Mitochondrial carrier protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein, putative

Species:

Leishmania mexicana

UniProt:

E9ARN7_LEIMU

TriTrypDb:

LmxM.18.1000

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 32
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	33
GO:0110165	cellular anatomical entity	1	33
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9ARN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARN7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006862	nucleotide transport	6	7
GO:0009987	cellular process	1	7
GO:0015748	organophosphate ester transport	5	7
GO:0015931	nucleobase-containing compound transport	5	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0055085	transmembrane transport	2	7
GO:0071702	organic substance transport	4	7
GO:0071705	nitrogen compound transport	4	7
GO:0035352	NAD transmembrane transport	4	1
GO:0043132	NAD transport	7	1
GO:1901679	nucleotide transmembrane transport	3	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015215	nucleotide transmembrane transporter activity	4	1
GO:0015605	organophosphate ester transmembrane transporter activity	3	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0051724	NAD transmembrane transporter activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	295	299	PF00656	0.365
CLV_NRD_NRD_1	381	383	PF00675	0.354
CLV_NRD_NRD_1	390	392	PF00675	0.291
CLV_NRD_NRD_1	400	402	PF00675	0.276
CLV_NRD_NRD_1	81	83	PF00675	0.322
CLV_PCSK_KEX2_1	390	392	PF00082	0.346
CLV_PCSK_KEX2_1	83	85	PF00082	0.307
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.316
CLV_PCSK_SKI1_1	202	206	PF00082	0.278
CLV_PCSK_SKI1_1	278	282	PF00082	0.545
CLV_PCSK_SKI1_1	297	301	PF00082	0.493
CLV_PCSK_SKI1_1	406	410	PF00082	0.246
CLV_PCSK_SKI1_1	69	73	PF00082	0.341
CLV_PCSK_SKI1_1	83	87	PF00082	0.302
DEG_APCC_DBOX_1	246	254	PF00400	0.581
DEG_SCF_FBW7_1	1	7	PF00400	0.363
DOC_CKS1_1	1	6	PF01111	0.364
DOC_CYCLIN_yCln2_LP_2	192	198	PF00134	0.362
DOC_CYCLIN_yCln2_LP_2	341	347	PF00134	0.351
DOC_CYCLIN_yCln2_LP_2	72	78	PF00134	0.414
DOC_MAPK_gen_1	276	283	PF00069	0.266
DOC_PP2B_LxvP_1	262	265	PF13499	0.444
DOC_PP2B_LxvP_1	53	56	PF13499	0.360
DOC_USP7_MATH_1	172	176	PF00917	0.387
DOC_USP7_MATH_1	20	24	PF00917	0.559
DOC_USP7_MATH_1	301	305	PF00917	0.462
DOC_USP7_MATH_1	328	332	PF00917	0.367
DOC_USP7_MATH_1	37	41	PF00917	0.450
DOC_USP7_MATH_1	373	377	PF00917	0.559
DOC_USP7_MATH_1	4	8	PF00917	0.585
DOC_USP7_MATH_1	414	418	PF00917	0.353
DOC_USP7_UBL2_3	383	387	PF12436	0.590
DOC_WW_Pin1_4	159	164	PF00397	0.373
DOC_WW_Pin1_4	191	196	PF00397	0.360
DOC_WW_Pin1_4	233	238	PF00397	0.570
DOC_WW_Pin1_4	316	321	PF00397	0.354
DOC_WW_Pin1_4	375	380	PF00397	0.592
DOC_WW_Pin1_4	7	12	PF00397	0.595
DOC_WW_Pin1_4	87	92	PF00397	0.605
LIG_14-3-3_CanoR_1	202	210	PF00244	0.481
