SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ARR0_LEIMU

TriTrypDb:

LmxM.18.1230

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARR0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.507
CLV_C14_Caspase3-7	439	443	PF00656	0.536
CLV_C14_Caspase3-7	46	50	PF00656	0.593
CLV_C14_Caspase3-7	478	482	PF00656	0.561
CLV_C14_Caspase3-7	538	542	PF00656	0.446
CLV_NRD_NRD_1	507	509	PF00675	0.570
CLV_NRD_NRD_1	559	561	PF00675	0.587
CLV_NRD_NRD_1	607	609	PF00675	0.410
CLV_PCSK_KEX2_1	2	4	PF00082	0.622
CLV_PCSK_KEX2_1	507	509	PF00082	0.649
CLV_PCSK_KEX2_1	559	561	PF00082	0.527
CLV_PCSK_KEX2_1	607	609	PF00082	0.410
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.489
CLV_PCSK_SKI1_1	525	529	PF00082	0.650
CLV_PCSK_SKI1_1	577	581	PF00082	0.290
CLV_Separin_Metazoa	522	526	PF03568	0.598
DEG_APCC_DBOX_1	180	188	PF00400	0.429
DEG_Nend_UBRbox_1	1	4	PF02207	0.719
DEG_SPOP_SBC_1	172	176	PF00917	0.622
DEG_SPOP_SBC_1	405	409	PF00917	0.461
DEG_SPOP_SBC_1	55	59	PF00917	0.505
DOC_CKS1_1	107	112	PF01111	0.485
DOC_CKS1_1	569	574	PF01111	0.487
DOC_CYCLIN_RxL_1	314	324	PF00134	0.536
DOC_CYCLIN_RxL_1	522	532	PF00134	0.599
DOC_CYCLIN_yCln2_LP_2	453	459	PF00134	0.442
DOC_MAPK_DCC_7	198	206	PF00069	0.392
DOC_MAPK_gen_1	181	189	PF00069	0.483
DOC_MAPK_gen_1	2	13	PF00069	0.487
DOC_MAPK_MEF2A_6	198	207	PF00069	0.267
DOC_PP1_RVXF_1	71	78	PF00149	0.444
DOC_PP4_FxxP_1	267	270	PF00568	0.442
DOC_PP4_FxxP_1	584	587	PF00568	0.445
DOC_USP7_MATH_1	160	164	PF00917	0.796
DOC_USP7_MATH_1	172	176	PF00917	0.567
DOC_USP7_MATH_1	477	481	PF00917	0.614
DOC_USP7_MATH_1	500	504	PF00917	0.778
DOC_USP7_MATH_1	55	59	PF00917	0.561
DOC_USP7_MATH_1	553	557	PF00917	0.439
DOC_WW_Pin1_4	106	111	PF00397	0.670
DOC_WW_Pin1_4	113	118	PF00397	0.665
DOC_WW_Pin1_4	123	128	PF00397	0.650
DOC_WW_Pin1_4	156	161	PF00397	0.732
DOC_WW_Pin1_4	199	204	PF00397	0.328
DOC_WW_Pin1_4	206	211	PF00397	0.353
DOC_WW_Pin1_4	213	218	PF00397	0.475
DOC_WW_Pin1_4	28	33	PF00397	0.440
DOC_WW_Pin1_4	359	364	PF00397	0.448
DOC_WW_Pin1_4	417	422	PF00397	0.498
DOC_WW_Pin1_4	568	573	PF00397	0.501
LIG_14-3-3_CanoR_1	235	240	PF00244	0.488
LIG_14-3-3_CanoR_1	332	337	PF00244	0.487
LIG_14-3-3_CanoR_1	404	414	PF00244	0.536
LIG_14-3-3_CanoR_1	525	533	PF00244	0.639
LIG_14-3-3_CanoR_1	54	63	PF00244	0.619
LIG_14-3-3_CanoR_1	6	12	PF00244	0.574
LIG_14-3-3_CanoR_1	612	616	PF00244	0.512
LIG_14-3-3_CanoR_1	97	107	PF00244	0.464
LIG_BIR_III_4	355	359	PF00653	0.461
LIG_BRCT_BRCA1_1	173	177	PF00533	0.534
LIG_BRCT_BRCA1_1	57	61	PF00533	0.454
LIG_BRCT_BRCA1_1	612	616	PF00533	0.586
LIG_FHA_1	107	113	PF00498	0.636
LIG_FHA_1	116	122	PF00498	0.714
LIG_FHA_1	246	252	PF00498	0.451
LIG_FHA_1	272	278	PF00498	0.458
LIG_FHA_1	322	328	PF00498	0.569
