Ethanolamine-phosphate cytidylyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cholinephosphate cytidylyltransferase A, putative

Species:

Leishmania mexicana

UniProt:

E9ARR7_LEIMU

TriTrypDb:

LmxM.18.1330

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1

Expansion

Sequence features

E9ARR7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARR7

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006646	phosphatidylethanolamine biosynthetic process	6	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0019637	organophosphate metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046337	phosphatidylethanolamine metabolic process	6	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004306	ethanolamine-phosphate cytidylyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	12
GO:0070567	cytidylyltransferase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	584	588	PF00656	0.745
CLV_NRD_NRD_1	388	390	PF00675	0.314
CLV_NRD_NRD_1	542	544	PF00675	0.355
CLV_PCSK_KEX2_1	199	201	PF00082	0.338
CLV_PCSK_KEX2_1	388	390	PF00082	0.314
CLV_PCSK_KEX2_1	479	481	PF00082	0.266
CLV_PCSK_KEX2_1	542	544	PF00082	0.355
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.316
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.276
CLV_PCSK_SKI1_1	134	138	PF00082	0.543
CLV_PCSK_SKI1_1	202	206	PF00082	0.335
CLV_PCSK_SKI1_1	303	307	PF00082	0.575
CLV_PCSK_SKI1_1	436	440	PF00082	0.308
CLV_PCSK_SKI1_1	88	92	PF00082	0.414
DEG_APCC_DBOX_1	302	310	PF00400	0.412
DEG_APCC_DBOX_1	87	95	PF00400	0.613
DEG_SCF_FBW7_1	550	557	PF00400	0.641
DOC_CKS1_1	431	436	PF01111	0.630
DOC_CKS1_1	530	535	PF01111	0.562
DOC_CKS1_1	551	556	PF01111	0.649
DOC_MAPK_gen_1	332	342	PF00069	0.547
DOC_MAPK_gen_1	388	396	PF00069	0.558
DOC_MAPK_HePTP_8	236	248	PF00069	0.337
DOC_MAPK_MEF2A_6	220	227	PF00069	0.449
DOC_MAPK_MEF2A_6	239	248	PF00069	0.337
DOC_MAPK_MEF2A_6	303	310	PF00069	0.395
DOC_MAPK_MEF2A_6	338	345	PF00069	0.486
DOC_MAPK_MEF2A_6	36	45	PF00069	0.607
DOC_MAPK_MEF2A_6	460	469	PF00069	0.537
DOC_MAPK_MEF2A_6	517	525	PF00069	0.459
DOC_MAPK_NFAT4_5	220	228	PF00069	0.449
DOC_MAPK_NFAT4_5	338	346	PF00069	0.484
DOC_MAPK_RevD_3	373	389	PF00069	0.377
DOC_PP1_RVXF_1	27	34	PF00149	0.645
DOC_PP1_SILK_1	544	549	PF00149	0.524
DOC_PP2B_LxvP_1	156	159	PF13499	0.511
DOC_PP2B_LxvP_1	427	430	PF13499	0.538
