Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARM4_LEIMU

TriTrypDb:

LmxM.18.0870

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARM4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	375	379	PF00656	0.609
CLV_NRD_NRD_1	231	233	PF00675	0.502
CLV_NRD_NRD_1	291	293	PF00675	0.449
CLV_NRD_NRD_1	393	395	PF00675	0.632
CLV_NRD_NRD_1	406	408	PF00675	0.698
CLV_NRD_NRD_1	426	428	PF00675	0.414
CLV_NRD_NRD_1	495	497	PF00675	0.613
CLV_NRD_NRD_1	51	53	PF00675	0.674
CLV_PCSK_KEX2_1	231	233	PF00082	0.475
CLV_PCSK_KEX2_1	392	394	PF00082	0.701
CLV_PCSK_KEX2_1	406	408	PF00082	0.706
CLV_PCSK_KEX2_1	421	423	PF00082	0.494
CLV_PCSK_KEX2_1	495	497	PF00082	0.539
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.561
CLV_PCSK_PC7_1	491	497	PF00082	0.479
CLV_PCSK_SKI1_1	232	236	PF00082	0.474
CLV_PCSK_SKI1_1	255	259	PF00082	0.426
CLV_PCSK_SKI1_1	406	410	PF00082	0.707
CLV_PCSK_SKI1_1	491	495	PF00082	0.441
CLV_PCSK_SKI1_1	81	85	PF00082	0.428
DEG_APCC_DBOX_1	485	493	PF00400	0.473
DEG_Nend_UBRbox_3	1	3	PF02207	0.520
DEG_SPOP_SBC_1	412	416	PF00917	0.607
DOC_ANK_TNKS_1	494	501	PF00023	0.516
DOC_CYCLIN_RxL_1	105	118	PF00134	0.592
DOC_MAPK_gen_1	105	114	PF00069	0.639
DOC_MAPK_gen_1	486	494	PF00069	0.476
DOC_MAPK_HePTP_8	7	19	PF00069	0.476
DOC_MAPK_MEF2A_6	10	19	PF00069	0.518
DOC_MAPK_MEF2A_6	149	156	PF00069	0.441
DOC_MAPK_MEF2A_6	246	253	PF00069	0.434
DOC_MAPK_MEF2A_6	30	37	PF00069	0.327
DOC_MAPK_MEF2A_6	343	352	PF00069	0.448
DOC_MAPK_MEF2A_6	354	361	PF00069	0.466
DOC_MAPK_MEF2A_6	57	66	PF00069	0.498
DOC_MAPK_NFAT4_5	246	254	PF00069	0.288
DOC_MAPK_RevD_3	492	508	PF00069	0.374
DOC_PP4_FxxP_1	253	256	PF00568	0.434
DOC_PP4_FxxP_1	516	519	PF00568	0.386
DOC_USP7_MATH_1	104	108	PF00917	0.610
DOC_USP7_MATH_1	205	209	PF00917	0.725
DOC_USP7_MATH_1	217	221	PF00917	0.577
DOC_USP7_MATH_1	341	345	PF00917	0.533
DOC_USP7_MATH_1	370	374	PF00917	0.685
DOC_USP7_MATH_1	411	415	PF00917	0.657
DOC_USP7_UBL2_3	428	432	PF12436	0.652
DOC_USP7_UBL2_3	503	507	PF12436	0.492
DOC_WW_Pin1_4	100	105	PF00397	0.643
DOC_WW_Pin1_4	174	179	PF00397	0.342
DOC_WW_Pin1_4	201	206	PF00397	0.704
DOC_WW_Pin1_4	213	218	PF00397	0.649
DOC_WW_Pin1_4	52	57	PF00397	0.702
LIG_14-3-3_CanoR_1	110	115	PF00244	0.667
LIG_14-3-3_CanoR_1	188	195	PF00244	0.450
LIG_14-3-3_CanoR_1	207	212	PF00244	0.506
LIG_14-3-3_CanoR_1	246	250	PF00244	0.391
LIG_14-3-3_CanoR_1	272	281	PF00244	0.507
LIG_14-3-3_CanoR_1	3	8	PF00244	0.576
