Dynein assembly factor 2, axonemal homolog

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-RNA processing PIH1/Nop17, putative

Species:

Leishmania mexicana

UniProt:

E9ARR1_LEIMU

TriTrypDb:

LmxM.18.1240

Length:

764

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARR1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	162	166	PF00656	0.499
CLV_C14_Caspase3-7	309	313	PF00656	0.587
CLV_C14_Caspase3-7	375	379	PF00656	0.511
CLV_C14_Caspase3-7	486	490	PF00656	0.752
CLV_C14_Caspase3-7	640	644	PF00656	0.560
CLV_NRD_NRD_1	180	182	PF00675	0.339
CLV_NRD_NRD_1	263	265	PF00675	0.259
CLV_NRD_NRD_1	405	407	PF00675	0.324
CLV_NRD_NRD_1	730	732	PF00675	0.499
CLV_NRD_NRD_1	75	77	PF00675	0.485
CLV_PCSK_KEX2_1	124	126	PF00082	0.419
CLV_PCSK_KEX2_1	180	182	PF00082	0.339
CLV_PCSK_KEX2_1	263	265	PF00082	0.259
CLV_PCSK_KEX2_1	387	389	PF00082	0.248
CLV_PCSK_KEX2_1	405	407	PF00082	0.248
CLV_PCSK_KEX2_1	730	732	PF00082	0.498
CLV_PCSK_KEX2_1	75	77	PF00082	0.485
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.422
CLV_PCSK_PC1ET2_1	387	389	PF00082	0.339
CLV_PCSK_PC7_1	383	389	PF00082	0.363
CLV_PCSK_SKI1_1	103	107	PF00082	0.513
CLV_PCSK_SKI1_1	144	148	PF00082	0.333
CLV_PCSK_SKI1_1	156	160	PF00082	0.339
CLV_PCSK_SKI1_1	455	459	PF00082	0.284
CLV_PCSK_SKI1_1	758	762	PF00082	0.525
DEG_COP1_1	550	558	PF00400	0.669
DEG_SPOP_SBC_1	209	213	PF00917	0.573
DEG_SPOP_SBC_1	560	564	PF00917	0.611
DOC_CKS1_1	272	277	PF01111	0.473
DOC_CKS1_1	555	560	PF01111	0.757
DOC_CYCLIN_yCln2_LP_2	436	442	PF00134	0.494
DOC_MAPK_FxFP_2	99	102	PF00069	0.358
DOC_MAPK_gen_1	141	149	PF00069	0.381
DOC_MAPK_gen_1	405	412	PF00069	0.539
DOC_MAPK_gen_1	747	755	PF00069	0.536
DOC_MAPK_MEF2A_6	405	414	PF00069	0.511
DOC_MAPK_MEF2A_6	431	440	PF00069	0.563
DOC_MAPK_MEF2A_6	455	464	PF00069	0.466
DOC_MAPK_NFAT4_5	455	463	PF00069	0.459
DOC_PP1_RVXF_1	218	225	PF00149	0.563
DOC_PP2B_LxvP_1	436	439	PF13499	0.511
DOC_PP4_FxxP_1	618	621	PF00568	0.479
DOC_PP4_FxxP_1	99	102	PF00568	0.358
DOC_USP7_MATH_1	137	141	PF00917	0.497
DOC_USP7_MATH_1	166	170	PF00917	0.563
DOC_USP7_MATH_1	17	21	PF00917	0.658
DOC_USP7_MATH_1	187	191	PF00917	0.540
DOC_USP7_MATH_1	192	196	PF00917	0.552
DOC_USP7_MATH_1	202	206	PF00917	0.610
DOC_USP7_MATH_1	207	211	PF00917	0.520
DOC_USP7_MATH_1	232	236	PF00917	0.457
DOC_USP7_MATH_1	332	336	PF00917	0.785
DOC_USP7_MATH_1	351	355	PF00917	0.680
DOC_USP7_MATH_1	358	362	PF00917	0.633
DOC_USP7_MATH_1	502	506	PF00917	0.727
DOC_USP7_MATH_1	561	565	PF00917	0.731
