Ribosomal_S8 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ribosomal protein S8, putative

Species:

Leishmania mexicana

UniProt:

E9ARL7_LEIMU

TriTrypDb:

LmxM.18.0800

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9ARL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARL7

PDB structure(s): 7ane_c

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	197	199	PF00675	0.242
CLV_NRD_NRD_1	270	272	PF00675	0.242
CLV_NRD_NRD_1	59	61	PF00675	0.619
CLV_NRD_NRD_1	99	101	PF00675	0.654
CLV_PCSK_KEX2_1	170	172	PF00082	0.410
CLV_PCSK_KEX2_1	199	201	PF00082	0.242
CLV_PCSK_KEX2_1	270	272	PF00082	0.242
CLV_PCSK_KEX2_1	59	61	PF00082	0.479
CLV_PCSK_KEX2_1	78	80	PF00082	0.577
CLV_PCSK_KEX2_1	99	101	PF00082	0.654
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.410
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.242
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.599
CLV_PCSK_SKI1_1	139	143	PF00082	0.416
CLV_PCSK_SKI1_1	215	219	PF00082	0.298
CLV_PCSK_SKI1_1	4	8	PF00082	0.608
CLV_PCSK_SKI1_1	54	58	PF00082	0.601
DEG_APCC_DBOX_1	80	88	PF00400	0.413
DEG_Nend_Nbox_1	1	3	PF02207	0.497
DEG_SPOP_SBC_1	23	27	PF00917	0.575
DOC_CKS1_1	180	185	PF01111	0.337
DOC_CYCLIN_RxL_1	211	219	PF00134	0.496
DOC_MAPK_gen_1	198	204	PF00069	0.469
DOC_PP1_RVXF_1	137	143	PF00149	0.415
DOC_PP2B_PxIxI_1	245	251	PF00149	0.536
DOC_SPAK_OSR1_1	200	204	PF12202	0.455
DOC_USP7_MATH_1	23	27	PF00917	0.706
DOC_USP7_MATH_1	35	39	PF00917	0.752
DOC_USP7_UBL2_3	170	174	PF12436	0.553
DOC_WW_Pin1_4	179	184	PF00397	0.347
DOC_WW_Pin1_4	262	267	PF00397	0.442
LIG_14-3-3_CanoR_1	4	13	PF00244	0.374
LIG_deltaCOP1_diTrp_1	175	181	PF00928	0.473
LIG_FHA_1	17	23	PF00498	0.532
LIG_FHA_1	175	181	PF00498	0.413
LIG_FHA_1	245	251	PF00498	0.442
LIG_FHA_1	273	279	PF00498	0.435
LIG_FHA_2	152	158	PF00498	0.429
LIG_FHA_2	258	264	PF00498	0.442
LIG_FHA_2	72	78	PF00498	0.429
LIG_LIR_Apic_2	154	158	PF02991	0.403
LIG_LIR_Gen_1	175	185	PF02991	0.456
LIG_LIR_Gen_1	7	17	PF02991	0.396
LIG_LIR_Nem_3	175	181	PF02991	0.423
LIG_LIR_Nem_3	7	12	PF02991	0.366
LIG_NRBOX	83	89	PF00104	0.458
LIG_SH2_NCK_1	155	159	PF00017	0.412
LIG_SH2_SRC	155	158	PF00017	0.419
LIG_SH2_STAT5	241	244	PF00017	0.442
LIG_SH2_STAT5	285	288	PF00017	0.457
LIG_SH2_STAT5	45	48	PF00017	0.476
LIG_SH3_1	113	119	PF00018	0.503
LIG_SH3_1	130	136	PF00018	0.436
LIG_SH3_3	113	119	PF00018	0.507
LIG_SH3_3	130	136	PF00018	0.487
LIG_SH3_3	177	183	PF00018	0.388
LIG_SH3_3	199	205	PF00018	0.442
LIG_SH3_3	247	253	PF00018	0.435
LIG_UBA3_1	294	302	PF00899	0.473
MOD_CDK_SPK_2	262	267	PF00069	0.442
MOD_CK1_1	25	31	PF00069	0.672
MOD_CK1_1	47	53	PF00069	0.433
MOD_CK2_1	151	157	PF00069	0.529
MOD_CK2_1	203	209	PF00069	0.442
MOD_CK2_1	257	263	PF00069	0.442
MOD_CK2_1	71	77	PF00069	0.535
MOD_Cter_Amidation	57	60	PF01082	0.463
MOD_GlcNHglycan	101	104	PF01048	0.646
MOD_GlcNHglycan	110	113	PF01048	0.641
MOD_GlcNHglycan	29	32	PF01048	0.701
MOD_GlcNHglycan	36	40	PF01048	0.693
MOD_GlcNHglycan	4	7	PF01048	0.548
MOD_GlcNHglycan	41	44	PF01048	0.710
MOD_GlcNHglycan	46	49	PF01048	0.410
MOD_GSK3_1	203	210	PF00069	0.442
MOD_GSK3_1	22	29	PF00069	0.622
MOD_GSK3_1	35	42	PF00069	0.687
MOD_NEK2_1	2	7	PF00069	0.464
MOD_NEK2_1	272	277	PF00069	0.423
MOD_PKA_1	99	105	PF00069	0.621
MOD_PKA_2	99	105	PF00069	0.621
MOD_PKB_1	190	198	PF00069	0.455
MOD_PKB_1	60	68	PF00069	0.389
MOD_Plk_1	174	180	PF00069	0.484
MOD_Plk_1	71	77	PF00069	0.535
MOD_Plk_2-3	252	258	PF00069	0.451
MOD_Plk_4	62	68	PF00069	0.440
MOD_ProDKin_1	179	185	PF00069	0.344
MOD_ProDKin_1	262	268	PF00069	0.442
MOD_SUMO_rev_2	232	242	PF00179	0.460
MOD_SUMO_rev_2	252	260	PF00179	0.384
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.519
TRG_ER_diArg_1	198	201	PF00400	0.442
TRG_ER_diArg_1	269	271	PF00400	0.442
TRG_ER_diArg_1	59	62	PF00400	0.551
TRG_Pf-PMV_PEXEL_1	130	135	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I854	Leptomonas seymouri	81%	100%
A0A1X0P6W5	Trypanosomatidae	79%	100%
A0A3S7WUX4	Leishmania donovani	94%	100%
A0A422P1R7	Trypanosoma rangeli	71%	100%
A4H9J1	Leishmania braziliensis	88%	100%
A4HXV4	Leishmania infantum	94%	100%
C9ZZU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
Q4QDW2	Leishmania major	92%	97%
V5DN42	Trypanosoma cruzi	76%	100%