V-type proton ATPase subunit C

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar ATP synthase subunit c, putative

Species:

Leishmania mexicana

UniProt:

E9ARJ3_LEIMU

TriTrypDb:

LmxM.18.0560

Length:

380

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	12
GO:0033180	proton-transporting V-type ATPase, V1 domain	4	12
GO:0098796	membrane protein complex	2	12
GO:0000221	vacuolar proton-transporting V-type ATPase, V1 domain	5	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARJ3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0005215	transporter activity	1	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015078	proton transmembrane transporter activity	5	12
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	12
GO:0015399	primary active transmembrane transporter activity	4	12
GO:0016787	hydrolase activity	2	8
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	3	12
GO:0022804	active transmembrane transporter activity	3	12
GO:0022853	active monoatomic ion transmembrane transporter activity	4	12
GO:0022857	transmembrane transporter activity	2	12
GO:0022890	inorganic cation transmembrane transporter activity	4	12
GO:0042625	ATPase-coupled ion transmembrane transporter activity	3	12
GO:0042626	ATPase-coupled transmembrane transporter activity	2	12
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	4	12
GO:0046961	proton-transporting ATPase activity, rotational mechanism	4	12
GO:0140657	ATP-dependent activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	160	162	PF00675	0.317
CLV_NRD_NRD_1	240	242	PF00675	0.311
CLV_NRD_NRD_1	251	253	PF00675	0.284
CLV_NRD_NRD_1	338	340	PF00675	0.319
CLV_PCSK_FUR_1	252	256	PF00082	0.317
CLV_PCSK_KEX2_1	254	256	PF00082	0.314
CLV_PCSK_KEX2_1	340	342	PF00082	0.402
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.303
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.402
CLV_PCSK_SKI1_1	109	113	PF00082	0.336
CLV_PCSK_SKI1_1	143	147	PF00082	0.302
CLV_PCSK_SKI1_1	283	287	PF00082	0.322
CLV_PCSK_SKI1_1	40	44	PF00082	0.420
DOC_CDC14_PxL_1	7	15	PF14671	0.418
DOC_CKS1_1	349	354	PF01111	0.387
DOC_MAPK_DCC_7	40	49	PF00069	0.317
DOC_MAPK_gen_1	161	169	PF00069	0.302
DOC_MAPK_gen_1	170	178	PF00069	0.302
DOC_MAPK_MEF2A_6	322	330	PF00069	0.315
DOC_MAPK_MEF2A_6	40	49	PF00069	0.317
DOC_PP2B_LxvP_1	328	331	PF13499	0.422
DOC_PP2B_LxvP_1	8	11	PF13499	0.382
DOC_PP4_FxxP_1	317	320	PF00568	0.387
DOC_PP4_FxxP_1	42	45	PF00568	0.302
DOC_USP7_MATH_1	19	23	PF00917	0.291
DOC_USP7_MATH_1	369	373	PF00917	0.360
DOC_WW_Pin1_4	348	353	PF00397	0.320
LIG_14-3-3_CanoR_1	133	142	PF00244	0.449
LIG_14-3-3_CanoR_1	88	96	PF00244	0.313
LIG_Actin_WH2_2	300	318	PF00022	0.302
LIG_APCC_ABBA_1	307	312	PF00400	0.302
LIG_BRCT_BRCA1_1	114	118	PF00533	0.158
LIG_deltaCOP1_diTrp_1	206	212	PF00928	0.302
LIG_FHA_1	187	193	PF00498	0.295
LIG_FHA_1	262	268	PF00498	0.422
LIG_FHA_1	294	300	PF00498	0.407
LIG_FHA_1	348	354	PF00498	0.339
LIG_FHA_1	359	365	PF00498	0.507
LIG_FHA_1	91	97	PF00498	0.422
LIG_FHA_2	135	141	PF00498	0.338
LIG_HP1_1	369	373	PF01393	0.376
LIG_LIR_Apic_2	215	220	PF02991	0.302
LIG_LIR_Gen_1	129	138	PF02991	0.392
LIG_LIR_Gen_1	182	191	PF02991	0.371
LIG_LIR_Gen_1	194	203	PF02991	0.302
LIG_LIR_Gen_1	2	13	PF02991	0.382
LIG_LIR_Gen_1	22	32	PF02991	0.118
LIG_LIR_Gen_1	367	378	PF02991	0.362
LIG_LIR_Nem_3	129	134	PF02991	0.352
LIG_LIR_Nem_3	182	186	PF02991	0.371
LIG_LIR_Nem_3	194	199	PF02991	0.302
LIG_LIR_Nem_3	2	8	PF02991	0.386
LIG_LIR_Nem_3	22	28	PF02991	0.118
LIG_LIR_Nem_3	288	294	PF02991	0.310
LIG_LIR_Nem_3	367	373	PF02991	0.372
LIG_LIR_Nem_3	38	42	PF02991	0.264
LIG_LYPXL_S_1	345	349	PF13949	0.317
LIG_LYPXL_yS_3	346	349	PF13949	0.317
LIG_LYPXL_yS_3	368	371	PF13949	0.412
