GPI mannosyltransferase 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

gpi mannosyltransferase 2

Species:

Leishmania mexicana

UniProt:

E9ARN3_LEIMU

TriTrypDb:

LmxM.18.0960

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	7
GO:0016020	membrane	2	7
GO:0031090	organelle membrane	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	1
GO:0031501	mannosyltransferase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

E9ARN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARN3

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	7
GO:0006505	GPI anchor metabolic process	6	7
GO:0006506	GPI anchor biosynthetic process	6	7
GO:0006629	lipid metabolic process	3	7
GO:0006643	membrane lipid metabolic process	4	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006650	glycerophospholipid metabolic process	5	7
GO:0006661	phosphatidylinositol biosynthetic process	6	7
GO:0006664	glycolipid metabolic process	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008610	lipid biosynthetic process	4	7
GO:0008654	phospholipid biosynthetic process	5	7
GO:0009058	biosynthetic process	2	7
GO:0009247	glycolipid biosynthetic process	5	7
GO:0009987	cellular process	1	7
GO:0019538	protein metabolic process	3	7
GO:0019637	organophosphate metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0045017	glycerolipid biosynthetic process	4	7
GO:0046467	membrane lipid biosynthetic process	4	7
GO:0046474	glycerophospholipid biosynthetic process	5	7
GO:0046486	glycerolipid metabolic process	4	7
GO:0046488	phosphatidylinositol metabolic process	6	7
GO:0071704	organic substance metabolic process	2	7
GO:0090407	organophosphate biosynthetic process	4	7
GO:1901135	carbohydrate derivative metabolic process	3	7
GO:1901137	carbohydrate derivative biosynthetic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901576	organic substance biosynthetic process	3	7
GO:1903509	liposaccharide metabolic process	4	7

