Putative ARP2/3 complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actin-related protein 2/3 complex subunit 1, putative

Species:

Leishmania mexicana

UniProt:

E9ARM9_LEIMU

TriTrypDb:

LmxM.18.0920

Length:

624

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005885	Arp2/3 protein complex	2	7
GO:0032991	protein-containing complex	1	7

Expansion

Sequence features

E9ARM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARM9

Function

Biological processes
Term	Name	Level	Count
GO:0007015	actin filament organization	5	7
GO:0008064	regulation of actin polymerization or depolymerization	6	7
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0030832	regulation of actin filament length	5	7
GO:0030833	regulation of actin filament polymerization	7	7
GO:0032271	regulation of protein polymerization	6	7
GO:0032535	regulation of cellular component size	4	7
GO:0032956	regulation of actin cytoskeleton organization	5	7
GO:0032970	regulation of actin filament-based process	4	7
GO:0033043	regulation of organelle organization	5	7
GO:0034314	Arp2/3 complex-mediated actin nucleation	7	7
GO:0043254	regulation of protein-containing complex assembly	5	7
GO:0044087	regulation of cellular component biogenesis	4	7
GO:0045010	actin nucleation	6	7
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0051128	regulation of cellular component organization	4	7
GO:0051493	regulation of cytoskeleton organization	6	7
GO:0065007	biological regulation	1	7
GO:0065008	regulation of biological quality	2	7
GO:0071840	cellular component organization or biogenesis	2	7
GO:0090066	regulation of anatomical structure size	3	7
GO:0097435	supramolecular fiber organization	4	7
GO:0110053	regulation of actin filament organization	6	7
GO:1902903	regulation of supramolecular fiber organization	5	7
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0030029	actin filament-based process	2	1
GO:0030036	actin cytoskeleton organization	3	1

