Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ARL2_LEIMU

TriTrypDb:

LmxM.18.0750

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARL2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	341	345	PF00656	0.491
CLV_C14_Caspase3-7	75	79	PF00656	0.510
CLV_NRD_NRD_1	121	123	PF00675	0.532
CLV_NRD_NRD_1	141	143	PF00675	0.723
CLV_NRD_NRD_1	188	190	PF00675	0.723
CLV_NRD_NRD_1	420	422	PF00675	0.737
CLV_NRD_NRD_1	469	471	PF00675	0.694
CLV_NRD_NRD_1	536	538	PF00675	0.676
CLV_PCSK_KEX2_1	101	103	PF00082	0.517
CLV_PCSK_KEX2_1	121	123	PF00082	0.779
CLV_PCSK_KEX2_1	140	142	PF00082	0.702
CLV_PCSK_KEX2_1	188	190	PF00082	0.723
CLV_PCSK_KEX2_1	420	422	PF00082	0.737
CLV_PCSK_KEX2_1	469	471	PF00082	0.694
CLV_PCSK_KEX2_1	536	538	PF00082	0.676
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.517
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.560
CLV_PCSK_PC7_1	136	142	PF00082	0.548
CLV_PCSK_PC7_1	184	190	PF00082	0.564
CLV_PCSK_SKI1_1	262	266	PF00082	0.549
CLV_PCSK_SKI1_1	470	474	PF00082	0.769
DEG_SPOP_SBC_1	60	64	PF00917	0.676
DOC_CKS1_1	177	182	PF01111	0.528
DOC_MAPK_gen_1	140	149	PF00069	0.683
DOC_MAPK_gen_1	33	41	PF00069	0.612
DOC_MAPK_MEF2A_6	140	149	PF00069	0.722
DOC_PP2B_LxvP_1	288	291	PF13499	0.556
DOC_PP4_FxxP_1	380	383	PF00568	0.690
DOC_PP4_FxxP_1	472	475	PF00568	0.717
DOC_PP4_FxxP_1	482	485	PF00568	0.628
DOC_PP4_FxxP_1	491	494	PF00568	0.603
DOC_USP7_MATH_1	12	16	PF00917	0.682
DOC_USP7_MATH_1	148	152	PF00917	0.684
DOC_USP7_MATH_1	264	268	PF00917	0.486
DOC_USP7_MATH_1	383	387	PF00917	0.712
DOC_USP7_MATH_1	500	504	PF00917	0.729
DOC_USP7_MATH_1	506	510	PF00917	0.705
DOC_USP7_MATH_1	535	539	PF00917	0.562
DOC_USP7_MATH_1	72	76	PF00917	0.631
DOC_USP7_MATH_1	85	89	PF00917	0.821
DOC_WW_Pin1_4	111	116	PF00397	0.794
DOC_WW_Pin1_4	14	19	PF00397	0.625
DOC_WW_Pin1_4	141	146	PF00397	0.747
DOC_WW_Pin1_4	176	181	PF00397	0.525
DOC_WW_Pin1_4	213	218	PF00397	0.725
DOC_WW_Pin1_4	409	414	PF00397	0.704
DOC_WW_Pin1_4	427	432	PF00397	0.722
DOC_WW_Pin1_4	498	503	PF00397	0.818
LIG_14-3-3_CanoR_1	105	113	PF00244	0.721
LIG_14-3-3_CanoR_1	141	145	PF00244	0.826
LIG_14-3-3_CanoR_1	162	168	PF00244	0.712
LIG_14-3-3_CanoR_1	266	272	PF00244	0.602
LIG_14-3-3_CanoR_1	279	285	PF00244	0.380
LIG_14-3-3_CanoR_1	309	316	PF00244	0.589
LIG_14-3-3_CanoR_1	469	475	PF00244	0.674
LIG_14-3-3_CanoR_1	536	542	PF00244	0.709
LIG_14-3-3_CanoR_1	65	72	PF00244	0.644
LIG_Actin_WH2_2	251	268	PF00022	0.453
LIG_APCC_Cbox_1	240	246	PF00515	0.461
LIG_BIR_II_1	1	5	PF00653	0.717
LIG_BIR_III_4	318	322	PF00653	0.686
LIG_CaM_NSCaTE_8	326	333	PF13499	0.324
LIG_deltaCOP1_diTrp_1	358	366	PF00928	0.481
