HEAT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HEAT repeats, putative

Species:

Leishmania mexicana

UniProt:

E9ARK4_LEIMU

TriTrypDb:

LmxM.18.0700

Length:

711

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARK4

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0019208	phosphatase regulator activity	3	1
GO:0019888	protein phosphatase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	351	355	PF00656	0.374
CLV_C14_Caspase3-7	603	607	PF00656	0.611
CLV_C14_Caspase3-7	9	13	PF00656	0.620
CLV_NRD_NRD_1	210	212	PF00675	0.362
CLV_NRD_NRD_1	367	369	PF00675	0.340
CLV_PCSK_KEX2_1	210	212	PF00082	0.502
CLV_PCSK_KEX2_1	406	408	PF00082	0.480
CLV_PCSK_KEX2_1	450	452	PF00082	0.495
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.480
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.495
CLV_PCSK_SKI1_1	231	235	PF00082	0.464
CLV_PCSK_SKI1_1	313	317	PF00082	0.463
CLV_PCSK_SKI1_1	46	50	PF00082	0.334
CLV_PCSK_SKI1_1	516	520	PF00082	0.528
CLV_PCSK_SKI1_1	526	530	PF00082	0.330
CLV_PCSK_SKI1_1	574	578	PF00082	0.463
CLV_PCSK_SKI1_1	85	89	PF00082	0.332
CLV_Separin_Metazoa	310	314	PF03568	0.501
DEG_APCC_DBOX_1	424	432	PF00400	0.358
DEG_SPOP_SBC_1	484	488	PF00917	0.417
DOC_CKS1_1	419	424	PF01111	0.504
DOC_CYCLIN_RxL_1	412	421	PF00134	0.489
DOC_MAPK_gen_1	450	457	PF00069	0.457
DOC_MAPK_MEF2A_6	231	240	PF00069	0.411
DOC_MAPK_MEF2A_6	450	459	PF00069	0.366
DOC_MAPK_NFAT4_5	231	239	PF00069	0.497
DOC_PP1_RVXF_1	266	272	PF00149	0.505
DOC_PP1_RVXF_1	359	366	PF00149	0.366
DOC_PP4_FxxP_1	271	274	PF00568	0.492
DOC_USP7_MATH_1	291	295	PF00917	0.394
DOC_USP7_MATH_1	319	323	PF00917	0.390
DOC_USP7_MATH_1	436	440	PF00917	0.380
DOC_USP7_MATH_1	471	475	PF00917	0.426
DOC_WW_Pin1_4	305	310	PF00397	0.393
DOC_WW_Pin1_4	324	329	PF00397	0.567
DOC_WW_Pin1_4	418	423	PF00397	0.514
DOC_WW_Pin1_4	457	462	PF00397	0.492
DOC_WW_Pin1_4	648	653	PF00397	0.801
LIG_14-3-3_CanoR_1	210	214	PF00244	0.404
LIG_14-3-3_CanoR_1	231	237	PF00244	0.492
LIG_14-3-3_CanoR_1	297	303	PF00244	0.440
LIG_14-3-3_CanoR_1	313	320	PF00244	0.450
LIG_14-3-3_CanoR_1	368	372	PF00244	0.334
LIG_14-3-3_CanoR_1	485	490	PF00244	0.367
LIG_APCC_ABBA_1	312	317	PF00400	0.367
LIG_APCC_ABBA_1	635	640	PF00400	0.540
LIG_BIR_III_2	79	83	PF00653	0.471
LIG_BRCT_BRCA1_1	462	466	PF00533	0.498
LIG_CtBP_PxDLS_1	264	268	PF00389	0.395
LIG_EH1_1	375	383	PF00400	0.402
LIG_FHA_1	1	7	PF00498	0.734
LIG_FHA_1	190	196	PF00498	0.443
LIG_FHA_1	531	537	PF00498	0.407
LIG_FHA_1	562	568	PF00498	0.459
LIG_FHA_1	617	623	PF00498	0.678
LIG_FHA_1	703	709	PF00498	0.643
LIG_FHA_2	116	122	PF00498	0.479
LIG_FHA_2	223	229	PF00498	0.478
LIG_GBD_Chelix_1	173	181	PF00786	0.331
LIG_LIR_Gen_1	105	116	PF02991	0.343
LIG_LIR_Gen_1	118	128	PF02991	0.485
LIG_LIR_Gen_1	235	245	PF02991	0.496
LIG_LIR_Gen_1	289	299	PF02991	0.409
LIG_LIR_Gen_1	347	357	PF02991	0.436
