Origin recognition complex subunit 4

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARK9_LEIMU

TriTrypDb:

LmxM.18.0720

Length:

851

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARK9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.664
CLV_C14_Caspase3-7	364	368	PF00656	0.419
CLV_NRD_NRD_1	180	182	PF00675	0.673
CLV_NRD_NRD_1	200	202	PF00675	0.637
CLV_NRD_NRD_1	380	382	PF00675	0.360
CLV_NRD_NRD_1	438	440	PF00675	0.480
CLV_NRD_NRD_1	604	606	PF00675	0.505
CLV_NRD_NRD_1	663	665	PF00675	0.607
CLV_NRD_NRD_1	70	72	PF00675	0.427
CLV_PCSK_KEX2_1	180	182	PF00082	0.673
CLV_PCSK_KEX2_1	200	202	PF00082	0.685
CLV_PCSK_KEX2_1	333	335	PF00082	0.478
CLV_PCSK_KEX2_1	379	381	PF00082	0.356
CLV_PCSK_KEX2_1	407	409	PF00082	0.488
CLV_PCSK_KEX2_1	438	440	PF00082	0.480
CLV_PCSK_KEX2_1	604	606	PF00082	0.504
CLV_PCSK_KEX2_1	663	665	PF00082	0.624
CLV_PCSK_KEX2_1	70	72	PF00082	0.427
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.478
CLV_PCSK_PC1ET2_1	407	409	PF00082	0.488
CLV_PCSK_PC7_1	329	335	PF00082	0.480
CLV_PCSK_SKI1_1	354	358	PF00082	0.562
CLV_PCSK_SKI1_1	439	443	PF00082	0.473
CLV_PCSK_SKI1_1	604	608	PF00082	0.503
CLV_PCSK_SKI1_1	740	744	PF00082	0.426
CLV_PCSK_SKI1_1	783	787	PF00082	0.415
CLV_PCSK_SKI1_1	819	823	PF00082	0.398
CLV_PCSK_SKI1_1	83	87	PF00082	0.527
CLV_Separin_Metazoa	843	847	PF03568	0.377
DEG_APCC_DBOX_1	437	445	PF00400	0.500
DEG_APCC_DBOX_1	604	612	PF00400	0.498
DEG_APCC_DBOX_1	739	747	PF00400	0.428
DEG_APCC_DBOX_1	794	802	PF00400	0.423
DEG_APCC_DBOX_1	818	826	PF00400	0.386
DEG_SPOP_SBC_1	244	248	PF00917	0.568
DOC_CDC14_PxL_1	710	718	PF14671	0.525
DOC_CKS1_1	658	663	PF01111	0.518
DOC_CYCLIN_RxL_1	435	446	PF00134	0.509
DOC_CYCLIN_RxL_1	54	68	PF00134	0.429
DOC_CYCLIN_yClb5_NLxxxL_5	718	727	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	479	485	PF00134	0.613
DOC_CYCLIN_yCln2_LP_2	682	688	PF00134	0.543
DOC_CYCLIN_yCln2_LP_2	718	721	PF00134	0.548
DOC_MAPK_DCC_7	475	485	PF00069	0.611
DOC_MAPK_DCC_7	708	718	PF00069	0.669
DOC_MAPK_gen_1	435	444	PF00069	0.459
DOC_MAPK_gen_1	817	825	PF00069	0.468
DOC_MAPK_MEF2A_6	740	747	PF00069	0.351
DOC_PP2B_LxvP_1	682	685	PF13499	0.533
DOC_PP2B_LxvP_1	718	721	PF13499	0.585
DOC_USP7_MATH_1	163	167	PF00917	0.549
DOC_USP7_MATH_1	219	223	PF00917	0.724
DOC_USP7_MATH_1	496	500	PF00917	0.665
DOC_USP7_MATH_1	513	517	PF00917	0.679
DOC_USP7_MATH_1	53	57	PF00917	0.507
