Vacuolar protein sorting complex subunit,putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar protein sorting-associated protein 16 homolog, putative

Species:

Leishmania mexicana

UniProt:

E9ARP4_LEIMU

TriTrypDb:

LmxM.18.1070

Length:

829

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0012505	endomembrane system	2	9
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0005768	endosome	7	1
GO:0030897	HOPS complex	3	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098796	membrane protein complex	2	1
GO:0099023	vesicle tethering complex	2	1

Expansion

Sequence features

E9ARP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARP4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0006886	intracellular protein transport	4	10
GO:0006996	organelle organization	4	10
GO:0007033	vacuole organization	5	10
GO:0008104	protein localization	4	10
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	10
GO:0016043	cellular component organization	3	10
GO:0033036	macromolecule localization	2	10
GO:0045184	establishment of protein localization	3	10
GO:0046907	intracellular transport	3	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051641	cellular localization	2	10
GO:0051649	establishment of localization in cell	3	10
GO:0070727	cellular macromolecule localization	3	10
GO:0071702	organic substance transport	4	10
GO:0071705	nitrogen compound transport	4	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0042144	vacuole fusion, non-autophagic	7	1
GO:0048284	organelle fusion	5	1
GO:0097576	vacuole fusion	6	1

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.479
CLV_C14_Caspase3-7	734	738	PF00656	0.461
CLV_NRD_NRD_1	178	180	PF00675	0.421
CLV_NRD_NRD_1	432	434	PF00675	0.507
CLV_PCSK_KEX2_1	100	102	PF00082	0.593
CLV_PCSK_KEX2_1	178	180	PF00082	0.421
CLV_PCSK_KEX2_1	334	336	PF00082	0.322
CLV_PCSK_KEX2_1	360	362	PF00082	0.412
CLV_PCSK_KEX2_1	500	502	PF00082	0.421
CLV_PCSK_KEX2_1	749	751	PF00082	0.421
CLV_PCSK_KEX2_1	785	787	PF00082	0.313
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.593
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.322
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.487
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.421
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.421
CLV_PCSK_PC1ET2_1	785	787	PF00082	0.421
CLV_PCSK_SKI1_1	121	125	PF00082	0.453
CLV_PCSK_SKI1_1	334	338	PF00082	0.421
CLV_PCSK_SKI1_1	446	450	PF00082	0.460
