C-CAP/cofactor C-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin cofactor C domain-containing protein RP2, putative

Species:

Leishmania mexicana

UniProt:

E9ARJ0_LEIMU

TriTrypDb:

LmxM.18.0530

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ARJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARJ0

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0034453	microtubule anchoring	4	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	11
GO:0008047	enzyme activator activity	3	11
GO:0030234	enzyme regulator activity	2	11
GO:0030695	GTPase regulator activity	4	11
GO:0060589	nucleoside-triphosphatase regulator activity	3	11
GO:0098772	molecular function regulator activity	1	11
GO:0140677	molecular function activator activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.481
CLV_C14_Caspase3-7	211	215	PF00656	0.379
CLV_C14_Caspase3-7	425	429	PF00656	0.631
CLV_PCSK_KEX2_1	183	185	PF00082	0.496
CLV_PCSK_KEX2_1	458	460	PF00082	0.745
CLV_PCSK_KEX2_1	64	66	PF00082	0.500
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.496
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.622
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.500
CLV_PCSK_SKI1_1	241	245	PF00082	0.279
DEG_SCF_FBW7_2	135	142	PF00400	0.467
DEG_SCF_FBW7_2	319	325	PF00400	0.405
DEG_SPOP_SBC_1	437	441	PF00917	0.775
DOC_CDC14_PxL_1	472	480	PF14671	0.588
DOC_CKS1_1	136	141	PF01111	0.467
DOC_CKS1_1	319	324	PF01111	0.403
DOC_CYCLIN_RxL_1	85	93	PF00134	0.577
DOC_MAPK_gen_1	238	247	PF00069	0.275
DOC_MAPK_gen_1	253	262	PF00069	0.234
DOC_MAPK_HePTP_8	235	247	PF00069	0.277
DOC_MAPK_HePTP_8	252	264	PF00069	0.217
DOC_MAPK_MEF2A_6	238	247	PF00069	0.277
DOC_MAPK_MEF2A_6	255	264	PF00069	0.217
DOC_PP2B_LxvP_1	285	288	PF13499	0.298
DOC_PP4_FxxP_1	434	437	PF00568	0.533
DOC_USP7_MATH_1	361	365	PF00917	0.405
DOC_USP7_MATH_1	411	415	PF00917	0.741
DOC_USP7_MATH_1	437	441	PF00917	0.677
DOC_USP7_MATH_1	445	449	PF00917	0.689
DOC_USP7_MATH_1	461	465	PF00917	0.576
DOC_USP7_UBL2_3	150	154	PF12436	0.488
DOC_WW_Pin1_4	135	140	PF00397	0.463
DOC_WW_Pin1_4	310	315	PF00397	0.423
DOC_WW_Pin1_4	318	323	PF00397	0.402
DOC_WW_Pin1_4	478	483	PF00397	0.773
LIG_14-3-3_CanoR_1	338	343	PF00244	0.524
LIG_14-3-3_CanoR_1	65	74	PF00244	0.554
LIG_Actin_WH2_2	89	104	PF00022	0.595
LIG_BIR_II_1	1	5	PF00653	0.573
LIG_CAP-Gly_1	518	526	PF01302	0.584
LIG_FHA_1	130	136	PF00498	0.581
LIG_FHA_1	173	179	PF00498	0.398
LIG_FHA_1	205	211	PF00498	0.312
LIG_FHA_1	242	248	PF00498	0.298
LIG_FHA_1	266	272	PF00498	0.269
LIG_FHA_1	479	485	PF00498	0.736
LIG_FHA_1	55	61	PF00498	0.596
LIG_FHA_1	7	13	PF00498	0.488
LIG_FHA_1	84	90	PF00498	0.410
LIG_FHA_2	101	107	PF00498	0.495
LIG_FHA_2	151	157	PF00498	0.746
LIG_FHA_2	215	221	PF00498	0.264
LIG_FHA_2	264	270	PF00498	0.279
LIG_FHA_2	3	9	PF00498	0.580
LIG_FHA_2	311	317	PF00498	0.379
LIG_FHA_2	423	429	PF00498	0.592
LIG_LIR_Apic_2	341	345	PF02991	0.514
LIG_LIR_Gen_1	499	508	PF02991	0.625
LIG_LIR_Nem_3	279	283	PF02991	0.390
LIG_LIR_Nem_3	336	342	PF02991	0.449
LIG_LIR_Nem_3	499	504	PF02991	0.609
LIG_LIR_Nem_3	76	80	PF02991	0.442
LIG_MYND_1	476	480	PF01753	0.594
LIG_PDZ_Class_3	521	526	PF00595	0.579
LIG_Pex14_2	177	181	PF04695	0.347
LIG_Pex14_2	324	328	PF04695	0.442
LIG_SH2_STAP1	85	89	PF00017	0.400