DOC_PP2B_LxvP_1	53	56	PF13499	0.614
DOC_USP7_MATH_1	110	114	PF00917	0.558
DOC_USP7_MATH_1	146	150	PF00917	0.464
DOC_USP7_MATH_1	189	193	PF00917	0.184
DOC_USP7_MATH_1	568	572	PF00917	0.695
DOC_USP7_UBL2_3	265	269	PF12436	0.661
DOC_USP7_UBL2_3	334	338	PF12436	0.565
DOC_USP7_UBL2_3	582	586	PF12436	0.626
DOC_WW_Pin1_4	430	435	PF00397	0.629
DOC_WW_Pin1_4	503	508	PF00397	0.476
DOC_WW_Pin1_4	529	534	PF00397	0.562
DOC_WW_Pin1_4	550	555	PF00397	0.631
LIG_14-3-3_CanoR_1	171	181	PF00244	0.356
LIG_14-3-3_CanoR_1	200	207	PF00244	0.533
LIG_14-3-3_CanoR_1	213	219	PF00244	0.479
LIG_14-3-3_CanoR_1	29	34	PF00244	0.568
LIG_14-3-3_CanoR_1	44	53	PF00244	0.615
LIG_14-3-3_CanoR_1	566	573	PF00244	0.628
LIG_Actin_WH2_2	91	106	PF00022	0.724
LIG_BIR_II_1	1	5	PF00653	0.655
LIG_BRCT_BRCA1_1	7	11	PF00533	0.562
LIG_Clathr_ClatBox_1	375	379	PF01394	0.344
LIG_EH1_1	285	293	PF00400	0.449
LIG_EH1_1	414	422	PF00400	0.522
LIG_eIF4E_1	337	343	PF01652	0.581
LIG_eIF4E_1	415	421	PF01652	0.549
LIG_FHA_1	173	179	PF00498	0.242
LIG_FHA_1	26	32	PF00498	0.615
LIG_FHA_1	317	323	PF00498	0.395
LIG_FHA_1	45	51	PF00498	0.540
LIG_FHA_1	551	557	PF00498	0.563
LIG_FHA_2	10	16	PF00498	0.546
LIG_FHA_2	224	230	PF00498	0.363
LIG_FHA_2	483	489	PF00498	0.473
LIG_FHA_2	530	536	PF00498	0.541
LIG_FHA_2	576	582	PF00498	0.728
LIG_IRF3_LxIS_1	181	187	PF10401	0.451
LIG_LIR_Apic_2	477	481	PF02991	0.562
LIG_LIR_Apic_2	528	533	PF02991	0.477
LIG_LIR_Apic_2	535	541	PF02991	0.538
LIG_LIR_Gen_1	160	167	PF02991	0.496
LIG_LIR_Gen_1	209	219	PF02991	0.481
LIG_LIR_Gen_1	283	294	PF02991	0.358
LIG_LIR_Gen_1	324	333	PF02991	0.365
LIG_LIR_Gen_1	359	367	PF02991	0.353
LIG_LIR_LC3C_4	319	322	PF02991	0.449
LIG_LIR_Nem_3	160	166	PF02991	0.481
LIG_LIR_Nem_3	209	214	PF02991	0.491
LIG_LIR_Nem_3	238	244	PF02991	0.288
LIG_LIR_Nem_3	283	289	PF02991	0.357
LIG_LIR_Nem_3	324	328	PF02991	0.403
LIG_LIR_Nem_3	35	41	PF02991	0.562
LIG_LIR_Nem_3	359	364	PF02991	0.403
LIG_LIR_Nem_3	534	540	PF02991	0.541
LIG_LIR_Nem_3	76	80	PF02991	0.598
LIG_NRBOX	178	184	PF00104	0.363
LIG_NRBOX	286	292	PF00104	0.475
LIG_NRBOX	398	404	PF00104	0.627
LIG_NRBOX	60	66	PF00104	0.598
LIG_PDZ_Class_3	584	589	PF00595	0.704
LIG_Pex14_2	38	42	PF04695	0.568
LIG_PTB_Apo_2	267	274	PF02174	0.657
LIG_PTB_Apo_2	72	79	PF02174	0.649
LIG_PTB_Phospho_1	267	273	PF10480	0.656
LIG_PTB_Phospho_1	72	78	PF10480	0.643