DOC_USP7_MATH_1	609	613	PF00917	0.757
DOC_USP7_MATH_1	641	645	PF00917	0.774
DOC_USP7_MATH_1	653	657	PF00917	0.658
DOC_USP7_MATH_2	425	431	PF00917	0.507
DOC_USP7_UBL2_3	628	632	PF12436	0.592
DOC_USP7_UBL2_3	728	732	PF12436	0.585
DOC_WW_Pin1_4	188	193	PF00397	0.561
DOC_WW_Pin1_4	210	215	PF00397	0.392
DOC_WW_Pin1_4	271	276	PF00397	0.461
DOC_WW_Pin1_4	286	291	PF00397	0.540
DOC_WW_Pin1_4	318	323	PF00397	0.722
DOC_WW_Pin1_4	328	333	PF00397	0.611
DOC_WW_Pin1_4	354	359	PF00397	0.655
DOC_WW_Pin1_4	39	44	PF00397	0.482
DOC_WW_Pin1_4	412	417	PF00397	0.558
DOC_WW_Pin1_4	509	514	PF00397	0.730
DOC_WW_Pin1_4	515	520	PF00397	0.686
DOC_WW_Pin1_4	533	538	PF00397	0.660
DOC_WW_Pin1_4	542	547	PF00397	0.651
DOC_WW_Pin1_4	554	559	PF00397	0.705
LIG_14-3-3_CanoR_1	359	364	PF00244	0.632
LIG_14-3-3_CanoR_1	383	391	PF00244	0.547
LIG_14-3-3_CanoR_1	455	461	PF00244	0.494
LIG_14-3-3_CanoR_1	480	484	PF00244	0.652
LIG_APCC_ABBAyCdc20_2	54	60	PF00400	0.556
LIG_BIR_III_4	165	169	PF00653	0.507
LIG_BRCT_BRCA1_1	234	238	PF00533	0.459
LIG_BRCT_BRCA1_1	256	260	PF00533	0.511
LIG_BRCT_BRCA1_1	643	647	PF00533	0.478
LIG_BRCT_BRCA1_1	95	99	PF00533	0.419
LIG_CtBP_PxDLS_1	43	47	PF00389	0.497
LIG_deltaCOP1_diTrp_1	378	382	PF00928	0.459
LIG_EH1_1	574	582	PF00400	0.575
LIG_FHA_1	191	197	PF00498	0.505
LIG_FHA_1	226	232	PF00498	0.469
LIG_FHA_1	302	308	PF00498	0.519
LIG_FHA_1	457	463	PF00498	0.461
LIG_FHA_1	668	674	PF00498	0.639
LIG_FHA_2	160	166	PF00498	0.485
LIG_FHA_2	307	313	PF00498	0.720
LIG_FHA_2	331	337	PF00498	0.706
LIG_FHA_2	40	46	PF00498	0.501
LIG_FHA_2	439	445	PF00498	0.502
LIG_FHA_2	539	545	PF00498	0.702
LIG_FHA_2	597	603	PF00498	0.610
LIG_FHA_2	638	644	PF00498	0.602
LIG_FHA_2	653	659	PF00498	0.608
LIG_FHA_2	72	78	PF00498	0.479
LIG_LIR_Apic_2	169	174	PF02991	0.460
LIG_LIR_Apic_2	96	102	PF02991	0.388
LIG_LIR_Gen_1	235	246	PF02991	0.459
LIG_LIR_Gen_1	55	66	PF02991	0.455
LIG_LIR_Gen_1	94	105	PF02991	0.400
LIG_LIR_Nem_3	183	188	PF02991	0.607
LIG_LIR_Nem_3	235	241	PF02991	0.459
LIG_LIR_Nem_3	400	404	PF02991	0.462
LIG_LIR_Nem_3	430	435	PF02991	0.563
LIG_LIR_Nem_3	55	61	PF02991	0.443
LIG_LIR_Nem_3	94	100	PF02991	0.416
LIG_PCNA_yPIPBox_3	574	588	PF02747	0.555
LIG_Pex14_2	95	99	PF04695	0.426
LIG_RPA_C_Fungi	705	717	PF08784	0.618
LIG_SH2_CRK	185	189	PF00017	0.534
LIG_SH2_SRC	185	188	PF00017	0.562
LIG_SH2_SRC	254	257	PF00017	0.165
LIG_SH2_STAT3	81	84	PF00017	0.494
LIG_SH2_STAT5	366	369	PF00017	0.358
LIG_SH2_STAT5	759	762	PF00017	0.598
LIG_SH2_STAT5	81	84	PF00017	0.510
