Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARM3_LEIMU

TriTrypDb:

LmxM.18.0860

Length:

878

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARM3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.483
CLV_C14_Caspase3-7	491	495	PF00656	0.495
CLV_C14_Caspase3-7	795	799	PF00656	0.668
CLV_C14_Caspase3-7	836	840	PF00656	0.526
CLV_NRD_NRD_1	201	203	PF00675	0.587
CLV_NRD_NRD_1	28	30	PF00675	0.486
CLV_NRD_NRD_1	42	44	PF00675	0.489
CLV_NRD_NRD_1	421	423	PF00675	0.607
CLV_NRD_NRD_1	432	434	PF00675	0.542
CLV_NRD_NRD_1	457	459	PF00675	0.605
CLV_NRD_NRD_1	584	586	PF00675	0.636
CLV_NRD_NRD_1	592	594	PF00675	0.641
CLV_NRD_NRD_1	829	831	PF00675	0.716
CLV_PCSK_FUR_1	419	423	PF00082	0.597
CLV_PCSK_KEX2_1	201	203	PF00082	0.587
CLV_PCSK_KEX2_1	41	43	PF00082	0.532
CLV_PCSK_KEX2_1	421	423	PF00082	0.612
CLV_PCSK_KEX2_1	432	434	PF00082	0.548
CLV_PCSK_KEX2_1	457	459	PF00082	0.605
CLV_PCSK_KEX2_1	584	586	PF00082	0.636
CLV_PCSK_KEX2_1	592	594	PF00082	0.641
CLV_PCSK_KEX2_1	829	831	PF00082	0.716
CLV_PCSK_PC7_1	197	203	PF00082	0.438
CLV_PCSK_PC7_1	453	459	PF00082	0.597
CLV_PCSK_SKI1_1	432	436	PF00082	0.525
CLV_PCSK_SKI1_1	485	489	PF00082	0.532
CLV_PCSK_SKI1_1	812	816	PF00082	0.460
DEG_APCC_DBOX_1	40	48	PF00400	0.513
DEG_APCC_DBOX_1	432	440	PF00400	0.555
DEG_SCF_FBW7_1	117	124	PF00400	0.685
DEG_SCF_TRCP1_1	684	690	PF00400	0.629
DEG_SPOP_SBC_1	129	133	PF00917	0.516
DEG_SPOP_SBC_1	281	285	PF00917	0.504
DEG_SPOP_SBC_1	688	692	PF00917	0.709
DEG_SPOP_SBC_1	864	868	PF00917	0.616
DOC_CKS1_1	118	123	PF01111	0.541
DOC_CKS1_1	23	28	PF01111	0.356
DOC_CKS1_1	345	350	PF01111	0.600
DOC_CKS1_1	402	407	PF01111	0.539
DOC_CYCLIN_RxL_1	669	680	PF00134	0.584
DOC_MAPK_DCC_7	202	212	PF00069	0.602
DOC_MAPK_gen_1	147	156	PF00069	0.555
DOC_MAPK_gen_1	400	409	PF00069	0.550
DOC_MAPK_gen_1	41	49	PF00069	0.546
DOC_MAPK_MEF2A_6	400	409	PF00069	0.585
DOC_MAPK_MEF2A_6	42	51	PF00069	0.384
DOC_PP2B_LxvP_1	211	214	PF13499	0.665
DOC_PP2B_LxvP_1	517	520	PF13499	0.583
DOC_USP7_MATH_1	100	104	PF00917	0.677
DOC_USP7_MATH_1	121	125	PF00917	0.654
DOC_USP7_MATH_1	130	134	PF00917	0.513
DOC_USP7_MATH_1	2	6	PF00917	0.730
DOC_USP7_MATH_1	200	204	PF00917	0.628
DOC_USP7_MATH_1	214	218	PF00917	0.640
DOC_USP7_MATH_1	281	285	PF00917	0.717
DOC_USP7_MATH_1	296	300	PF00917	0.713
DOC_USP7_MATH_1	495	499	PF00917	0.517
DOC_USP7_MATH_1	57	61	PF00917	0.588
DOC_USP7_MATH_1	776	780	PF00917	0.685
DOC_USP7_MATH_1	790	794	PF00917	0.629
DOC_USP7_MATH_1	863	867	PF00917	0.618
DOC_WW_Pin1_4	117	122	PF00397	0.699
DOC_WW_Pin1_4	203	208	PF00397	0.667
DOC_WW_Pin1_4	22	27	PF00397	0.359
DOC_WW_Pin1_4	228	233	PF00397	0.711
DOC_WW_Pin1_4	334	339	PF00397	0.742
DOC_WW_Pin1_4	344	349	PF00397	0.545
DOC_WW_Pin1_4	377	382	PF00397	0.585
DOC_WW_Pin1_4	401	406	PF00397	0.542
DOC_WW_Pin1_4	464	469	PF00397	0.614
