TMEM135_C_rich domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARJ1_LEIMU

TriTrypDb:

LmxM.18.0540

Length:

511

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9ARJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARJ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.448
CLV_NRD_NRD_1	282	284	PF00675	0.367
CLV_NRD_NRD_1	351	353	PF00675	0.321
CLV_NRD_NRD_1	409	411	PF00675	0.443
CLV_NRD_NRD_1	496	498	PF00675	0.494
CLV_PCSK_KEX2_1	284	286	PF00082	0.391
CLV_PCSK_KEX2_1	351	353	PF00082	0.308
CLV_PCSK_KEX2_1	409	411	PF00082	0.443
CLV_PCSK_KEX2_1	496	498	PF00082	0.494
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.289
CLV_PCSK_SKI1_1	144	148	PF00082	0.604
CLV_PCSK_SKI1_1	260	264	PF00082	0.536
CLV_PCSK_SKI1_1	285	289	PF00082	0.380
CLV_PCSK_SKI1_1	299	303	PF00082	0.203
CLV_PCSK_SKI1_1	331	335	PF00082	0.447
CLV_PCSK_SKI1_1	365	369	PF00082	0.407
CLV_PCSK_SKI1_1	412	416	PF00082	0.394
CLV_PCSK_SKI1_1	57	61	PF00082	0.610
CLV_PCSK_SKI1_1	94	98	PF00082	0.588
DEG_APCC_DBOX_1	143	151	PF00400	0.414
DEG_APCC_DBOX_1	411	419	PF00400	0.608
DEG_APCC_DBOX_1	56	64	PF00400	0.461
DEG_APCC_DBOX_1	85	93	PF00400	0.385
DEG_Nend_UBRbox_3	1	3	PF02207	0.811
DOC_CKS1_1	95	100	PF01111	0.391
DOC_CYCLIN_RxL_1	13	26	PF00134	0.616
DOC_CYCLIN_RxL_1	410	421	PF00134	0.630
DOC_CYCLIN_yClb5_NLxxxL_5	368	377	PF00134	0.518
DOC_CYCLIN_yCln2_LP_2	269	275	PF00134	0.305
DOC_MAPK_gen_1	123	133	PF00069	0.325
DOC_MAPK_gen_1	349	357	PF00069	0.515
DOC_MAPK_gen_1	409	419	PF00069	0.637
DOC_MAPK_HePTP_8	407	419	PF00069	0.632
DOC_MAPK_MEF2A_6	126	135	PF00069	0.299
DOC_MAPK_MEF2A_6	24	31	PF00069	0.606
DOC_MAPK_MEF2A_6	260	269	PF00069	0.278
DOC_MAPK_MEF2A_6	349	357	PF00069	0.526
DOC_MAPK_MEF2A_6	410	419	PF00069	0.635
DOC_MAPK_NFAT4_5	126	134	PF00069	0.317
DOC_MAPK_NFAT4_5	412	420	PF00069	0.638
DOC_USP7_MATH_1	335	339	PF00917	0.415
DOC_USP7_MATH_1	363	367	PF00917	0.328
DOC_USP7_MATH_1	433	437	PF00917	0.782
DOC_USP7_MATH_1	459	463	PF00917	0.766
DOC_USP7_MATH_2	64	70	PF00917	0.437
DOC_USP7_UBL2_3	24	28	PF12436	0.592
DOC_USP7_UBL2_3	48	52	PF12436	0.456
DOC_WW_Pin1_4	113	118	PF00397	0.271
DOC_WW_Pin1_4	3	8	PF00397	0.739
DOC_WW_Pin1_4	429	434	PF00397	0.751
DOC_WW_Pin1_4	94	99	PF00397	0.453
LIG_14-3-3_CanoR_1	136	142	PF00244	0.329
LIG_14-3-3_CanoR_1	18	24	PF00244	0.605
LIG_14-3-3_CanoR_1	193	198	PF00244	0.371
LIG_14-3-3_CanoR_1	274	279	PF00244	0.540
LIG_14-3-3_CanoR_1	409	419	PF00244	0.637
LIG_14-3-3_CanoR_1	496	500	PF00244	0.705
LIG_Actin_WH2_2	258	276	PF00022	0.275
LIG_Actin_WH2_2	303	319	PF00022	0.475
LIG_BRCT_BRCA1_1	101	105	PF00533	0.423
LIG_BRCT_BRCA1_1	303	307	PF00533	0.319
LIG_BRCT_BRCA1_1	317	321	PF00533	0.340
LIG_BRCT_BRCA1_1	391	395	PF00533	0.372
