Histone acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acetyltransferase (GNAT) family, putative

Species:

Leishmania mexicana

UniProt:

E9ARR5_LEIMU

TriTrypDb:

LmxM.18.1310

Length:

696

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0000139	Golgi membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

E9ARR5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARR5

Function

Biological processes
Term	Name	Level	Count
GO:0007059	chromosome segregation	2	6
GO:0009987	cellular process	1	6
GO:0006473	protein acetylation	6	1
GO:0006474	N-terminal protein amino acid acetylation	5	1
GO:0006475	internal protein amino acid acetylation	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016570	histone modification	5	1
GO:0016573	histone acetylation	6	1
GO:0017196	N-terminal peptidyl-methionine acetylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0018206	peptidyl-methionine modification	6	1
GO:0018393	internal peptidyl-lysine acetylation	8	1
GO:0018394	peptidyl-lysine acetylation	7	1
GO:0019538	protein metabolic process	3	1
GO:0031365	N-terminal protein amino acid modification	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0043966	histone H3 acetylation	7	1
GO:0043967	histone H4 acetylation	7	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004596	peptide alpha-N-acetyltransferase activity	8	7
GO:0008080	N-acetyltransferase activity	6	7
GO:0016407	acetyltransferase activity	5	7
GO:0016410	N-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7
GO:0034212	peptide N-acetyltransferase activity	7	7
GO:0004402	histone acetyltransferase activity	4	1
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	223	227	PF00656	0.665
CLV_C14_Caspase3-7	494	498	PF00656	0.536
CLV_C14_Caspase3-7	597	601	PF00656	0.698
CLV_NRD_NRD_1	205	207	PF00675	0.352
CLV_NRD_NRD_1	301	303	PF00675	0.381
CLV_NRD_NRD_1	315	317	PF00675	0.377
CLV_NRD_NRD_1	433	435	PF00675	0.384
CLV_NRD_NRD_1	437	439	PF00675	0.378
CLV_NRD_NRD_1	563	565	PF00675	0.497
CLV_NRD_NRD_1	645	647	PF00675	0.447
CLV_NRD_NRD_1	92	94	PF00675	0.317
CLV_PCSK_FUR_1	561	565	PF00082	0.525
CLV_PCSK_KEX2_1	301	303	PF00082	0.436
CLV_PCSK_KEX2_1	315	317	PF00082	0.333
CLV_PCSK_KEX2_1	346	348	PF00082	0.493
CLV_PCSK_KEX2_1	433	435	PF00082	0.384
CLV_PCSK_KEX2_1	437	439	PF00082	0.378
CLV_PCSK_KEX2_1	522	524	PF00082	0.338
CLV_PCSK_KEX2_1	561	563	PF00082	0.491
CLV_PCSK_KEX2_1	644	646	PF00082	0.445
CLV_PCSK_KEX2_1	92	94	PF00082	0.317
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.436
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.333
