Putative calpain-like cysteine peptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cysteine peptidase, Clan CA, family C2, putative

Species:

Leishmania mexicana

UniProt:

E9ARP3_LEIMU

TriTrypDb:

LmxM.18.1060

Length:

763

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	8
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9ARP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARP3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0019538	protein metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004175	endopeptidase activity	4	10
GO:0004197	cysteine-type endopeptidase activity	5	10
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	6	10
GO:0008233	peptidase activity	3	10
GO:0008234	cysteine-type peptidase activity	4	10
GO:0016787	hydrolase activity	2	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	689	693	PF00656	0.392
CLV_NRD_NRD_1	170	172	PF00675	0.617
CLV_NRD_NRD_1	187	189	PF00675	0.392
CLV_NRD_NRD_1	367	369	PF00675	0.237
CLV_NRD_NRD_1	422	424	PF00675	0.203
CLV_NRD_NRD_1	43	45	PF00675	0.460
CLV_NRD_NRD_1	562	564	PF00675	0.356
CLV_PCSK_KEX2_1	276	278	PF00082	0.276
CLV_PCSK_KEX2_1	367	369	PF00082	0.330
CLV_PCSK_KEX2_1	562	564	PF00082	0.356
CLV_PCSK_KEX2_1	642	644	PF00082	0.481
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.214
CLV_PCSK_PC1ET2_1	642	644	PF00082	0.448
CLV_PCSK_SKI1_1	164	168	PF00082	0.408
CLV_PCSK_SKI1_1	442	446	PF00082	0.549
CLV_PCSK_SKI1_1	477	481	PF00082	0.353
CLV_PCSK_SKI1_1	48	52	PF00082	0.431
CLV_PCSK_SKI1_1	546	550	PF00082	0.329
CLV_PCSK_SKI1_1	76	80	PF00082	0.434
DEG_APCC_DBOX_1	47	55	PF00400	0.355
DEG_SPOP_SBC_1	144	148	PF00917	0.350
DOC_ANK_TNKS_1	187	194	PF00023	0.260
DOC_CYCLIN_yClb1_LxF_4	260	266	PF00134	0.484
DOC_MAPK_gen_1	276	285	PF00069	0.403
DOC_MAPK_gen_1	423	432	PF00069	0.599
DOC_MAPK_gen_1	44	53	PF00069	0.499
DOC_MAPK_MEF2A_6	524	533	PF00069	0.388
DOC_MAPK_MEF2A_6	653	662	PF00069	0.409
DOC_PIKK_1	55	63	PF02985	0.435
DOC_PP1_RVXF_1	162	169	PF00149	0.322
DOC_PP2B_PxIxI_1	303	309	PF00149	0.370
DOC_PP4_FxxP_1	212	215	PF00568	0.515
DOC_PP4_FxxP_1	723	726	PF00568	0.402
DOC_USP7_MATH_1	144	148	PF00917	0.470
DOC_USP7_MATH_1	229	233	PF00917	0.418
DOC_USP7_MATH_1	394	398	PF00917	0.514
DOC_USP7_MATH_1	436	440	PF00917	0.443
DOC_USP7_MATH_1	501	505	PF00917	0.341
DOC_USP7_MATH_1	718	722	PF00917	0.416
DOC_USP7_UBL2_3	276	280	PF12436	0.370
DOC_USP7_UBL2_3	331	335	PF12436	0.432