DOC_WW_Pin1_4	534	539	PF00397	0.669
DOC_WW_Pin1_4	632	637	PF00397	0.662
DOC_WW_Pin1_4	760	765	PF00397	0.777
LIG_14-3-3_CanoR_1	113	121	PF00244	0.655
LIG_14-3-3_CanoR_1	128	138	PF00244	0.640
LIG_14-3-3_CanoR_1	147	156	PF00244	0.601
LIG_14-3-3_CanoR_1	201	208	PF00244	0.611
LIG_14-3-3_CanoR_1	448	452	PF00244	0.605
LIG_14-3-3_CanoR_1	614	624	PF00244	0.553
LIG_14-3-3_CanoR_1	672	677	PF00244	0.609
LIG_14-3-3_CanoR_1	812	820	PF00244	0.415
LIG_14-3-3_CanoR_1	829	835	PF00244	0.684
LIG_FHA_1	113	119	PF00498	0.520
LIG_FHA_1	233	239	PF00498	0.631
LIG_FHA_1	321	327	PF00498	0.627
LIG_FHA_1	374	380	PF00498	0.574
LIG_FHA_1	397	403	PF00498	0.553
LIG_FHA_1	471	477	PF00498	0.562
LIG_FHA_1	676	682	PF00498	0.654
LIG_FHA_1	689	695	PF00498	0.510
LIG_FHA_1	707	713	PF00498	0.415
LIG_FHA_1	813	819	PF00498	0.483
LIG_FHA_1	820	826	PF00498	0.492
LIG_FHA_1	849	855	PF00498	0.666
LIG_FHA_2	312	318	PF00498	0.580
LIG_FHA_2	344	350	PF00498	0.606
LIG_FHA_2	524	530	PF00498	0.620
LIG_FHA_2	770	776	PF00498	0.616
LIG_FHA_2	834	840	PF00498	0.525
LIG_IBAR_NPY_1	308	310	PF08397	0.653
LIG_LIR_Gen_1	151	160	PF02991	0.586
LIG_LIR_Gen_1	17	26	PF02991	0.557
LIG_LIR_Gen_1	349	360	PF02991	0.560
LIG_LIR_Nem_3	151	156	PF02991	0.580
LIG_LIR_Nem_3	172	176	PF02991	0.490
LIG_LIR_Nem_3	307	313	PF02991	0.614
LIG_LIR_Nem_3	349	355	PF02991	0.564
LIG_LIR_Nem_3	512	517	PF02991	0.529
LIG_MYND_1	183	187	PF01753	0.611
LIG_NBox_RRM_1	758	768	PF00076	0.483
LIG_PCNA_yPIPBox_3	576	585	PF02747	0.613
LIG_PCNA_yPIPBox_3	667	677	PF02747	0.567
LIG_PDZ_Class_1	873	878	PF00595	0.667
LIG_Pex14_1	645	649	PF04695	0.495
LIG_Pex14_2	169	173	PF04695	0.543
LIG_Pex14_2	706	710	PF04695	0.540
LIG_PTAP_UEV_1	300	305	PF05743	0.559
LIG_RPA_C_Fungi	144	156	PF08784	0.578
LIG_RPA_C_Fungi	38	50	PF08784	0.516
LIG_SH2_CRK	259	263	PF00017	0.555
LIG_SH2_NCK_1	313	317	PF00017	0.572
LIG_SH2_SRC	650	653	PF00017	0.646
LIG_SH2_STAP1	150	154	PF00017	0.553
LIG_SH2_STAP1	483	487	PF00017	0.572
LIG_SH2_STAT5	14	17	PF00017	0.559
LIG_SH2_STAT5	310	313	PF00017	0.626
LIG_SH2_STAT5	496	499	PF00017	0.587
LIG_SH2_STAT5	567	570	PF00017	0.622
LIG_SH2_STAT5	722	725	PF00017	0.602
LIG_SH3_2	135	140	PF14604	0.663
LIG_SH3_3	1	7	PF00018	0.773
LIG_SH3_3	132	138	PF00018	0.604
LIG_SH3_3	202	208	PF00018	0.545
LIG_SH3_3	227	233	PF00018	0.644
LIG_SH3_3	298	304	PF00018	0.690
LIG_SH3_3	342	348	PF00018	0.629
LIG_SH3_3	367	373	PF00018	0.628
LIG_SH3_3	399	405	PF00018	0.564
LIG_SH3_3	462	468	PF00018	0.594
LIG_SH3_3	517	523	PF00018	0.643
LIG_SH3_3	715	721	PF00018	0.569
LIG_SUMO_SIM_anti_2	323	328	PF11976	0.588
LIG_SUMO_SIM_par_1	672	680	PF11976	0.549
LIG_WW_3	206	210	PF00397	0.524
MOD_CDC14_SPxK_1	537	540	PF00782	0.621
MOD_CDK_SPxK_1	203	209	PF00069	0.465
MOD_CDK_SPxK_1	534	540	PF00069	0.617
MOD_CDK_SPxxK_3	22	29	PF00069	0.357