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.493
CLV_PCSK_PC1ET2_1	522	524	PF00082	0.338
CLV_PCSK_PC7_1	433	439	PF00082	0.355
CLV_PCSK_SKI1_1	280	284	PF00082	0.291
CLV_PCSK_SKI1_1	321	325	PF00082	0.364
CLV_PCSK_SKI1_1	472	476	PF00082	0.359
CLV_Separin_Metazoa	664	668	PF03568	0.520
DEG_COP1_1	583	593	PF00400	0.627
DEG_SCF_TRCP1_1	572	577	PF00400	0.628
DEG_SPOP_SBC_1	157	161	PF00917	0.678
DEG_SPOP_SBC_1	55	59	PF00917	0.653
DOC_CDC14_PxL_1	381	389	PF14671	0.592
DOC_CKS1_1	590	595	PF01111	0.776
DOC_MAPK_gen_1	301	307	PF00069	0.556
DOC_MAPK_RevD_3	191	207	PF00069	0.520
DOC_MAPK_RevD_3	548	564	PF00069	0.683
DOC_PP1_RVXF_1	657	663	PF00149	0.641
DOC_PP1_RVXF_1	79	85	PF00149	0.533
DOC_PP2B_LxvP_1	550	553	PF13499	0.691
DOC_SPAK_OSR1_1	438	442	PF12202	0.545
DOC_USP7_MATH_1	157	161	PF00917	0.671
DOC_USP7_MATH_1	325	329	PF00917	0.563
DOC_USP7_MATH_1	361	365	PF00917	0.679
DOC_USP7_MATH_1	372	376	PF00917	0.597
DOC_USP7_MATH_1	44	48	PF00917	0.586
DOC_USP7_MATH_1	49	53	PF00917	0.752
DOC_USP7_MATH_1	503	507	PF00917	0.699
DOC_USP7_MATH_1	546	550	PF00917	0.666
DOC_USP7_MATH_1	55	59	PF00917	0.640
DOC_USP7_MATH_1	649	653	PF00917	0.680
DOC_WW_Pin1_4	143	148	PF00397	0.647
DOC_WW_Pin1_4	160	165	PF00397	0.681
DOC_WW_Pin1_4	168	173	PF00397	0.610
DOC_WW_Pin1_4	340	345	PF00397	0.670
DOC_WW_Pin1_4	365	370	PF00397	0.626
DOC_WW_Pin1_4	4	9	PF00397	0.651
DOC_WW_Pin1_4	480	485	PF00397	0.474
DOC_WW_Pin1_4	51	56	PF00397	0.758
DOC_WW_Pin1_4	514	519	PF00397	0.628
DOC_WW_Pin1_4	537	542	PF00397	0.629
DOC_WW_Pin1_4	564	569	PF00397	0.653
DOC_WW_Pin1_4	589	594	PF00397	0.794
DOC_WW_Pin1_4	604	609	PF00397	0.679
DOC_WW_Pin1_4	610	615	PF00397	0.710
DOC_WW_Pin1_4	618	623	PF00397	0.645
LIG_14-3-3_CanoR_1	280	285	PF00244	0.491
LIG_14-3-3_CanoR_1	644	649	PF00244	0.700
LIG_BIR_II_1	1	5	PF00653	0.609
LIG_BIR_III_2	100	104	PF00653	0.511
LIG_BRCT_BRCA1_1	505	509	PF00533	0.613
LIG_deltaCOP1_diTrp_1	134	139	PF00928	0.553
LIG_eIF4E_1	299	305	PF01652	0.565
LIG_EVH1_1	550	554	PF00568	0.665
LIG_FHA_1	214	220	PF00498	0.734
LIG_FHA_1	229	235	PF00498	0.467
LIG_FHA_1	254	260	PF00498	0.487
LIG_FHA_1	268	274	PF00498	0.569
LIG_FHA_2	129	135	PF00498	0.537
LIG_FHA_2	333	339	PF00498	0.681
LIG_FHA_2	404	410	PF00498	0.662
LIG_FHA_2	423	429	PF00498	0.633
LIG_FHA_2	481	487	PF00498	0.482
LIG_FHA_2	515	521	PF00498	0.623
LIG_FHA_2	581	587	PF00498	0.695
LIG_FHA_2	595	601	PF00498	0.639
LIG_LIR_Apic_2	616	622	PF02991	0.643
LIG_LIR_Gen_1	109	119	PF02991	0.508
LIG_LIR_Gen_1	375	385	PF02991	0.647
LIG_LIR_Gen_1	483	493	PF02991	0.547
LIG_LIR_Gen_1	76	86	PF02991	0.451
LIG_LIR_Nem_3	109	114	PF02991	0.477