DOC_WW_Pin1_4	243	248	PF00397	0.516
DOC_WW_Pin1_4	290	295	PF00397	0.479
DOC_WW_Pin1_4	319	324	PF00397	0.564
DOC_WW_Pin1_4	524	529	PF00397	0.511
DOC_WW_Pin1_4	670	675	PF00397	0.545
LIG_14-3-3_CanoR_1	226	233	PF00244	0.384
LIG_14-3-3_CanoR_1	367	372	PF00244	0.515
LIG_14-3-3_CanoR_1	379	388	PF00244	0.526
LIG_14-3-3_CanoR_1	594	600	PF00244	0.406
LIG_14-3-3_CanoR_1	602	608	PF00244	0.484
LIG_14-3-3_CanoR_1	643	651	PF00244	0.453
LIG_14-3-3_CanoR_1	704	708	PF00244	0.461
LIG_14-3-3_CanoR_1	751	758	PF00244	0.515
LIG_14-3-3_CterR_2	759	763	PF00244	0.505
LIG_Actin_WH2_2	65	81	PF00022	0.238
LIG_Actin_WH2_2	9	24	PF00022	0.258
LIG_APCC_ABBA_1	295	300	PF00400	0.549
LIG_APCC_ABBA_1	482	487	PF00400	0.430
LIG_BRCT_BRCA1_1	320	324	PF00533	0.458
LIG_BRCT_BRCA1_1	371	375	PF00533	0.515
LIG_BRCT_BRCA1_1	507	511	PF00533	0.333
LIG_BRCT_BRCA1_1	574	578	PF00533	0.481
LIG_BRCT_BRCA1_1	583	587	PF00533	0.470
LIG_BRCT_BRCA1_1	672	676	PF00533	0.622
LIG_BRCT_BRCA1_2	507	513	PF00533	0.306
LIG_CaM_IQ_9	21	36	PF13499	0.378
LIG_EH1_1	127	135	PF00400	0.382
LIG_FHA_1	177	183	PF00498	0.582
LIG_FHA_1	185	191	PF00498	0.372
LIG_FHA_1	217	223	PF00498	0.405
LIG_FHA_1	309	315	PF00498	0.599
LIG_FHA_1	453	459	PF00498	0.448
LIG_FHA_1	590	596	PF00498	0.349
LIG_FHA_1	657	663	PF00498	0.458
LIG_FHA_1	704	710	PF00498	0.431
LIG_FHA_1	752	758	PF00498	0.592
LIG_FHA_2	194	200	PF00498	0.543
LIG_FHA_2	357	363	PF00498	0.569
LIG_FHA_2	371	377	PF00498	0.414
LIG_FHA_2	394	400	PF00498	0.465
LIG_FHA_2	465	471	PF00498	0.386
LIG_FHA_2	684	690	PF00498	0.552
LIG_FHA_2	698	704	PF00498	0.415
LIG_Integrin_isoDGR_2	440	442	PF01839	0.361
LIG_KLC1_Yacidic_2	296	300	PF13176	0.443
LIG_LIR_Apic_2	210	215	PF02991	0.543
LIG_LIR_Apic_2	720	726	PF02991	0.411
LIG_LIR_Gen_1	196	205	PF02991	0.404
LIG_LIR_Gen_1	264	274	PF02991	0.443
LIG_LIR_Gen_1	322	333	PF02991	0.484
LIG_LIR_Gen_1	372	381	PF02991	0.497
LIG_LIR_Gen_1	467	475	PF02991	0.382
LIG_LIR_Gen_1	476	485	PF02991	0.390
LIG_LIR_Gen_1	584	595	PF02991	0.459
LIG_LIR_Gen_1	6	16	PF02991	0.461
LIG_LIR_Gen_1	632	641	PF02991	0.410
LIG_LIR_LC3C_4	272	275	PF02991	0.443
LIG_LIR_Nem_3	196	201	PF02991	0.428
LIG_LIR_Nem_3	264	269	PF02991	0.443
LIG_LIR_Nem_3	322	328	PF02991	0.451
LIG_LIR_Nem_3	372	378	PF02991	0.456
LIG_LIR_Nem_3	406	412	PF02991	0.425
LIG_LIR_Nem_3	449	453	PF02991	0.505
LIG_LIR_Nem_3	467	471	PF02991	0.375
LIG_LIR_Nem_3	474	478	PF02991	0.372
