Putative dynein-light chain-protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein light chain Tctex-type, putative

Species:

Leishmania mexicana

UniProt:

E9ARL0_LEIMU

TriTrypDb:

LmxM.18.0730

Length:

253

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0005930	axoneme	2	1
GO:0030286	dynein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9ARL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARL0

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045505	dynein intermediate chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.443
CLV_NRD_NRD_1	210	212	PF00675	0.336
CLV_PCSK_SKI1_1	199	203	PF00082	0.419
CLV_PCSK_SKI1_1	42	46	PF00082	0.729
DOC_CYCLIN_yCln2_LP_2	197	203	PF00134	0.395
DOC_MAPK_gen_1	211	219	PF00069	0.302
DOC_USP7_MATH_1	149	153	PF00917	0.600
DOC_USP7_MATH_1	2	6	PF00917	0.732
DOC_USP7_MATH_1	44	48	PF00917	0.566
DOC_USP7_MATH_1	71	75	PF00917	0.653
DOC_WW_Pin1_4	125	130	PF00397	0.422
LIG_14-3-3_CanoR_1	113	123	PF00244	0.507
LIG_APCC_ABBA_1	127	132	PF00400	0.443
LIG_BIR_II_1	1	5	PF00653	0.716
LIG_BRCT_BRCA1_1	127	131	PF00533	0.432
LIG_EH1_1	202	210	PF00400	0.302
LIG_FHA_2	81	87	PF00498	0.822
LIG_LIR_Apic_2	221	227	PF02991	0.395
LIG_LIR_Gen_1	108	119	PF02991	0.373
LIG_LIR_Gen_1	180	190	PF02991	0.395
LIG_LIR_Gen_1	247	253	PF02991	0.355
LIG_LIR_Nem_3	108	114	PF02991	0.422
LIG_LIR_Nem_3	180	185	PF02991	0.395
LIG_LIR_Nem_3	247	253	PF02991	0.389
LIG_MLH1_MIPbox_1	127	131	PF16413	0.432
LIG_PTAP_UEV_1	155	160	PF05743	0.533
LIG_SH2_CRK	243	247	PF00017	0.276
LIG_SH2_NCK_1	243	247	PF00017	0.353
LIG_SH2_STAT5	130	133	PF00017	0.493
LIG_SH3_3	123	129	PF00018	0.377
LIG_SH3_3	153	159	PF00018	0.666
LIG_SH3_3	18	24	PF00018	0.587
LIG_SUMO_SIM_anti_2	180	188	PF11976	0.395
LIG_TRAF2_1	160	163	PF00917	0.658
LIG_UBA3_1	190	199	PF00899	0.395
MOD_CK1_1	154	160	PF00069	0.703
MOD_CK1_1	34	40	PF00069	0.640
MOD_CK1_1	58	64	PF00069	0.551
MOD_CK1_1	6	12	PF00069	0.807
MOD_CK2_1	80	86	PF00069	0.596
MOD_GlcNHglycan	151	154	PF01048	0.678
MOD_GlcNHglycan	156	159	PF01048	0.702
MOD_GlcNHglycan	237	241	PF01048	0.355
MOD_GlcNHglycan	46	49	PF01048	0.630
MOD_GlcNHglycan	57	60	PF01048	0.688
MOD_GlcNHglycan	86	90	PF01048	0.695
MOD_GSK3_1	2	9	PF00069	0.757
MOD_GSK3_1	27	34	PF00069	0.695
MOD_GSK3_1	38	45	PF00069	0.745
MOD_GSK3_1	76	83	PF00069	0.776
MOD_N-GLC_1	32	37	PF02516	0.736
MOD_N-GLC_1	42	47	PF02516	0.793
MOD_N-GLC_1	7	12	PF02516	0.807
MOD_NEK2_1	19	24	PF00069	0.715
MOD_NEK2_1	31	36	PF00069	0.743
MOD_NEK2_2	244	249	PF00069	0.276
MOD_Plk_4	244	250	PF00069	0.303
MOD_ProDKin_1	125	131	PF00069	0.422
MOD_SUMO_for_1	177	180	PF00179	0.395
MOD_SUMO_rev_2	112	122	PF00179	0.430
TRG_DiLeu_BaEn_1	181	186	PF01217	0.395
TRG_ENDOCYTIC_2	174	177	PF00928	0.330
TRG_ENDOCYTIC_2	225	228	PF00928	0.466
TRG_ENDOCYTIC_2	243	246	PF00928	0.184

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P343	Leptomonas seymouri	57%	91%
A0A3R7KQL0	Trypanosoma rangeli	45%	100%
A0A3S7WUW6	Leishmania donovani	85%	100%
A4H9I4	Leishmania braziliensis	68%	98%
A4HXU8	Leishmania infantum	85%	100%
Q4QDW9	Leishmania major	83%	99%
V5DN82	Trypanosoma cruzi	43%	100%