Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARJ2_LEIMU

TriTrypDb:

LmxM.18.0550

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 4, no: 6
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARJ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.565
CLV_C14_Caspase3-7	35	39	PF00656	0.437
CLV_NRD_NRD_1	299	301	PF00675	0.540
CLV_NRD_NRD_1	303	305	PF00675	0.541
CLV_NRD_NRD_1	308	310	PF00675	0.470
CLV_NRD_NRD_1	338	340	PF00675	0.605
CLV_NRD_NRD_1	41	43	PF00675	0.506
CLV_PCSK_FUR_1	300	304	PF00082	0.575
CLV_PCSK_KEX2_1	233	235	PF00082	0.652
CLV_PCSK_KEX2_1	299	301	PF00082	0.524
CLV_PCSK_KEX2_1	302	304	PF00082	0.527
CLV_PCSK_KEX2_1	338	340	PF00082	0.605
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.652
CLV_PCSK_PC7_1	299	305	PF00082	0.532
CLV_PCSK_SKI1_1	233	237	PF00082	0.633
CLV_PCSK_SKI1_1	312	316	PF00082	0.495
CLV_PCSK_SKI1_1	322	326	PF00082	0.539
CLV_PCSK_SKI1_1	349	353	PF00082	0.506
DEG_APCC_DBOX_1	250	258	PF00400	0.650
DEG_APCC_KENBOX_2	42	46	PF00400	0.451
DEG_Nend_UBRbox_4	1	3	PF02207	0.536
DEG_SCF_FBW7_1	161	167	PF00400	0.638
DOC_CDC14_PxL_1	108	116	PF14671	0.482
DOC_CKS1_1	161	166	PF01111	0.582
DOC_CYCLIN_RxL_1	231	241	PF00134	0.575
DOC_MAPK_gen_1	232	238	PF00069	0.662
DOC_MAPK_gen_1	309	316	PF00069	0.578
DOC_MAPK_gen_1	338	347	PF00069	0.575
DOC_PP1_RVXF_1	347	354	PF00149	0.544
DOC_PP1_RVXF_1	46	53	PF00149	0.299
DOC_USP7_MATH_1	209	213	PF00917	0.754
DOC_USP7_MATH_1	227	231	PF00917	0.557
DOC_WW_Pin1_4	160	165	PF00397	0.592
DOC_WW_Pin1_4	215	220	PF00397	0.674
LIG_14-3-3_CanoR_1	128	133	PF00244	0.518
LIG_14-3-3_CanoR_1	151	159	PF00244	0.561
LIG_14-3-3_CanoR_1	213	221	PF00244	0.400
LIG_14-3-3_CanoR_1	251	255	PF00244	0.561
LIG_14-3-3_CanoR_1	312	317	PF00244	0.564
LIG_BRCT_BRCA1_1	166	170	PF00533	0.566
LIG_BRCT_BRCA1_1	343	347	PF00533	0.565
LIG_BRCT_BRCA1_2	343	349	PF00533	0.449
LIG_Clathr_ClatBox_1	254	258	PF01394	0.610
LIG_FHA_1	14	20	PF00498	0.521
LIG_FHA_1	238	244	PF00498	0.648
LIG_FHA_1	56	62	PF00498	0.467
LIG_FHA_2	313	319	PF00498	0.575
LIG_IRF3_LxIS_1	156	162	PF10401	0.361
LIG_LIR_Gen_1	218	227	PF02991	0.588
LIG_LIR_Gen_1	26	36	PF02991	0.475
LIG_LIR_Gen_1	350	356	PF02991	0.557
LIG_LIR_Gen_1	76	86	PF02991	0.526
LIG_LIR_Nem_3	139	144	PF02991	0.561
LIG_LIR_Nem_3	218	223	PF02991	0.613
LIG_LIR_Nem_3	26	32	PF02991	0.463
LIG_LIR_Nem_3	350	356	PF02991	0.574
LIG_LIR_Nem_3	76	82	PF02991	0.506
LIG_PDZ_Class_1	351	356	PF00595	0.600
LIG_REV1ctd_RIR_1	325	334	PF16727	0.549
LIG_SH2_CRK	105	109	PF00017	0.528
LIG_SH2_CRK	141	145	PF00017	0.566
LIG_SH2_CRK	29	33	PF00017	0.424
LIG_SH2_GRB2like	65	68	PF00017	0.544
LIG_SH2_NCK_1	105	109	PF00017	0.445