LIG_14-3-3_CanoR_1	382	387	PF00244	0.537
LIG_14-3-3_CanoR_1	48	56	PF00244	0.328
LIG_BRCT_BRCA1_1	145	149	PF00533	0.256
LIG_Clathr_ClatBox_1	148	152	PF01394	0.412
LIG_FHA_1	143	149	PF00498	0.353
LIG_FHA_1	304	310	PF00498	0.458
LIG_FHA_1	336	342	PF00498	0.324
LIG_FHA_1	372	378	PF00498	0.397
LIG_FHA_1	41	47	PF00498	0.376
LIG_IRF3_LxIS_1	75	81	PF10401	0.511
LIG_LIR_Gen_1	213	223	PF02991	0.578
LIG_LIR_Gen_1	335	345	PF02991	0.185
LIG_LIR_Gen_1	431	439	PF02991	0.344
LIG_LIR_Gen_1	47	56	PF02991	0.354
LIG_LIR_Gen_1	57	66	PF02991	0.322
LIG_LIR_Nem_3	213	219	PF02991	0.573
LIG_LIR_Nem_3	222	226	PF02991	0.525
LIG_LIR_Nem_3	251	257	PF02991	0.472
LIG_LIR_Nem_3	267	273	PF02991	0.352
LIG_LIR_Nem_3	335	340	PF02991	0.321
LIG_LIR_Nem_3	385	389	PF02991	0.538
LIG_LIR_Nem_3	422	428	PF02991	0.370
LIG_LIR_Nem_3	431	435	PF02991	0.266
LIG_LIR_Nem_3	47	53	PF02991	0.350
LIG_LIR_Nem_3	57	62	PF02991	0.297
LIG_LIR_Nem_3	70	76	PF02991	0.403
LIG_NRBOX	137	143	PF00104	0.256
LIG_NRBOX	186	192	PF00104	0.351
LIG_PALB2_WD40_1	54	62	PF16756	0.317
LIG_Pex14_1	270	274	PF04695	0.298
LIG_Pex14_1	292	296	PF04695	0.300
LIG_Pex14_2	223	227	PF04695	0.472
LIG_Pex14_2	426	430	PF04695	0.333
LIG_REV1ctd_RIR_1	406	414	PF16727	0.468
LIG_SH2_CRK	130	134	PF00017	0.500
LIG_SH2_CRK	216	220	PF00017	0.563
LIG_SH2_CRK	254	258	PF00017	0.332
LIG_SH2_NCK_1	208	212	PF00017	0.631
LIG_SH2_SRC	13	16	PF00017	0.413
LIG_SH2_SRC	157	160	PF00017	0.404
LIG_SH2_STAP1	176	180	PF00017	0.353
LIG_SH2_STAT5	147	150	PF00017	0.332
LIG_SH2_STAT5	157	160	PF00017	0.354
LIG_SH2_STAT5	274	277	PF00017	0.309
LIG_SH2_STAT5	282	285	PF00017	0.296
LIG_SH3_3	281	287	PF00018	0.430
LIG_SUMO_SIM_anti_2	186	192	PF11976	0.372
LIG_SUMO_SIM_anti_2	194	200	PF11976	0.345
LIG_SUMO_SIM_anti_2	417	422	PF11976	0.378
LIG_SUMO_SIM_par_1	189	194	PF11976	0.341
LIG_UBA3_1	148	155	PF00899	0.457
LIG_WRPW_2	386	389	PF00400	0.356
MOD_CDC14_SPxK_1	236	239	PF00782	0.489
MOD_CDK_SPK_2	159	164	PF00069	0.289
MOD_CDK_SPK_2	375	380	PF00069	0.356
MOD_CDK_SPK_2	7	12	PF00069	0.468
MOD_CDK_SPxK_1	233	239	PF00069	0.480
MOD_CDK_SPxxK_3	375	382	PF00069	0.406
MOD_CK1_1	174	180	PF00069	0.346
MOD_CK1_1	209	215	PF00069	0.618
MOD_CK1_1	25	31	PF00069	0.381
MOD_CK1_1	335	341	PF00069	0.326
MOD_CK1_1	375	381	PF00069	0.573
MOD_CK1_1	40	46	PF00069	0.387
MOD_CK1_1	6	12	PF00069	0.561
MOD_GlcNHglycan	107	110	PF01048	0.352
MOD_GlcNHglycan	176	179	PF01048	0.503
MOD_GlcNHglycan	21	25	PF01048	0.751
MOD_GlcNHglycan	250	253	PF01048	0.348
MOD_GlcNHglycan	257	260	PF01048	0.320
MOD_GlcNHglycan	266	269	PF01048	0.255
MOD_GlcNHglycan	37	40	PF01048	0.664
MOD_GlcNHglycan	62	65	PF01048	0.358
MOD_GSK3_1	105	112	PF00069	0.499
MOD_GSK3_1	143	150	PF00069	0.329
MOD_GSK3_1	20	27	PF00069	0.494
MOD_GSK3_1	202	209	PF00069	0.539
MOD_GSK3_1	215	222	PF00069	0.552
