Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARQ1_LEIMU

TriTrypDb:

LmxM.18.1140

Length:

945

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARQ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARQ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.561
CLV_MEL_PAP_1	621	627	PF00089	0.405
CLV_NRD_NRD_1	365	367	PF00675	0.580
CLV_NRD_NRD_1	376	378	PF00675	0.509
CLV_NRD_NRD_1	485	487	PF00675	0.640
CLV_NRD_NRD_1	59	61	PF00675	0.530
CLV_NRD_NRD_1	662	664	PF00675	0.675
CLV_NRD_NRD_1	666	668	PF00675	0.719
CLV_NRD_NRD_1	693	695	PF00675	0.701
CLV_NRD_NRD_1	932	934	PF00675	0.740
CLV_PCSK_FUR_1	374	378	PF00082	0.649
CLV_PCSK_FUR_1	656	660	PF00082	0.657
CLV_PCSK_KEX2_1	228	230	PF00082	0.683
CLV_PCSK_KEX2_1	262	264	PF00082	0.690
CLV_PCSK_KEX2_1	278	280	PF00082	0.492
CLV_PCSK_KEX2_1	358	360	PF00082	0.604
CLV_PCSK_KEX2_1	365	367	PF00082	0.558
CLV_PCSK_KEX2_1	376	378	PF00082	0.501
CLV_PCSK_KEX2_1	485	487	PF00082	0.640
CLV_PCSK_KEX2_1	517	519	PF00082	0.580
CLV_PCSK_KEX2_1	658	660	PF00082	0.631
CLV_PCSK_KEX2_1	661	663	PF00082	0.680
CLV_PCSK_KEX2_1	666	668	PF00082	0.720
CLV_PCSK_KEX2_1	695	697	PF00082	0.737
CLV_PCSK_KEX2_1	932	934	PF00082	0.697
CLV_PCSK_KEX2_1	95	97	PF00082	0.458
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.683
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.685
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.428
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.658
CLV_PCSK_PC1ET2_1	517	519	PF00082	0.607
CLV_PCSK_PC1ET2_1	695	697	PF00082	0.790
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.489
CLV_PCSK_PC7_1	656	662	PF00082	0.714
CLV_PCSK_SKI1_1	145	149	PF00082	0.326
CLV_PCSK_SKI1_1	278	282	PF00082	0.638
CLV_PCSK_SKI1_1	485	489	PF00082	0.595
CLV_PCSK_SKI1_1	547	551	PF00082	0.523
CLV_PCSK_SKI1_1	912	916	PF00082	0.645
CLV_PCSK_SKI1_1	92	96	PF00082	0.575
CLV_Separin_Metazoa	583	587	PF03568	0.467
CLV_Separin_Metazoa	590	594	PF03568	0.445
CLV_Separin_Metazoa	649	653	PF03568	0.610
DEG_APCC_DBOX_1	300	308	PF00400	0.684
DEG_APCC_DBOX_1	501	509	PF00400	0.660
DEG_SPOP_SBC_1	345	349	PF00917	0.674
DEG_SPOP_SBC_1	673	677	PF00917	0.770
DOC_CYCLIN_RxL_1	37	51	PF00134	0.575
DOC_CYCLIN_RxL_1	746	759	PF00134	0.554
DOC_CYCLIN_yClb5_NLxxxL_5	260	269	PF00134	0.634
DOC_MAPK_gen_1	438	446	PF00069	0.552
DOC_MAPK_gen_1	578	587	PF00069	0.559
DOC_MAPK_gen_1	746	755	PF00069	0.551
DOC_MAPK_MEF2A_6	440	448	PF00069	0.555
DOC_USP7_MATH_1	181	185	PF00917	0.530
DOC_USP7_MATH_1	188	192	PF00917	0.515
DOC_USP7_MATH_1	241	245	PF00917	0.670
DOC_USP7_MATH_1	346	350	PF00917	0.677
DOC_USP7_MATH_1	665	669	PF00917	0.772