LIG_LIR_Gen_1	414	423	PF02991	0.419
LIG_LIR_LC3C_4	564	568	PF02991	0.504
LIG_LIR_Nem_3	105	111	PF02991	0.350
LIG_LIR_Nem_3	118	123	PF02991	0.462
LIG_LIR_Nem_3	16	22	PF02991	0.492
LIG_LIR_Nem_3	168	173	PF02991	0.373
LIG_LIR_Nem_3	235	240	PF02991	0.505
LIG_LIR_Nem_3	289	295	PF02991	0.412
LIG_LIR_Nem_3	330	335	PF02991	0.414
LIG_LIR_Nem_3	347	352	PF02991	0.354
LIG_LIR_Nem_3	414	419	PF02991	0.368
LIG_LIR_Nem_3	463	469	PF02991	0.506
LIG_LIR_Nem_3	486	492	PF02991	0.496
LIG_LIR_Nem_3	504	510	PF02991	0.460
LIG_LIR_Nem_3	56	62	PF02991	0.358
LIG_NRBOX	294	300	PF00104	0.481
LIG_PCNA_PIPBox_1	109	118	PF02747	0.432
LIG_PCNA_PIPBox_1	230	239	PF02747	0.428
LIG_PCNA_PIPBox_1	86	95	PF02747	0.479
LIG_PCNA_yPIPBox_3	85	93	PF02747	0.480
LIG_Pex14_2	185	189	PF04695	0.501
LIG_SH2_CRK	108	112	PF00017	0.427
LIG_SH2_CRK	170	174	PF00017	0.353
LIG_SH2_CRK	335	339	PF00017	0.477
LIG_SH2_GRB2like	507	510	PF00017	0.514
LIG_SH2_NCK_1	489	493	PF00017	0.480
LIG_SH2_PTP2	237	240	PF00017	0.419
LIG_SH2_SRC	489	492	PF00017	0.482
LIG_SH2_SRC	62	65	PF00017	0.504
LIG_SH2_STAP1	356	360	PF00017	0.360
LIG_SH2_STAP1	62	66	PF00017	0.503
LIG_SH2_STAT5	237	240	PF00017	0.403
LIG_SH2_STAT5	332	335	PF00017	0.415
LIG_SH2_STAT5	510	513	PF00017	0.459
LIG_SH2_STAT5	531	534	PF00017	0.374
LIG_SH3_3	322	328	PF00018	0.567
LIG_SH3_3	340	346	PF00018	0.484
LIG_SH3_3	458	464	PF00018	0.459
LIG_SH3_3	671	677	PF00018	0.529
LIG_Sin3_3	416	423	PF02671	0.501
LIG_SUMO_SIM_anti_2	197	202	PF11976	0.362
LIG_SUMO_SIM_anti_2	468	474	PF11976	0.410
LIG_SUMO_SIM_anti_2	490	496	PF11976	0.483
LIG_SUMO_SIM_anti_2	590	596	PF11976	0.548
LIG_SUMO_SIM_par_1	131	136	PF11976	0.494
LIG_SUMO_SIM_par_1	190	197	PF11976	0.492
LIG_SUMO_SIM_par_1	46	52	PF11976	0.442
LIG_SUMO_SIM_par_1	468	474	PF11976	0.495
LIG_TRAF2_1	13	16	PF00917	0.648
LIG_TRAF2_1	225	228	PF00917	0.545
LIG_TRAF2_1	600	603	PF00917	0.608
LIG_UBA3_1	398	406	PF00899	0.493
LIG_UBA3_1	549	555	PF00899	0.466
LIG_WRC_WIRS_1	73	78	PF05994	0.510
MOD_CDK_SPxxK_3	418	425	PF00069	0.503
MOD_CK1_1	187	193	PF00069	0.498
MOD_CK1_1	202	208	PF00069	0.355
MOD_CK1_1	327	333	PF00069	0.496
MOD_CK1_1	40	46	PF00069	0.379
MOD_CK1_1	460	466	PF00069	0.451
MOD_CK1_1	65	71	PF00069	0.493
MOD_CK1_1	690	696	PF00069	0.758
MOD_CK1_1	698	704	PF00069	0.735
MOD_CK2_1	115	121	PF00069	0.472
MOD_CK2_1	222	228	PF00069	0.491
MOD_CK2_1	371	377	PF00069	0.333
MOD_CK2_1	477	483	PF00069	0.394
MOD_CK2_1	484	490	PF00069	0.491
MOD_CK2_1	598	604	PF00069	0.569
MOD_GlcNHglycan	188	192	PF01048	0.292
MOD_GlcNHglycan	260	263	PF01048	0.459
MOD_GlcNHglycan	546	549	PF01048	0.505
MOD_GlcNHglycan	64	67	PF01048	0.448
MOD_GlcNHglycan	691	695	PF01048	0.834
MOD_GSK3_1	199	206	PF00069	0.389
MOD_GSK3_1	232	239	PF00069	0.426
MOD_GSK3_1	301	308	PF00069	0.406
MOD_GSK3_1	367	374	PF00069	0.334
MOD_GSK3_1	683	690	PF00069	0.776