LIG_LIR_Nem_3	584	590	PF02991	0.449
LIG_LIR_Nem_3	6	12	PF02991	0.340
LIG_LIR_Nem_3	632	638	PF02991	0.567
LIG_MLH1_MIPbox_1	583	587	PF16413	0.413
LIG_NRBOX	477	483	PF00104	0.225
LIG_PCNA_yPIPBox_3	106	119	PF02747	0.371
LIG_Pex14_1	635	639	PF04695	0.374
LIG_Pex14_2	371	375	PF04695	0.522
LIG_Pex14_2	471	475	PF04695	0.426
LIG_Pex14_2	479	483	PF04695	0.440
LIG_PTB_Apo_2	511	518	PF02174	0.316
LIG_PTB_Apo_2	692	699	PF02174	0.474
LIG_REV1ctd_RIR_1	636	647	PF16727	0.263
LIG_SH2_CRK	198	202	PF00017	0.416
LIG_SH2_CRK	227	231	PF00017	0.415
LIG_SH2_CRK	266	270	PF00017	0.515
LIG_SH2_CRK	325	329	PF00017	0.486
LIG_SH2_CRK	340	344	PF00017	0.380
LIG_SH2_CRK	414	418	PF00017	0.467
LIG_SH2_GRB2like	250	253	PF00017	0.307
LIG_SH2_NCK_1	198	202	PF00017	0.385
LIG_SH2_NCK_1	278	282	PF00017	0.370
LIG_SH2_PTP2	429	432	PF00017	0.392
LIG_SH2_PTP2	9	12	PF00017	0.338
LIG_SH2_STAP1	198	202	PF00017	0.560
LIG_SH2_STAP1	325	329	PF00017	0.580
LIG_SH2_STAP1	446	450	PF00017	0.533
LIG_SH2_STAP1	737	741	PF00017	0.345
LIG_SH2_STAT3	251	254	PF00017	0.407
LIG_SH2_STAT5	128	131	PF00017	0.471
LIG_SH2_STAT5	284	287	PF00017	0.525
LIG_SH2_STAT5	298	301	PF00017	0.449
LIG_SH2_STAT5	342	345	PF00017	0.564
LIG_SH2_STAT5	41	44	PF00017	0.422
LIG_SH2_STAT5	429	432	PF00017	0.524
LIG_SH2_STAT5	727	730	PF00017	0.430
LIG_SH2_STAT5	9	12	PF00017	0.386
LIG_SH3_3	241	247	PF00018	0.422
LIG_SH3_3	432	438	PF00018	0.574
LIG_SH3_3	671	677	PF00018	0.501
LIG_SUMO_SIM_anti_2	131	138	PF11976	0.373
LIG_SUMO_SIM_anti_2	350	356	PF11976	0.511
LIG_SUMO_SIM_anti_2	659	664	PF11976	0.506
LIG_SUMO_SIM_anti_2	686	692	PF11976	0.560
LIG_SUMO_SIM_par_1	131	138	PF11976	0.373
LIG_SUMO_SIM_par_1	526	532	PF11976	0.366
LIG_SUMO_SIM_par_1	661	667	PF11976	0.369
LIG_TRAF2_1	232	235	PF00917	0.454
LIG_TRAF2_1	397	400	PF00917	0.443
LIG_TRAF2_1	402	405	PF00917	0.421
LIG_TRAF2_1	700	703	PF00917	0.467
LIG_TRFH_1	587	591	PF08558	0.445
LIG_TYR_ITIM	412	417	PF00017	0.501
LIG_TYR_ITIM	427	432	PF00017	0.501
LIG_TYR_ITSM	194	201	PF00017	0.419
LIG_WRC_WIRS_1	230	235	PF05994	0.428
LIG_WRC_WIRS_1	262	267	PF05994	0.399
LIG_WRC_WIRS_1	533	538	PF05994	0.288
LIG_WRC_WIRS_1	709	714	PF05994	0.525
MOD_CK1_1	146	152	PF00069	0.600
MOD_CK1_1	197	203	PF00069	0.446
MOD_CK1_1	319	325	PF00069	0.492
MOD_CK1_1	369	375	PF00069	0.508
MOD_CK1_1	506	512	PF00069	0.365
MOD_CK1_1	532	538	PF00069	0.430
MOD_CK1_1	629	635	PF00069	0.450
MOD_CK1_1	667	673	PF00069	0.481