Molecular functions
Term	Name	Level	Count
GO:0000009	alpha-1,6-mannosyltransferase activity	6	7
GO:0000030	mannosyltransferase activity	5	7
GO:0003824	catalytic activity	1	7
GO:0004376	glycolipid mannosyltransferase activity	6	7
GO:0016740	transferase activity	2	7
GO:0016757	glycosyltransferase activity	3	7
GO:0016758	hexosyltransferase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.643
CLV_C14_Caspase3-7	354	358	PF00656	0.679
CLV_NRD_NRD_1	164	166	PF00675	0.280
CLV_NRD_NRD_1	198	200	PF00675	0.525
CLV_NRD_NRD_1	259	261	PF00675	0.289
CLV_NRD_NRD_1	594	596	PF00675	0.296
CLV_PCSK_FUR_1	257	261	PF00082	0.301
CLV_PCSK_KEX2_1	164	166	PF00082	0.271
CLV_PCSK_KEX2_1	257	259	PF00082	0.361
CLV_PCSK_KEX2_1	522	524	PF00082	0.432
CLV_PCSK_KEX2_1	594	596	PF00082	0.296
CLV_PCSK_PC1ET2_1	522	524	PF00082	0.400
CLV_PCSK_SKI1_1	164	168	PF00082	0.319
CLV_PCSK_SKI1_1	200	204	PF00082	0.470
CLV_PCSK_SKI1_1	381	385	PF00082	0.438
CLV_PCSK_SKI1_1	50	54	PF00082	0.374
CLV_PCSK_SKI1_1	511	515	PF00082	0.471
CLV_PCSK_SKI1_1	635	639	PF00082	0.443
DEG_APCC_DBOX_1	181	189	PF00400	0.557
DEG_APCC_DBOX_1	49	57	PF00400	0.306
DEG_MDM2_SWIB_1	662	669	PF02201	0.204
DEG_ODPH_VHL_1	134	146	PF01847	0.233
DEG_SCF_FBW7_1	373	380	PF00400	0.604
DOC_AGCK_PIF_1	546	551	PF00069	0.281
DOC_CDC14_PxL_1	117	125	PF14671	0.271
DOC_CKS1_1	190	195	PF01111	0.654
DOC_CKS1_1	270	275	PF01111	0.306
DOC_CYCLIN_yCln2_LP_2	338	341	PF00134	0.669
DOC_CYCLIN_yCln2_LP_2	420	426	PF00134	0.374
DOC_CYCLIN_yCln2_LP_2	559	565	PF00134	0.306
DOC_MAPK_gen_1	164	171	PF00069	0.479
DOC_MAPK_gen_1	199	208	PF00069	0.611
DOC_MAPK_gen_1	461	469	PF00069	0.578
DOC_MAPK_gen_1	538	545	PF00069	0.304
DOC_MAPK_gen_1	594	603	PF00069	0.485
DOC_MAPK_MEF2A_6	50	57	PF00069	0.204
DOC_MAPK_MEF2A_6	594	603	PF00069	0.409
DOC_MAPK_NFAT4_5	50	58	PF00069	0.204
DOC_PP1_RVXF_1	12	19	PF00149	0.320
DOC_PP2B_LxvP_1	235	238	PF13499	0.628
DOC_PP2B_LxvP_1	338	341	PF13499	0.707
DOC_PP2B_LxvP_1	474	477	PF13499	0.658
DOC_PP2B_LxvP_1	559	562	PF13499	0.352
DOC_PP4_FxxP_1	171	174	PF00568	0.521
DOC_PP4_FxxP_1	68	71	PF00568	0.523
DOC_USP7_MATH_1	213	217	PF00917	0.526
DOC_USP7_MATH_1	317	321	PF00917	0.559
DOC_USP7_MATH_1	332	336	PF00917	0.760
DOC_USP7_MATH_1	377	381	PF00917	0.596
DOC_USP7_MATH_1	436	440	PF00917	0.616
DOC_USP7_MATH_1	443	447	PF00917	0.565
DOC_USP7_MATH_1	607	611	PF00917	0.309
DOC_WW_Pin1_4	186	191	PF00397	0.689
DOC_WW_Pin1_4	269	274	PF00397	0.306
DOC_WW_Pin1_4	318	323	PF00397	0.644
DOC_WW_Pin1_4	373	378	PF00397	0.649
DOC_WW_Pin1_4	637	642	PF00397	0.282
LIG_14-3-3_CanoR_1	178	185	PF00244	0.623
LIG_14-3-3_CanoR_1	311	316	PF00244	0.663
LIG_14-3-3_CanoR_1	381	386	PF00244	0.614
LIG_14-3-3_CanoR_1	464	468	PF00244	0.691
LIG_14-3-3_CanoR_1	635	641	PF00244	0.330
LIG_14-3-3_CanoR_1	88	92	PF00244	0.519
LIG_APCC_ABBA_1	20	25	PF00400	0.482
LIG_APCC_ABBA_1	279	284	PF00400	0.321
LIG_BIR_II_1	1	5	PF00653	0.597
LIG_BRCT_BRCA1_1	410	414	PF00533	0.297