CLV_PCSK_SKI1_1	59	63	PF00082	0.470
CLV_PCSK_SKI1_1	707	711	PF00082	0.336
CLV_PCSK_SKI1_1	733	737	PF00082	0.398
DEG_APCC_DBOX_1	256	264	PF00400	0.463
DEG_ODPH_VHL_1	265	276	PF01847	0.385
DOC_CDC14_PxL_1	483	491	PF14671	0.171
DOC_CYCLIN_RxL_1	69	81	PF00134	0.474
DOC_MAPK_DCC_7	365	375	PF00069	0.559
DOC_MAPK_gen_1	100	108	PF00069	0.585
DOC_MAPK_gen_1	360	370	PF00069	0.493
DOC_MAPK_gen_1	433	440	PF00069	0.427
DOC_MAPK_MEF2A_6	5	14	PF00069	0.475
DOC_PP1_RVXF_1	151	158	PF00149	0.378
DOC_PP2B_LxvP_1	134	137	PF13499	0.596
DOC_PP2B_LxvP_1	76	79	PF13499	0.468
DOC_PP4_FxxP_1	698	701	PF00568	0.421
DOC_USP7_MATH_1	112	116	PF00917	0.517
DOC_USP7_MATH_1	126	130	PF00917	0.366
DOC_USP7_MATH_1	230	234	PF00917	0.339
DOC_USP7_MATH_1	29	33	PF00917	0.464
DOC_USP7_MATH_1	427	431	PF00917	0.316
DOC_USP7_MATH_1	607	611	PF00917	0.515
DOC_USP7_MATH_1	818	822	PF00917	0.617
DOC_USP7_UBL2_3	442	446	PF12436	0.522
DOC_USP7_UBL2_3	797	801	PF12436	0.322
DOC_WW_Pin1_4	108	113	PF00397	0.532
DOC_WW_Pin1_4	146	151	PF00397	0.322
DOC_WW_Pin1_4	180	185	PF00397	0.385
DOC_WW_Pin1_4	623	628	PF00397	0.725
LIG_14-3-3_CanoR_1	101	108	PF00244	0.460
LIG_14-3-3_CanoR_1	178	184	PF00244	0.396
LIG_14-3-3_CanoR_1	344	350	PF00244	0.419
LIG_14-3-3_CanoR_1	393	397	PF00244	0.529
LIG_14-3-3_CanoR_1	428	432	PF00244	0.536
LIG_14-3-3_CanoR_1	452	459	PF00244	0.536
LIG_14-3-3_CanoR_1	680	684	PF00244	0.462
LIG_14-3-3_CanoR_1	687	691	PF00244	0.444
LIG_14-3-3_CanoR_1	820	826	PF00244	0.413
LIG_14-3-3_CanoR_1	83	92	PF00244	0.559
LIG_Actin_WH2_2	485	502	PF00022	0.421
LIG_BIR_III_2	181	185	PF00653	0.288
LIG_BRCT_BRCA1_1	114	118	PF00533	0.566
LIG_BRCT_BRCA1_1	258	262	PF00533	0.324
LIG_BRCT_BRCA1_1	351	355	PF00533	0.346
LIG_BRCT_BRCA1_1	774	778	PF00533	0.463
LIG_Clathr_ClatBox_1	224	228	PF01394	0.346
LIG_Clathr_ClatBox_1	91	95	PF01394	0.540
LIG_EH_1	480	484	PF12763	0.171
LIG_FHA_1	101	107	PF00498	0.325
LIG_FHA_1	14	20	PF00498	0.459
LIG_FHA_1	511	517	PF00498	0.326
LIG_FHA_1	741	747	PF00498	0.452
LIG_FHA_1	86	92	PF00498	0.549
LIG_FHA_2	286	292	PF00498	0.420
LIG_FHA_2	40	46	PF00498	0.496
LIG_FHA_2	52	58	PF00498	0.444
LIG_FHA_2	529	535	PF00498	0.380
LIG_FHA_2	70	76	PF00498	0.410
LIG_FHA_2	732	738	PF00498	0.421
LIG_FHA_2	764	770	PF00498	0.463
LIG_GBD_Chelix_1	440	448	PF00786	0.493
LIG_LIR_Apic_2	697	701	PF02991	0.353
LIG_LIR_Apic_2	747	751	PF02991	0.421
LIG_LIR_Gen_1	129	138	PF02991	0.544
LIG_LIR_Gen_1	16	24	PF02991	0.527