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	7
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0008092	cytoskeletal protein binding	3	7
GO:0005198	structural molecule activity	1	1
GO:0044877	protein-containing complex binding	2	1
GO:0051015	actin filament binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.587
CLV_NRD_NRD_1	231	233	PF00675	0.565
CLV_NRD_NRD_1	51	53	PF00675	0.477
CLV_PCSK_KEX2_1	231	233	PF00082	0.565
CLV_PCSK_KEX2_1	51	53	PF00082	0.477
CLV_PCSK_SKI1_1	582	586	PF00082	0.473
DEG_APCC_DBOX_1	600	608	PF00400	0.461
DEG_SCF_TRCP1_1	339	344	PF00400	0.399
DEG_SPOP_SBC_1	244	248	PF00917	0.501
DEG_SPOP_SBC_1	350	354	PF00917	0.526
DEG_SPOP_SBC_1	545	549	PF00917	0.608
DOC_ANK_TNKS_1	538	545	PF00023	0.603
DOC_CDC14_PxL_1	172	180	PF14671	0.386
DOC_CDC14_PxL_1	382	390	PF14671	0.453
DOC_MAPK_gen_1	509	518	PF00069	0.518
DOC_MAPK_HePTP_8	506	518	PF00069	0.537
DOC_MAPK_MEF2A_6	509	518	PF00069	0.518
DOC_USP7_MATH_1	11	15	PF00917	0.543
DOC_USP7_MATH_1	164	168	PF00917	0.458
DOC_USP7_MATH_1	243	247	PF00917	0.619
DOC_USP7_MATH_1	288	292	PF00917	0.567
DOC_USP7_MATH_1	349	353	PF00917	0.564
DOC_USP7_MATH_1	409	413	PF00917	0.467
DOC_USP7_MATH_1	439	443	PF00917	0.531
DOC_USP7_MATH_1	545	549	PF00917	0.763
DOC_WW_Pin1_4	324	329	PF00397	0.367
DOC_WW_Pin1_4	566	571	PF00397	0.521
DOC_WW_Pin1_4	618	623	PF00397	0.596
LIG_14-3-3_CanoR_1	231	235	PF00244	0.525
LIG_14-3-3_CanoR_1	351	356	PF00244	0.466
LIG_14-3-3_CanoR_1	423	428	PF00244	0.544
LIG_14-3-3_CanoR_1	467	471	PF00244	0.594
LIG_14-3-3_CanoR_1	474	482	PF00244	0.603
LIG_14-3-3_CanoR_1	564	570	PF00244	0.583
LIG_CSL_BTD_1	134	137	PF09270	0.455
LIG_CSL_BTD_1	325	328	PF09270	0.439
LIG_FHA_1	118	124	PF00498	0.489
LIG_FHA_1	207	213	PF00498	0.445
LIG_FHA_1	231	237	PF00498	0.604
LIG_FHA_1	272	278	PF00498	0.363
LIG_FHA_1	424	430	PF00498	0.479
LIG_FHA_1	448	454	PF00498	0.795
LIG_FHA_1	566	572	PF00498	0.636
LIG_FHA_2	124	130	PF00498	0.448
LIG_LIR_Apic_2	81	87	PF02991	0.513
LIG_LIR_Gen_1	169	180	PF02991	0.412
LIG_LIR_Nem_3	169	175	PF02991	0.488
LIG_LIR_Nem_3	344	350	PF02991	0.457
LIG_MYND_1	21	25	PF01753	0.652
LIG_REV1ctd_RIR_1	516	525	PF16727	0.512
LIG_SH2_STAT5	202	205	PF00017	0.374
LIG_SH2_STAT5	312	315	PF00017	0.377
LIG_SH3_1	232	238	PF00018	0.469
LIG_SH3_1	616	622	PF00018	0.686
LIG_SH3_3	131	137	PF00018	0.453
LIG_SH3_3	232	238	PF00018	0.469
LIG_SH3_3	26	32	PF00018	0.557
LIG_SH3_3	616	622	PF00018	0.684
LIG_SUMO_SIM_anti_2	568	575	PF11976	0.542
LIG_SUMO_SIM_par_1	177	182	PF11976	0.353
LIG_UBA3_1	573	582	PF00899	0.557
MOD_CK1_1	16	22	PF00069	0.560
MOD_CK1_1	206	212	PF00069	0.452
MOD_CK1_1	297	303	PF00069	0.498
MOD_CK1_1	416	422	PF00069	0.452
MOD_CK1_1	569	575	PF00069	0.644
MOD_CK1_1	82	88	PF00069	0.601
MOD_CK2_1	150	156	PF00069	0.527
MOD_CK2_1	544	550	PF00069	0.723
MOD_GlcNHglycan	103	106	PF01048	0.463
MOD_GlcNHglycan	126	129	PF01048	0.396
MOD_GlcNHglycan	15	18	PF01048	0.641
MOD_GlcNHglycan	166	169	PF01048	0.556
MOD_GlcNHglycan	181	184	PF01048	0.362
MOD_GlcNHglycan	194	197	PF01048	0.388
MOD_GlcNHglycan	205	208	PF01048	0.338
MOD_GlcNHglycan	237	241	PF01048	0.547
MOD_GlcNHglycan	26	29	PF01048	0.543
MOD_GlcNHglycan	290	293	PF01048	0.638
MOD_GlcNHglycan	296	299	PF01048	0.558
MOD_GlcNHglycan	328	331	PF01048	0.425
MOD_GlcNHglycan	339	342	PF01048	0.494
MOD_GlcNHglycan	364	368	PF01048	0.642
MOD_GlcNHglycan	411	414	PF01048	0.437
MOD_GlcNHglycan	418	421	PF01048	0.538
MOD_GlcNHglycan	440	444	PF01048	0.763
MOD_GlcNHglycan	534	537	PF01048	0.609
MOD_GlcNHglycan	539	542	PF01048	0.706
MOD_GlcNHglycan	578	581	PF01048	0.568
MOD_GlcNHglycan	582	585	PF01048	0.597
MOD_GlcNHglycan	594	597	PF01048	0.504
MOD_GlcNHglycan	84	87	PF01048	0.594
MOD_GSK3_1	192	199	PF00069	0.390
MOD_GSK3_1	202	209	PF00069	0.451
MOD_GSK3_1	277	284	PF00069	0.463
MOD_GSK3_1	293	300	PF00069	0.497
MOD_GSK3_1	337	344	PF00069	0.405
MOD_GSK3_1	363	370	PF00069	0.659
MOD_GSK3_1	37	44	PF00069	0.490
MOD_GSK3_1	409	416	PF00069	0.511
MOD_GSK3_1	469	476	PF00069	0.683
MOD_GSK3_1	5	12	PF00069	0.616
MOD_GSK3_1	565	572	PF00069	0.680
MOD_GSK3_1	576	583	PF00069	0.679
MOD_GSK3_1	585	592	PF00069	0.438
MOD_GSK3_1	608	615	PF00069	0.531
MOD_GSK3_1	78	85	PF00069	0.607
MOD_N-GLC_1	589	594	PF02516	0.342
MOD_NEK2_1	123	128	PF00069	0.513
MOD_NEK2_1	271	276	PF00069	0.569
MOD_NEK2_1	495	500	PF00069	0.514
MOD_NEK2_1	589	594	PF00069	0.597
MOD_PIKK_1	414	420	PF00454	0.497
MOD_PIKK_1	433	439	PF00454	0.664
MOD_PIKK_1	469	475	PF00454	0.572
MOD_PIKK_1	495	501	PF00454	0.656
MOD_PKA_2	230	236	PF00069	0.548
MOD_PKA_2	350	356	PF00069	0.657
MOD_PKA_2	358	364	PF00069	0.623
MOD_PKA_2	466	472	PF00069	0.610
MOD_PKA_2	473	479	PF00069	0.620
MOD_Plk_1	261	267	PF00069	0.409
MOD_Plk_1	458	464	PF00069	0.508
MOD_Plk_1	502	508	PF00069	0.536
MOD_Plk_1	589	595	PF00069	0.435
MOD_Plk_2-3	391	397	PF00069	0.442
MOD_Plk_4	351	357	PF00069	0.509
MOD_Plk_4	377	383	PF00069	0.427
MOD_Plk_4	502	508	PF00069	0.476
MOD_Plk_4	589	595	PF00069	0.471
MOD_Plk_4	64	70	PF00069	0.406
MOD_ProDKin_1	324	330	PF00069	0.367
MOD_ProDKin_1	566	572	PF00069	0.513
MOD_ProDKin_1	618	624	PF00069	0.602
TRG_DiLeu_BaLyEn_6	222	227	PF01217	0.452
TRG_DiLeu_BaLyEn_6	383	388	PF01217	0.459
TRG_ER_diArg_1	50	52	PF00400	0.445
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	493	497	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8H8	Leptomonas seymouri	37%	100%
A0A3Q8IA03	Leishmania donovani	85%	100%
A4H9K0	Leishmania braziliensis	70%	100%
A4HXW5	Leishmania infantum	85%	100%
Q4QDV0	Leishmania major	84%	100%