MOD_CDK_SPxxK_3	377	384	PF00069	0.605
MOD_CK1_1	112	118	PF00069	0.652
MOD_CK1_1	203	209	PF00069	0.733
MOD_CK1_1	215	221	PF00069	0.674
MOD_CK1_1	231	237	PF00069	0.686
MOD_CK1_1	282	288	PF00069	0.652
MOD_CK1_1	299	305	PF00069	0.632
MOD_CK1_1	337	343	PF00069	0.703
MOD_CK1_1	380	386	PF00069	0.584
MOD_CK1_1	60	66	PF00069	0.656
MOD_CK1_1	615	621	PF00069	0.677
MOD_CK1_1	622	628	PF00069	0.624
MOD_CK1_1	653	659	PF00069	0.556
MOD_CK1_1	675	681	PF00069	0.755
MOD_CK1_1	690	696	PF00069	0.584
MOD_CK1_1	71	77	PF00069	0.754
MOD_CK1_1	736	742	PF00069	0.613
MOD_CK1_1	789	795	PF00069	0.680
MOD_CK1_1	802	808	PF00069	0.640
MOD_CK1_1	83	89	PF00069	0.738
MOD_CK1_1	91	97	PF00069	0.669
MOD_CK1_1	98	104	PF00069	0.824
MOD_CK2_1	343	349	PF00069	0.709
MOD_CK2_1	538	544	PF00069	0.512
MOD_CK2_1	828	834	PF00069	0.695
MOD_DYRK1A_RPxSP_1	464	468	PF00069	0.429
MOD_GlcNHglycan	102	105	PF01048	0.666
MOD_GlcNHglycan	125	128	PF01048	0.679
MOD_GlcNHglycan	150	153	PF01048	0.576
MOD_GlcNHglycan	160	163	PF01048	0.571
MOD_GlcNHglycan	214	217	PF01048	0.699
MOD_GlcNHglycan	332	335	PF01048	0.664
MOD_GlcNHglycan	425	428	PF01048	0.534
MOD_GlcNHglycan	490	493	PF01048	0.635
MOD_GlcNHglycan	568	571	PF01048	0.620
MOD_GlcNHglycan	59	62	PF01048	0.768
MOD_GlcNHglycan	618	621	PF01048	0.828
MOD_GlcNHglycan	652	655	PF01048	0.644
MOD_GlcNHglycan	684	687	PF01048	0.730
MOD_GlcNHglycan	694	697	PF01048	0.609
MOD_GlcNHglycan	70	73	PF01048	0.507
MOD_GlcNHglycan	750	753	PF01048	0.562
MOD_GlcNHglycan	788	791	PF01048	0.685
MOD_GlcNHglycan	792	795	PF01048	0.683
MOD_GlcNHglycan	825	828	PF01048	0.590
MOD_GlcNHglycan	844	847	PF01048	0.712
MOD_GlcNHglycan	97	100	PF01048	0.679
MOD_GSK3_1	100	107	PF00069	0.592
MOD_GSK3_1	108	115	PF00069	0.638
MOD_GSK3_1	117	124	PF00069	0.722
MOD_GSK3_1	217	224	PF00069	0.691
MOD_GSK3_1	228	235	PF00069	0.762
MOD_GSK3_1	275	282	PF00069	0.711
MOD_GSK3_1	299	306	PF00069	0.804
MOD_GSK3_1	330	337	PF00069	0.708
MOD_GSK3_1	340	347	PF00069	0.740
MOD_GSK3_1	368	375	PF00069	0.563
MOD_GSK3_1	523	530	PF00069	0.558
MOD_GSK3_1	534	541	PF00069	0.574
MOD_GSK3_1	551	558	PF00069	0.660
MOD_GSK3_1	56	63	PF00069	0.603
MOD_GSK3_1	612	619	PF00069	0.716
MOD_GSK3_1	684	691	PF00069	0.712
MOD_GSK3_1	744	751	PF00069	0.694
MOD_GSK3_1	786	793	PF00069	0.762
MOD_GSK3_1	819	826	PF00069	0.448
MOD_GSK3_1	82	89	PF00069	0.723
MOD_GSK3_1	853	860	PF00069	0.534
MOD_GSK3_1	91	98	PF00069	0.774
MOD_N-GLC_1	575	580	PF02516	0.613
MOD_N-GLC_1	848	853	PF02516	0.671
MOD_NEK2_1	311	316	PF00069	0.654
MOD_NEK2_1	322	327	PF00069	0.576
MOD_NEK2_1	355	360	PF00069	0.543
MOD_NEK2_1	423	428	PF00069	0.591
MOD_NEK2_1	469	474	PF00069	0.580
MOD_NEK2_1	527	532	PF00069	0.644
MOD_NEK2_1	566	571	PF00069	0.629
MOD_NEK2_1	706	711	PF00069	0.542
MOD_NEK2_2	523	528	PF00069	0.715
MOD_PIKK_1	2	8	PF00454	0.623