LIG_LIR_Gen_1	169	177	PF02991	0.325
LIG_LIR_Gen_1	259	270	PF02991	0.325
LIG_LIR_Gen_1	288	297	PF02991	0.379
LIG_LIR_Gen_1	345	351	PF02991	0.322
LIG_LIR_Gen_1	352	362	PF02991	0.394
LIG_LIR_Gen_1	45	55	PF02991	0.524
LIG_LIR_Gen_1	454	463	PF02991	0.420
LIG_LIR_Gen_1	509	519	PF02991	0.346
LIG_LIR_Gen_1	590	598	PF02991	0.478
LIG_LIR_Gen_1	644	655	PF02991	0.355
LIG_LIR_Gen_1	716	725	PF02991	0.378
LIG_LIR_Gen_1	811	818	PF02991	0.513
LIG_LIR_Nem_3	105	110	PF02991	0.409
LIG_LIR_Nem_3	129	134	PF02991	0.532
LIG_LIR_Nem_3	16	21	PF02991	0.447
LIG_LIR_Nem_3	169	174	PF02991	0.325
LIG_LIR_Nem_3	259	265	PF02991	0.325
LIG_LIR_Nem_3	288	292	PF02991	0.379
LIG_LIR_Nem_3	345	349	PF02991	0.392
LIG_LIR_Nem_3	45	51	PF02991	0.511
LIG_LIR_Nem_3	454	459	PF02991	0.331
LIG_LIR_Nem_3	590	596	PF02991	0.486
LIG_LIR_Nem_3	625	631	PF02991	0.674
LIG_LIR_Nem_3	644	650	PF02991	0.355
LIG_LIR_Nem_3	664	668	PF02991	0.132
LIG_LIR_Nem_3	716	722	PF02991	0.363
LIG_LIR_Nem_3	769	773	PF02991	0.322
LIG_LIR_Nem_3	811	817	PF02991	0.495
LIG_LIR_Nem_3	824	828	PF02991	0.590
LIG_MAD2	142	150	PF02301	0.463
LIG_MLH1_MIPbox_1	258	262	PF16413	0.407
LIG_PCNA_PIPBox_1	551	560	PF02747	0.407
LIG_PCNA_yPIPBox_3	551	563	PF02747	0.407
LIG_Pex14_2	342	346	PF04695	0.322
LIG_Pex14_2	825	829	PF04695	0.612
LIG_PTB_Apo_2	12	19	PF02174	0.551
LIG_SH2_CRK	668	672	PF00017	0.463
LIG_SH2_CRK	748	752	PF00017	0.421
LIG_SH2_GRB2like	557	560	PF00017	0.339
LIG_SH2_PTP2	543	546	PF00017	0.378
LIG_SH2_STAP1	218	222	PF00017	0.385
LIG_SH2_STAP1	289	293	PF00017	0.378
LIG_SH2_STAT3	261	264	PF00017	0.407
LIG_SH2_STAT5	200	203	PF00017	0.328
LIG_SH2_STAT5	24	27	PF00017	0.571
LIG_SH2_STAT5	261	264	PF00017	0.407
LIG_SH2_STAT5	543	546	PF00017	0.346
LIG_SH2_STAT5	557	560	PF00017	0.282
LIG_SH2_STAT5	567	570	PF00017	0.280
LIG_SH2_STAT5	573	576	PF00017	0.264
LIG_SH2_STAT5	681	684	PF00017	0.171
LIG_SH2_STAT5	71	74	PF00017	0.459
LIG_SH2_STAT5	713	716	PF00017	0.386
LIG_SH2_STAT5	741	744	PF00017	0.295
LIG_SH2_STAT5	757	760	PF00017	0.333
LIG_SH2_STAT5	771	774	PF00017	0.322
LIG_SH3_3	224	230	PF00018	0.378
LIG_SH3_3	28	34	PF00018	0.405
LIG_SH3_3	624	630	PF00018	0.567
LIG_Sin3_3	48	55	PF02671	0.522
LIG_SUMO_SIM_anti_2	172	178	PF11976	0.396
LIG_SUMO_SIM_anti_2	8	14	PF11976	0.402
LIG_SUMO_SIM_anti_2	87	93	PF11976	0.536
LIG_SUMO_SIM_par_1	10	16	PF11976	0.421
LIG_SUMO_SIM_par_1	415	420	PF11976	0.504
LIG_SUMO_SIM_par_1	472	477	PF11976	0.411
LIG_SUMO_SIM_par_1	488	494	PF11976	0.286