LIG_SH2_STAT5	176	179	PF00017	0.355
LIG_SH2_STAT5	201	204	PF00017	0.343
LIG_SH2_STAT5	77	80	PF00017	0.396
LIG_SH2_STAT5	85	88	PF00017	0.434
LIG_SH3_1	342	348	PF00018	0.370
LIG_SH3_3	311	317	PF00018	0.410
LIG_SH3_3	323	329	PF00018	0.332
LIG_SH3_3	342	348	PF00018	0.338
LIG_SH3_3	50	56	PF00018	0.578
LIG_SUMO_SIM_anti_2	69	76	PF11976	0.476
LIG_SUMO_SIM_par_1	206	212	PF11976	0.388
LIG_SUMO_SIM_par_1	56	62	PF11976	0.564
LIG_TRAF2_1	103	106	PF00917	0.433
LIG_TRAF2_1	155	158	PF00917	0.555
LIG_TYR_ITIM	78	83	PF00017	0.492
LIG_WRC_WIRS_1	501	506	PF05994	0.622
MOD_CK1_1	364	370	PF00069	0.473
MOD_CK1_1	440	446	PF00069	0.719
MOD_CK2_1	100	106	PF00069	0.520
MOD_CK2_1	150	156	PF00069	0.733
MOD_CK2_1	2	8	PF00069	0.634
MOD_CK2_1	310	316	PF00069	0.513
MOD_CK2_1	411	417	PF00069	0.699
MOD_CK2_1	445	451	PF00069	0.801
MOD_GlcNHglycan	123	126	PF01048	0.538
MOD_GlcNHglycan	18	22	PF01048	0.451
MOD_GlcNHglycan	192	195	PF01048	0.398
MOD_GlcNHglycan	2	5	PF01048	0.620
MOD_GlcNHglycan	366	369	PF01048	0.506
MOD_GlcNHglycan	38	41	PF01048	0.383
MOD_GlcNHglycan	405	408	PF01048	0.616
MOD_GlcNHglycan	434	437	PF01048	0.705
MOD_GlcNHglycan	44	48	PF01048	0.673
MOD_GlcNHglycan	440	443	PF01048	0.716
MOD_GlcNHglycan	463	466	PF01048	0.648
MOD_GSK3_1	134	141	PF00069	0.674
MOD_GSK3_1	172	179	PF00069	0.414
MOD_GSK3_1	2	9	PF00069	0.568
MOD_GSK3_1	200	207	PF00069	0.424
MOD_GSK3_1	272	279	PF00069	0.383
MOD_GSK3_1	34	41	PF00069	0.541
MOD_GSK3_1	385	392	PF00069	0.458
MOD_GSK3_1	422	429	PF00069	0.720
MOD_GSK3_1	432	439	PF00069	0.696
MOD_GSK3_1	440	447	PF00069	0.661
MOD_GSK3_1	470	477	PF00069	0.550
MOD_N-GLC_1	172	177	PF02516	0.456
MOD_N-GLC_1	241	246	PF02516	0.324
MOD_N-GLC_1	369	374	PF02516	0.498
MOD_NEK2_1	134	139	PF00069	0.661
MOD_NEK2_1	17	22	PF00069	0.546
MOD_NEK2_1	83	88	PF00069	0.426
MOD_NEK2_2	231	236	PF00069	0.264
MOD_PKA_2	101	107	PF00069	0.502
MOD_Plk_1	171	177	PF00069	0.414
MOD_Plk_1	241	247	PF00069	0.324
MOD_Plk_1	369	375	PF00069	0.512
MOD_Plk_1	499	505	PF00069	0.714
MOD_Plk_1	69	75	PF00069	0.496
MOD_Plk_2-3	214	220	PF00069	0.264
MOD_Plk_2-3	424	430	PF00069	0.742
MOD_Plk_2-3	500	506	PF00069	0.726
MOD_Plk_4	172	178	PF00069	0.384
MOD_Plk_4	204	210	PF00069	0.257
MOD_Plk_4	231	237	PF00069	0.264
MOD_Plk_4	69	75	PF00069	0.444
MOD_ProDKin_1	135	141	PF00069	0.464
MOD_ProDKin_1	310	316	PF00069	0.420
MOD_ProDKin_1	318	324	PF00069	0.399
MOD_ProDKin_1	478	484	PF00069	0.775
MOD_SUMO_rev_2	296	303	PF00179	0.324
TRG_DiLeu_BaEn_1	222	227	PF01217	0.279
TRG_DiLeu_BaEn_1	330	335	PF01217	0.352
TRG_DiLeu_BaEn_1	350	355	PF01217	0.349
TRG_DiLeu_BaEn_2	231	237	PF01217	0.279
TRG_ENDOCYTIC_2	23	26	PF00928	0.599
TRG_ENDOCYTIC_2	501	504	PF00928	0.626
TRG_ENDOCYTIC_2	80	83	PF00928	0.474
TRG_ER_diArg_1	252	255	PF00400	0.264
TRG_NES_CRM1_1	91	105	PF08389	0.338
TRG_NLS_MonoExtN_4	180	186	PF00514	0.415
TRG_NLS_MonoExtN_4	455	461	PF00514	0.494
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Z4	Leptomonas seymouri	57%	100%
A0A0S4J201	Bodo saltans	48%	100%
A0A1X0P6T6	Trypanosomatidae	55%	100%
A0A3R7NEX5	Trypanosoma rangeli	52%	100%
A0A3S5H730	Leishmania donovani	90%	100%
A4H9G1	Leishmania braziliensis	79%	99%
A4HXS8	Leishmania infantum	90%	100%
D0A060	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
V5BRP2	Trypanosoma cruzi	51%	100%