Zinc finger (CCCH type) motif-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARR8_LEIMU

TriTrypDb:

LmxM.18.1340

Length:

766

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARR8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.598
CLV_C14_Caspase3-7	185	189	PF00656	0.699
CLV_NRD_NRD_1	370	372	PF00675	0.735
CLV_NRD_NRD_1	439	441	PF00675	0.598
CLV_NRD_NRD_1	463	465	PF00675	0.580
CLV_PCSK_FUR_1	543	547	PF00082	0.552
CLV_PCSK_KEX2_1	370	372	PF00082	0.735
CLV_PCSK_KEX2_1	545	547	PF00082	0.580
CLV_PCSK_PC1ET2_1	545	547	PF00082	0.580
CLV_PCSK_SKI1_1	435	439	PF00082	0.544
DEG_SPOP_SBC_1	244	248	PF00917	0.737
DEG_SPOP_SBC_1	280	284	PF00917	0.553
DOC_CDC14_PxL_1	482	490	PF14671	0.556
DOC_CKS1_1	320	325	PF01111	0.742
DOC_CKS1_1	53	58	PF01111	0.688
DOC_CKS1_1	709	714	PF01111	0.750
DOC_CKS1_1	93	98	PF01111	0.684
DOC_CYCLIN_RxL_1	472	484	PF00134	0.532
DOC_CYCLIN_yCln2_LP_2	707	710	PF00134	0.510
DOC_MAPK_gen_1	464	473	PF00069	0.541
DOC_MAPK_MEF2A_6	41	49	PF00069	0.542
DOC_MAPK_MEF2A_6	426	433	PF00069	0.535
DOC_PP2B_LxvP_1	416	419	PF13499	0.543
DOC_PP2B_LxvP_1	707	710	PF13499	0.510
DOC_PP2B_LxvP_1	723	726	PF13499	0.684
DOC_PP2B_PxIxI_1	44	50	PF00149	0.798
DOC_PP4_FxxP_1	302	305	PF00568	0.721
DOC_PP4_FxxP_1	650	653	PF00568	0.715
DOC_USP7_MATH_1	121	125	PF00917	0.709
DOC_USP7_MATH_1	133	137	PF00917	0.549
DOC_USP7_MATH_1	182	186	PF00917	0.691
DOC_USP7_MATH_1	208	212	PF00917	0.594
DOC_USP7_MATH_1	33	37	PF00917	0.577
DOC_USP7_MATH_1	338	342	PF00917	0.620
DOC_USP7_MATH_1	351	355	PF00917	0.694
DOC_USP7_MATH_1	374	378	PF00917	0.554
DOC_USP7_MATH_1	574	578	PF00917	0.691
DOC_USP7_MATH_1	579	583	PF00917	0.655
DOC_USP7_MATH_1	728	732	PF00917	0.746
DOC_USP7_MATH_1	88	92	PF00917	0.668
DOC_USP7_MATH_1	9	13	PF00917	0.518
DOC_WW_Pin1_4	128	133	PF00397	0.743
DOC_WW_Pin1_4	154	159	PF00397	0.708
DOC_WW_Pin1_4	161	166	PF00397	0.623
DOC_WW_Pin1_4	168	173	PF00397	0.700
DOC_WW_Pin1_4	180	185	PF00397	0.636
DOC_WW_Pin1_4	238	243	PF00397	0.710
DOC_WW_Pin1_4	246	251	PF00397	0.654
DOC_WW_Pin1_4	257	262	PF00397	0.535
DOC_WW_Pin1_4	274	279	PF00397	0.535
DOC_WW_Pin1_4	301	306	PF00397	0.721
DOC_WW_Pin1_4	316	321	PF00397	0.601
DOC_WW_Pin1_4	324	329	PF00397	0.685
DOC_WW_Pin1_4	346	351	PF00397	0.794
DOC_WW_Pin1_4	394	399	PF00397	0.690
DOC_WW_Pin1_4	41	46	PF00397	0.785
DOC_WW_Pin1_4	500	505	PF00397	0.565
DOC_WW_Pin1_4	52	57	PF00397	0.607
DOC_WW_Pin1_4	64	69	PF00397	0.597
DOC_WW_Pin1_4	665	670	PF00397	0.709
DOC_WW_Pin1_4	708	713	PF00397	0.749
