RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zn-finger in Ran binding protein and others/FYVE zinc finger, putative

Species:

Leishmania mexicana

UniProt:

E9ARJ8_LEIMU

TriTrypDb:

LmxM.18.0600

Length:

636

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARJ8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	492	496	PF00656	0.574
CLV_NRD_NRD_1	249	251	PF00675	0.469
CLV_NRD_NRD_1	260	262	PF00675	0.492
CLV_NRD_NRD_1	519	521	PF00675	0.321
CLV_NRD_NRD_1	581	583	PF00675	0.321
CLV_NRD_NRD_1	624	626	PF00675	0.451
CLV_NRD_NRD_1	631	633	PF00675	0.594
CLV_PCSK_FUR_1	247	251	PF00082	0.467
CLV_PCSK_KEX2_1	249	251	PF00082	0.468
CLV_PCSK_KEX2_1	529	531	PF00082	0.365
CLV_PCSK_KEX2_1	581	583	PF00082	0.321
CLV_PCSK_KEX2_1	631	633	PF00082	0.609
CLV_PCSK_PC1ET2_1	529	531	PF00082	0.365
DEG_APCC_DBOX_1	238	246	PF00400	0.474
DEG_APCC_DBOX_1	276	284	PF00400	0.321
DEG_MDM2_SWIB_1	382	390	PF02201	0.464
DEG_Nend_UBRbox_3	1	3	PF02207	0.637
DEG_SCF_FBW7_1	377	384	PF00400	0.478
DEG_SPOP_SBC_1	120	124	PF00917	0.671
DEG_SPOP_SBC_1	359	363	PF00917	0.495
DOC_CYCLIN_RxL_1	244	257	PF00134	0.508
DOC_MAPK_gen_1	244	254	PF00069	0.504
DOC_PP4_FxxP_1	514	517	PF00568	0.321
DOC_PP4_MxPP_1	131	134	PF00568	0.578
DOC_USP7_MATH_1	120	124	PF00917	0.719
DOC_USP7_MATH_1	200	204	PF00917	0.689
DOC_USP7_MATH_1	228	232	PF00917	0.674
DOC_USP7_MATH_1	351	355	PF00917	0.478
DOC_USP7_MATH_1	360	364	PF00917	0.616
DOC_USP7_MATH_1	432	436	PF00917	0.658
DOC_USP7_MATH_1	462	466	PF00917	0.321
DOC_USP7_MATH_1	594	598	PF00917	0.321
DOC_USP7_MATH_1	71	75	PF00917	0.658
DOC_USP7_UBL2_3	399	403	PF12436	0.544
DOC_USP7_UBL2_3	476	480	PF12436	0.581
DOC_WW_Pin1_4	107	112	PF00397	0.709
DOC_WW_Pin1_4	113	118	PF00397	0.643
DOC_WW_Pin1_4	125	130	PF00397	0.553
DOC_WW_Pin1_4	205	210	PF00397	0.637
DOC_WW_Pin1_4	316	321	PF00397	0.797
DOC_WW_Pin1_4	377	382	PF00397	0.467
LIG_14-3-3_CanoR_1	292	298	PF00244	0.511
LIG_BRCT_BRCA1_1	117	121	PF00533	0.512
LIG_FHA_1	414	420	PF00498	0.658
LIG_FHA_1	575	581	PF00498	0.411
LIG_LIR_Apic_2	268	272	PF02991	0.358
LIG_LIR_Apic_2	511	517	PF02991	0.321
LIG_LIR_Apic_2	597	602	PF02991	0.411
LIG_LIR_Gen_1	48	56	PF02991	0.732
LIG_LIR_Gen_1	574	580	PF02991	0.411
LIG_LIR_Nem_3	154	158	PF02991	0.518
LIG_LIR_Nem_3	22	28	PF02991	0.537
