Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9ARJ6_LEIMU

TriTrypDb:

LmxM.18.0590

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9ARJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARJ6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	359	363	PF00656	0.590
CLV_PCSK_SKI1_1	197	201	PF00082	0.269
CLV_PCSK_SKI1_1	3	7	PF00082	0.607
DEG_Nend_UBRbox_2	1	3	PF02207	0.662
DOC_CKS1_1	113	118	PF01111	0.643
DOC_CKS1_1	150	155	PF01111	0.661
DOC_CKS1_1	156	161	PF01111	0.601
DOC_CKS1_1	296	301	PF01111	0.640
DOC_CKS1_1	396	401	PF01111	0.630
DOC_PP1_RVXF_1	252	258	PF00149	0.433
DOC_PP4_FxxP_1	257	260	PF00568	0.471
DOC_USP7_MATH_1	104	108	PF00917	0.650
DOC_USP7_MATH_1	129	133	PF00917	0.619
DOC_USP7_MATH_1	258	262	PF00917	0.562
DOC_USP7_MATH_1	271	275	PF00917	0.452
DOC_USP7_MATH_1	332	336	PF00917	0.598
DOC_USP7_MATH_1	5	9	PF00917	0.612
DOC_USP7_MATH_1	69	73	PF00917	0.790
DOC_WW_Pin1_4	112	117	PF00397	0.651
DOC_WW_Pin1_4	144	149	PF00397	0.628
DOC_WW_Pin1_4	155	160	PF00397	0.623
DOC_WW_Pin1_4	295	300	PF00397	0.779
DOC_WW_Pin1_4	314	319	PF00397	0.562
DOC_WW_Pin1_4	323	328	PF00397	0.694
DOC_WW_Pin1_4	34	39	PF00397	0.678
DOC_WW_Pin1_4	374	379	PF00397	0.599
DOC_WW_Pin1_4	395	400	PF00397	0.632
DOC_WW_Pin1_4	62	67	PF00397	0.684
LIG_14-3-3_CanoR_1	140	148	PF00244	0.712
LIG_14-3-3_CanoR_1	3	12	PF00244	0.615
LIG_BRCT_BRCA1_1	107	111	PF00533	0.627
LIG_BRCT_BRCA1_1	179	183	PF00533	0.459
LIG_BRCT_BRCA1_1	92	96	PF00533	0.663
LIG_FHA_1	152	158	PF00498	0.630
LIG_FHA_1	248	254	PF00498	0.463
LIG_FHA_1	260	266	PF00498	0.531
LIG_FHA_2	203	209	PF00498	0.484
LIG_FHA_2	357	363	PF00498	0.593
LIG_Integrin_isoDGR_2	216	218	PF01839	0.269
LIG_LIR_Apic_2	295	299	PF02991	0.642
LIG_LIR_Apic_2	61	66	PF02991	0.620
LIG_LIR_Nem_3	10	15	PF02991	0.506
LIG_LIR_Nem_3	222	227	PF02991	0.469
LIG_LIR_Nem_3	93	99	PF02991	0.594
LIG_MLH1_MIPbox_1	108	112	PF16413	0.640
LIG_SH2_CRK	113	117	PF00017	0.580
LIG_SH2_CRK	12	16	PF00017	0.512
LIG_SH2_CRK	296	300	PF00017	0.642
LIG_SH2_CRK	63	67	PF00017	0.618
LIG_SH2_GRB2like	12	15	PF00017	0.630
LIG_SH2_NCK_1	113	117	PF00017	0.645
LIG_SH2_NCK_1	12	16	PF00017	0.676
LIG_SH2_NCK_1	290	294	PF00017	0.622
LIG_SH2_NCK_1	296	300	PF00017	0.554
LIG_SH2_NCK_1	353	357	PF00017	0.582
LIG_SH2_NCK_1	63	67	PF00017	0.577
LIG_SH2_STAP1	290	294	PF00017	0.598
LIG_SH2_STAT5	32	35	PF00017	0.643
LIG_SH2_STAT5	342	345	PF00017	0.579
LIG_SH2_STAT5	385	388	PF00017	0.583
LIG_SH2_STAT5	397	400	PF00017	0.565
LIG_SH3_3	145	151	PF00018	0.635
LIG_SH3_3	242	248	PF00018	0.593
LIG_SH3_3	278	284	PF00018	0.640