DOC_WW_Pin1_4	741	746	PF00397	0.693
DOC_WW_Pin1_4	747	752	PF00397	0.626
DOC_WW_Pin1_4	92	97	PF00397	0.686
LIG_14-3-3_CanoR_1	112	116	PF00244	0.756
LIG_14-3-3_CanoR_1	13	23	PF00244	0.569
LIG_14-3-3_CanoR_1	210	218	PF00244	0.507
LIG_14-3-3_CanoR_1	299	303	PF00244	0.611
LIG_14-3-3_CanoR_1	41	45	PF00244	0.593
LIG_14-3-3_CanoR_1	440	445	PF00244	0.420
LIG_BIR_II_1	1	5	PF00653	0.533
LIG_BIR_III_4	292	296	PF00653	0.713
LIG_BRCT_BRCA1_1	124	128	PF00533	0.724
LIG_BRCT_BRCA1_1	130	134	PF00533	0.681
LIG_BRCT_BRCA1_1	150	154	PF00533	0.490
LIG_BRCT_BRCA1_1	265	269	PF00533	0.689
LIG_eIF4E_1	702	708	PF01652	0.769
LIG_FHA_1	158	164	PF00498	0.732
LIG_FHA_1	254	260	PF00498	0.709
LIG_FHA_1	262	268	PF00498	0.643
LIG_FHA_1	284	290	PF00498	0.558
LIG_FHA_1	524	530	PF00498	0.599
LIG_FHA_1	77	83	PF00498	0.744
LIG_FHA_2	397	403	PF00498	0.441
LIG_HP1_1	686	690	PF01393	0.750
LIG_LIR_Apic_2	301	305	PF02991	0.720
LIG_LIR_Apic_2	648	653	PF02991	0.720
LIG_LIR_Gen_1	409	420	PF02991	0.549
LIG_LIR_Nem_3	409	415	PF02991	0.556
LIG_LIR_Nem_3	484	488	PF02991	0.569
LIG_LIR_Nem_3	755	759	PF02991	0.697
LIG_LYPXL_yS_3	485	488	PF13949	0.541
LIG_LYPXL_yS_3	660	663	PF13949	0.765
LIG_MYND_1	661	665	PF01753	0.664
LIG_REV1ctd_RIR_1	61	67	PF16727	0.700
LIG_SH2_GRB2like	536	539	PF00017	0.556
LIG_SH2_PTP2	687	690	PF00017	0.758
LIG_SH2_SRC	702	705	PF00017	0.733
LIG_SH2_STAP1	408	412	PF00017	0.564
LIG_SH2_STAT5	536	539	PF00017	0.556
LIG_SH2_STAT5	687	690	PF00017	0.758
LIG_SH2_STAT5	702	705	PF00017	0.766
LIG_SH3_3	104	110	PF00018	0.537
LIG_SH3_3	175	181	PF00018	0.700
LIG_SH3_3	200	206	PF00018	0.787
LIG_SH3_3	218	224	PF00018	0.681
LIG_SH3_3	317	323	PF00018	0.820
LIG_SH3_3	345	351	PF00018	0.658
LIG_SH3_3	483	489	PF00018	0.549
LIG_SH3_3	493	499	PF00018	0.434
LIG_SH3_3	50	56	PF00018	0.686
LIG_SH3_3	706	712	PF00018	0.694
LIG_SH3_3	742	748	PF00018	0.742
LIG_SH3_3	90	96	PF00018	0.691
LIG_SUMO_SIM_anti_2	492	498	PF11976	0.575
LIG_SUMO_SIM_par_1	159	164	PF11976	0.706
LIG_SUMO_SIM_par_1	402	411	PF11976	0.428
LIG_SxIP_EBH_1	210	220	PF03271	0.507
LIG_TRFH_1	650	654	PF08558	0.650
MOD_CDC14_SPxK_1	327	330	PF00782	0.541
MOD_CDK_SPK_2	316	321	PF00069	0.817
MOD_CDK_SPxK_1	324	330	PF00069	0.685
MOD_CDK_SPxK_1	346	352	PF00069	0.627
MOD_CDK_SPxxK_3	161	168	PF00069	0.696
MOD_CDK_SPxxK_3	64	71	PF00069	0.511
MOD_CDK_SPxxK_3	92	99	PF00069	0.686
MOD_CK1_1	103	109	PF00069	0.737
MOD_CK1_1	111	117	PF00069	0.669
MOD_CK1_1	12	18	PF00069	0.752
MOD_CK1_1	122	128	PF00069	0.536