LIG_LIR_Nem_3	295	299	PF02991	0.538
LIG_LIR_Nem_3	375	380	PF02991	0.680
LIG_LIR_Nem_3	483	488	PF02991	0.545
LIG_LIR_Nem_3	673	679	PF02991	0.318
LIG_LIR_Nem_3	76	82	PF02991	0.464
LIG_MYND_1	548	552	PF01753	0.626
LIG_NRBOX	303	309	PF00104	0.591
LIG_PCNA_yPIPBox_3	437	449	PF02747	0.529
LIG_RPA_C_Fungi	240	252	PF08784	0.334
LIG_RPA_C_Fungi	461	473	PF08784	0.371
LIG_SH2_CRK	485	489	PF00017	0.425
LIG_SH2_CRK	687	691	PF00017	0.334
LIG_SH2_STAP1	106	110	PF00017	0.380
LIG_SH2_STAP1	111	115	PF00017	0.318
LIG_SH2_STAP1	292	296	PF00017	0.445
LIG_SH2_STAP1	485	489	PF00017	0.400
LIG_SH2_STAT3	284	287	PF00017	0.334
LIG_SH2_STAT5	106	109	PF00017	0.371
LIG_SH2_STAT5	258	261	PF00017	0.288
LIG_SH2_STAT5	284	287	PF00017	0.298
LIG_SH2_STAT5	296	299	PF00017	0.447
LIG_SH2_STAT5	383	386	PF00017	0.487
LIG_SH2_STAT5	492	495	PF00017	0.441
LIG_SH3_3	169	175	PF00018	0.518
LIG_SH3_3	261	267	PF00018	0.324
LIG_SH3_3	29	35	PF00018	0.432
LIG_SH3_3	545	551	PF00018	0.684
LIG_SH3_3	587	593	PF00018	0.612
LIG_SUMO_SIM_par_1	122	128	PF11976	0.275
LIG_TRAF2_1	131	134	PF00917	0.334
LIG_TRAF2_1	186	189	PF00917	0.453
LIG_TRAF2_1	406	409	PF00917	0.414
LIG_TRAF2_1	425	428	PF00917	0.494
LIG_TRAF2_1	533	536	PF00917	0.608
LIG_TYR_ITIM	685	690	PF00017	0.334
LIG_WRC_WIRS_1	259	264	PF05994	0.290
MOD_CDC14_SPxK_1	343	346	PF00782	0.515
MOD_CDC14_SPxK_1	567	570	PF00782	0.556
MOD_CDK_SPK_2	143	148	PF00069	0.553
MOD_CDK_SPxK_1	340	346	PF00069	0.516
MOD_CDK_SPxK_1	564	570	PF00069	0.560
MOD_CDK_SPxK_1	604	610	PF00069	0.616
MOD_CDK_SPxxK_3	340	347	PF00069	0.517
MOD_CK1_1	156	162	PF00069	0.598
MOD_CK1_1	16	22	PF00069	0.537
MOD_CK1_1	163	169	PF00069	0.571
MOD_CK1_1	178	184	PF00069	0.571
MOD_CK1_1	2	8	PF00069	0.535
MOD_CK1_1	222	228	PF00069	0.562
MOD_CK1_1	253	259	PF00069	0.334
MOD_CK1_1	364	370	PF00069	0.592
MOD_CK1_1	54	60	PF00069	0.549
MOD_CK1_1	555	561	PF00069	0.629
MOD_CK1_1	573	579	PF00069	0.597
MOD_CK1_1	613	619	PF00069	0.576
MOD_CK1_1	621	627	PF00069	0.490
MOD_CK2_1	106	112	PF00069	0.401
MOD_CK2_1	128	134	PF00069	0.396
MOD_CK2_1	386	392	PF00069	0.424
MOD_CK2_1	403	409	PF00069	0.468
MOD_CK2_1	422	428	PF00069	0.524
MOD_CK2_1	514	520	PF00069	0.557
MOD_CK2_1	60	66	PF00069	0.593
MOD_CK2_1	649	655	PF00069	0.576
MOD_GlcNHglycan	155	158	PF01048	0.605
MOD_GlcNHglycan	165	168	PF01048	0.579
MOD_GlcNHglycan	226	229	PF01048	0.470
MOD_GlcNHglycan	327	330	PF01048	0.554
MOD_GlcNHglycan	359	362	PF01048	0.646
MOD_GlcNHglycan	46	49	PF01048	0.459
MOD_GlcNHglycan	493	496	PF01048	0.348
MOD_GlcNHglycan	505	508	PF01048	0.600
MOD_GlcNHglycan	571	575	PF01048	0.583
MOD_GlcNHglycan	651	654	PF01048	0.552