DOC_USP7_MATH_1	673	677	PF00917	0.741
DOC_USP7_MATH_1	705	709	PF00917	0.801
DOC_USP7_MATH_1	805	809	PF00917	0.744
DOC_USP7_MATH_1	884	888	PF00917	0.726
DOC_USP7_MATH_1	914	918	PF00917	0.615
DOC_USP7_UBL2_3	170	174	PF12436	0.631
DOC_WW_Pin1_4	10	15	PF00397	0.627
DOC_WW_Pin1_4	602	607	PF00397	0.549
DOC_WW_Pin1_4	801	806	PF00397	0.680
DOC_WW_Pin1_4	812	817	PF00397	0.634
DOC_WW_Pin1_4	865	870	PF00397	0.728
DOC_WW_Pin1_4	880	885	PF00397	0.698
LIG_14-3-3_CanoR_1	180	190	PF00244	0.605
LIG_14-3-3_CanoR_1	204	212	PF00244	0.632
LIG_14-3-3_CanoR_1	303	308	PF00244	0.662
LIG_14-3-3_CanoR_1	586	594	PF00244	0.492
LIG_14-3-3_CanoR_1	624	628	PF00244	0.397
LIG_14-3-3_CanoR_1	856	865	PF00244	0.727
LIG_14-3-3_CanoR_1	875	880	PF00244	0.678
LIG_14-3-3_CanoR_1	898	903	PF00244	0.698
LIG_14-3-3_CanoR_1	96	104	PF00244	0.474
LIG_Actin_WH2_2	202	219	PF00022	0.633
LIG_Actin_WH2_2	766	784	PF00022	0.473
LIG_BIR_II_1	1	5	PF00653	0.482
LIG_BIR_III_3	1	5	PF00653	0.482
LIG_CaM_IQ_9	209	225	PF13499	0.655
LIG_Clathr_ClatBox_1	189	193	PF01394	0.528
LIG_FHA_1	13	19	PF00498	0.681
LIG_FHA_1	146	152	PF00498	0.312
LIG_FHA_1	473	479	PF00498	0.580
LIG_FHA_1	587	593	PF00498	0.495
LIG_FHA_1	716	722	PF00498	0.695
LIG_FHA_2	100	106	PF00498	0.622
LIG_FHA_2	284	290	PF00498	0.589
LIG_FHA_2	318	324	PF00498	0.670
LIG_FHA_2	346	352	PF00498	0.589
LIG_FHA_2	355	361	PF00498	0.518
LIG_FHA_2	387	393	PF00498	0.597
LIG_FHA_2	431	437	PF00498	0.342
LIG_FHA_2	523	529	PF00498	0.581
LIG_FHA_2	597	603	PF00498	0.672
LIG_FHA_2	898	904	PF00498	0.700
LIG_LIR_Apic_2	874	880	PF02991	0.706
LIG_LIR_Gen_1	17	24	PF02991	0.548
LIG_LIR_Gen_1	638	647	PF02991	0.574
LIG_LIR_Nem_3	17	23	PF02991	0.575
LIG_MYND_1	880	884	PF01753	0.476
LIG_NRBOX	772	778	PF00104	0.468
LIG_SH2_CRK	70	74	PF00017	0.514
LIG_SH2_CRK	877	881	PF00017	0.704
LIG_SH2_NCK_1	70	74	PF00017	0.557
LIG_SH2_NCK_1	877	881	PF00017	0.704
LIG_SH2_PTP2	20	23	PF00017	0.586
LIG_SH2_SRC	20	23	PF00017	0.530
LIG_SH2_STAP1	322	326	PF00017	0.677
LIG_SH2_STAP1	647	651	PF00017	0.608
LIG_SH2_STAT5	140	143	PF00017	0.595
LIG_SH2_STAT5	146	149	PF00017	0.502
LIG_SH2_STAT5	20	23	PF00017	0.586
LIG_SH2_STAT5	317	320	PF00017	0.545
LIG_SH3_2	3	8	PF14604	0.596
LIG_SH3_3	708	714	PF00018	0.746
LIG_SUMO_SIM_par_1	392	399	PF11976	0.553
LIG_SUMO_SIM_par_1	769	775	PF11976	0.479
LIG_TRAF2_1	175	178	PF00917	0.618
LIG_TRAF2_1	232	235	PF00917	0.718
LIG_TRAF2_1	287	290	PF00917	0.671
LIG_TRAF2_1	368	371	PF00917	0.638
LIG_TRAF2_1	389	392	PF00917	0.609
LIG_TRAF2_1	434	437	PF00917	0.506
LIG_TRAF2_1	646	649	PF00917	0.608
LIG_TRAF2_1	79	82	PF00917	0.499