LIG_deltaCOP1_diTrp_1	456	466	PF00928	0.676
LIG_EH1_1	47	55	PF00400	0.710
LIG_FHA_1	142	148	PF00498	0.748
LIG_FHA_1	23	29	PF00498	0.657
LIG_FHA_1	292	298	PF00498	0.537
LIG_FHA_1	393	399	PF00498	0.557
LIG_FHA_1	49	55	PF00498	0.598
LIG_FHA_2	162	168	PF00498	0.654
LIG_FHA_2	194	200	PF00498	0.642
LIG_FHA_2	207	213	PF00498	0.480
LIG_FHA_2	339	345	PF00498	0.500
LIG_FHA_2	474	480	PF00498	0.666
LIG_FXI_DFP_1	463	467	PF00024	0.682
LIG_LIR_Apic_2	379	383	PF02991	0.688
LIG_LIR_Apic_2	479	485	PF02991	0.606
LIG_LIR_Apic_2	489	494	PF02991	0.637
LIG_LIR_Apic_2	529	534	PF02991	0.645
LIG_LIR_Gen_1	150	159	PF02991	0.690
LIG_LIR_Gen_1	337	346	PF02991	0.552
LIG_LIR_Gen_1	358	369	PF02991	0.585
LIG_LIR_Gen_1	476	485	PF02991	0.664
LIG_LIR_Nem_3	150	156	PF02991	0.757
LIG_LIR_Nem_3	165	171	PF02991	0.508
LIG_LIR_Nem_3	323	329	PF02991	0.447
LIG_LIR_Nem_3	337	342	PF02991	0.549
LIG_LIR_Nem_3	358	364	PF02991	0.495
LIG_LIR_Nem_3	379	384	PF02991	0.692
LIG_LIR_Nem_3	476	481	PF02991	0.662
LIG_NRBOX	203	209	PF00104	0.624
LIG_NRBOX	283	289	PF00104	0.546
LIG_NRBOX	5	11	PF00104	0.485
LIG_PDZ_Class_1	537	542	PF00595	0.710
LIG_SH2_CRK	531	535	PF00017	0.767
LIG_SH2_NCK_1	272	276	PF00017	0.403
LIG_SH2_SRC	272	275	PF00017	0.378
LIG_SH2_STAP1	478	482	PF00017	0.663
LIG_SH2_STAT5	336	339	PF00017	0.598
LIG_SH2_STAT5	531	534	PF00017	0.768
LIG_SH3_1	142	148	PF00018	0.730
LIG_SH3_3	142	148	PF00018	0.730
LIG_SH3_3	177	183	PF00018	0.648
LIG_SH3_3	489	495	PF00018	0.721
LIG_SUMO_SIM_anti_2	198	206	PF11976	0.624
LIG_SUMO_SIM_par_1	19	25	PF11976	0.635
LIG_SUMO_SIM_par_1	280	286	PF11976	0.570
LIG_TRAF2_1	209	212	PF00917	0.610
LIG_TRAF2_1	235	238	PF00917	0.706
LIG_TRAF2_1	271	274	PF00917	0.372
LIG_TRAF2_1	29	32	PF00917	0.586
LIG_TRAF2_1	517	520	PF00917	0.713
LIG_UBA3_1	254	260	PF00899	0.517
MOD_CK1_1	176	182	PF00069	0.739
MOD_CK1_1	193	199	PF00069	0.600
MOD_CK1_1	206	212	PF00069	0.684
MOD_CK1_1	236	242	PF00069	0.699
MOD_CK1_1	283	289	PF00069	0.594
MOD_CK1_1	320	326	PF00069	0.658
MOD_CK1_1	331	337	PF00069	0.450
MOD_CK1_1	89	95	PF00069	0.753
MOD_CK2_1	105	111	PF00069	0.687
MOD_CK2_1	140	146	PF00069	0.742
MOD_CK2_1	161	167	PF00069	0.651
MOD_CK2_1	206	212	PF00069	0.553
MOD_CK2_1	268	274	PF00069	0.362
MOD_CK2_1	427	433	PF00069	0.567
MOD_CK2_1	76	82	PF00069	0.726
MOD_Cter_Amidation	138	141	PF01082	0.545
MOD_GlcNHglycan	1	4	PF01048	0.684
MOD_GlcNHglycan	125	128	PF01048	0.704
MOD_GlcNHglycan	129	132	PF01048	0.703
MOD_GlcNHglycan	221	224	PF01048	0.578
MOD_GlcNHglycan	318	322	PF01048	0.760
MOD_GlcNHglycan	385	388	PF01048	0.727
MOD_GlcNHglycan	409	412	PF01048	0.796