LIG_MYND_1	11	15	PF01753	0.275
LIG_NRBOX	285	291	PF00104	0.387
LIG_Pex14_1	207	211	PF04695	0.302
LIG_Pex14_2	39	43	PF04695	0.371
LIG_PTB_Apo_2	177	184	PF02174	0.274
LIG_PTB_Phospho_1	177	183	PF10480	0.274
LIG_SH2_PTP2	217	220	PF00017	0.422
LIG_SH2_PTP2	370	373	PF00017	0.334
LIG_SH2_STAP1	25	29	PF00017	0.422
LIG_SH2_STAP1	287	291	PF00017	0.300
LIG_SH2_STAT5	107	110	PF00017	0.317
LIG_SH2_STAT5	12	15	PF00017	0.542
LIG_SH2_STAT5	149	152	PF00017	0.371
LIG_SH2_STAT5	217	220	PF00017	0.381
LIG_SH2_STAT5	232	235	PF00017	0.304
LIG_SH2_STAT5	287	290	PF00017	0.308
LIG_SH2_STAT5	294	297	PF00017	0.301
LIG_SH2_STAT5	298	301	PF00017	0.291
LIG_SH2_STAT5	370	373	PF00017	0.334
LIG_SH3_3	194	200	PF00018	0.336
LIG_TRFH_1	317	321	PF08558	0.302
LIG_WRC_WIRS_1	91	96	PF05994	0.422
LIG_WW_3	319	323	PF00397	0.302
MOD_CK1_1	89	95	PF00069	0.336
MOD_CK2_1	134	140	PF00069	0.318
MOD_CK2_1	265	271	PF00069	0.306
MOD_CK2_1	51	57	PF00069	0.302
MOD_GlcNHglycan	103	106	PF01048	0.385
MOD_GlcNHglycan	114	117	PF01048	0.228
MOD_GlcNHglycan	21	24	PF01048	0.493
MOD_GlcNHglycan	268	271	PF01048	0.431
MOD_GlcNHglycan	81	86	PF01048	0.404
MOD_GSK3_1	261	268	PF00069	0.387
MOD_GSK3_1	369	376	PF00069	0.381
MOD_GSK3_1	86	93	PF00069	0.347
MOD_GSK3_1	96	103	PF00069	0.250
MOD_N-GLC_1	134	139	PF02516	0.405
MOD_N-GLC_1	165	170	PF02516	0.316
MOD_N-GLC_1	96	101	PF02516	0.316
MOD_NEK2_1	1	6	PF00069	0.532
MOD_NEK2_1	111	116	PF00069	0.316
MOD_NEK2_1	191	196	PF00069	0.302
MOD_NEK2_1	35	40	PF00069	0.449
MOD_NEK2_1	373	378	PF00069	0.413
MOD_NEK2_1	80	85	PF00069	0.312
MOD_NEK2_2	165	170	PF00069	0.336
MOD_NEK2_2	369	374	PF00069	0.367
MOD_PIKK_1	13	19	PF00454	0.517
MOD_PIKK_1	96	102	PF00454	0.359
MOD_PK_1	86	92	PF00069	0.320
MOD_Plk_1	165	171	PF00069	0.317
MOD_Plk_4	1	7	PF00069	0.509
MOD_Plk_4	191	197	PF00069	0.352
MOD_Plk_4	207	213	PF00069	0.219
MOD_Plk_4	233	239	PF00069	0.311
MOD_Plk_4	285	291	PF00069	0.317
MOD_Plk_4	51	57	PF00069	0.302
MOD_ProDKin_1	348	354	PF00069	0.320
MOD_SUMO_rev_2	114	123	PF00179	0.422
MOD_SUMO_rev_2	245	250	PF00179	0.317
MOD_SUMO_rev_2	280	286	PF00179	0.374
TRG_ENDOCYTIC_2	183	186	PF00928	0.371
TRG_ENDOCYTIC_2	211	214	PF00928	0.302
TRG_ENDOCYTIC_2	25	28	PF00928	0.387
TRG_ENDOCYTIC_2	287	290	PF00928	0.336
TRG_ENDOCYTIC_2	346	349	PF00928	0.317
TRG_ENDOCYTIC_2	368	371	PF00928	0.367
TRG_ER_diArg_1	141	144	PF00400	0.314
TRG_ER_diArg_1	338	341	PF00400	0.422
TRG_NES_CRM1_1	190	204	PF08389	0.294
TRG_NLS_Bipartite_1	241	257	PF00514	0.302
TRG_NLS_MonoCore_2	251	256	PF00514	0.317
TRG_NLS_MonoExtN_4	252	257	PF00514	0.302
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2N6	Leptomonas seymouri	86%	100%
A0A0S4IV71	Bodo saltans	53%	90%
A0A1X0P723	Trypanosomatidae	69%	100%
A0A3S5IRA4	Trypanosoma rangeli	64%	100%
A0A3S7WV19	Leishmania donovani	97%	92%
A4H9G4	Leishmania braziliensis	90%	100%
A4HXT1	Leishmania infantum	97%	92%
D0A063	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
P21282	Bos taurus	30%	99%
P21283	Homo sapiens	30%	99%
P31412	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	97%
P54648	Dictyostelium discoideum	27%	100%
Q4QDY6	Leishmania major	94%	100%
Q4R5H9	Macaca fascicularis	30%	99%
Q5FVI6	Rattus norvegicus	29%	99%
Q5RDQ7	Pongo abelii	30%	99%
Q5XH14	Xenopus laevis	31%	99%
Q5XIY6	Danio rerio	31%	100%
Q612A4	Caenorhabditis briggsae	28%	99%
Q6P4Y9	Xenopus tropicalis	30%	99%
Q7T385	Danio rerio	28%	99%
Q9HDW6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	96%
Q9NDR5	Ascidia sydneiensis samea	31%	99%
Q9SCB9	Hordeum vulgare	28%	100%
Q9SDS7	Arabidopsis thaliana	29%	100%
Q9U5N1	Manduca sexta	28%	99%
Q9XXU9	Caenorhabditis elegans	28%	99%
Q9Z1G3	Mus musculus	30%	99%
V5B6H3	Trypanosoma cruzi	68%	100%