LIG_FHA_1	331	337	PF00498	0.381
LIG_FHA_1	405	411	PF00498	0.496
LIG_FHA_2	235	241	PF00498	0.536
LIG_FHA_2	321	327	PF00498	0.561
LIG_FHA_2	65	71	PF00498	0.428
LIG_HP1_1	203	207	PF01393	0.222
LIG_LIR_Apic_2	101	107	PF02991	0.475
LIG_LIR_Apic_2	176	182	PF02991	0.496
LIG_LIR_Gen_1	139	150	PF02991	0.569
LIG_LIR_Gen_1	174	184	PF02991	0.463
LIG_LIR_Gen_1	279	288	PF02991	0.458
LIG_LIR_LC3C_4	202	206	PF02991	0.223
LIG_LIR_Nem_3	139	145	PF02991	0.533
LIG_LIR_Nem_3	174	180	PF02991	0.480
LIG_LIR_Nem_3	279	284	PF02991	0.458
LIG_LIR_Nem_3	451	457	PF02991	0.549
LIG_LIR_Nem_3	613	619	PF02991	0.529
LIG_NRBOX	440	446	PF00104	0.496
LIG_PTB_Apo_2	193	200	PF02174	0.446
LIG_PTB_Apo_2	421	428	PF02174	0.536
LIG_PTB_Phospho_1	421	427	PF10480	0.536
LIG_REV1ctd_RIR_1	75	84	PF16727	0.383
LIG_SH2_NCK_1	27	31	PF00017	0.559
LIG_SH2_NCK_1	427	431	PF00017	0.455
LIG_SH2_NCK_1	476	480	PF00017	0.423
LIG_SH2_PTP2	457	460	PF00017	0.536
LIG_SH2_SRC	457	460	PF00017	0.536
LIG_SH2_STAP1	305	309	PF00017	0.536
LIG_SH2_STAP1	393	397	PF00017	0.442
LIG_SH2_STAT3	592	595	PF00017	0.486
LIG_SH2_STAT5	308	311	PF00017	0.449
LIG_SH2_STAT5	383	386	PF00017	0.514
LIG_SH2_STAT5	427	430	PF00017	0.442
LIG_SH2_STAT5	457	460	PF00017	0.473
LIG_SH3_1	489	495	PF00018	0.491
LIG_SH3_3	104	110	PF00018	0.619
LIG_SH3_3	295	301	PF00018	0.496
LIG_SH3_3	340	346	PF00018	0.579
LIG_SH3_3	357	363	PF00018	0.401
LIG_SH3_3	488	494	PF00018	0.518
LIG_SH3_3	566	572	PF00018	0.532
LIG_SH3_3	59	65	PF00018	0.503
LIG_SH3_5	379	383	PF00018	0.518
LIG_SUMO_SIM_anti_2	186	192	PF11976	0.473
LIG_SUMO_SIM_anti_2	202	209	PF11976	0.462
LIG_SUMO_SIM_par_1	202	209	PF11976	0.443
LIG_TRAF2_1	238	241	PF00917	0.554
LIG_TRAF2_1	67	70	PF00917	0.497
LIG_TYR_ITSM	277	284	PF00017	0.496
LIG_UBA3_1	410	416	PF00899	0.455
LIG_WRC_WIRS_1	112	117	PF05994	0.454
LIG_WRC_WIRS_1	277	282	PF05994	0.455
LIG_WRC_WIRS_1	367	372	PF05994	0.536
LIG_WW_3	216	220	PF00397	0.530
MOD_CDC14_SPxK_1	216	219	PF00782	0.448
MOD_CDK_SPxK_1	213	219	PF00069	0.439
MOD_CDK_SPxxK_3	568	575	PF00069	0.495
MOD_CK1_1	111	117	PF00069	0.626
MOD_CK1_1	119	125	PF00069	0.722
MOD_CK1_1	154	160	PF00069	0.592
MOD_CK1_1	171	177	PF00069	0.591
MOD_CK1_1	222	228	PF00069	0.497
MOD_CK1_1	259	265	PF00069	0.498
MOD_CK1_1	366	372	PF00069	0.494
MOD_CK1_1	57	63	PF00069	0.455
MOD_CK2_1	234	240	PF00069	0.563
MOD_CK2_1	386	392	PF00069	0.442
MOD_CK2_1	64	70	PF00069	0.505
MOD_GlcNHglycan	153	156	PF01048	0.520
MOD_GlcNHglycan	163	166	PF01048	0.729
MOD_GlcNHglycan	170	173	PF01048	0.553
MOD_GlcNHglycan	191	194	PF01048	0.378
MOD_GlcNHglycan	225	228	PF01048	0.704
MOD_GlcNHglycan	292	295	PF01048	0.333
MOD_GlcNHglycan	337	340	PF01048	0.337
MOD_GlcNHglycan	355	359	PF01048	0.381
MOD_GlcNHglycan	477	480	PF01048	0.523