MOD_GlcNHglycan	488	491	PF01048	0.687
MOD_GlcNHglycan	509	512	PF01048	0.687
MOD_GlcNHglycan	88	91	PF01048	0.664
MOD_GSK3_1	105	112	PF00069	0.745
MOD_GSK3_1	123	130	PF00069	0.711
MOD_GSK3_1	189	196	PF00069	0.708
MOD_GSK3_1	203	210	PF00069	0.471
MOD_GSK3_1	213	220	PF00069	0.607
MOD_GSK3_1	264	271	PF00069	0.570
MOD_GSK3_1	330	337	PF00069	0.497
MOD_GSK3_1	405	412	PF00069	0.781
MOD_GSK3_1	61	68	PF00069	0.689
MOD_GSK3_1	72	79	PF00069	0.620
MOD_GSK3_1	85	92	PF00069	0.734
MOD_NEK2_1	120	125	PF00069	0.752
MOD_NEK2_1	203	208	PF00069	0.525
MOD_NEK2_1	265	270	PF00069	0.627
MOD_NEK2_1	329	334	PF00069	0.501
MOD_NEK2_1	338	343	PF00069	0.474
MOD_NEK2_1	376	381	PF00069	0.531
MOD_NEK2_1	54	59	PF00069	0.614
MOD_NEK2_1	61	66	PF00069	0.623
MOD_PIKK_1	173	179	PF00454	0.733
MOD_PIKK_1	207	213	PF00454	0.706
MOD_PIKK_1	233	239	PF00454	0.716
MOD_PIKK_1	265	271	PF00454	0.630
MOD_PIKK_1	308	314	PF00454	0.506
MOD_PIKK_1	76	82	PF00454	0.725
MOD_PKA_1	140	146	PF00069	0.641
MOD_PKA_2	120	126	PF00069	0.687
MOD_PKA_2	140	146	PF00069	0.634
MOD_PKA_2	161	167	PF00069	0.663
MOD_PKA_2	193	199	PF00069	0.688
MOD_PKA_2	233	239	PF00069	0.716
MOD_PKA_2	265	271	PF00069	0.630
MOD_PKA_2	308	314	PF00069	0.506
MOD_PKA_2	507	513	PF00069	0.738
MOD_PKA_2	535	541	PF00069	0.489
MOD_Plk_1	48	54	PF00069	0.711
MOD_Plk_2-3	161	167	PF00069	0.663
MOD_Plk_4	148	154	PF00069	0.765
MOD_Plk_4	203	209	PF00069	0.640
MOD_Plk_4	22	28	PF00069	0.596
MOD_Plk_4	253	259	PF00069	0.420
MOD_Plk_4	283	289	PF00069	0.546
MOD_Plk_4	331	337	PF00069	0.548
MOD_Plk_4	338	344	PF00069	0.520
MOD_Plk_4	376	382	PF00069	0.673
MOD_Plk_4	473	479	PF00069	0.667
MOD_Plk_4	5	11	PF00069	0.653
MOD_Plk_4	54	60	PF00069	0.433
MOD_Plk_4	95	101	PF00069	0.572
MOD_ProDKin_1	111	117	PF00069	0.796
MOD_ProDKin_1	14	20	PF00069	0.622
MOD_ProDKin_1	141	147	PF00069	0.741
MOD_ProDKin_1	176	182	PF00069	0.525
MOD_ProDKin_1	213	219	PF00069	0.728
MOD_ProDKin_1	409	415	PF00069	0.704
MOD_ProDKin_1	427	433	PF00069	0.718
MOD_ProDKin_1	498	504	PF00069	0.821
MOD_SUMO_for_1	517	520	PF00179	0.713
TRG_DiLeu_LyEn_5	293	298	PF01217	0.584
TRG_ENDOCYTIC_2	463	466	PF00928	0.684
TRG_ENDOCYTIC_2	478	481	PF00928	0.663
TRG_ER_diArg_1	120	122	PF00400	0.537
TRG_ER_diArg_1	188	190	PF00400	0.723
TRG_ER_diArg_1	419	421	PF00400	0.735
TRG_ER_diArg_1	468	470	PF00400	0.782
TRG_ER_diArg_1	536	539	PF00400	0.679
TRG_Pf-PMV_PEXEL_1	396	401	PF00026	0.751

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2K4	Leptomonas seymouri	38%	100%
A0A3Q8IE86	Leishmania donovani	84%	99%
A4H9I6	Leishmania braziliensis	57%	97%
A4HXU9	Leishmania infantum	83%	100%
Q4QDW7	Leishmania major	79%	100%