LIG_SUMO_SIM_par_1	90	96	PF11976	0.552
LIG_SxIP_EBH_1	754	763	PF03271	0.463
LIG_TYR_ITIM	541	546	PF00017	0.378
LIG_UBA3_1	62	69	PF00899	0.266
LIG_UBA3_1	792	801	PF00899	0.322
MOD_CDK_SPxxK_3	146	153	PF00069	0.378
MOD_CK1_1	111	117	PF00069	0.554
MOD_CK1_1	127	133	PF00069	0.327
MOD_CK1_1	163	169	PF00069	0.398
MOD_CK1_1	172	178	PF00069	0.385
MOD_CK1_1	256	262	PF00069	0.300
MOD_CK1_1	275	281	PF00069	0.435
MOD_CK1_1	521	527	PF00069	0.403
MOD_CK1_1	587	593	PF00069	0.619
MOD_CK1_1	726	732	PF00069	0.366
MOD_CK1_1	821	827	PF00069	0.660
MOD_CK2_1	127	133	PF00069	0.560
MOD_CK2_1	285	291	PF00069	0.421
MOD_CK2_1	488	494	PF00069	0.398
MOD_CK2_1	51	57	PF00069	0.505
MOD_CK2_1	528	534	PF00069	0.246
MOD_CK2_1	638	644	PF00069	0.463
MOD_CK2_1	69	75	PF00069	0.422
MOD_CK2_1	763	769	PF00069	0.432
MOD_GlcNHglycan	168	171	PF01048	0.475
MOD_GlcNHglycan	209	212	PF01048	0.381
MOD_GlcNHglycan	296	300	PF01048	0.390
MOD_GlcNHglycan	309	312	PF01048	0.414
MOD_GlcNHglycan	523	526	PF01048	0.464
MOD_GlcNHglycan	589	592	PF01048	0.648
MOD_GlcNHglycan	633	636	PF01048	0.586
MOD_GlcNHglycan	673	676	PF01048	0.421
MOD_GlcNHglycan	723	728	PF01048	0.409
MOD_GlcNHglycan	820	823	PF01048	0.570
MOD_GSK3_1	108	115	PF00069	0.476
MOD_GSK3_1	160	167	PF00069	0.380
MOD_GSK3_1	188	195	PF00069	0.428
MOD_GSK3_1	230	237	PF00069	0.440
MOD_GSK3_1	25	32	PF00069	0.480
MOD_GSK3_1	291	298	PF00069	0.394
MOD_GSK3_1	345	352	PF00069	0.378
MOD_GSK3_1	463	470	PF00069	0.225
MOD_GSK3_1	529	536	PF00069	0.359
MOD_GSK3_1	622	629	PF00069	0.646
MOD_GSK3_1	671	678	PF00069	0.322
MOD_GSK3_1	723	730	PF00069	0.404
MOD_GSK3_1	74	81	PF00069	0.570
MOD_GSK3_1	740	747	PF00069	0.282
MOD_N-GLC_1	127	132	PF02516	0.554
MOD_N-GLC_2	23	25	PF02516	0.559
MOD_NEK2_1	124	129	PF00069	0.578
MOD_NEK2_1	160	165	PF00069	0.388
MOD_NEK2_1	306	311	PF00069	0.401
MOD_NEK2_1	342	347	PF00069	0.390
MOD_NEK2_1	349	354	PF00069	0.322
MOD_NEK2_1	356	361	PF00069	0.391
MOD_NEK2_1	488	493	PF00069	0.421
MOD_NEK2_1	51	56	PF00069	0.511
MOD_NEK2_1	510	515	PF00069	0.322
MOD_NEK2_1	518	523	PF00069	0.322
MOD_NEK2_1	650	655	PF00069	0.464
MOD_NEK2_1	671	676	PF00069	0.322
MOD_NEK2_1	714	719	PF00069	0.460
MOD_NEK2_1	85	90	PF00069	0.480
MOD_NEK2_2	218	223	PF00069	0.385
MOD_NEK2_2	427	432	PF00069	0.587
MOD_NEK2_2	675	680	PF00069	0.421
MOD_PIKK_1	582	588	PF00454	0.625
MOD_PIKK_1	656	662	PF00454	0.416
MOD_PIKK_1	714	720	PF00454	0.407
MOD_PIKK_1	791	797	PF00454	0.351
MOD_PKA_1	100	106	PF00069	0.521