MOD_CK1_1	149	155	PF00069	0.710
MOD_CK1_1	157	163	PF00069	0.666
MOD_CK1_1	230	236	PF00069	0.765
MOD_CK1_1	238	244	PF00069	0.639
MOD_CK1_1	257	263	PF00069	0.539
MOD_CK1_1	314	320	PF00069	0.661
MOD_CK1_1	324	330	PF00069	0.659
MOD_CK1_1	334	340	PF00069	0.746
MOD_CK1_1	377	383	PF00069	0.732
MOD_CK1_1	396	402	PF00069	0.638
MOD_CK1_1	43	49	PF00069	0.786
MOD_CK1_1	467	473	PF00069	0.579
MOD_CK1_1	577	583	PF00069	0.617
MOD_CK1_1	67	73	PF00069	0.712
MOD_CK1_1	731	737	PF00069	0.702
MOD_CK1_1	755	761	PF00069	0.737
MOD_CK2_1	301	307	PF00069	0.737
MOD_CK2_1	397	403	PF00069	0.657
MOD_CK2_1	407	413	PF00069	0.456
MOD_CK2_1	448	454	PF00069	0.410
MOD_CK2_1	500	506	PF00069	0.588
MOD_CK2_1	69	75	PF00069	0.523
MOD_Cter_Amidation	543	546	PF01082	0.561
MOD_DYRK1A_RPxSP_1	180	184	PF00069	0.604
MOD_DYRK1A_RPxSP_1	41	45	PF00069	0.533
MOD_GlcNHglycan	102	105	PF01048	0.571
MOD_GlcNHglycan	115	118	PF01048	0.618
MOD_GlcNHglycan	121	124	PF01048	0.605
MOD_GlcNHglycan	135	138	PF01048	0.589
MOD_GlcNHglycan	18	21	PF01048	0.705
MOD_GlcNHglycan	184	187	PF01048	0.706
MOD_GlcNHglycan	237	240	PF01048	0.740
MOD_GlcNHglycan	261	264	PF01048	0.688
MOD_GlcNHglycan	313	316	PF01048	0.614
MOD_GlcNHglycan	333	336	PF01048	0.768
MOD_GlcNHglycan	35	38	PF01048	0.567
MOD_GlcNHglycan	588	591	PF01048	0.701
MOD_GlcNHglycan	602	605	PF01048	0.595
MOD_GlcNHglycan	615	618	PF01048	0.590
MOD_GlcNHglycan	676	679	PF01048	0.548
MOD_GlcNHglycan	692	695	PF01048	0.764
MOD_GlcNHglycan	730	733	PF01048	0.706
MOD_GlcNHglycan	738	741	PF01048	0.754
MOD_GlcNHglycan	75	79	PF01048	0.714
MOD_GlcNHglycan	84	87	PF01048	0.665
MOD_GlcNHglycan	90	93	PF01048	0.610
MOD_GSK3_1	111	118	PF00069	0.764
MOD_GSK3_1	12	19	PF00069	0.742
MOD_GSK3_1	146	153	PF00069	0.764
MOD_GSK3_1	157	164	PF00069	0.646
MOD_GSK3_1	170	177	PF00069	0.665
MOD_GSK3_1	227	234	PF00069	0.762
MOD_GSK3_1	253	260	PF00069	0.629
MOD_GSK3_1	279	286	PF00069	0.651
MOD_GSK3_1	294	301	PF00069	0.729
MOD_GSK3_1	334	341	PF00069	0.567
MOD_GSK3_1	373	380	PF00069	0.567
MOD_GSK3_1	393	400	PF00069	0.731
MOD_GSK3_1	403	410	PF00069	0.440
MOD_GSK3_1	41	48	PF00069	0.751
MOD_GSK3_1	414	421	PF00069	0.419
MOD_GSK3_1	51	58	PF00069	0.620
MOD_GSK3_1	513	520	PF00069	0.568
MOD_GSK3_1	523	530	PF00069	0.460
MOD_GSK3_1	582	589	PF00069	0.672
MOD_GSK3_1	724	731	PF00069	0.727
MOD_GSK3_1	88	95	PF00069	0.716
MOD_N-GLC_1	149	154	PF02516	0.808
MOD_N-GLC_1	254	259	PF02516	0.743
MOD_N-GLC_1	273	278	PF02516	0.572
MOD_N-GLC_1	352	357	PF02516	0.636
MOD_N-GLC_1	377	382	PF02516	0.711