LIG_SH2_CRK	317	321	PF00017	0.343
LIG_SH2_CRK	337	341	PF00017	0.587
LIG_SH2_CRK	361	365	PF00017	0.324
LIG_SH2_CRK	478	482	PF00017	0.562
LIG_SH2_CRK	530	534	PF00017	0.501
LIG_SH2_CRK	538	542	PF00017	0.501
LIG_SH2_CRK	71	75	PF00017	0.531
LIG_SH2_GRB2like	518	521	PF00017	0.562
LIG_SH2_NCK_1	530	534	PF00017	0.476
LIG_SH2_SRC	415	418	PF00017	0.536
LIG_SH2_STAP1	425	429	PF00017	0.534
LIG_SH2_STAT5	163	166	PF00017	0.475
LIG_SH2_STAT5	241	244	PF00017	0.363
LIG_SH2_STAT5	273	276	PF00017	0.577
LIG_SH2_STAT5	277	280	PF00017	0.548
LIG_SH2_STAT5	354	357	PF00017	0.601
LIG_SH2_STAT5	381	384	PF00017	0.561
LIG_SH2_STAT5	415	418	PF00017	0.509
LIG_SH2_STAT5	498	501	PF00017	0.562
LIG_SH3_1	548	554	PF00018	0.630
LIG_SH3_3	501	507	PF00018	0.501
LIG_SH3_3	548	554	PF00018	0.641
LIG_SH3_5	159	163	PF00018	0.516
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.453
LIG_SUMO_SIM_anti_2	285	291	PF11976	0.420
LIG_SUMO_SIM_anti_2	327	332	PF11976	0.452
LIG_SUMO_SIM_anti_2	362	369	PF11976	0.364
LIG_SUMO_SIM_par_1	181	187	PF11976	0.362
LIG_SUMO_SIM_par_1	247	253	PF11976	0.449
LIG_SUMO_SIM_par_1	318	324	PF11976	0.364
LIG_SUMO_SIM_par_1	374	379	PF11976	0.384
LIG_SUMO_SIM_par_1	419	424	PF11976	0.515
LIG_TRAF2_1	12	15	PF00917	0.655
LIG_TRAF2_1	485	488	PF00917	0.469
LIG_TRFH_1	353	357	PF08558	0.413
LIG_TYR_ITIM	315	320	PF00017	0.475
LIG_TYR_ITIM	516	521	PF00017	0.562
LIG_UBA3_1	305	312	PF00899	0.437
LIG_UBA3_1	330	338	PF00899	0.558
LIG_WRC_WIRS_1	322	327	PF05994	0.344
MOD_CDK_SPxK_1	430	436	PF00069	0.630
MOD_CK1_1	113	119	PF00069	0.747
MOD_CK1_1	149	155	PF00069	0.398
MOD_CK1_1	203	209	PF00069	0.556
MOD_CK1_1	282	288	PF00069	0.328
MOD_CK1_1	32	38	PF00069	0.557
MOD_CK1_1	359	365	PF00069	0.283
MOD_CK1_1	506	512	PF00069	0.487
MOD_CK1_1	569	575	PF00069	0.660
MOD_CK1_1	580	586	PF00069	0.638
MOD_CK2_1	223	229	PF00069	0.363
MOD_CK2_1	482	488	PF00069	0.458
MOD_CK2_1	9	15	PF00069	0.554
MOD_GlcNHglycan	122	125	PF01048	0.551
MOD_GlcNHglycan	148	151	PF01048	0.464
MOD_GlcNHglycan	202	205	PF01048	0.337
MOD_GSK3_1	145	152	PF00069	0.470
MOD_GSK3_1	209	216	PF00069	0.538
MOD_GSK3_1	21	28	PF00069	0.595
MOD_GSK3_1	405	412	PF00069	0.520
MOD_GSK3_1	5	12	PF00069	0.578
MOD_GSK3_1	529	536	PF00069	0.562
MOD_GSK3_1	546	553	PF00069	0.414
MOD_GSK3_1	556	563	PF00069	0.545
MOD_GSK3_1	577	584	PF00069	0.699
MOD_GSK3_1	80	87	PF00069	0.641
