Complex1_LYR_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Complex 1 protein (LYR family), putative

Species:

Leishmania mexicana

UniProt:

E9ARQ7_LEIMU

TriTrypDb:

LmxM.18.1200

Length:

270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9ARQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARQ7

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	5
GO:0016043	cellular component organization	3	5
GO:0022607	cellular component assembly	4	5
GO:0033108	mitochondrial respiratory chain complex assembly	6	5
GO:0034552	respiratory chain complex II assembly	6	5
GO:0034553	mitochondrial respiratory chain complex II assembly	7	5
GO:0043933	protein-containing complex organization	4	5
GO:0065003	protein-containing complex assembly	5	5
GO:0071840	cellular component organization or biogenesis	2	5

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	158	160	PF00675	0.731
CLV_NRD_NRD_1	190	192	PF00675	0.573
CLV_NRD_NRD_1	218	220	PF00675	0.431
CLV_NRD_NRD_1	236	238	PF00675	0.310
CLV_NRD_NRD_1	251	253	PF00675	0.310
CLV_NRD_NRD_1	46	48	PF00675	0.628
CLV_PCSK_FUR_1	12	16	PF00082	0.668
CLV_PCSK_KEX2_1	14	16	PF00082	0.595
CLV_PCSK_KEX2_1	157	159	PF00082	0.731
CLV_PCSK_KEX2_1	190	192	PF00082	0.573
CLV_PCSK_KEX2_1	218	220	PF00082	0.431
CLV_PCSK_KEX2_1	251	253	PF00082	0.310
CLV_PCSK_KEX2_1	46	48	PF00082	0.628
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.663
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.310
CLV_PCSK_SKI1_1	203	207	PF00082	0.310
DEG_APCC_DBOX_1	202	210	PF00400	0.310
DEG_Nend_UBRbox_1	1	4	PF02207	0.542
DEG_SCF_FBW7_1	179	184	PF00400	0.643
DEG_SPOP_SBC_1	130	134	PF00917	0.650
DEG_SPOP_SBC_1	67	71	PF00917	0.594
DOC_MAPK_gen_1	237	243	PF00069	0.275
DOC_MAPK_gen_1	32	40	PF00069	0.574
DOC_PP1_RVXF_1	240	246	PF00149	0.310
DOC_PP2B_LxvP_1	65	68	PF13499	0.637
DOC_USP7_MATH_1	117	121	PF00917	0.678
DOC_USP7_MATH_1	137	141	PF00917	0.621
DOC_USP7_MATH_1	183	187	PF00917	0.621
DOC_USP7_MATH_1	189	193	PF00917	0.486
DOC_USP7_MATH_1	68	72	PF00917	0.631
DOC_USP7_UBL2_3	14	18	PF12436	0.664
DOC_USP7_UBL2_3	238	242	PF12436	0.310
DOC_WW_Pin1_4	120	125	PF00397	0.606
DOC_WW_Pin1_4	131	136	PF00397	0.681
DOC_WW_Pin1_4	175	180	PF00397	0.721
DOC_WW_Pin1_4	185	190	PF00397	0.649
DOC_WW_Pin1_4	52	57	PF00397	0.613
LIG_Actin_WH2_2	194	209	PF00022	0.322
LIG_FHA_1	73	79	PF00498	0.595
LIG_FHA_2	143	149	PF00498	0.642
LIG_GBD_Chelix_1	87	95	PF00786	0.608
LIG_PCNA_yPIPBox_3	190	202	PF02747	0.440
LIG_Pex14_1	245	249	PF04695	0.310
LIG_RPA_C_Fungi	214	226	PF08784	0.383
LIG_SH2_STAT3	224	227	PF00017	0.373
LIG_SH2_STAT3	229	232	PF00017	0.342
LIG_SH2_STAT3	39	42	PF00017	0.524
LIG_SH2_STAT5	224	227	PF00017	0.310
LIG_SH2_STAT5	39	42	PF00017	0.555
LIG_SH3_1	168	174	PF00018	0.624
LIG_SH3_3	168	174	PF00018	0.633
LIG_SH3_3	35	41	PF00018	0.586
LIG_SH3_3	53	59	PF00018	0.532
LIG_TRAF2_1	145	148	PF00917	0.667
MOD_CDC14_SPxK_1	188	191	PF00782	0.588
MOD_CDK_SPK_2	185	190	PF00069	0.623
MOD_CDK_SPxK_1	185	191	PF00069	0.738
MOD_CDK_SPxxK_3	120	127	PF00069	0.587
MOD_CK1_1	120	126	PF00069	0.720
MOD_CK1_1	129	135	PF00069	0.600
MOD_CK1_1	69	75	PF00069	0.625
MOD_CK1_1	86	92	PF00069	0.521
MOD_CK2_1	142	148	PF00069	0.663
MOD_Cter_Amidation	249	252	PF01082	0.294
MOD_GlcNHglycan	115	118	PF01048	0.680
MOD_GlcNHglycan	139	142	PF01048	0.689
MOD_GlcNHglycan	185	188	PF01048	0.593
MOD_GlcNHglycan	191	194	PF01048	0.518
MOD_GlcNHglycan	221	224	PF01048	0.445
MOD_GSK3_1	109	116	PF00069	0.700
MOD_GSK3_1	126	133	PF00069	0.607
MOD_GSK3_1	142	149	PF00069	0.727
MOD_GSK3_1	159	166	PF00069	0.526
MOD_GSK3_1	173	180	PF00069	0.678
MOD_GSK3_1	181	188	PF00069	0.770
MOD_GSK3_1	197	204	PF00069	0.301
MOD_GSK3_1	68	75	PF00069	0.624
MOD_GSK3_1	82	89	PF00069	0.606
MOD_N-GLC_1	219	224	PF02516	0.238
MOD_NEK2_1	5	10	PF00069	0.577
MOD_PKA_2	126	132	PF00069	0.571
MOD_PKA_2	189	195	PF00069	0.568
MOD_PKB_1	157	165	PF00069	0.481
MOD_Plk_1	146	152	PF00069	0.712
MOD_Plk_1	207	213	PF00069	0.389
MOD_Plk_1	219	225	PF00069	0.248
MOD_Plk_4	197	203	PF00069	0.310
MOD_ProDKin_1	120	126	PF00069	0.608
MOD_ProDKin_1	131	137	PF00069	0.681
MOD_ProDKin_1	175	181	PF00069	0.721
MOD_ProDKin_1	185	191	PF00069	0.639
MOD_ProDKin_1	52	58	PF00069	0.614
MOD_SUMO_for_1	241	244	PF00179	0.275
TRG_ENDOCYTIC_2	202	205	PF00928	0.310
TRG_ER_diArg_1	156	159	PF00400	0.727
TRG_ER_diArg_1	189	191	PF00400	0.599
TRG_ER_diArg_1	45	47	PF00400	0.621
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.310
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U5	Leptomonas seymouri	51%	98%
A0A3Q8IJR9	Leishmania donovani	85%	100%
A4H9N0	Leishmania braziliensis	71%	100%
A4HXZ4	Leishmania infantum	86%	100%
Q4QDS2	Leishmania major	89%	100%