Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARM4_LEIMU

TriTrypDb:

LmxM.18.0870

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9ARM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARM4

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	375	379	PF00656	0.609
CLV_NRD_NRD_1	231	233	PF00675	0.502
CLV_NRD_NRD_1	291	293	PF00675	0.449
CLV_NRD_NRD_1	393	395	PF00675	0.632
CLV_NRD_NRD_1	406	408	PF00675	0.698
CLV_NRD_NRD_1	426	428	PF00675	0.414
CLV_NRD_NRD_1	495	497	PF00675	0.613
CLV_NRD_NRD_1	51	53	PF00675	0.674
CLV_PCSK_KEX2_1	231	233	PF00082	0.475
CLV_PCSK_KEX2_1	392	394	PF00082	0.701

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMJ2	Leptomonas seymouri	53%	90%
A0A1X0P774	Trypanosomatidae	31%	100%
A0A3Q8IB16	Leishmania donovani	88%	98%
A4H9J5	Leishmania braziliensis	72%	100%
A4HXW1	Leishmania infantum	89%	98%
C9ZZU2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4QDV5	Leishmania major	88%	100%

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