DOC_USP7_MATH_1	623	627	PF00917	0.648
DOC_USP7_MATH_1	631	635	PF00917	0.601
DOC_WW_Pin1_4	102	107	PF00397	0.389
DOC_WW_Pin1_4	478	483	PF00397	0.531
DOC_WW_Pin1_4	626	631	PF00397	0.593
DOC_WW_Pin1_4	657	662	PF00397	0.607
DOC_WW_Pin1_4	69	74	PF00397	0.520
LIG_14-3-3_CanoR_1	183	188	PF00244	0.692
LIG_14-3-3_CanoR_1	203	211	PF00244	0.548
LIG_14-3-3_CanoR_1	338	346	PF00244	0.477
LIG_14-3-3_CanoR_1	423	431	PF00244	0.442
LIG_14-3-3_CanoR_1	439	445	PF00244	0.577
LIG_14-3-3_CanoR_1	475	483	PF00244	0.665
LIG_14-3-3_CanoR_1	504	509	PF00244	0.556
LIG_14-3-3_CanoR_1	605	611	PF00244	0.615
LIG_14-3-3_CanoR_1	71	77	PF00244	0.396
LIG_14-3-3_CanoR_1	846	851	PF00244	0.467
LIG_Actin_WH2_2	786	802	PF00022	0.480
LIG_Actin_WH2_2	96	114	PF00022	0.367
LIG_BRCT_BRCA1_1	496	500	PF00533	0.671
LIG_Clathr_ClatBox_1	128	132	PF01394	0.473
LIG_EH1_1	58	66	PF00400	0.416
LIG_eIF4E_1	295	301	PF01652	0.387
LIG_FHA_1	190	196	PF00498	0.555
LIG_FHA_1	246	252	PF00498	0.544
LIG_FHA_1	341	347	PF00498	0.467
LIG_FHA_1	503	509	PF00498	0.640
LIG_FHA_1	516	522	PF00498	0.440
LIG_FHA_1	752	758	PF00498	0.417
LIG_FHA_2	229	235	PF00498	0.638
LIG_FHA_2	362	368	PF00498	0.423
LIG_FHA_2	404	410	PF00498	0.406
LIG_FHA_2	566	572	PF00498	0.611
LIG_FHA_2	759	765	PF00498	0.421
LIG_GBD_Chelix_1	562	570	PF00786	0.582
LIG_GBD_Chelix_1	95	103	PF00786	0.372
LIG_LIR_Gen_1	609	615	PF02991	0.413
LIG_LIR_Nem_3	122	128	PF02991	0.377
LIG_LIR_Nem_3	26	32	PF02991	0.471
LIG_LIR_Nem_3	342	348	PF02991	0.512
LIG_LIR_Nem_3	609	613	PF02991	0.430
LIG_MYND_1	711	715	PF01753	0.584
LIG_NRBOX	352	358	PF00104	0.491
LIG_NRBOX	440	446	PF00104	0.532
LIG_NRBOX	722	728	PF00104	0.559
LIG_PDZ_Class_1	846	851	PF00595	0.467
LIG_Pex14_2	125	129	PF04695	0.387
LIG_SH2_CRK	29	33	PF00017	0.421
LIG_SH2_PTP2	345	348	PF00017	0.460
LIG_SH2_STAT5	116	119	PF00017	0.473
LIG_SH2_STAT5	250	253	PF00017	0.549
LIG_SH2_STAT5	295	298	PF00017	0.383
LIG_SH2_STAT5	345	348	PF00017	0.460
LIG_SH2_STAT5	469	472	PF00017	0.496
LIG_SH3_1	344	350	PF00018	0.468
LIG_SH3_1	616	622	PF00018	0.594
LIG_SH3_1	708	714	PF00018	0.620
LIG_SH3_3	184	190	PF00018	0.633
LIG_SH3_3	344	350	PF00018	0.468
LIG_SH3_3	616	622	PF00018	0.650
LIG_SH3_3	624	630	PF00018	0.696
LIG_SH3_3	708	714	PF00018	0.620
LIG_SUMO_SIM_anti_2	574	585	PF11976	0.528
LIG_SUMO_SIM_anti_2	741	747	PF11976	0.349
LIG_SUMO_SIM_par_1	265	271	PF11976	0.368