LIG_LIR_Nem_3	48	52	PF02991	0.636
LIG_LIR_Nem_3	574	579	PF02991	0.321
LIG_LYPXL_S_1	157	161	PF13949	0.513
LIG_LYPXL_yS_3	158	161	PF13949	0.660
LIG_Pex14_2	382	386	PF04695	0.465
LIG_PTB_Apo_2	376	383	PF02174	0.495
LIG_SH2_CRK	295	299	PF00017	0.548
LIG_SH2_CRK	49	53	PF00017	0.640
LIG_SH2_CRK	599	603	PF00017	0.411
LIG_SH2_CRK	99	103	PF00017	0.641
LIG_SH2_NCK_1	295	299	PF00017	0.548
LIG_SH2_NCK_1	56	60	PF00017	0.722
LIG_SH2_PTP2	181	184	PF00017	0.593
LIG_SH2_PTP2	5	8	PF00017	0.588
LIG_SH2_STAP1	534	538	PF00017	0.565
LIG_SH2_STAT5	181	184	PF00017	0.593
LIG_SH2_STAT5	295	298	PF00017	0.535
LIG_SH2_STAT5	5	8	PF00017	0.566
LIG_SH2_STAT5	590	593	PF00017	0.321
LIG_SH3_1	5	11	PF00018	0.616
LIG_SH3_3	156	162	PF00018	0.651
LIG_SH3_3	165	171	PF00018	0.713
LIG_SH3_3	186	192	PF00018	0.539
LIG_SH3_3	212	218	PF00018	0.643
LIG_SH3_3	3	9	PF00018	0.638
LIG_SH3_3	38	44	PF00018	0.683
LIG_SH3_3	391	397	PF00018	0.430
LIG_SH3_3	416	422	PF00018	0.797
LIG_SH3_3	435	441	PF00018	0.458
LIG_SxIP_EBH_1	353	363	PF03271	0.598
LIG_TRAF2_1	233	236	PF00917	0.595
LIG_TRAF2_1	547	550	PF00917	0.630
LIG_WRC_WIRS_1	448	453	PF05994	0.321
LIG_WW_1	46	49	PF00397	0.616
LIG_WW_2	438	441	PF00397	0.566
MOD_CK1_1	115	121	PF00069	0.643
MOD_CK1_1	122	128	PF00069	0.721
MOD_CK1_1	15	21	PF00069	0.735
MOD_CK1_1	203	209	PF00069	0.613
MOD_CK1_1	316	322	PF00069	0.676
MOD_CK1_1	423	429	PF00069	0.646
MOD_CK1_1	447	453	PF00069	0.321
MOD_CK1_1	489	495	PF00069	0.679
MOD_CK1_1	502	508	PF00069	0.373
MOD_CK1_1	597	603	PF00069	0.411
MOD_CK2_1	230	236	PF00069	0.625
MOD_CK2_1	562	568	PF00069	0.321
MOD_Cter_Amidation	518	521	PF01082	0.321
MOD_GlcNHglycan	107	110	PF01048	0.670
MOD_GlcNHglycan	209	212	PF01048	0.720
MOD_GlcNHglycan	225	228	PF01048	0.518
MOD_GlcNHglycan	232	235	PF01048	0.539
MOD_GlcNHglycan	315	318	PF01048	0.592
MOD_GlcNHglycan	354	357	PF01048	0.630
MOD_GlcNHglycan	364	367	PF01048	0.633
MOD_GlcNHglycan	373	376	PF01048	0.617
MOD_GlcNHglycan	405	408	PF01048	0.503
MOD_GlcNHglycan	425	428	PF01048	0.493
MOD_GlcNHglycan	434	437	PF01048	0.739
MOD_GlcNHglycan	455	458	PF01048	0.321
MOD_GlcNHglycan	464	467	PF01048	0.511
MOD_GlcNHglycan	482	485	PF01048	0.641
MOD_GlcNHglycan	491	494	PF01048	0.669
MOD_GlcNHglycan	57	60	PF01048	0.716