MOD_GlcNHglycan	510	513	PF01048	0.671
MOD_GlcNHglycan	538	541	PF01048	0.613
MOD_GlcNHglycan	544	547	PF01048	0.617
MOD_GlcNHglycan	592	595	PF01048	0.491
MOD_GSK3_1	111	118	PF00069	0.638
MOD_GSK3_1	119	126	PF00069	0.671
MOD_GSK3_1	136	143	PF00069	0.400
MOD_GSK3_1	156	163	PF00069	0.732
MOD_GSK3_1	166	173	PF00069	0.608
MOD_GSK3_1	219	226	PF00069	0.615
MOD_GSK3_1	309	316	PF00069	0.473
MOD_GSK3_1	331	338	PF00069	0.508
MOD_GSK3_1	359	366	PF00069	0.490
MOD_GSK3_1	395	402	PF00069	0.442
MOD_N-GLC_1	417	422	PF02516	0.298
MOD_NEK2_1	121	126	PF00069	0.572
MOD_NEK2_1	256	261	PF00069	0.477
MOD_NEK2_1	309	314	PF00069	0.442
MOD_NEK2_1	330	335	PF00069	0.531
MOD_NEK2_1	399	404	PF00069	0.442
MOD_NEK2_1	611	616	PF00069	0.512
MOD_NEK2_1	7	12	PF00069	0.448
MOD_NEK2_1	96	101	PF00069	0.464
MOD_NEK2_2	276	281	PF00069	0.455
MOD_PIKK_1	121	127	PF00454	0.726
MOD_PIKK_1	553	559	PF00454	0.514
MOD_PIKK_1	98	104	PF00454	0.557
MOD_PKA_2	234	240	PF00069	0.501
MOD_PKA_2	331	337	PF00069	0.479
MOD_PKA_2	386	392	PF00069	0.456
MOD_PKA_2	500	506	PF00069	0.677
MOD_PKA_2	611	617	PF00069	0.514
MOD_PKA_2	96	102	PF00069	0.440
MOD_PKB_1	52	60	PF00069	0.510
MOD_Plk_1	240	246	PF00069	0.502
MOD_Plk_1	431	437	PF00069	0.455
MOD_Plk_1	470	476	PF00069	0.442
MOD_Plk_4	108	114	PF00069	0.672
MOD_Plk_4	116	122	PF00069	0.640
MOD_Plk_4	173	179	PF00069	0.517
MOD_Plk_4	276	282	PF00069	0.439
MOD_Plk_4	304	310	PF00069	0.468
MOD_Plk_4	363	369	PF00069	0.538
MOD_Plk_4	395	401	PF00069	0.466
MOD_Plk_4	406	412	PF00069	0.442
MOD_Plk_4	611	617	PF00069	0.574
MOD_Plk_4	7	13	PF00069	0.441
MOD_ProDKin_1	106	112	PF00069	0.672
MOD_ProDKin_1	113	119	PF00069	0.665
MOD_ProDKin_1	123	129	PF00069	0.649
MOD_ProDKin_1	156	162	PF00069	0.731
MOD_ProDKin_1	199	205	PF00069	0.326
MOD_ProDKin_1	206	212	PF00069	0.363
MOD_ProDKin_1	213	219	PF00069	0.484
MOD_ProDKin_1	28	34	PF00069	0.449
MOD_ProDKin_1	359	365	PF00069	0.448
MOD_ProDKin_1	417	423	PF00069	0.498
MOD_ProDKin_1	568	574	PF00069	0.494
MOD_SUMO_rev_2	568	576	PF00179	0.484
TRG_DiLeu_BaEn_1	599	604	PF01217	0.560
TRG_ENDOCYTIC_2	281	284	PF00928	0.496
TRG_ENDOCYTIC_2	426	429	PF00928	0.442
TRG_ENDOCYTIC_2	457	460	PF00928	0.480
TRG_ER_diArg_1	180	183	PF00400	0.473
TRG_ER_diArg_1	384	387	PF00400	0.455
TRG_ER_diArg_1	558	560	PF00400	0.525
TRG_ER_diArg_1	607	609	PF00400	0.410
TRG_Pf-PMV_PEXEL_1	577	581	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJT8	Leptomonas seymouri	55%	98%
A0A1X0P6Z4	Trypanosomatidae	38%	100%
A0A3R7RRC6	Trypanosoma rangeli	40%	100%
A0A3S5H741	Leishmania donovani	90%	100%
A4H9N2	Leishmania braziliensis	80%	100%
A4HXZ6	Leishmania infantum	90%	100%
D0A5B0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4QDR9	Leishmania major	88%	100%
V5BNM7	Trypanosoma cruzi	40%	100%