MOD_GSK3_1	694	701	PF00069	0.743
MOD_N-GLC_1	202	207	PF02516	0.388
MOD_NEK2_1	189	194	PF00069	0.445
MOD_NEK2_1	236	241	PF00069	0.485
MOD_NEK2_1	298	303	PF00069	0.347
MOD_NEK2_1	371	376	PF00069	0.326
MOD_NEK2_1	381	386	PF00069	0.363
MOD_NEK2_1	477	482	PF00069	0.393
MOD_NEK2_1	53	58	PF00069	0.364
MOD_NEK2_1	6	11	PF00069	0.625
MOD_NEK2_1	702	707	PF00069	0.758
MOD_NEK2_1	72	77	PF00069	0.410
MOD_PIKK_1	598	604	PF00454	0.606
MOD_PIKK_1	616	622	PF00454	0.657
MOD_PIKK_1	7	13	PF00454	0.601
MOD_PIKK_1	74	80	PF00454	0.516
MOD_PKA_2	209	215	PF00069	0.421
MOD_PKA_2	367	373	PF00069	0.334
MOD_PKA_2	484	490	PF00069	0.367
MOD_Plk_1	202	208	PF00069	0.380
MOD_Plk_1	24	30	PF00069	0.395
MOD_Plk_1	281	287	PF00069	0.388
MOD_Plk_1	40	46	PF00069	0.457
MOD_Plk_1	477	483	PF00069	0.405
MOD_Plk_2-3	631	637	PF00069	0.714
MOD_Plk_4	189	195	PF00069	0.421
MOD_Plk_4	232	238	PF00069	0.465
MOD_Plk_4	355	361	PF00069	0.373
MOD_Plk_4	465	471	PF00069	0.386
MOD_Plk_4	477	483	PF00069	0.431
MOD_Plk_4	510	516	PF00069	0.399
MOD_Plk_4	695	701	PF00069	0.635
MOD_ProDKin_1	305	311	PF00069	0.386
MOD_ProDKin_1	324	330	PF00069	0.555
MOD_ProDKin_1	418	424	PF00069	0.507
MOD_ProDKin_1	457	463	PF00069	0.486
MOD_ProDKin_1	648	654	PF00069	0.801
TRG_DiLeu_BaEn_1	377	382	PF01217	0.488
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.475
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.367
TRG_DiLeu_BaLyEn_6	427	432	PF01217	0.365
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.360
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.383
TRG_ENDOCYTIC_2	108	111	PF00928	0.338
TRG_ENDOCYTIC_2	170	173	PF00928	0.360
TRG_ENDOCYTIC_2	237	240	PF00928	0.423
TRG_ENDOCYTIC_2	292	295	PF00928	0.371
TRG_ENDOCYTIC_2	356	359	PF00928	0.363
TRG_ENDOCYTIC_2	489	492	PF00928	0.480
TRG_ER_diArg_1	209	211	PF00400	0.499
TRG_ER_diArg_1	287	290	PF00400	0.512
TRG_ER_diArg_1	442	445	PF00400	0.378
TRG_ER_diArg_1	523	526	PF00400	0.456
TRG_NES_CRM1_1	26	39	PF08389	0.514
TRG_NES_CRM1_1	426	440	PF08389	0.393
TRG_NES_CRM1_1	90	102	PF08389	0.442
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHR7	Leptomonas seymouri	86%	97%
A0A0S4J1S0	Bodo saltans	55%	100%
A0A1X0P6U3	Trypanosomatidae	58%	100%
A0A3R7KDP1	Trypanosoma rangeli	56%	100%
A0A3S7WUV3	Leishmania donovani	97%	100%
A4H9H6	Leishmania braziliensis	92%	100%
A4HXU2	Leishmania infantum	97%	100%
C9ZZW6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
P30153	Homo sapiens	21%	100%
P30154	Homo sapiens	21%	100%
P36179	Drosophila melanogaster	22%	100%
P54612	Sus scrofa	21%	100%
P54613	Sus scrofa	21%	100%
Q32PI5	Bos taurus	21%	100%
Q38950	Arabidopsis thaliana	22%	100%
Q4QDX5	Leishmania major	97%	100%
Q4QQT4	Rattus norvegicus	20%	100%
Q54QR9	Dictyostelium discoideum	24%	100%
Q6NUP7	Homo sapiens	20%	81%
Q76MZ3	Mus musculus	21%	100%
V5DN32	Trypanosoma cruzi	55%	100%