LIG_BRCT_BRCA1_1	55	59	PF00533	0.420
LIG_BRCT_BRCA1_1	83	87	PF00533	0.390
LIG_eIF4E_1	379	385	PF01652	0.254
LIG_FHA_1	138	144	PF00498	0.317
LIG_FHA_1	24	30	PF00498	0.621
LIG_FHA_1	262	268	PF00498	0.394
LIG_FHA_1	286	292	PF00498	0.593
LIG_FHA_1	328	334	PF00498	0.353
LIG_FHA_1	368	374	PF00498	0.460
LIG_FHA_1	385	391	PF00498	0.319
LIG_FHA_1	429	435	PF00498	0.791
LIG_FHA_1	473	479	PF00498	0.725
LIG_FHA_2	123	129	PF00498	0.320
LIG_FHA_2	194	200	PF00498	0.385
LIG_FHA_2	342	348	PF00498	0.328
LIG_LIR_Apic_2	142	148	PF02991	0.400
LIG_LIR_Gen_1	102	110	PF02991	0.405
LIG_LIR_Gen_1	304	315	PF02991	0.327
LIG_LIR_Gen_1	34	44	PF02991	0.449
LIG_LIR_Gen_1	65	73	PF02991	0.416
LIG_LIR_Nem_3	102	108	PF02991	0.438
LIG_LIR_Nem_3	156	160	PF02991	0.347
LIG_LIR_Nem_3	186	190	PF02991	0.349
LIG_LIR_Nem_3	304	310	PF02991	0.327
LIG_LIR_Nem_3	34	39	PF02991	0.427
LIG_LIR_Nem_3	392	398	PF02991	0.361
LIG_LIR_Nem_3	65	70	PF02991	0.405
LIG_NRBOX	341	347	PF00104	0.437
LIG_NRBOX	414	420	PF00104	0.613
LIG_NRBOX	88	94	PF00104	0.398
LIG_PCNA_PIPBox_1	361	370	PF02747	0.413
LIG_Pex14_1	253	257	PF04695	0.394
LIG_Pex14_1	75	79	PF04695	0.349
LIG_PTB_Apo_2	30	37	PF02174	0.604
LIG_PTB_Phospho_1	30	36	PF10480	0.606
LIG_SH2_CRK	160	164	PF00017	0.306
LIG_SH2_CRK	174	178	PF00017	0.293
LIG_SH2_CRK	270	274	PF00017	0.384
LIG_SH2_CRK	311	315	PF00017	0.455
LIG_SH2_CRK	36	40	PF00017	0.413
LIG_SH2_NCK_1	36	40	PF00017	0.385
LIG_SH2_NCK_1	441	445	PF00017	0.645
LIG_SH2_SRC	441	444	PF00017	0.574
LIG_SH2_STAP1	160	164	PF00017	0.322
LIG_SH2_STAP1	248	252	PF00017	0.434
LIG_SH2_STAP1	311	315	PF00017	0.455
LIG_SH2_STAT5	132	135	PF00017	0.319
LIG_SH2_STAT5	145	148	PF00017	0.321
LIG_SH2_STAT5	220	223	PF00017	0.409
LIG_SH2_STAT5	358	361	PF00017	0.328
LIG_SH2_STAT5	389	392	PF00017	0.343
LIG_SH3_1	145	151	PF00018	0.380
LIG_SH3_3	1	7	PF00018	0.730
LIG_SH3_3	145	151	PF00018	0.332
LIG_SH3_3	467	473	PF00018	0.729
LIG_SH3_3	58	64	PF00018	0.434
LIG_SUMO_SIM_anti_2	161	166	PF11976	0.323
LIG_SUMO_SIM_par_1	474	481	PF11976	0.686
LIG_TYR_ITIM	172	177	PF00017	0.290
LIG_UBA3_1	146	152	PF00899	0.442
LIG_UBA3_1	255	260	PF00899	0.369
LIG_WRC_WIRS_1	364	369	PF05994	0.344
LIG_WRC_WIRS_1	82	87	PF05994	0.365
MOD_CDK_SPK_2	3	8	PF00069	0.628
MOD_CK1_1	137	143	PF00069	0.384
MOD_CK1_1	246	252	PF00069	0.346
MOD_CK1_1	436	442	PF00069	0.629
MOD_CK2_1	122	128	PF00069	0.347
MOD_CK2_1	193	199	PF00069	0.412
MOD_CK2_1	341	347	PF00069	0.328
MOD_Cter_Amidation	349	352	PF01082	0.343
MOD_GlcNHglycan	113	116	PF01048	0.581
MOD_GlcNHglycan	136	139	PF01048	0.572
MOD_GlcNHglycan	168	171	PF01048	0.439
MOD_GlcNHglycan	205	208	PF01048	0.578
MOD_GlcNHglycan	303	306	PF01048	0.344