MOD_N-GLC_1	728	733	PF02516	0.691
MOD_NEK2_1	1	6	PF00069	0.680
MOD_NEK2_1	115	120	PF00069	0.753
MOD_NEK2_1	16	21	PF00069	0.564
MOD_NEK2_1	174	179	PF00069	0.518
MOD_NEK2_1	243	248	PF00069	0.738
MOD_NEK2_1	28	33	PF00069	0.753
MOD_NEK2_1	294	299	PF00069	0.765
MOD_NEK2_1	331	336	PF00069	0.615
MOD_NEK2_1	431	436	PF00069	0.620
MOD_NEK2_1	690	695	PF00069	0.750
MOD_NEK2_1	735	740	PF00069	0.527
MOD_NEK2_1	74	79	PF00069	0.782
MOD_NEK2_1	752	757	PF00069	0.744
MOD_NEK2_2	338	343	PF00069	0.532
MOD_PIKK_1	283	289	PF00454	0.558
MOD_PIKK_1	397	403	PF00454	0.624
MOD_PIKK_1	418	424	PF00454	0.576
MOD_PKA_1	440	446	PF00069	0.418
MOD_PKA_1	464	470	PF00069	0.558
MOD_PKA_2	111	117	PF00069	0.806
MOD_PKA_2	12	18	PF00069	0.523
MOD_PKA_2	209	215	PF00069	0.611
MOD_PKA_2	298	304	PF00069	0.606
MOD_PKA_2	40	46	PF00069	0.531
MOD_PKA_2	467	473	PF00069	0.581
MOD_PKA_2	516	522	PF00069	0.579
MOD_Plk_1	149	155	PF00069	0.726
MOD_Plk_1	254	260	PF00069	0.709
MOD_Plk_1	492	498	PF00069	0.529
MOD_Plk_2-3	403	409	PF00069	0.510
MOD_Plk_4	170	176	PF00069	0.610
MOD_Plk_4	263	269	PF00069	0.740
MOD_Plk_4	298	304	PF00069	0.790
MOD_Plk_4	403	409	PF00069	0.601
MOD_Plk_4	411	417	PF00069	0.453
MOD_Plk_4	645	651	PF00069	0.728
MOD_Plk_4	698	704	PF00069	0.794
MOD_ProDKin_1	128	134	PF00069	0.744
MOD_ProDKin_1	154	160	PF00069	0.709
MOD_ProDKin_1	161	167	PF00069	0.622
MOD_ProDKin_1	168	174	PF00069	0.702
MOD_ProDKin_1	180	186	PF00069	0.636
MOD_ProDKin_1	238	244	PF00069	0.714
MOD_ProDKin_1	246	252	PF00069	0.652
MOD_ProDKin_1	257	263	PF00069	0.535
MOD_ProDKin_1	274	280	PF00069	0.538
MOD_ProDKin_1	301	307	PF00069	0.721
MOD_ProDKin_1	316	322	PF00069	0.598
MOD_ProDKin_1	324	330	PF00069	0.684
MOD_ProDKin_1	346	352	PF00069	0.794
MOD_ProDKin_1	394	400	PF00069	0.684
MOD_ProDKin_1	41	47	PF00069	0.789
MOD_ProDKin_1	500	506	PF00069	0.563
MOD_ProDKin_1	52	58	PF00069	0.607
MOD_ProDKin_1	64	70	PF00069	0.597
MOD_ProDKin_1	665	671	PF00069	0.712
MOD_ProDKin_1	708	714	PF00069	0.751
MOD_ProDKin_1	741	747	PF00069	0.693
MOD_ProDKin_1	92	98	PF00069	0.687
MOD_SUMO_rev_2	556	566	PF00179	0.613
TRG_DiLeu_BaEn_2	453	459	PF01217	0.404
TRG_DiLeu_BaLyEn_6	658	663	PF01217	0.761
TRG_ENDOCYTIC_2	485	488	PF00928	0.574
TRG_ENDOCYTIC_2	660	663	PF00928	0.765
TRG_ENDOCYTIC_2	687	690	PF00928	0.758

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID50	Leishmania donovani	87%	100%
A4H9L3	Leishmania braziliensis	63%	100%
A4HY05	Leishmania infantum	87%	100%
Q4QDQ5	Leishmania major	86%	100%