LIG_SUMO_SIM_par_1	440	449	PF11976	0.549
LIG_SUMO_SIM_par_1	820	827	PF11976	0.403
LIG_TYR_ITIM	746	751	PF00017	0.353
LIG_UBA3_1	266	270	PF00899	0.360
LIG_UBA3_1	822	828	PF00899	0.457
LIG_UBA3_1	99	104	PF00899	0.278
LIG_ULM_U2AF65_1	200	205	PF00076	0.692
LIG_WRC_WIRS_1	99	104	PF05994	0.446
MOD_CDK_SPxK_1	657	663	PF00069	0.515
MOD_CDK_SPxxK_3	657	664	PF00069	0.516
MOD_CK1_1	105	111	PF00069	0.398
MOD_CK1_1	185	191	PF00069	0.591
MOD_CK1_1	246	252	PF00069	0.557
MOD_CK1_1	337	343	PF00069	0.485
MOD_CK1_1	390	396	PF00069	0.506
MOD_CK1_1	473	479	PF00069	0.511
MOD_CK1_1	492	498	PF00069	0.605
MOD_CK1_1	499	505	PF00069	0.602
MOD_CK1_1	507	513	PF00069	0.569
MOD_CK1_1	515	521	PF00069	0.438
MOD_CK1_1	574	580	PF00069	0.511
MOD_CK1_1	626	632	PF00069	0.636
MOD_CK1_1	772	778	PF00069	0.452
MOD_CK2_1	223	229	PF00069	0.668
MOD_CK2_1	403	409	PF00069	0.418
MOD_CK2_1	457	463	PF00069	0.510
MOD_CK2_1	565	571	PF00069	0.603
MOD_CK2_1	699	705	PF00069	0.691
MOD_Cter_Amidation	377	380	PF01082	0.348
MOD_Cter_Amidation	602	605	PF01082	0.490
MOD_GlcNHglycan	107	110	PF01048	0.470
MOD_GlcNHglycan	175	178	PF01048	0.677
MOD_GlcNHglycan	239	242	PF01048	0.586
MOD_GlcNHglycan	256	259	PF01048	0.427
MOD_GlcNHglycan	297	300	PF01048	0.388
MOD_GlcNHglycan	322	325	PF01048	0.422
MOD_GlcNHglycan	389	392	PF01048	0.452
MOD_GlcNHglycan	400	404	PF01048	0.590
MOD_GlcNHglycan	459	462	PF01048	0.763
MOD_GlcNHglycan	476	479	PF01048	0.645
MOD_GlcNHglycan	491	494	PF01048	0.600
MOD_GlcNHglycan	55	58	PF01048	0.436
MOD_GlcNHglycan	553	556	PF01048	0.642
MOD_GlcNHglycan	592	595	PF01048	0.603
MOD_GlcNHglycan	6	9	PF01048	0.688
MOD_GlcNHglycan	601	604	PF01048	0.632
MOD_GlcNHglycan	754	757	PF01048	0.510
MOD_GSK3_1	163	170	PF00069	0.580
MOD_GSK3_1	185	192	PF00069	0.708
MOD_GSK3_1	219	226	PF00069	0.607
MOD_GSK3_1	242	249	PF00069	0.557
MOD_GSK3_1	268	275	PF00069	0.381
MOD_GSK3_1	28	35	PF00069	0.421
MOD_GSK3_1	333	340	PF00069	0.486
MOD_GSK3_1	357	364	PF00069	0.433
MOD_GSK3_1	399	406	PF00069	0.453
MOD_GSK3_1	440	447	PF00069	0.535
MOD_GSK3_1	469	476	PF00069	0.672
MOD_GSK3_1	488	495	PF00069	0.606
MOD_GSK3_1	498	505	PF00069	0.598
MOD_GSK3_1	547	554	PF00069	0.568
MOD_GSK3_1	561	568	PF00069	0.667
MOD_GSK3_1	571	578	PF00069	0.574
MOD_GSK3_1	652	659	PF00069	0.545
MOD_GSK3_1	768	775	PF00069	0.431
MOD_GSK3_1	98	105	PF00069	0.447
MOD_N-GLC_1	572	577	PF02516	0.613
MOD_NEK2_1	117	122	PF00069	0.444