LIG_SH2_PTP2	79	82	PF00017	0.516
LIG_SH2_STAP1	29	33	PF00017	0.259
LIG_SH2_STAT5	141	144	PF00017	0.481
LIG_SH2_STAT5	191	194	PF00017	0.689
LIG_SH2_STAT5	65	68	PF00017	0.503
LIG_SH2_STAT5	79	82	PF00017	0.290
LIG_SH3_1	203	209	PF00018	0.681
LIG_SH3_3	16	22	PF00018	0.572
LIG_SH3_3	203	209	PF00018	0.778
LIG_SUMO_SIM_par_1	127	135	PF11976	0.568
LIG_SUMO_SIM_par_1	234	241	PF11976	0.605
LIG_TRAF2_1	113	116	PF00917	0.304
LIG_TRAF2_1	260	263	PF00917	0.614
LIG_WRC_WIRS_1	133	138	PF05994	0.574
MOD_CK1_1	131	137	PF00069	0.462
MOD_CK1_1	139	145	PF00069	0.421
MOD_CK1_1	181	187	PF00069	0.612
MOD_CK1_1	212	218	PF00069	0.681
MOD_CK1_1	253	259	PF00069	0.673
MOD_CK2_1	110	116	PF00069	0.365
MOD_CK2_1	257	263	PF00069	0.610
MOD_CK2_1	312	318	PF00069	0.593
MOD_GlcNHglycan	145	148	PF01048	0.489
MOD_GlcNHglycan	153	156	PF01048	0.521
MOD_GlcNHglycan	171	174	PF01048	0.495
MOD_GlcNHglycan	258	262	PF01048	0.685
MOD_GSK3_1	106	113	PF00069	0.510
MOD_GSK3_1	128	135	PF00069	0.457
MOD_GSK3_1	139	146	PF00069	0.401
MOD_GSK3_1	159	166	PF00069	0.571
MOD_GSK3_1	209	216	PF00069	0.691
MOD_GSK3_1	221	228	PF00069	0.557
MOD_GSK3_1	253	260	PF00069	0.634
MOD_GSK3_1	55	62	PF00069	0.463
MOD_N-GLC_1	136	141	PF02516	0.435
MOD_N-GLC_1	159	164	PF02516	0.581
MOD_N-GLC_1	181	186	PF02516	0.597
MOD_NEK2_1	136	141	PF00069	0.511
MOD_NEK2_1	159	164	PF00069	0.573
MOD_NEK2_1	221	226	PF00069	0.496
MOD_NEK2_1	81	86	PF00069	0.480
MOD_PIKK_1	59	65	PF00454	0.534
MOD_PK_1	128	134	PF00069	0.559
MOD_PKA_2	212	218	PF00069	0.430
MOD_PKA_2	245	251	PF00069	0.574
MOD_Plk_1	37	43	PF00069	0.553
MOD_Plk_4	128	134	PF00069	0.498
MOD_Plk_4	136	142	PF00069	0.530
MOD_Plk_4	250	256	PF00069	0.546
MOD_Plk_4	81	87	PF00069	0.276
MOD_ProDKin_1	160	166	PF00069	0.589
MOD_ProDKin_1	215	221	PF00069	0.667
MOD_SUMO_rev_2	228	235	PF00179	0.686
MOD_SUMO_rev_2	306	311	PF00179	0.606
MOD_SUMO_rev_2	88	94	PF00179	0.540
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.577
TRG_ENDOCYTIC_2	105	108	PF00928	0.531
TRG_ENDOCYTIC_2	141	144	PF00928	0.560
TRG_ENDOCYTIC_2	29	32	PF00928	0.491
TRG_ENDOCYTIC_2	79	82	PF00928	0.527
TRG_ER_diArg_1	298	300	PF00400	0.605
TRG_ER_diArg_1	302	304	PF00400	0.588
TRG_ER_diArg_1	337	339	PF00400	0.619
TRG_Pf-PMV_PEXEL_1	234	239	PF00026	0.563
TRG_PTS2	1	12	PF00400	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDN8	Leptomonas seymouri	47%	81%
A0A0S4J078	Bodo saltans	24%	76%
A0A1X0P6U2	Trypanosomatidae	30%	81%
A0A3S7WUV0	Leishmania donovani	89%	100%
A0A422NJ54	Trypanosoma rangeli	26%	79%
A4H9G3	Leishmania braziliensis	71%	100%
A4HXT0	Leishmania infantum	89%	100%
D0A062	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	79%
Q4QDY7	Leishmania major	86%	100%