MOD_GSK3_1	297	304	PF00069	0.423
MOD_GSK3_1	3	10	PF00069	0.537
MOD_GSK3_1	328	335	PF00069	0.287
MOD_GSK3_1	35	42	PF00069	0.440
MOD_GSK3_1	371	378	PF00069	0.571
MOD_GSK3_1	430	437	PF00069	0.288
MOD_GSK3_1	44	51	PF00069	0.363
MOD_GSK3_1	83	90	PF00069	0.562
MOD_N-GLC_1	414	419	PF02516	0.351
MOD_N-GLC_1	48	53	PF02516	0.550
MOD_NEK2_1	142	147	PF00069	0.375
MOD_NEK2_1	171	176	PF00069	0.383
MOD_NEK2_1	210	215	PF00069	0.579
MOD_NEK2_1	409	414	PF00069	0.494
MOD_NEK2_1	430	435	PF00069	0.245
MOD_NEK2_1	78	83	PF00069	0.488
MOD_PKA_1	382	388	PF00069	0.406
MOD_PKA_1	83	89	PF00069	0.564
MOD_PKA_2	105	111	PF00069	0.627
MOD_PKA_2	83	89	PF00069	0.564
MOD_PKB_1	380	388	PF00069	0.519
MOD_Plk_1	143	149	PF00069	0.375
MOD_Plk_1	361	367	PF00069	0.406
MOD_Plk_1	414	420	PF00069	0.375
MOD_Plk_4	143	149	PF00069	0.355
MOD_Plk_4	212	218	PF00069	0.624
MOD_Plk_4	328	334	PF00069	0.318
MOD_Plk_4	336	342	PF00069	0.294
MOD_Plk_4	54	60	PF00069	0.247
MOD_Plk_4	90	96	PF00069	0.563
MOD_ProDKin_1	159	165	PF00069	0.381
MOD_ProDKin_1	191	197	PF00069	0.360
MOD_ProDKin_1	233	239	PF00069	0.574
MOD_ProDKin_1	316	322	PF00069	0.350
MOD_ProDKin_1	375	381	PF00069	0.592
MOD_ProDKin_1	7	13	PF00069	0.595
MOD_ProDKin_1	87	93	PF00069	0.608
MOD_SUMO_rev_2	304	309	PF00179	0.343
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.409
TRG_ENDOCYTIC_2	130	133	PF00928	0.475
TRG_ENDOCYTIC_2	216	219	PF00928	0.558
TRG_ENDOCYTIC_2	254	257	PF00928	0.316
TRG_ER_diArg_1	379	382	PF00400	0.565
TRG_ER_diArg_1	389	391	PF00400	0.494
TRG_ER_diArg_1	82	85	PF00400	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8S5	Leptomonas seymouri	25%	100%
A0A0N1IBB8	Leptomonas seymouri	59%	93%
A0A0N1IHK9	Leptomonas seymouri	27%	100%
A0A0S4JF45	Bodo saltans	37%	100%
A0A0S4JH99	Bodo saltans	27%	88%
A0A0S4JIT1	Bodo saltans	23%	100%
A0A1X0NN16	Trypanosomatidae	23%	100%
A0A1X0NQB5	Trypanosomatidae	26%	100%
A0A1X0P6Z0	Trypanosomatidae	46%	100%
A0A3Q8IC78	Leishmania donovani	26%	100%
A0A3Q8IS12	Leishmania donovani	27%	100%
A0A3R7L1P3	Trypanosoma rangeli	24%	100%
A0A3S7WUZ5	Leishmania donovani	93%	100%
A0A422NGL1	Trypanosoma rangeli	26%	100%
A0A422P0Q3	Trypanosoma rangeli	44%	100%
A4H690	Leishmania braziliensis	27%	100%
A4H9K7	Leishmania braziliensis	83%	100%
A4HQI4	Leishmania braziliensis	26%	89%
A4HUL3	Leishmania infantum	26%	100%
A4HXX3	Leishmania infantum	93%	100%
C9ZVP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZZS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AHZ3	Leishmania infantum	27%	100%
E9ANB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AU97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4Q094	Leishmania major	26%	93%
Q4QDU2	Leishmania major	89%	99%
Q4QHB2	Leishmania major	26%	97%
V5BTU3	Trypanosoma cruzi	26%	100%
V5DDT9	Trypanosoma cruzi	24%	100%
V5DN72	Trypanosoma cruzi	46%	100%