MOD_CK1_1	8	14	PF00069	0.344
MOD_CK1_1	85	91	PF00069	0.365
MOD_CK2_1	148	154	PF00069	0.694
MOD_CK2_1	229	235	PF00069	0.469
MOD_CK2_1	290	296	PF00069	0.501
MOD_CK2_1	356	362	PF00069	0.569
MOD_CK2_1	393	399	PF00069	0.475
MOD_CK2_1	609	615	PF00069	0.349
MOD_CK2_1	697	703	PF00069	0.487
MOD_Cter_Amidation	169	172	PF01082	0.426
MOD_GlcNHglycan	159	162	PF01048	0.500
MOD_GlcNHglycan	227	230	PF01048	0.277
MOD_GlcNHglycan	36	40	PF01048	0.550
MOD_GlcNHglycan	404	408	PF01048	0.352
MOD_GlcNHglycan	505	508	PF01048	0.426
MOD_GlcNHglycan	536	539	PF01048	0.618
MOD_GlcNHglycan	631	634	PF01048	0.394
MOD_GlcNHglycan	654	657	PF01048	0.366
MOD_GlcNHglycan	98	101	PF01048	0.400
MOD_GSK3_1	1	8	PF00069	0.438
MOD_GSK3_1	110	117	PF00069	0.489
MOD_GSK3_1	120	127	PF00069	0.359
MOD_GSK3_1	143	150	PF00069	0.568
MOD_GSK3_1	176	183	PF00069	0.530
MOD_GSK3_1	193	200	PF00069	0.412
MOD_GSK3_1	225	232	PF00069	0.379
MOD_GSK3_1	366	373	PF00069	0.574
MOD_GSK3_1	399	406	PF00069	0.489
MOD_GSK3_1	499	506	PF00069	0.357
MOD_GSK3_1	532	539	PF00069	0.509
MOD_GSK3_1	598	605	PF00069	0.364
MOD_GSK3_1	625	632	PF00069	0.532
MOD_GSK3_1	652	659	PF00069	0.523
MOD_GSK3_1	666	673	PF00069	0.305
MOD_GSK3_1	708	715	PF00069	0.457
MOD_GSK3_1	743	750	PF00069	0.550
MOD_GSK3_1	78	85	PF00069	0.471
MOD_N-GLC_1	524	529	PF02516	0.335
MOD_N-GLC_1	615	620	PF02516	0.309
MOD_N-GLC_2	255	257	PF02516	0.461
MOD_N-GLC_2	318	320	PF02516	0.301
MOD_N-GLC_2	565	567	PF02516	0.333
MOD_N-GLC_2	731	733	PF02516	0.282
MOD_NEK2_1	120	125	PF00069	0.404
MOD_NEK2_1	176	181	PF00069	0.568
MOD_NEK2_1	182	187	PF00069	0.492
MOD_NEK2_1	238	243	PF00069	0.531
MOD_NEK2_1	269	274	PF00069	0.506
MOD_NEK2_1	35	40	PF00069	0.340
MOD_NEK2_1	366	371	PF00069	0.501
MOD_NEK2_1	403	408	PF00069	0.479
MOD_NEK2_1	505	510	PF00069	0.401
MOD_NEK2_1	595	600	PF00069	0.301
MOD_NEK2_1	626	631	PF00069	0.495
MOD_NEK2_1	664	669	PF00069	0.521
MOD_NEK2_1	712	717	PF00069	0.384
MOD_NEK2_1	747	752	PF00069	0.412
MOD_NEK2_1	758	763	PF00069	0.585
MOD_NEK2_1	78	83	PF00069	0.429
MOD_NEK2_2	718	723	PF00069	0.509
MOD_NEK2_2	737	742	PF00069	0.344
MOD_OFUCOSY	305	312	PF10250	0.199
MOD_PIKK_1	506	512	PF00454	0.364
MOD_PIKK_1	664	670	PF00454	0.369
MOD_PIKK_1	697	703	PF00454	0.442
MOD_PIKK_1	745	751	PF00454	0.371
MOD_PK_1	684	690	PF00069	0.563
MOD_PK_1	753	759	PF00069	0.402
MOD_PKA_1	367	373	PF00069	0.495
MOD_PKA_1	642	648	PF00069	0.411
MOD_PKA_2	120	126	PF00069	0.379