LIG_TYR_ITIM	18	23	PF00017	0.640
LIG_UBA3_1	507	512	PF00899	0.539
MOD_CK1_1	13	19	PF00069	0.592
MOD_CK1_1	184	190	PF00069	0.619
MOD_CK1_1	191	197	PF00069	0.581
MOD_CK1_1	386	392	PF00069	0.476
MOD_CK1_1	638	644	PF00069	0.598
MOD_CK1_1	672	678	PF00069	0.720
MOD_CK1_1	681	687	PF00069	0.675
MOD_CK1_1	716	722	PF00069	0.618
MOD_CK1_1	878	884	PF00069	0.719
MOD_CK2_1	283	289	PF00069	0.621
MOD_CK2_1	292	298	PF00069	0.597
MOD_CK2_1	336	342	PF00069	0.645
MOD_CK2_1	345	351	PF00069	0.574
MOD_CK2_1	354	360	PF00069	0.419
MOD_CK2_1	365	371	PF00069	0.315
MOD_CK2_1	386	392	PF00069	0.582
MOD_CK2_1	430	436	PF00069	0.548
MOD_CK2_1	522	528	PF00069	0.582
MOD_CK2_1	596	602	PF00069	0.620
MOD_CK2_1	643	649	PF00069	0.551
MOD_CK2_1	680	686	PF00069	0.751
MOD_CK2_1	897	903	PF00069	0.701
MOD_CK2_1	99	105	PF00069	0.615
MOD_GlcNHglycan	10	13	PF01048	0.733
MOD_GlcNHglycan	185	189	PF01048	0.648
MOD_GlcNHglycan	243	246	PF01048	0.676
MOD_GlcNHglycan	348	351	PF01048	0.579
MOD_GlcNHglycan	367	370	PF01048	0.466
MOD_GlcNHglycan	426	429	PF01048	0.566
MOD_GlcNHglycan	671	674	PF01048	0.759
MOD_GlcNHglycan	807	810	PF01048	0.712
MOD_GlcNHglycan	81	86	PF01048	0.562
MOD_GlcNHglycan	843	846	PF01048	0.699
MOD_GlcNHglycan	860	865	PF01048	0.714
MOD_GlcNHglycan	877	880	PF01048	0.651
MOD_GlcNHglycan	890	893	PF01048	0.621
MOD_GlcNHglycan	934	937	PF01048	0.706
MOD_GSK3_1	184	191	PF00069	0.556
MOD_GSK3_1	200	207	PF00069	0.617
MOD_GSK3_1	299	306	PF00069	0.679
MOD_GSK3_1	37	44	PF00069	0.504
MOD_GSK3_1	382	389	PF00069	0.600
MOD_GSK3_1	392	399	PF00069	0.489
MOD_GSK3_1	619	626	PF00069	0.644
MOD_GSK3_1	665	672	PF00069	0.757
MOD_GSK3_1	674	681	PF00069	0.711
MOD_GSK3_1	8	15	PF00069	0.660
MOD_GSK3_1	801	808	PF00069	0.749
MOD_GSK3_1	850	857	PF00069	0.744
MOD_GSK3_1	871	878	PF00069	0.771
MOD_GSK3_1	880	887	PF00069	0.685
MOD_GSK3_1	912	919	PF00069	0.585
MOD_GSK3_1	95	102	PF00069	0.554
MOD_N-GLC_1	619	624	PF02516	0.419
MOD_N-GLC_1	679	684	PF02516	0.804
MOD_NEK2_1	299	304	PF00069	0.633
MOD_NEK2_1	344	349	PF00069	0.598
MOD_NEK2_1	354	359	PF00069	0.530
MOD_NEK2_1	41	46	PF00069	0.501
MOD_NEK2_1	430	435	PF00069	0.543
MOD_NEK2_1	522	527	PF00069	0.579
MOD_NEK2_1	573	578	PF00069	0.494
MOD_PIKK_1	549	555	PF00454	0.549
MOD_PIKK_1	884	890	PF00454	0.698
MOD_PKA_1	365	371	PF00069	0.354
MOD_PKA_1	932	938	PF00069	0.604
MOD_PKA_1	95	101	PF00069	0.496
MOD_PKA_2	292	298	PF00069	0.655
MOD_PKA_2	327	333	PF00069	0.608
MOD_PKA_2	365	371	PF00069	0.556
MOD_PKA_2	472	478	PF00069	0.525
MOD_PKA_2	623	629	PF00069	0.398
MOD_PKA_2	643	649	PF00069	0.608
MOD_PKA_2	665	671	PF00069	0.721
MOD_PKA_2	716	722	PF00069	0.618