MOD_GlcNHglycan	317	320	PF01048	0.547
MOD_GlcNHglycan	435	438	PF01048	0.602
MOD_GlcNHglycan	459	462	PF01048	0.574
MOD_GlcNHglycan	502	505	PF01048	0.358
MOD_GSK3_1	179	186	PF00069	0.342
MOD_GSK3_1	19	26	PF00069	0.648
MOD_GSK3_1	285	292	PF00069	0.599
MOD_GSK3_1	297	304	PF00069	0.413
MOD_GSK3_1	327	334	PF00069	0.363
MOD_GSK3_1	363	370	PF00069	0.342
MOD_GSK3_1	429	436	PF00069	0.783
MOD_GSK3_1	62	69	PF00069	0.396
MOD_NEK2_1	134	139	PF00069	0.371
MOD_NEK2_1	165	170	PF00069	0.306
MOD_NEK2_1	23	28	PF00069	0.568
MOD_NEK2_1	301	306	PF00069	0.391
MOD_NEK2_1	357	362	PF00069	0.391
MOD_NEK2_1	367	372	PF00069	0.297
MOD_NEK2_1	384	389	PF00069	0.281
MOD_NEK2_1	502	507	PF00069	0.561
MOD_NEK2_1	99	104	PF00069	0.363
MOD_NEK2_2	81	86	PF00069	0.322
MOD_PIKK_1	367	373	PF00454	0.339
MOD_PKA_2	192	198	PF00069	0.383
MOD_PKA_2	31	37	PF00069	0.531
MOD_PKA_2	495	501	PF00069	0.650
MOD_PKB_1	283	291	PF00069	0.639
MOD_Plk_4	104	110	PF00069	0.365
MOD_Plk_4	274	280	PF00069	0.520
MOD_Plk_4	290	296	PF00069	0.494
MOD_Plk_4	31	37	PF00069	0.544
MOD_Plk_4	341	347	PF00069	0.328
MOD_Plk_4	384	390	PF00069	0.392
MOD_Plk_4	436	442	PF00069	0.661
MOD_Plk_4	88	94	PF00069	0.353
MOD_ProDKin_1	113	119	PF00069	0.275
MOD_ProDKin_1	3	9	PF00069	0.737
MOD_ProDKin_1	429	435	PF00069	0.750
MOD_ProDKin_1	94	100	PF00069	0.455
MOD_SUMO_rev_2	401	407	PF00179	0.609
TRG_DiLeu_BaEn_1	402	407	PF01217	0.624
TRG_DiLeu_BaEn_4	402	408	PF01217	0.623
TRG_DiLeu_BaEn_4	429	435	PF01217	0.586
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.419
TRG_DiLeu_BaLyEn_6	224	229	PF01217	0.425
TRG_DiLeu_BaLyEn_6	413	418	PF01217	0.631
TRG_ENDOCYTIC_2	132	135	PF00928	0.333
TRG_ENDOCYTIC_2	160	163	PF00928	0.305
TRG_ENDOCYTIC_2	174	177	PF00928	0.291
TRG_ENDOCYTIC_2	187	190	PF00928	0.319
TRG_ENDOCYTIC_2	270	273	PF00928	0.305
TRG_ENDOCYTIC_2	311	314	PF00928	0.425
TRG_ENDOCYTIC_2	358	361	PF00928	0.344
TRG_ENDOCYTIC_2	36	39	PF00928	0.413
TRG_ER_diArg_1	283	286	PF00400	0.616
TRG_ER_diArg_1	351	353	PF00400	0.534
TRG_ER_diArg_1	373	376	PF00400	0.416
TRG_ER_diArg_1	409	412	PF00400	0.591
TRG_ER_diArg_1	495	497	PF00400	0.711
TRG_ER_diLys_1	506	511	PF00400	0.726
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	416	420	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	466	471	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXD2	Leptomonas seymouri	71%	100%
A0A0S4IY50	Bodo saltans	35%	100%
A0A1X0P7N6	Trypanosomatidae	45%	100%
A0A3R7MN24	Trypanosoma rangeli	41%	100%
A0A3S7WUW0	Leishmania donovani	91%	100%
A4H9G2	Leishmania braziliensis	82%	100%
A4HXS9	Leishmania infantum	91%	100%
D0A061	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4QDY8	Leishmania major	90%	100%
V5BWB3	Trypanosoma cruzi	43%	100%