Der GTPase-activating protein YihI

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARN5_LEIMU

TriTrypDb:

LmxM.18.0980

Length:

191

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARN5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.298
CLV_C14_Caspase3-7	168	172	PF00656	0.609
CLV_C14_Caspase3-7	24	28	PF00656	0.702
CLV_NRD_NRD_1	102	104	PF00675	0.507
CLV_NRD_NRD_1	111	113	PF00675	0.575
CLV_NRD_NRD_1	13	15	PF00675	0.606
CLV_NRD_NRD_1	4	6	PF00675	0.556
CLV_NRD_NRD_1	41	43	PF00675	0.560
CLV_NRD_NRD_1	96	98	PF00675	0.414
CLV_PCSK_FUR_1	100	104	PF00082	0.609
CLV_PCSK_FUR_1	14	18	PF00082	0.513
CLV_PCSK_KEX2_1	102	104	PF00082	0.520
CLV_PCSK_KEX2_1	111	113	PF00082	0.297
CLV_PCSK_KEX2_1	141	143	PF00082	0.587
CLV_PCSK_KEX2_1	16	18	PF00082	0.608
CLV_PCSK_KEX2_1	4	6	PF00082	0.558
CLV_PCSK_KEX2_1	41	43	PF00082	0.609
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.585
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.580
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.605
CLV_PCSK_SKI1_1	119	123	PF00082	0.433
CLV_PCSK_SKI1_1	16	20	PF00082	0.559
CLV_PCSK_SKI1_1	5	9	PF00082	0.687
CLV_PCSK_SKI1_1	75	79	PF00082	0.421
CLV_PCSK_SKI1_1	84	88	PF00082	0.376
DOC_MAPK_gen_1	41	49	PF00069	0.447
DOC_MAPK_MEF2A_6	42	51	PF00069	0.522
DOC_USP7_MATH_1	21	25	PF00917	0.669
DOC_USP7_UBL2_3	15	19	PF12436	0.571
DOC_USP7_UBL2_3	37	41	PF12436	0.638
DOC_USP7_UBL2_3	71	75	PF12436	0.481
LIG_14-3-3_CanoR_1	17	26	PF00244	0.614
LIG_LIR_Gen_1	163	172	PF02991	0.581
LIG_LIR_Nem_3	163	169	PF02991	0.583
LIG_SH2_STAT3	117	120	PF00017	0.391
LIG_SH2_STAT5	117	120	PF00017	0.427
MOD_CK1_1	131	137	PF00069	0.461
MOD_CK2_1	131	137	PF00069	0.491
MOD_Cter_Amidation	39	42	PF01082	0.767
MOD_GlcNHglycan	27	31	PF01048	0.615
MOD_GlcNHglycan	37	40	PF01048	0.512
MOD_GSK3_1	17	24	PF00069	0.612
MOD_GSK3_1	67	74	PF00069	0.367
MOD_PK_1	22	28	PF00069	0.690
MOD_PKA_1	22	28	PF00069	0.629
MOD_SUMO_for_1	107	110	PF00179	0.396
MOD_SUMO_for_1	121	124	PF00179	0.450
MOD_SUMO_rev_2	134	143	PF00179	0.454
TRG_DiLeu_BaEn_1	139	144	PF01217	0.523
TRG_DiLeu_LyEn_5	139	144	PF01217	0.455
TRG_ER_diArg_1	100	103	PF00400	0.488
TRG_ER_diArg_1	4	6	PF00400	0.571
TRG_ER_diArg_1	47	50	PF00400	0.712
TRG_NLS_Bipartite_1	4	20	PF00514	0.553
TRG_NLS_MonoCore_2	13	18	PF00514	0.571
TRG_NLS_MonoExtC_3	14	19	PF00514	0.556
TRG_NLS_MonoExtN_4	11	18	PF00514	0.572
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9L1	Leptomonas seymouri	70%	98%
A0A0S4JFM3	Bodo saltans	38%	100%
A0A1X0P6Y6	Trypanosomatidae	44%	100%
A0A3S7WUY3	Leishmania donovani	90%	100%
A0A422P1T8	Trypanosoma rangeli	50%	100%
A4H9K6	Leishmania braziliensis	84%	100%
A4HXX1	Leishmania infantum	90%	100%
C9ZZT1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
Q4QDU4	Leishmania major	93%	99%
V5B6M9	Trypanosoma cruzi	44%	100%