MOD_PKA_2	897	903	PF00069	0.684
MOD_PKA_2	932	938	PF00069	0.548
MOD_PKA_2	95	101	PF00069	0.495
MOD_PKB_1	301	309	PF00069	0.680
MOD_PKB_1	667	675	PF00069	0.727
MOD_PKB_1	839	847	PF00069	0.700
MOD_PKB_1	854	862	PF00069	0.611
MOD_PKB_1	910	918	PF00069	0.444
MOD_Plk_1	184	190	PF00069	0.619
MOD_Plk_1	299	305	PF00069	0.631
MOD_Plk_1	370	376	PF00069	0.637
MOD_Plk_1	41	47	PF00069	0.501
MOD_Plk_1	430	436	PF00069	0.565
MOD_Plk_1	638	644	PF00069	0.672
MOD_Plk_1	860	866	PF00069	0.740
MOD_Plk_1	99	105	PF00069	0.575
MOD_Plk_2-3	392	398	PF00069	0.556
MOD_Plk_2-3	766	772	PF00069	0.471
MOD_Plk_4	303	309	PF00069	0.677
MOD_Plk_4	738	744	PF00069	0.531
MOD_Plk_4	766	772	PF00069	0.471
MOD_ProDKin_1	10	16	PF00069	0.621
MOD_ProDKin_1	602	608	PF00069	0.550
MOD_ProDKin_1	801	807	PF00069	0.679
MOD_ProDKin_1	812	818	PF00069	0.630
MOD_ProDKin_1	865	871	PF00069	0.727
MOD_ProDKin_1	880	886	PF00069	0.699
MOD_SUMO_for_1	566	569	PF00179	0.309
MOD_SUMO_for_1	749	752	PF00179	0.564
MOD_SUMO_rev_2	109	118	PF00179	0.538
MOD_SUMO_rev_2	420	425	PF00179	0.542
TRG_DiLeu_BaEn_1	332	337	PF01217	0.623
TRG_DiLeu_BaEn_1	766	771	PF01217	0.468
TRG_DiLeu_BaEn_4	370	376	PF01217	0.637
TRG_DiLeu_BaEn_4	50	56	PF01217	0.490
TRG_DiLeu_BaEn_4	582	588	PF01217	0.520
TRG_ENDOCYTIC_2	20	23	PF00928	0.530
TRG_ENDOCYTIC_2	640	643	PF00928	0.568
TRG_ENDOCYTIC_2	647	650	PF00928	0.519
TRG_ENDOCYTIC_2	70	73	PF00928	0.459
TRG_ENDOCYTIC_2	91	94	PF00928	0.479
TRG_ER_diArg_1	119	122	PF00400	0.549
TRG_ER_diArg_1	301	304	PF00400	0.648
TRG_ER_diArg_1	365	367	PF00400	0.602
TRG_ER_diArg_1	374	377	PF00400	0.607
TRG_ER_diArg_1	656	659	PF00400	0.632
TRG_ER_diArg_1	660	663	PF00400	0.681
TRG_ER_diArg_1	666	669	PF00400	0.695
TRG_ER_diArg_1	728	731	PF00400	0.479
TRG_ER_diArg_1	785	788	PF00400	0.601
TRG_ER_diArg_1	840	843	PF00400	0.678
TRG_ER_diArg_1	931	933	PF00400	0.736
TRG_NLS_MonoExtC_3	693	699	PF00514	0.733
TRG_NLS_MonoExtN_4	692	698	PF00514	0.732
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	263	267	PF00026	0.680
TRG_Pf-PMV_PEXEL_1	279	284	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	365	370	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	486	490	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	652	657	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBB1	Leptomonas seymouri	61%	80%
A0A3R7MU41	Trypanosoma rangeli	39%	96%
A0A3S5H739	Leishmania donovani	94%	100%
A4H9M4	Leishmania braziliensis	83%	100%
A4HXY8	Leishmania infantum	94%	100%
D0A5B9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	99%
Q4QDS8	Leishmania major	93%	100%
V5BEK2	Trypanosoma cruzi	37%	95%