LIG_14-3-3_CanoR_1	400	409	PF00244	0.716
LIG_14-3-3_CanoR_1	427	436	PF00244	0.568
LIG_14-3-3_CanoR_1	91	95	PF00244	0.502
LIG_Actin_WH2_2	69	87	PF00022	0.434
LIG_BIR_III_4	169	173	PF00653	0.463
LIG_BRCT_BRCA1_1	78	82	PF00533	0.352
LIG_BRCT_BRCA1_1	91	95	PF00533	0.502
LIG_CtBP_PxDLS_1	4	8	PF00389	0.451
LIG_EH1_1	459	467	PF00400	0.474
LIG_FHA_1	169	175	PF00498	0.462
LIG_FHA_1	246	252	PF00498	0.396
LIG_FHA_1	276	282	PF00498	0.446
LIG_FHA_1	283	289	PF00498	0.452
LIG_FHA_1	32	38	PF00498	0.317
LIG_FHA_1	345	351	PF00498	0.507
LIG_FHA_1	453	459	PF00498	0.328
LIG_FHA_1	512	518	PF00498	0.347
LIG_FHA_2	155	161	PF00498	0.484
LIG_FHA_2	369	375	PF00498	0.623
LIG_LIR_Apic_2	250	256	PF02991	0.420
LIG_LIR_Apic_2	513	519	PF02991	0.382
LIG_LIR_Gen_1	123	133	PF02991	0.584
LIG_LIR_Nem_3	123	129	PF02991	0.551
LIG_LIR_Nem_3	79	83	PF02991	0.374
LIG_MYND_3	498	502	PF01753	0.510
LIG_NRBOX	488	494	PF00104	0.522
LIG_PDZ_Class_1	520	525	PF00595	0.426
LIG_SH2_CRK	22	26	PF00017	0.508
LIG_SH2_CRK	80	84	PF00017	0.402
LIG_SH2_STAP1	166	170	PF00017	0.472
LIG_SH2_STAP1	512	516	PF00017	0.343
LIG_SH2_STAT5	243	246	PF00017	0.456
LIG_SH2_STAT5	28	31	PF00017	0.478
LIG_SH2_STAT5	36	39	PF00017	0.418
LIG_SH2_STAT5	512	515	PF00017	0.329
LIG_SH3_3	331	337	PF00018	0.582
LIG_SH3_3	38	44	PF00018	0.426
LIG_SH3_3	98	104	PF00018	0.582
LIG_SUMO_SIM_anti_2	347	353	PF11976	0.396
LIG_SUMO_SIM_anti_2	455	461	PF11976	0.317
LIG_SUMO_SIM_par_1	518	523	PF11976	0.370
LIG_TYR_ITIM	20	25	PF00017	0.510
MOD_CDK_SPK_2	100	105	PF00069	0.589
MOD_CDK_SPK_2	52	57	PF00069	0.634
MOD_CDK_SPxK_1	201	207	PF00069	0.686
MOD_CK1_1	103	109	PF00069	0.759
MOD_CK1_1	136	142	PF00069	0.554
MOD_CK1_1	144	150	PF00069	0.578
MOD_CK1_1	194	200	PF00069	0.632
MOD_CK1_1	213	219	PF00069	0.693
MOD_CK1_1	310	316	PF00069	0.680
MOD_CK1_1	344	350	PF00069	0.449
MOD_CK1_1	396	402	PF00069	0.772
MOD_CK1_1	441	447	PF00069	0.690
MOD_CK1_1	467	473	PF00069	0.521
MOD_CK1_1	55	61	PF00069	0.657
MOD_CK2_1	193	199	PF00069	0.503
MOD_CK2_1	234	240	PF00069	0.477
MOD_CK2_1	357	363	PF00069	0.639
MOD_CK2_1	417	423	PF00069	0.561
MOD_Cter_Amidation	425	428	PF01082	0.573
MOD_GlcNHglycan	117	120	PF01048	0.467
MOD_GlcNHglycan	143	146	PF01048	0.663
MOD_GlcNHglycan	219	222	PF01048	0.681
MOD_GlcNHglycan	315	318	PF01048	0.683
MOD_GlcNHglycan	382	385	PF01048	0.676
MOD_GlcNHglycan	395	398	PF01048	0.665
MOD_GlcNHglycan	403	406	PF01048	0.583