LIG_SH3_3	409	415	PF00018	0.688
LIG_UBA3_1	206	210	PF00899	0.469
MOD_CK1_1	10	16	PF00069	0.651
MOD_CK1_1	105	111	PF00069	0.560
MOD_CK1_1	114	120	PF00069	0.634
MOD_CK1_1	219	225	PF00069	0.469
MOD_CK1_1	31	37	PF00069	0.636
MOD_CK1_1	345	351	PF00069	0.587
MOD_CK1_1	354	360	PF00069	0.549
MOD_CK1_1	55	61	PF00069	0.619
MOD_CK1_1	90	96	PF00069	0.663
MOD_CK2_1	202	208	PF00069	0.516
MOD_GlcNHglycan	104	107	PF01048	0.605
MOD_GlcNHglycan	108	111	PF01048	0.656
MOD_GlcNHglycan	116	119	PF01048	0.567
MOD_GlcNHglycan	127	130	PF01048	0.721
MOD_GlcNHglycan	170	173	PF01048	0.510
MOD_GlcNHglycan	221	224	PF01048	0.269
MOD_GlcNHglycan	230	234	PF01048	0.269
MOD_GlcNHglycan	269	272	PF01048	0.575
MOD_GlcNHglycan	278	281	PF01048	0.509
MOD_GlcNHglycan	334	337	PF01048	0.571
MOD_GlcNHglycan	347	350	PF01048	0.520
MOD_GlcNHglycan	38	41	PF01048	0.531
MOD_GlcNHglycan	92	95	PF01048	0.650
MOD_GSK3_1	102	109	PF00069	0.476
MOD_GSK3_1	125	132	PF00069	0.659
MOD_GSK3_1	140	147	PF00069	0.535
MOD_GSK3_1	151	158	PF00069	0.646
MOD_GSK3_1	17	24	PF00069	0.555
MOD_GSK3_1	267	274	PF00069	0.533
MOD_GSK3_1	27	34	PF00069	0.677
MOD_GSK3_1	3	10	PF00069	0.625
MOD_GSK3_1	351	358	PF00069	0.550
MOD_GSK3_1	58	65	PF00069	0.632
MOD_GSK3_1	85	92	PF00069	0.663
MOD_N-GLC_1	17	22	PF02516	0.761
MOD_N-GLC_1	34	39	PF02516	0.474
MOD_N-GLC_1	345	350	PF02516	0.460
MOD_N-GLC_1	46	51	PF02516	0.549
MOD_N-GLC_1	85	90	PF02516	0.664
MOD_NEK2_1	111	116	PF00069	0.668
MOD_NEK2_1	229	234	PF00069	0.484
MOD_NEK2_1	351	356	PF00069	0.566
MOD_NEK2_1	402	407	PF00069	0.783
MOD_NEK2_1	87	92	PF00069	0.664
MOD_PIKK_1	146	152	PF00454	0.601
MOD_PIKK_1	5	11	PF00454	0.588
MOD_PIKK_1	64	70	PF00454	0.618
MOD_PIKK_1	85	91	PF00454	0.620
MOD_Plk_4	202	208	PF00069	0.516
MOD_Plk_4	271	277	PF00069	0.618
MOD_Plk_4	28	34	PF00069	0.665
MOD_Plk_4	58	64	PF00069	0.611
MOD_Plk_4	7	13	PF00069	0.746
MOD_ProDKin_1	112	118	PF00069	0.649
MOD_ProDKin_1	144	150	PF00069	0.628
MOD_ProDKin_1	155	161	PF00069	0.618
MOD_ProDKin_1	295	301	PF00069	0.777
MOD_ProDKin_1	314	320	PF00069	0.562
MOD_ProDKin_1	323	329	PF00069	0.693
MOD_ProDKin_1	34	40	PF00069	0.681
MOD_ProDKin_1	374	380	PF00069	0.601
MOD_ProDKin_1	395	401	PF00069	0.632
MOD_ProDKin_1	62	68	PF00069	0.687
TRG_ENDOCYTIC_2	12	15	PF00928	0.510
TRG_Pf-PMV_PEXEL_1	197	202	PF00026	0.269

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Z4	Leptomonas seymouri	48%	86%
A0A3S7WUU6	Leishmania donovani	92%	100%
A4H9G7	Leishmania braziliensis	78%	100%
A4HXT4	Leishmania infantum	92%	100%
Q4QDY3	Leishmania major	93%	99%