LIG_CaM_NSCaTE_8	541	548	PF13499	0.319
LIG_DLG_GKlike_1	311	319	PF00625	0.622
LIG_eIF4E_1	540	546	PF01652	0.281
LIG_EVH1_1	339	343	PF00568	0.582
LIG_FHA_1	129	135	PF00498	0.293
LIG_FHA_1	190	196	PF00498	0.662
LIG_FHA_1	229	235	PF00498	0.613
LIG_FHA_1	276	282	PF00498	0.293
LIG_FHA_1	38	44	PF00498	0.319
LIG_FHA_1	464	470	PF00498	0.666
LIG_FHA_1	638	644	PF00498	0.433
LIG_FHA_2	231	237	PF00498	0.573
LIG_FHA_2	245	251	PF00498	0.587
LIG_FHA_2	34	40	PF00498	0.367
LIG_FHA_2	77	83	PF00498	0.541
LIG_GBD_Chelix_1	397	405	PF00786	0.374
LIG_GBD_Chelix_1	48	56	PF00786	0.374
LIG_LIR_Apic_2	170	174	PF02991	0.471
LIG_LIR_Gen_1	25	34	PF02991	0.342
LIG_LIR_Gen_1	384	392	PF02991	0.517
LIG_LIR_Gen_1	550	559	PF02991	0.227
LIG_LIR_Gen_1	660	669	PF02991	0.469
LIG_LIR_Gen_1	86	96	PF02991	0.471
LIG_LIR_Nem_3	25	31	PF02991	0.364
LIG_LIR_Nem_3	384	390	PF02991	0.528
LIG_LIR_Nem_3	544	549	PF02991	0.313
LIG_LIR_Nem_3	550	554	PF02991	0.347
LIG_LIR_Nem_3	596	601	PF02991	0.432
LIG_LIR_Nem_3	660	665	PF02991	0.493
LIG_LIR_Nem_3	86	92	PF02991	0.471
LIG_LYPXL_S_1	532	536	PF13949	0.471
LIG_LYPXL_yS_3	533	536	PF13949	0.271
LIG_MYND_1	472	476	PF01753	0.662
LIG_NRBOX	50	56	PF00104	0.204
LIG_NRBOX	616	622	PF00104	0.282
LIG_NRBOX	642	648	PF00104	0.306
LIG_PCNA_PIPBox_1	309	318	PF02747	0.665
LIG_Pex14_1	387	391	PF04695	0.584
LIG_Pex14_2	662	666	PF04695	0.204
LIG_RPA_C_Fungi	254	266	PF08784	0.374
LIG_SH2_CRK	106	110	PF00017	0.316
LIG_SH2_GRB2like	110	113	PF00017	0.203
LIG_SH2_NCK_1	201	205	PF00017	0.511
LIG_SH2_NCK_1	23	27	PF00017	0.523
LIG_SH2_PTP2	147	150	PF00017	0.374
LIG_SH2_SRC	84	87	PF00017	0.473
LIG_SH2_STAP1	106	110	PF00017	0.284
LIG_SH2_STAP1	282	286	PF00017	0.335
LIG_SH2_STAT3	110	113	PF00017	0.282
LIG_SH2_STAT5	108	111	PF00017	0.325
LIG_SH2_STAT5	129	132	PF00017	0.217
LIG_SH2_STAT5	147	150	PF00017	0.473
LIG_SH2_STAT5	23	26	PF00017	0.581
LIG_SH2_STAT5	282	285	PF00017	0.339
LIG_SH2_STAT5	296	299	PF00017	0.306
LIG_SH2_STAT5	315	318	PF00017	0.521
LIG_SH2_STAT5	33	36	PF00017	0.365
LIG_SH2_STAT5	501	504	PF00017	0.329
LIG_SH2_STAT5	549	552	PF00017	0.306
LIG_SH2_STAT6	508	512	PF00017	0.257
LIG_SH3_1	187	193	PF00018	0.562
LIG_SH3_1	337	343	PF00018	0.635
LIG_SH3_3	115	121	PF00018	0.308
LIG_SH3_3	16	22	PF00018	0.401
LIG_SH3_3	187	193	PF00018	0.562
LIG_SH3_3	316	322	PF00018	0.491
LIG_SH3_3	337	343	PF00018	0.635
LIG_SH3_3	425	431	PF00018	0.410
LIG_SH3_3	466	472	PF00018	0.575
LIG_SH3_3	494	500	PF00018	0.377
LIG_SUMO_SIM_par_1	277	285	PF11976	0.244
LIG_SUMO_SIM_par_1	488	493	PF11976	0.306
LIG_SUMO_SIM_par_1	561	567	PF11976	0.374
LIG_SxIP_EBH_1	362	371	PF03271	0.611
LIG_TRAF2_1	79	82	PF00917	0.401
LIG_TRFH_1	18	22	PF08558	0.320
LIG_ULM_U2AF65_1	594	599	PF00076	0.320
LIG_Vh1_VBS_1	390	408	PF01044	0.204
LIG_WRC_WIRS_1	168	173	PF05994	0.306
MOD_CK1_1	186	192	PF00069	0.558
MOD_CK1_1	285	291	PF00069	0.320
MOD_CK1_1	318	324	PF00069	0.545
MOD_CK1_1	446	452	PF00069	0.363
MOD_CK1_1	544	550	PF00069	0.374