MOD_N-GLC_1	258	263	PF02516	0.411
MOD_NEK2_1	184	189	PF00069	0.393
MOD_NEK2_1	223	228	PF00069	0.324
MOD_NEK2_1	423	428	PF00069	0.520
MOD_NEK2_1	5	10	PF00069	0.648
MOD_NEK2_1	64	69	PF00069	0.528
MOD_NEK2_1	73	78	PF00069	0.528
MOD_NEK2_1	80	85	PF00069	0.627
MOD_PIKK_1	356	362	PF00454	0.459
MOD_PIKK_1	80	86	PF00454	0.641
MOD_PKA_2	279	285	PF00069	0.476
MOD_PKA_2	43	49	PF00069	0.583
MOD_PKB_1	200	208	PF00069	0.606
MOD_PKB_1	564	572	PF00069	0.595
MOD_Plk_1	113	119	PF00069	0.761
MOD_Plk_1	169	175	PF00069	0.419
MOD_Plk_1	282	288	PF00069	0.343
MOD_Plk_1	421	427	PF00069	0.521
MOD_Plk_1	5	11	PF00069	0.581
MOD_Plk_1	569	575	PF00069	0.707
MOD_Plk_1	580	586	PF00069	0.736
MOD_Plk_2-3	581	587	PF00069	0.714
MOD_Plk_4	113	119	PF00069	0.761
MOD_Plk_4	174	180	PF00069	0.320
MOD_Plk_4	223	229	PF00069	0.339
MOD_Plk_4	250	256	PF00069	0.344
MOD_Plk_4	282	288	PF00069	0.348
MOD_Plk_4	29	35	PF00069	0.568
MOD_Plk_4	316	322	PF00069	0.351
MOD_Plk_4	359	365	PF00069	0.291
MOD_Plk_4	398	404	PF00069	0.522
MOD_Plk_4	409	415	PF00069	0.508
MOD_Plk_4	5	11	PF00069	0.581
MOD_Plk_4	533	539	PF00069	0.568
MOD_Plk_4	556	562	PF00069	0.537
MOD_Plk_4	73	79	PF00069	0.629
MOD_ProDKin_1	430	436	PF00069	0.631
MOD_ProDKin_1	503	509	PF00069	0.476
MOD_ProDKin_1	529	535	PF00069	0.562
MOD_ProDKin_1	550	556	PF00069	0.628
MOD_SUMO_rev_2	571	580	PF00179	0.724
MOD_SUMO_rev_2	87	97	PF00179	0.675
TRG_DiLeu_BaEn_1	14	19	PF01217	0.649
TRG_DiLeu_BaEn_1	283	288	PF01217	0.363
TRG_DiLeu_BaLyEn_6	461	466	PF01217	0.476
TRG_ENDOCYTIC_2	163	166	PF00928	0.456
TRG_ENDOCYTIC_2	241	244	PF00928	0.344
TRG_ENDOCYTIC_2	317	320	PF00928	0.364
TRG_ENDOCYTIC_2	337	340	PF00928	0.630
TRG_ENDOCYTIC_2	361	364	PF00928	0.313
TRG_ENDOCYTIC_2	518	521	PF00928	0.558
TRG_ENDOCYTIC_2	537	540	PF00928	0.432
TRG_ENDOCYTIC_2	71	74	PF00928	0.515
TRG_ENDOCYTIC_2	77	80	PF00928	0.573
TRG_ER_diArg_1	388	390	PF00400	0.515
TRG_ER_diArg_1	541	543	PF00400	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I259	Leptomonas seymouri	78%	100%
A0A0S4JNN5	Bodo saltans	46%	100%
A0A1X0P717	Trypanosomatidae	63%	100%
A0A3Q8IA23	Leishmania donovani	96%	100%
A0A422P0J5	Trypanosoma rangeli	61%	100%
A4H9L4	Leishmania braziliensis	90%	99%
A4HY04	Leishmania infantum	96%	100%
D0A5A2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
Q4QDQ6	Leishmania major	94%	100%
V5BEI8	Trypanosoma cruzi	59%	100%