MOD_PKA_2	225	231	PF00069	0.383
MOD_PKA_2	366	372	PF00069	0.544
MOD_PKA_2	394	400	PF00069	0.414
MOD_PKA_2	642	648	PF00069	0.469
MOD_PKA_2	652	658	PF00069	0.583
MOD_PKA_2	703	709	PF00069	0.345
MOD_Plk_1	203	209	PF00069	0.471
MOD_Plk_1	344	350	PF00069	0.521
MOD_Plk_1	399	405	PF00069	0.545
MOD_Plk_1	5	11	PF00069	0.573
MOD_Plk_1	615	621	PF00069	0.270
MOD_Plk_1	702	708	PF00069	0.401
MOD_Plk_1	737	743	PF00069	0.359
MOD_Plk_2-3	399	405	PF00069	0.501
MOD_Plk_4	114	120	PF00069	0.455
MOD_Plk_4	124	130	PF00069	0.408
MOD_Plk_4	197	203	PF00069	0.410
MOD_Plk_4	261	267	PF00069	0.538
MOD_Plk_4	269	275	PF00069	0.468
MOD_Plk_4	310	316	PF00069	0.561
MOD_Plk_4	5	11	PF00069	0.415
MOD_Plk_4	513	519	PF00069	0.328
MOD_Plk_4	581	587	PF00069	0.428
MOD_Plk_4	634	640	PF00069	0.489
MOD_Plk_4	658	664	PF00069	0.511
MOD_Plk_4	708	714	PF00069	0.418
MOD_Plk_4	718	724	PF00069	0.381
MOD_Plk_4	737	743	PF00069	0.300
MOD_Plk_4	753	759	PF00069	0.386
MOD_Plk_4	78	84	PF00069	0.336
MOD_ProDKin_1	243	249	PF00069	0.520
MOD_ProDKin_1	290	296	PF00069	0.479
MOD_ProDKin_1	319	325	PF00069	0.564
MOD_ProDKin_1	524	530	PF00069	0.505
MOD_ProDKin_1	670	676	PF00069	0.536
MOD_SUMO_rev_2	232	238	PF00179	0.515
MOD_SUMO_rev_2	486	495	PF00179	0.490
MOD_SUMO_rev_2	516	526	PF00179	0.261
MOD_SUMO_rev_2	73	78	PF00179	0.359
TRG_DiLeu_BaEn_1	111	116	PF01217	0.449
TRG_DiLeu_BaEn_1	476	481	PF01217	0.372
TRG_DiLeu_BaEn_1	73	78	PF01217	0.416
TRG_DiLeu_BaEn_4	73	79	PF01217	0.421
TRG_ENDOCYTIC_2	198	201	PF00928	0.433
TRG_ENDOCYTIC_2	227	230	PF00928	0.499
TRG_ENDOCYTIC_2	266	269	PF00928	0.482
TRG_ENDOCYTIC_2	325	328	PF00928	0.486
TRG_ENDOCYTIC_2	340	343	PF00928	0.380
TRG_ENDOCYTIC_2	414	417	PF00928	0.489
TRG_ENDOCYTIC_2	429	432	PF00928	0.448
TRG_ENDOCYTIC_2	9	12	PF00928	0.324
TRG_ER_diArg_1	168	171	PF00400	0.309
TRG_ER_diArg_1	366	368	PF00400	0.410
TRG_ER_diArg_1	561	563	PF00400	0.379
TRG_NES_CRM1_1	59	74	PF08389	0.269
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.315
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.279
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF13	Leptomonas seymouri	47%	100%
A0A1X0P7A0	Trypanosomatidae	25%	100%
A0A3Q8IB60	Leishmania donovani	89%	100%
A0A3R7KWU1	Trypanosoma rangeli	27%	100%
A4H9L6	Leishmania braziliensis	70%	100%
A4HXY0	Leishmania infantum	89%	100%
D0A5C8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q4QDT6	Leishmania major	88%	100%