PF00069	0.556
MOD_CK1_1	234	240	PF00069	0.726
MOD_CK1_1	426	432	PF00069	0.652
MOD_CK1_1	434	440	PF00069	0.712
MOD_CK1_1	450	456	PF00069	0.518
MOD_CK1_1	464	470	PF00069	0.626
MOD_CK1_1	481	487	PF00069	0.542
MOD_CK1_1	490	496	PF00069	0.622
MOD_CK1_1	560	566	PF00069	0.488
MOD_CK1_1	575	581	PF00069	0.513
MOD_CK2_1	235	241	PF00069	0.650
MOD_CK2_1	242	248	PF00069	0.534
MOD_CK2_1	251	257	PF00069	0.457
MOD_CK2_1	450	456	PF00069	0.568
MOD_CK2_1	506	512	PF00069	0.617
MOD_GlcNHglycan	108	111	PF01048	0.694
MOD_GlcNHglycan	160	163	PF01048	0.736
MOD_GlcNHglycan	178	181	PF01048	0.535
MOD_GlcNHglycan	204	207	PF01048	0.741
MOD_GlcNHglycan	221	224	PF01048	0.704
MOD_GlcNHglycan	229	232	PF01048	0.776
MOD_GlcNHglycan	234	237	PF01048	0.688
MOD_GlcNHglycan	388	392	PF01048	0.437
MOD_GlcNHglycan	449	452	PF01048	0.640
MOD_GlcNHglycan	456	460	PF01048	0.636
MOD_GlcNHglycan	463	466	PF01048	0.544
MOD_GlcNHglycan	47	50	PF01048	0.617
MOD_GlcNHglycan	517	520	PF01048	0.579
MOD_GSK3_1	132	139	PF00069	0.798
MOD_GSK3_1	171	178	PF00069	0.645
MOD_GSK3_1	225	232	PF00069	0.684
MOD_GSK3_1	248	255	PF00069	0.647
MOD_GSK3_1	379	386	PF00069	0.485
MOD_GSK3_1	426	433	PF00069	0.684
MOD_GSK3_1	486	493	PF00069	0.639
MOD_GSK3_1	534	541	PF00069	0.614
MOD_GSK3_1	542	549	PF00069	0.625
MOD_GSK3_1	554	561	PF00069	0.490
MOD_GSK3_1	83	90	PF00069	0.490
MOD_N-GLC_1	135	140	PF02516	0.691
MOD_N-GLC_1	158	163	PF02516	0.523
MOD_N-GLC_1	214	219	PF02516	0.677
MOD_N-GLC_1	232	237	PF02516	0.644
MOD_N-GLC_1	282	287	PF02516	0.414
MOD_N-GLC_1	430	435	PF02516	0.637
MOD_N-GLC_1	487	492	PF02516	0.629
MOD_N-GLC_1	493	498	PF02516	0.611
MOD_N-GLC_1	515	520	PF02516	0.671
MOD_NEK2_1	176	181	PF00069	0.650
MOD_NEK2_1	249	254	PF00069	0.424
MOD_NEK2_1	282	287	PF00069	0.453
MOD_NEK2_1	303	308	PF00069	0.469
MOD_NEK2_1	515	520	PF00069	0.710
MOD_NEK2_1	546	551	PF00069	0.509
MOD_NEK2_1	558	563	PF00069	0.464
MOD_NEK2_1	588	593	PF00069	0.632
MOD_NEK2_1	98	103	PF00069	0.767
MOD_NEK2_2	20	25	PF00069	0.668
MOD_OFUCOSY	301	307	PF10250	0.470
MOD_PIKK_1	113	119	PF00454	0.683
MOD_PIKK_1	558	564	PF00454	0.545
MOD_PIKK_1	586	592	PF00454	0.629
MOD_PIKK_1	8	14	PF00454	0.649
MOD_PIKK_1	87	93	PF00454	0.437
MOD_PKA_1	476	482	PF00069	0.630
MOD_PKA_2	20	26	PF00069	0.721
MOD_PKA_2	36	42	PF00069	0.622
MOD_PKA_2	397	403	PF00069	0.276
MOD_PKA_2	476	482	PF00069	0.633
MOD_Plk_1	282	288	PF00069	0.408
MOD_Plk_1	431	437	PF00069	0.584
MOD_Plk_1	493	499	PF00069	0.645
MOD_Plk_1	575	581	PF00069	0.528
MOD_Plk_4	126	132	PF00069	0.687
MOD_Plk_4	20	26	PF00069	0.722
MOD_Plk_4	397	403	PF00069	0.279
MOD_Plk_4	493	499	PF00069	0.800
MOD_Plk_4	56	62	PF00069	0.583
MOD_Plk_4	563	569	PF00069	0.452
MOD_Plk_4	575	581	PF00069	0.452
MOD_ProDKin_1	142	148	PF00069	0.764
MOD_ProDKin_1	192	198	PF00069	0.657
MOD_ProDKin_1	204	210	PF00069	0.561
MOD_ProDKin_1	214	220	PF00069	0.718
MOD_ProDKin_1	464	470	PF00069	0.677
MOD_ProDKin_1	478	484	PF00069	0.623
MOD_ProDKin_1	504	510	PF00069	0.625
MOD_ProDKin_1	540	546	PF00069	0.648
MOD_ProDKin_1	548	554	PF00069	0.627
MOD_ProDKin_1	6	12	PF00069	0.789
MOD_SUMO_rev_2	257	266	PF00179	0.375
MOD_SUMO_rev_2	408	418	PF00179	0.492
TRG_DiLeu_BaEn_2	396	402	PF01217	0.407
TRG_ENDOCYTIC_2	25	28	PF00928	0.664
TRG_ENDOCYTIC_2	316	319	PF00928	0.399
TRG_ENDOCYTIC_2	338	341	PF00928	0.421
TRG_ENDOCYTIC_2	63	66	PF00928	0.681
TRG_ENDOCYTIC_2	96	99	PF00928	0.453
TRG_ER_diArg_1	208	211	PF00400	0.646
TRG_ER_diArg_1	419	422	PF00400	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBV5	Leptomonas seymouri	41%	94%
A0A3S5H743	Leishmania donovani	91%	95%
A4H9L2	Leishmania braziliensis	76%	100%
A4HY06	Leishmania infantum	91%	95%
Q4QDQ4	Leishmania major	88%	100%