MOD_CK1_1	653	659	PF00069	0.324
MOD_CK1_1	660	666	PF00069	0.288
MOD_CK2_1	188	194	PF00069	0.632
MOD_CK2_1	213	219	PF00069	0.618
MOD_CK2_1	244	250	PF00069	0.642
MOD_CK2_1	390	396	PF00069	0.306
MOD_CK2_1	76	82	PF00069	0.400
MOD_GlcNHglycan	323	326	PF01048	0.574
MOD_GlcNHglycan	332	335	PF01048	0.564
MOD_GlcNHglycan	438	441	PF01048	0.524
MOD_GlcNHglycan	445	448	PF01048	0.458
MOD_GlcNHglycan	451	454	PF01048	0.448
MOD_GlcNHglycan	5	8	PF01048	0.288
MOD_GlcNHglycan	518	522	PF01048	0.215
MOD_GlcNHglycan	546	549	PF01048	0.374
MOD_GSK3_1	209	216	PF00069	0.693
MOD_GSK3_1	3	10	PF00069	0.385
MOD_GSK3_1	311	318	PF00069	0.610
MOD_GSK3_1	33	40	PF00069	0.567
MOD_GSK3_1	367	374	PF00069	0.697
MOD_GSK3_1	377	384	PF00069	0.563
MOD_GSK3_1	408	415	PF00069	0.355
MOD_GSK3_1	650	657	PF00069	0.318
MOD_N-GLC_1	330	335	PF02516	0.466
MOD_NEK2_1	195	200	PF00069	0.470
MOD_NEK2_1	230	235	PF00069	0.444
MOD_NEK2_1	275	280	PF00069	0.277
MOD_NEK2_1	390	395	PF00069	0.318
MOD_NEK2_1	405	410	PF00069	0.335
MOD_NEK2_1	57	62	PF00069	0.357
MOD_NEK2_1	608	613	PF00069	0.438
MOD_NEK2_1	623	628	PF00069	0.245
MOD_NEK2_1	636	641	PF00069	0.321
MOD_NEK2_2	282	287	PF00069	0.306
MOD_NEK2_2	541	546	PF00069	0.374
MOD_PKA_1	164	170	PF00069	0.374
MOD_PKA_2	164	170	PF00069	0.374
MOD_PKA_2	177	183	PF00069	0.360
MOD_PKA_2	228	234	PF00069	0.454
MOD_PKA_2	463	469	PF00069	0.501
MOD_PKA_2	593	599	PF00069	0.317
MOD_PKA_2	653	659	PF00069	0.347
MOD_PKA_2	87	93	PF00069	0.374
MOD_Plk_1	218	224	PF00069	0.434
MOD_Plk_4	104	110	PF00069	0.264
MOD_Plk_4	164	170	PF00069	0.371
MOD_Plk_4	230	236	PF00069	0.555
MOD_Plk_4	244	250	PF00069	0.545
MOD_Plk_4	282	288	PF00069	0.317
MOD_Plk_4	311	317	PF00069	0.588
MOD_Plk_4	367	373	PF00069	0.615
MOD_Plk_4	541	547	PF00069	0.306
MOD_Plk_4	623	629	PF00069	0.374
MOD_Plk_4	71	77	PF00069	0.384
MOD_ProDKin_1	186	192	PF00069	0.610
MOD_ProDKin_1	269	275	PF00069	0.306
MOD_ProDKin_1	318	324	PF00069	0.551
MOD_ProDKin_1	373	379	PF00069	0.548
MOD_ProDKin_1	637	643	PF00069	0.282
MOD_SUMO_for_1	385	388	PF00179	0.501
MOD_SUMO_for_1	521	524	PF00179	0.204
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.320
TRG_DiLeu_BaLyEn_6	334	339	PF01217	0.466
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.374
TRG_ENDOCYTIC_2	106	109	PF00928	0.286
TRG_ENDOCYTIC_2	147	150	PF00928	0.306
TRG_ENDOCYTIC_2	224	227	PF00928	0.424
TRG_ENDOCYTIC_2	501	504	PF00928	0.306
TRG_ENDOCYTIC_2	509	512	PF00928	0.306
TRG_ENDOCYTIC_2	533	536	PF00928	0.306
TRG_ENDOCYTIC_2	540	543	PF00928	0.306
TRG_ENDOCYTIC_2	644	647	PF00928	0.306
TRG_ER_diArg_1	163	165	PF00400	0.306
TRG_ER_diArg_1	256	259	PF00400	0.441
TRG_ER_diArg_1	362	365	PF00400	0.587
TRG_ER_diArg_1	593	595	PF00400	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDL0	Leptomonas seymouri	51%	99%
A0A3S7WV16	Leishmania donovani	88%	97%
A4H9K3	Leishmania braziliensis	73%	100%
A4HXW9	Leishmania infantum	87%	97%
Q4QDU6	Leishmania major	86%	100%