LIG_SH3_3	181	187	PF00018	0.205
LIG_SH3_3	220	226	PF00018	0.322
LIG_SH3_3	292	298	PF00018	0.666
LIG_SH3_3	386	392	PF00018	0.385
LIG_SH3_3	461	467	PF00018	0.309
LIG_SH3_3	504	510	PF00018	0.720
LIG_SH3_3	511	517	PF00018	0.693
LIG_SH3_3	550	556	PF00018	0.695
LIG_SUMO_SIM_anti_2	433	439	PF11976	0.457
LIG_SUMO_SIM_par_1	106	112	PF11976	0.374
LIG_SUMO_SIM_par_1	172	178	PF11976	0.316
LIG_SUMO_SIM_par_1	227	233	PF11976	0.394
LIG_SUMO_SIM_par_1	267	274	PF11976	0.426
LIG_SUMO_SIM_par_1	456	461	PF11976	0.424
LIG_TRAF2_1	42	45	PF00917	0.502
LIG_TRAF2_1	441	444	PF00917	0.392
LIG_TRAF2_1	655	658	PF00917	0.684
LIG_TRAF2_1	709	712	PF00917	0.556
LIG_TRAF2_1	718	721	PF00917	0.561
LIG_WW_2	467	470	PF00397	0.646
MOD_CDC14_SPxK_1	545	548	PF00782	0.758
MOD_CDK_SPK_2	354	359	PF00069	0.674
MOD_CDK_SPxK_1	542	548	PF00069	0.736
MOD_CK1_1	131	137	PF00069	0.444
MOD_CK1_1	190	196	PF00069	0.515
MOD_CK1_1	205	211	PF00069	0.604
MOD_CK1_1	212	218	PF00069	0.409
MOD_CK1_1	268	274	PF00069	0.332
MOD_CK1_1	318	324	PF00069	0.695
MOD_CK1_1	325	331	PF00069	0.691
MOD_CK1_1	334	340	PF00069	0.763
MOD_CK1_1	354	360	PF00069	0.693
MOD_CK1_1	536	542	PF00069	0.700
MOD_CK1_1	626	632	PF00069	0.730
MOD_CK2_1	166	172	PF00069	0.393
MOD_CK2_1	39	45	PF00069	0.492
MOD_CK2_1	427	433	PF00069	0.465
MOD_CK2_1	438	444	PF00069	0.255
MOD_CK2_1	538	544	PF00069	0.682
MOD_CK2_1	561	567	PF00069	0.683
MOD_CK2_1	652	658	PF00069	0.619
MOD_CK2_1	71	77	PF00069	0.483
MOD_GlcNHglycan	129	133	PF01048	0.604
MOD_GlcNHglycan	14	17	PF01048	0.695
MOD_GlcNHglycan	20	23	PF01048	0.729
MOD_GlcNHglycan	207	210	PF01048	0.668
MOD_GlcNHglycan	251	254	PF01048	0.326
MOD_GlcNHglycan	26	29	PF01048	0.731
MOD_GlcNHglycan	317	320	PF01048	0.701
MOD_GlcNHglycan	327	330	PF01048	0.644
MOD_GlcNHglycan	353	356	PF01048	0.696
MOD_GlcNHglycan	474	477	PF01048	0.584
MOD_GlcNHglycan	549	552	PF01048	0.748
MOD_GlcNHglycan	563	566	PF01048	0.751
MOD_GlcNHglycan	610	614	PF01048	0.679
MOD_GlcNHglycan	627	631	PF01048	0.671
MOD_GlcNHglycan	643	646	PF01048	0.722
MOD_GlcNHglycan	664	667	PF01048	0.499
MOD_GSK3_1	133	140	PF00069	0.337
MOD_GSK3_1	156	163	PF00069	0.310
MOD_GSK3_1	188	195	PF00069	0.504
MOD_GSK3_1	203	210	PF00069	0.565
MOD_GSK3_1	264	271	PF00069	0.340
MOD_GSK3_1	276	283	PF00069	0.127
MOD_GSK3_1	318	325	PF00069	0.687
MOD_GSK3_1	327	334	PF00069	0.739
MOD_GSK3_1	35	42	PF00069	0.500
MOD_GSK3_1	354	361	PF00069	0.646
MOD_GSK3_1	366	373	PF00069	0.329
MOD_GSK3_1	423	430	PF00069	0.389
MOD_GSK3_1	496	503	PF00069	0.714