MOD_PKA_2	100	106	PF00069	0.555
MOD_PKA_2	177	183	PF00069	0.394
MOD_PKA_2	256	262	PF00069	0.385
MOD_PKA_2	392	398	PF00069	0.540
MOD_PKA_2	427	433	PF00069	0.588
MOD_PKA_2	451	457	PF00069	0.541
MOD_PKA_2	521	527	PF00069	0.378
MOD_PKA_2	679	685	PF00069	0.424
MOD_PKA_2	686	692	PF00069	0.419
MOD_Plk_1	127	133	PF00069	0.554
MOD_Plk_1	172	178	PF00069	0.322
MOD_Plk_1	295	301	PF00069	0.378
MOD_Plk_1	350	356	PF00069	0.463
MOD_Plk_1	575	581	PF00069	0.467
MOD_Plk_1	656	662	PF00069	0.388
MOD_Plk_1	69	75	PF00069	0.573
MOD_Plk_4	114	120	PF00069	0.409
MOD_Plk_4	160	166	PF00069	0.346
MOD_Plk_4	172	178	PF00069	0.327
MOD_Plk_4	183	189	PF00069	0.382
MOD_Plk_4	218	224	PF00069	0.355
MOD_Plk_4	256	262	PF00069	0.375
MOD_Plk_4	351	357	PF00069	0.384
MOD_Plk_4	638	644	PF00069	0.591
MOD_Plk_4	650	656	PF00069	0.421
MOD_Plk_4	731	737	PF00069	0.361
MOD_ProDKin_1	108	114	PF00069	0.545
MOD_ProDKin_1	146	152	PF00069	0.322
MOD_ProDKin_1	180	186	PF00069	0.385
MOD_ProDKin_1	623	629	PF00069	0.724
MOD_SUMO_for_1	694	697	PF00179	0.208
MOD_SUMO_for_1	762	765	PF00179	0.463
MOD_SUMO_rev_2	408	417	PF00179	0.497
MOD_SUMO_rev_2	53	61	PF00179	0.531
MOD_SUMO_rev_2	594	602	PF00179	0.473
TRG_DiLeu_BaEn_1	657	662	PF01217	0.322
TRG_DiLeu_BaEn_2	257	263	PF01217	0.463
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.421
TRG_DiLeu_BaLyEn_6	386	391	PF01217	0.503
TRG_ENDOCYTIC_2	289	292	PF00928	0.378
TRG_ENDOCYTIC_2	543	546	PF00928	0.346
TRG_ENDOCYTIC_2	567	570	PF00928	0.342
TRG_ENDOCYTIC_2	668	671	PF00928	0.463
TRG_ENDOCYTIC_2	770	773	PF00928	0.346
TRG_ER_diArg_1	177	179	PF00400	0.421
TRG_ER_diArg_1	361	364	PF00400	0.417
TRG_ER_diArg_1	519	522	PF00400	0.416
TRG_ER_diArg_1	618	621	PF00400	0.442
TRG_NES_CRM1_1	84	96	PF08389	0.562
TRG_NLS_Bipartite_1	433	450	PF00514	0.263
TRG_Pf-PMV_PEXEL_1	646	651	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	808	812	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I839	Leptomonas seymouri	70%	100%
A0A1X0P6Z7	Trypanosomatidae	39%	90%
A0A3S7WUZ3	Leishmania donovani	94%	100%
A0A422P0I7	Trypanosoma rangeli	39%	90%
A4H9L7	Leishmania braziliensis	88%	100%
A4HXY1	Leishmania infantum	94%	100%
D0A5C7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	91%
Q4QDT5	Leishmania major	93%	100%
Q55C58	Dictyostelium discoideum	25%	100%
Q5E9L7	Bos taurus	27%	99%
Q93VQ0	Arabidopsis thaliana	25%	97%
Q9H269	Homo sapiens	26%	99%
Q9UT38	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	99%