MOD_GlcNHglycan	466	469	PF01048	0.389
MOD_GSK3_1	110	117	PF00069	0.676
MOD_GSK3_1	124	131	PF00069	0.598
MOD_GSK3_1	150	157	PF00069	0.495
MOD_GSK3_1	187	194	PF00069	0.478
MOD_GSK3_1	201	208	PF00069	0.563
MOD_GSK3_1	213	220	PF00069	0.754
MOD_GSK3_1	234	241	PF00069	0.485
MOD_GSK3_1	306	313	PF00069	0.622
MOD_GSK3_1	31	38	PF00069	0.318
MOD_GSK3_1	395	402	PF00069	0.759
MOD_GSK3_1	407	414	PF00069	0.502
MOD_GSK3_1	62	69	PF00069	0.477
MOD_GSK3_1	99	106	PF00069	0.590
MOD_N-GLC_1	60	65	PF02516	0.544
MOD_NEK2_1	114	119	PF00069	0.699
MOD_NEK2_1	135	140	PF00069	0.677
MOD_NEK2_1	154	159	PF00069	0.405
MOD_NEK2_1	273	278	PF00069	0.502
MOD_NEK2_1	380	385	PF00069	0.692
MOD_NEK2_1	388	393	PF00069	0.800
MOD_NEK2_1	458	463	PF00069	0.374
MOD_NEK2_1	466	471	PF00069	0.381
MOD_PIKK_1	144	150	PF00454	0.645
MOD_PIKK_1	282	288	PF00454	0.508
MOD_PKA_1	393	399	PF00069	0.700
MOD_PKA_1	427	433	PF00069	0.616
MOD_PKA_2	104	110	PF00069	0.673
MOD_PKA_2	187	193	PF00069	0.444
MOD_PKA_2	245	251	PF00069	0.378
MOD_PKA_2	393	399	PF00069	0.747
MOD_PKA_2	417	423	PF00069	0.716
MOD_PKA_2	90	96	PF00069	0.514
MOD_PKB_1	108	116	PF00069	0.675
MOD_PKB_1	425	433	PF00069	0.568
MOD_Plk_1	31	37	PF00069	0.319
MOD_Plk_1	60	66	PF00069	0.528
MOD_Plk_2-3	320	326	PF00069	0.610
MOD_Plk_4	150	156	PF00069	0.539
MOD_Plk_4	3	9	PF00069	0.511
MOD_Plk_4	511	517	PF00069	0.385
MOD_Plk_4	90	96	PF00069	0.508
MOD_ProDKin_1	100	106	PF00069	0.644
MOD_ProDKin_1	174	180	PF00069	0.346
MOD_ProDKin_1	201	207	PF00069	0.707
MOD_ProDKin_1	213	219	PF00069	0.645
MOD_ProDKin_1	52	58	PF00069	0.699
MOD_SUMO_rev_2	363	371	PF00179	0.470
TRG_DiLeu_BaEn_4	303	309	PF01217	0.471
TRG_DiLeu_BaLyEn_6	488	493	PF01217	0.521
TRG_ENDOCYTIC_2	22	25	PF00928	0.415
TRG_ENDOCYTIC_2	80	83	PF00928	0.367
TRG_ER_diArg_1	108	111	PF00400	0.594
TRG_ER_diArg_1	206	209	PF00400	0.620
TRG_ER_diArg_1	230	232	PF00400	0.524
TRG_ER_diArg_1	392	394	PF00400	0.639
TRG_ER_diArg_1	485	488	PF00400	0.615
TRG_ER_diArg_1	494	496	PF00400	0.567
TRG_Pf-PMV_PEXEL_1	110	115	PF00026	0.640
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.314
TRG_PTS1	522	525	PF00515	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMJ2	Leptomonas seymouri	53%	90%
A0A1X0P774	Trypanosomatidae	31%	100%
A0A3Q8IB16	Leishmania donovani	88%	98%
A4H9J5	Leishmania braziliensis	72%	100%
A4HXW1	Leishmania infantum	89%	98%
C9ZZU2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4QDV5	Leishmania major	88%	100%