MOD_PIKK_1	793	799	PF00454	0.668
MOD_PIKK_1	848	854	PF00454	0.678
MOD_PIKK_1	88	94	PF00454	0.729
MOD_PK_1	518	524	PF00069	0.429
MOD_PKA_1	421	427	PF00069	0.584
MOD_PKA_1	744	750	PF00069	0.653
MOD_PKA_2	112	118	PF00069	0.640
MOD_PKA_2	148	154	PF00069	0.638
MOD_PKA_2	158	164	PF00069	0.584
MOD_PKA_2	200	206	PF00069	0.632
MOD_PKA_2	276	282	PF00069	0.573
MOD_PKA_2	299	305	PF00069	0.585
MOD_PKA_2	421	427	PF00069	0.649
MOD_PKA_2	447	453	PF00069	0.595
MOD_PKA_2	613	619	PF00069	0.521
MOD_PKA_2	786	792	PF00069	0.587
MOD_PKA_2	823	829	PF00069	0.651
MOD_PKB_1	419	427	PF00069	0.584
MOD_Plk_1	189	195	PF00069	0.427
MOD_Plk_1	575	581	PF00069	0.619
MOD_Plk_1	848	854	PF00069	0.565
MOD_Plk_2-3	447	453	PF00069	0.579
MOD_Plk_4	181	187	PF00069	0.576
MOD_Plk_4	322	328	PF00069	0.583
MOD_Plk_4	355	361	PF00069	0.559
MOD_Plk_4	776	782	PF00069	0.666
MOD_ProDKin_1	117	123	PF00069	0.700
MOD_ProDKin_1	203	209	PF00069	0.671
MOD_ProDKin_1	22	28	PF00069	0.354
MOD_ProDKin_1	228	234	PF00069	0.708
MOD_ProDKin_1	334	340	PF00069	0.745
MOD_ProDKin_1	344	350	PF00069	0.538
MOD_ProDKin_1	377	383	PF00069	0.579
MOD_ProDKin_1	401	407	PF00069	0.543
MOD_ProDKin_1	464	470	PF00069	0.613
MOD_ProDKin_1	534	540	PF00069	0.671
MOD_ProDKin_1	632	638	PF00069	0.662
MOD_ProDKin_1	760	766	PF00069	0.778
MOD_SUMO_rev_2	606	612	PF00179	0.679
TRG_DiLeu_BaEn_1	431	436	PF01217	0.577
TRG_DiLeu_BaEn_2	171	177	PF01217	0.514
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.478
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.414
TRG_DiLeu_BaLyEn_6	430	435	PF01217	0.582
TRG_DiLeu_BaLyEn_6	465	470	PF01217	0.586
TRG_DiLeu_BaLyEn_6	578	583	PF01217	0.610
TRG_DiLeu_BaLyEn_6	598	603	PF01217	0.482
TRG_ENDOCYTIC_2	649	652	PF00928	0.644
TRG_ENDOCYTIC_2	722	725	PF00928	0.602
TRG_ENDOCYTIC_2	732	735	PF00928	0.629
TRG_ER_diArg_1	147	150	PF00400	0.577
TRG_ER_diArg_1	156	159	PF00400	0.599
TRG_ER_diArg_1	41	43	PF00400	0.535
TRG_ER_diArg_1	419	422	PF00400	0.661
TRG_ER_diArg_1	432	434	PF00400	0.597
TRG_ER_diArg_1	457	459	PF00400	0.605
TRG_ER_diArg_1	547	550	PF00400	0.621
TRG_ER_diArg_1	583	585	PF00400	0.669
TRG_ER_diArg_1	591	593	PF00400	0.674
TRG_ER_diArg_1	755	758	PF00400	0.640
TRG_ER_diArg_1	806	809	PF00400	0.483
TRG_ER_diArg_1	828	830	PF00400	0.691
TRG_Pf-PMV_PEXEL_1	241	246	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	581	586	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	601	606	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	812	816	PF00026	0.412
TRG_PTS1	875	878	PF00515	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBC4	Leptomonas seymouri	50%	100%
A0A3Q8IB49	Leishmania donovani	87%	100%
A0A422P1W2	Trypanosoma rangeli	25%	100%
A4H9S5	Leishmania braziliensis	75%	100%
A4HXW0	Leishmania infantum	87%	100%
Q4QDV6	Leishmania major	86%	100%