zf-C2H2_jaz domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc-finger double-stranded RNA-binding, putative

Species:

Leishmania mexicana

UniProt:

E9ARL3_LEIMU

TriTrypDb:

LmxM.18.0760

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARL3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0003676	nucleic acid binding	3	5
GO:0008270	zinc ion binding	6	5
GO:0046914	transition metal ion binding	5	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	44	46	PF00675	0.563
CLV_NRD_NRD_1	73	75	PF00675	0.428
CLV_PCSK_KEX2_1	44	46	PF00082	0.565
CLV_PCSK_KEX2_1	73	75	PF00082	0.437
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.518
DOC_MAPK_gen_1	73	81	PF00069	0.434
DOC_MAPK_RevD_3	61	75	PF00069	0.481
DOC_PP4_FxxP_1	19	22	PF00568	0.608
DOC_USP7_MATH_1	5	9	PF00917	0.690
DOC_WW_Pin1_4	61	66	PF00397	0.601
DOC_WW_Pin1_4	7	12	PF00397	0.585
LIG_14-3-3_CanoR_1	16	20	PF00244	0.546
LIG_Actin_WH2_2	75	90	PF00022	0.509
LIG_BIR_II_1	1	5	PF00653	0.622
LIG_FHA_2	62	68	PF00498	0.430
LIG_LIR_Apic_2	18	22	PF02991	0.328
LIG_LIR_Gen_1	66	77	PF02991	0.614
LIG_LIR_Nem_3	18	23	PF02991	0.341
LIG_LIR_Nem_3	66	72	PF02991	0.614
LIG_SH2_CRK	20	24	PF00017	0.506
LIG_SH2_STAT5	20	23	PF00017	0.463
MOD_CK1_1	10	16	PF00069	0.555
MOD_GlcNHglycan	3	6	PF01048	0.715
MOD_GlcNHglycan	46	49	PF01048	0.468
MOD_GlcNHglycan	7	10	PF01048	0.655
MOD_GlcNHglycan	91	95	PF01048	0.493
MOD_GSK3_1	1	8	PF00069	0.630
MOD_GSK3_1	11	18	PF00069	0.501
MOD_NEK2_1	1	6	PF00069	0.633
MOD_PKA_1	44	50	PF00069	0.435
MOD_PKA_2	15	21	PF00069	0.457
MOD_PKA_2	44	50	PF00069	0.476
MOD_Plk_4	15	21	PF00069	0.530
MOD_ProDKin_1	61	67	PF00069	0.599
MOD_ProDKin_1	7	13	PF00069	0.580
MOD_SUMO_rev_2	85	90	PF00179	0.650
TRG_ENDOCYTIC_2	20	23	PF00928	0.506
TRG_ER_diArg_1	72	74	PF00400	0.426
TRG_NLS_MonoExtC_3	43	49	PF00514	0.595
TRG_NLS_MonoExtN_4	41	48	PF00514	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P725	Trypanosomatidae	51%	90%
A0A3Q8I9Z0	Leishmania donovani	91%	99%
A4H9I7	Leishmania braziliensis	82%	100%
A4HXV0	Leishmania infantum	90%	99%
Q4QDW6	Leishmania major	87%	100%
V5BM68	Trypanosoma cruzi	55%	100%