MOD_GSK3_1	102	109	PF00069	0.339
MOD_GSK3_1	139	146	PF00069	0.503
MOD_GSK3_1	149	156	PF00069	0.573
MOD_GSK3_1	158	165	PF00069	0.577
MOD_GSK3_1	215	222	PF00069	0.624
MOD_GSK3_1	224	231	PF00069	0.507
MOD_GSK3_1	357	364	PF00069	0.576
MOD_GSK3_1	39	46	PF00069	0.741
MOD_GSK3_1	50	57	PF00069	0.530
MOD_GSK3_1	503	510	PF00069	0.625
MOD_GSK3_1	570	577	PF00069	0.610
MOD_GSK3_1	9	16	PF00069	0.532
MOD_N-GLC_1	457	462	PF02516	0.279
MOD_NEK2_1	324	329	PF00069	0.623
MOD_NEK2_1	457	462	PF00069	0.520
MOD_NEK2_1	509	514	PF00069	0.641
MOD_NEK2_1	56	61	PF00069	0.567
MOD_PIKK_1	125	131	PF00454	0.343
MOD_PIKK_1	149	155	PF00454	0.602
MOD_PIKK_1	175	181	PF00454	0.481
MOD_PIKK_1	283	289	PF00454	0.334
MOD_PIKK_1	361	367	PF00454	0.645
MOD_PKA_1	644	650	PF00069	0.602
MOD_PKA_2	139	145	PF00069	0.486
MOD_PKA_2	213	219	PF00069	0.453
MOD_PKA_2	644	650	PF00069	0.684
MOD_Plk_2-3	386	392	PF00069	0.424
MOD_Plk_2-3	422	428	PF00069	0.507
MOD_Plk_4	106	112	PF00069	0.401
MOD_Plk_4	228	234	PF00069	0.360
MOD_Plk_4	372	378	PF00069	0.572
MOD_Plk_4	379	385	PF00069	0.381
MOD_Plk_4	386	392	PF00069	0.440
MOD_Plk_4	615	621	PF00069	0.542
MOD_ProDKin_1	143	149	PF00069	0.560
MOD_ProDKin_1	160	166	PF00069	0.601
MOD_ProDKin_1	168	174	PF00069	0.488
MOD_ProDKin_1	340	346	PF00069	0.588
MOD_ProDKin_1	365	371	PF00069	0.521
MOD_ProDKin_1	4	10	PF00069	0.557
MOD_ProDKin_1	480	486	PF00069	0.308
MOD_ProDKin_1	51	57	PF00069	0.709
MOD_ProDKin_1	514	520	PF00069	0.519
MOD_ProDKin_1	537	543	PF00069	0.530
MOD_ProDKin_1	564	570	PF00069	0.560
MOD_ProDKin_1	589	595	PF00069	0.756
MOD_ProDKin_1	604	610	PF00069	0.597
MOD_ProDKin_1	618	624	PF00069	0.541
MOD_SUMO_rev_2	210	219	PF00179	0.424
MOD_SUMO_rev_2	516	524	PF00179	0.422
MOD_SUMO_rev_2	642	652	PF00179	0.558
TRG_DiLeu_BaEn_2	434	440	PF01217	0.458
TRG_ENDOCYTIC_2	111	114	PF00928	0.338
TRG_ENDOCYTIC_2	477	480	PF00928	0.383
TRG_ENDOCYTIC_2	485	488	PF00928	0.490
TRG_ENDOCYTIC_2	687	690	PF00928	0.334
TRG_ER_diArg_1	397	400	PF00400	0.448
TRG_ER_diArg_1	432	434	PF00400	0.451
TRG_ER_diArg_1	437	439	PF00400	0.351
TRG_ER_diArg_1	560	563	PF00400	0.613
TRG_ER_diArg_1	643	646	PF00400	0.581
TRG_ER_diArg_1	80	83	PF00400	0.407
TRG_ER_diArg_1	91	93	PF00400	0.321
TRG_NLS_Bipartite_1	301	319	PF00514	0.423
TRG_NLS_MonoCore_2	313	318	PF00514	0.458
TRG_NLS_MonoExtN_4	314	319	PF00514	0.429
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	92	96	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4M7	Leptomonas seymouri	44%	84%
A0A3S7WV24	Leishmania donovani	86%	99%
A4H9N7	Leishmania braziliensis	66%	98%
A4HY02	Leishmania infantum	86%	86%
Q4QDQ8	Leishmania major	85%	100%