MOD_GlcNHglycan	79	82	PF01048	0.713
MOD_GSK3_1	115	122	PF00069	0.670
MOD_GSK3_1	201	208	PF00069	0.718
MOD_GSK3_1	293	300	PF00069	0.522
MOD_GSK3_1	358	365	PF00069	0.605
MOD_GSK3_1	371	378	PF00069	0.702
MOD_GSK3_1	413	420	PF00069	0.494
MOD_GSK3_1	447	454	PF00069	0.390
MOD_GSK3_1	489	496	PF00069	0.624
MOD_GSK3_1	498	505	PF00069	0.599
MOD_GSK3_1	597	604	PF00069	0.330
MOD_GSK3_1	77	84	PF00069	0.676
MOD_N-GLC_1	201	206	PF02516	0.586
MOD_N-GLC_1	371	376	PF02516	0.505
MOD_N-GLC_1	410	415	PF02516	0.488
MOD_N-GLC_1	597	602	PF02516	0.344
MOD_N-GLC_1	77	82	PF02516	0.720
MOD_N-GLC_2	570	572	PF02516	0.321
MOD_NEK2_1	121	126	PF00069	0.620
MOD_NEK2_1	287	292	PF00069	0.321
MOD_NEK2_1	451	456	PF00069	0.375
MOD_NEK2_2	272	277	PF00069	0.299
MOD_NEK2_2	81	86	PF00069	0.734
MOD_PIKK_1	115	121	PF00454	0.512
MOD_PIKK_1	134	140	PF00454	0.516
MOD_PIKK_1	318	324	PF00454	0.658
MOD_PIKK_1	502	508	PF00454	0.525
MOD_PKA_1	498	504	PF00069	0.625
MOD_PKA_2	15	21	PF00069	0.735
MOD_PKA_2	352	358	PF00069	0.520
MOD_PKA_2	489	495	PF00069	0.738
MOD_PKA_2	624	630	PF00069	0.362
MOD_Plk_1	451	457	PF00069	0.411
MOD_Plk_1	562	568	PF00069	0.321
MOD_Plk_1	597	603	PF00069	0.328
MOD_Plk_1	81	87	PF00069	0.735
MOD_Plk_2-3	562	568	PF00069	0.321
MOD_Plk_4	439	445	PF00069	0.524
MOD_Plk_4	510	516	PF00069	0.321
MOD_Plk_4	81	87	PF00069	0.735
MOD_ProDKin_1	107	113	PF00069	0.709
MOD_ProDKin_1	125	131	PF00069	0.556
MOD_ProDKin_1	205	211	PF00069	0.639
MOD_ProDKin_1	316	322	PF00069	0.793
MOD_ProDKin_1	377	383	PF00069	0.493
MOD_SUMO_for_1	283	286	PF00179	0.321
MOD_SUMO_for_1	547	550	PF00179	0.630
MOD_SUMO_rev_2	492	501	PF00179	0.710
MOD_SUMO_rev_2	622	627	PF00179	0.453
TRG_DiLeu_BaEn_4	235	241	PF01217	0.579
TRG_ENDOCYTIC_2	158	161	PF00928	0.660
TRG_ENDOCYTIC_2	49	52	PF00928	0.637
TRG_ER_diArg_1	246	249	PF00400	0.467
TRG_ER_diArg_1	580	582	PF00400	0.411
TRG_ER_diArg_1	631	633	PF00400	0.609
TRG_NES_CRM1_1	243	257	PF08389	0.507
TRG_NLS_MonoExtC_3	627	632	PF00514	0.585
TRG_NLS_MonoExtN_4	625	632	PF00514	0.578
TRG_Pf-PMV_PEXEL_1	250	255	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2D5	Leptomonas seymouri	55%	100%
A0A3Q8I9Y5	Leishmania donovani	89%	100%
A4H9G8	Leishmania braziliensis	78%	99%
A4HXT6	Leishmania infantum	89%	100%
Q4QDY1	Leishmania major	89%	98%