MOD_GSK3_1	538	545	PF00069	0.741
MOD_GSK3_1	619	626	PF00069	0.742
MOD_GSK3_1	637	644	PF00069	0.631
MOD_GSK3_1	662	669	PF00069	0.628
MOD_GSK3_1	749	756	PF00069	0.596
MOD_N-GLC_1	276	281	PF02516	0.312
MOD_N-GLC_1	623	628	PF02516	0.557
MOD_N-GLC_2	148	150	PF02516	0.312
MOD_NEK2_1	128	133	PF00069	0.567
MOD_NEK2_1	276	281	PF00069	0.421
MOD_NEK2_1	451	456	PF00069	0.441
MOD_NEK2_1	458	463	PF00069	0.402
MOD_NEK2_1	479	484	PF00069	0.612
MOD_NEK2_1	662	667	PF00069	0.594
MOD_NEK2_1	704	709	PF00069	0.391
MOD_PIKK_1	175	181	PF00454	0.424
MOD_PIKK_1	334	340	PF00454	0.766
MOD_PIKK_1	502	508	PF00454	0.776
MOD_PIKK_1	653	659	PF00454	0.737
MOD_PKA_2	166	172	PF00069	0.423
MOD_PKA_2	233	239	PF00069	0.379
MOD_PKA_2	280	286	PF00069	0.646
MOD_PKA_2	301	307	PF00069	0.679
MOD_PKA_2	358	364	PF00069	0.624
MOD_PKA_2	370	376	PF00069	0.372
MOD_PKA_2	382	388	PF00069	0.405
MOD_PKA_2	479	485	PF00069	0.652
MOD_PKA_2	584	590	PF00069	0.344
MOD_PKA_2	641	647	PF00069	0.660
MOD_PKA_2	740	746	PF00069	0.551
MOD_PKB_1	10	18	PF00069	0.641
MOD_Plk_1	128	134	PF00069	0.352
MOD_Plk_1	276	282	PF00069	0.312
MOD_Plk_1	684	690	PF00069	0.520
MOD_Plk_1	93	99	PF00069	0.435
MOD_Plk_4	113	119	PF00069	0.310
MOD_Plk_4	265	271	PF00069	0.457
MOD_ProDKin_1	188	194	PF00069	0.553
MOD_ProDKin_1	210	216	PF00069	0.392
MOD_ProDKin_1	271	277	PF00069	0.314
MOD_ProDKin_1	286	292	PF00069	0.534
MOD_ProDKin_1	318	324	PF00069	0.721
MOD_ProDKin_1	328	334	PF00069	0.610
MOD_ProDKin_1	354	360	PF00069	0.652
MOD_ProDKin_1	39	45	PF00069	0.478
MOD_ProDKin_1	412	418	PF00069	0.451
MOD_ProDKin_1	509	515	PF00069	0.732
MOD_ProDKin_1	533	539	PF00069	0.662
MOD_ProDKin_1	542	548	PF00069	0.653
MOD_ProDKin_1	554	560	PF00069	0.709
TRG_DiLeu_BaEn_2	657	663	PF01217	0.749
TRG_DiLeu_BaEn_4	77	83	PF01217	0.492
TRG_ENDOCYTIC_2	185	188	PF00928	0.529
TRG_ENDOCYTIC_2	432	435	PF00928	0.454
TRG_ER_diArg_1	180	182	PF00400	0.424
TRG_ER_diArg_1	262	264	PF00400	0.312
TRG_ER_diArg_1	404	406	PF00400	0.399
TRG_ER_diArg_1	689	692	PF00400	0.507
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3H0	Leptomonas seymouri	50%	95%
A0A1X0P812	Trypanosomatidae	37%	100%
A0A3Q8IB73	Leishmania donovani	86%	100%
A0A3R7N1E2	Trypanosoma rangeli	38%	100%
A4H9N3	Leishmania braziliensis	76%	100%
A4HXZ7	Leishmania infantum	85%	100%
B4GDK5	Drosophila persimilis	23%	90%
D0A5A8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q292G3	Drosophila pseudoobscura pseudoobscura	23%	90%
Q4QDR8	Leishmania major	88%	100%
V5AZ63	Trypanosoma cruzi	37%	100%