AN1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AN1-like zinc finger, putative

Species:

Leishmania mexicana

UniProt:

E9ARP9_LEIMU

TriTrypDb:

LmxM.18.1120

Length:

355

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARP9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.709
CLV_NRD_NRD_1	111	113	PF00675	0.682
CLV_NRD_NRD_1	304	306	PF00675	0.339
CLV_NRD_NRD_1	337	339	PF00675	0.513
CLV_PCSK_KEX2_1	111	113	PF00082	0.682
CLV_PCSK_KEX2_1	33	35	PF00082	0.360
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.360
CLV_PCSK_SKI1_1	331	335	PF00082	0.458
DEG_COP1_1	235	243	PF00400	0.338
DEG_Nend_UBRbox_3	1	3	PF02207	0.503
DEG_SPOP_SBC_1	343	347	PF00917	0.464
DOC_MAPK_MEF2A_6	171	179	PF00069	0.570
DOC_PP1_RVXF_1	312	319	PF00149	0.404
DOC_PP4_FxxP_1	219	222	PF00568	0.463
DOC_PP4_FxxP_1	318	321	PF00568	0.464
DOC_USP7_MATH_1	159	163	PF00917	0.613
DOC_USP7_MATH_1	239	243	PF00917	0.353
DOC_USP7_MATH_1	26	30	PF00917	0.334
DOC_USP7_MATH_1	264	268	PF00917	0.489
DOC_USP7_MATH_1	90	94	PF00917	0.640
DOC_USP7_UBL2_3	200	204	PF12436	0.580
DOC_WW_Pin1_4	164	169	PF00397	0.572
DOC_WW_Pin1_4	194	199	PF00397	0.435
DOC_WW_Pin1_4	265	270	PF00397	0.470
DOC_WW_Pin1_4	293	298	PF00397	0.453
DOC_WW_Pin1_4	317	322	PF00397	0.528
LIG_14-3-3_CanoR_1	161	168	PF00244	0.628
LIG_14-3-3_CanoR_1	263	269	PF00244	0.512
LIG_14-3-3_CanoR_1	305	311	PF00244	0.431
LIG_APCC_ABBA_1	284	289	PF00400	0.567
LIG_FHA_1	139	145	PF00498	0.425
LIG_FHA_1	212	218	PF00498	0.348
LIG_FHA_1	281	287	PF00498	0.458
LIG_FHA_1	35	41	PF00498	0.404
LIG_FHA_1	55	61	PF00498	0.290
LIG_FHA_2	17	23	PF00498	0.300
LIG_FHA_2	230	236	PF00498	0.585
LIG_FHA_2	257	263	PF00498	0.533
LIG_FHA_2	286	292	PF00498	0.494
LIG_LIR_Apic_2	291	297	PF02991	0.422
LIG_LIR_Apic_2	315	321	PF02991	0.444
LIG_LIR_Gen_1	242	252	PF02991	0.401
LIG_LIR_Nem_3	235	240	PF02991	0.460
LIG_LIR_Nem_3	242	246	PF02991	0.354
LIG_NRBOX	252	258	PF00104	0.422
LIG_PCNA_yPIPBox_3	249	257	PF02747	0.480
LIG_SH2_CRK	295	299	PF00017	0.453
LIG_SH2_CRK	62	66	PF00017	0.403
LIG_SH2_STAT3	69	72	PF00017	0.479
LIG_SH3_3	174	180	PF00018	0.742
LIG_SH3_3	279	285	PF00018	0.365
LIG_SUMO_SIM_anti_2	19	25	PF11976	0.360
LIG_TRAF2_2	70	75	PF00917	0.520
LIG_TYR_ITIM	60	65	PF00017	0.388
LIG_UBA3_1	175	183	PF00899	0.544
LIG_WRC_WIRS_1	240	245	PF05994	0.336
MOD_CDK_SPxK_1	194	200	PF00069	0.489
MOD_CDK_SPxxK_3	164	171	PF00069	0.619
MOD_CDK_SPxxK_3	265	272	PF00069	0.468
MOD_CK1_1	166	172	PF00069	0.599
MOD_CK1_1	344	350	PF00069	0.542
MOD_CK2_1	164	170	PF00069	0.664
MOD_CK2_1	285	291	PF00069	0.572
MOD_CK2_1	317	323	PF00069	0.328
MOD_Cter_Amidation	109	112	PF01082	0.683
MOD_GlcNHglycan	108	111	PF01048	0.595
MOD_GlcNHglycan	306	309	PF01048	0.374
MOD_GlcNHglycan	42	45	PF01048	0.343
MOD_GSK3_1	159	166	PF00069	0.554
MOD_GSK3_1	203	210	PF00069	0.535
MOD_GSK3_1	34	41	PF00069	0.356
MOD_GSK3_1	341	348	PF00069	0.672
MOD_NEK2_1	113	118	PF00069	0.509
MOD_NEK2_1	160	165	PF00069	0.662
MOD_NEK2_1	256	261	PF00069	0.428
MOD_NEK2_1	280	285	PF00069	0.444
MOD_NEK2_1	40	45	PF00069	0.297
MOD_PIKK_1	346	352	PF00454	0.590
MOD_PK_1	118	124	PF00069	0.393
MOD_PK_1	183	189	PF00069	0.559
MOD_PKA_2	160	166	PF00069	0.660
MOD_PKA_2	26	32	PF00069	0.383
MOD_PKA_2	304	310	PF00069	0.417
MOD_Plk_1	312	318	PF00069	0.437
MOD_Plk_2-3	16	22	PF00069	0.411
MOD_Plk_4	221	227	PF00069	0.525
MOD_Plk_4	239	245	PF00069	0.315
MOD_Plk_4	299	305	PF00069	0.458
MOD_Plk_4	325	331	PF00069	0.477
MOD_Plk_4	91	97	PF00069	0.539
MOD_ProDKin_1	164	170	PF00069	0.577
MOD_ProDKin_1	194	200	PF00069	0.444
MOD_ProDKin_1	265	271	PF00069	0.462
MOD_ProDKin_1	293	299	PF00069	0.454
MOD_ProDKin_1	317	323	PF00069	0.542
MOD_SUMO_rev_2	335	341	PF00179	0.466
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.456
TRG_ENDOCYTIC_2	295	298	PF00928	0.518
TRG_ENDOCYTIC_2	62	65	PF00928	0.397
TRG_ER_diArg_1	111	113	PF00400	0.686
TRG_ER_diArg_1	70	73	PF00400	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2X2	Leptomonas seymouri	67%	99%
A0A0S4KFT8	Bodo saltans	31%	100%
A0A1X0P6Y8	Trypanosomatidae	31%	100%
A0A3S5ISH4	Trypanosoma rangeli	34%	100%
A0A3S7WV04	Leishmania donovani	91%	100%
A4H9M2	Leishmania braziliensis	79%	100%
A4HXY6	Leishmania infantum	91%	100%
D0A5C1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4QDT0	Leishmania major	91%	100%
V5AZ68	Trypanosoma cruzi	32%	100%