MOD_NEK2_1	214	219	PF00069	0.570
MOD_NEK2_1	243	248	PF00069	0.552
MOD_NEK2_1	268	273	PF00069	0.374
MOD_NEK2_1	32	37	PF00069	0.481
MOD_NEK2_1	357	362	PF00069	0.529
MOD_NEK2_1	384	389	PF00069	0.396
MOD_NEK2_1	413	418	PF00069	0.461
MOD_NEK2_1	572	577	PF00069	0.550
MOD_NEK2_1	599	604	PF00069	0.555
MOD_NEK2_1	656	661	PF00069	0.509
MOD_NEK2_1	821	826	PF00069	0.374
MOD_NEK2_2	28	33	PF00069	0.420
MOD_OFUCOSY	40	47	PF10250	0.413
MOD_PIKK_1	163	169	PF00454	0.608
MOD_PIKK_1	803	809	PF00454	0.439
MOD_PK_1	504	510	PF00069	0.602
MOD_PKA_1	333	339	PF00069	0.482
MOD_PKA_2	182	188	PF00069	0.803
MOD_PKA_2	204	210	PF00069	0.645
MOD_PKA_2	32	38	PF00069	0.413
MOD_PKA_2	333	339	PF00069	0.492
MOD_PKA_2	474	480	PF00069	0.643
MOD_PKA_2	53	59	PF00069	0.446
MOD_PKB_1	181	189	PF00069	0.702
MOD_PKB_1	201	209	PF00069	0.608
MOD_PKB_1	394	402	PF00069	0.404
MOD_Plk_1	758	764	PF00069	0.504
MOD_Plk_2-3	220	226	PF00069	0.766
MOD_Plk_2-3	228	234	PF00069	0.761
MOD_Plk_2-3	565	571	PF00069	0.589
MOD_Plk_4	157	163	PF00069	0.626
MOD_Plk_4	246	252	PF00069	0.565
MOD_Plk_4	272	278	PF00069	0.346
MOD_Plk_4	315	321	PF00069	0.384
MOD_Plk_4	440	446	PF00069	0.588
MOD_Plk_4	576	582	PF00069	0.518
MOD_Plk_4	606	612	PF00069	0.535
MOD_Plk_4	714	720	PF00069	0.572
MOD_Plk_4	72	78	PF00069	0.391
MOD_Plk_4	821	827	PF00069	0.382
MOD_Plk_4	98	104	PF00069	0.446
MOD_ProDKin_1	102	108	PF00069	0.383
MOD_ProDKin_1	478	484	PF00069	0.532
MOD_ProDKin_1	626	632	PF00069	0.594
MOD_ProDKin_1	657	663	PF00069	0.609
MOD_ProDKin_1	69	75	PF00069	0.513
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.462
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.428
TRG_DiLeu_BaLyEn_6	788	793	PF01217	0.394
TRG_DiLeu_BaLyEn_6	794	799	PF01217	0.428
TRG_DiLeu_BaLyEn_6	80	85	PF01217	0.278
TRG_ENDOCYTIC_2	29	32	PF00928	0.417
TRG_ENDOCYTIC_2	345	348	PF00928	0.502
TRG_ENDOCYTIC_2	748	751	PF00928	0.357
TRG_ER_diArg_1	180	183	PF00400	0.840
TRG_ER_diArg_1	200	203	PF00400	0.668
TRG_ER_diArg_1	379	381	PF00400	0.392
TRG_ER_diArg_1	604	606	PF00400	0.501
TRG_ER_diArg_1	611	614	PF00400	0.515
TRG_ER_diArg_1	69	71	PF00400	0.411
TRG_ER_FFAT_2	494	505	PF00635	0.667
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN4	Leptomonas seymouri	55%	76%
A0A3S5H733	Leishmania donovani	91%	100%
A4H9I3	Leishmania braziliensis	77%	100%
A4HXU7	Leishmania infantum	91%	100%
Q4QDX0	Leishmania major	90%	100%