BTB_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

btb/poz domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ARI6_LEIMU

TriTrypDb:

LmxM.18.0490

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARI6

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0022607	cellular component assembly	4	7
GO:0043933	protein-containing complex organization	4	7
GO:0051259	protein complex oligomerization	6	7
GO:0051260	protein homooligomerization	7	7
GO:0065003	protein-containing complex assembly	5	7
GO:0071840	cellular component organization or biogenesis	2	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.299
CLV_C14_Caspase3-7	87	91	PF00656	0.416
CLV_NRD_NRD_1	126	128	PF00675	0.657
CLV_NRD_NRD_1	242	244	PF00675	0.602
CLV_NRD_NRD_1	36	38	PF00675	0.411
CLV_PCSK_KEX2_1	126	128	PF00082	0.556
CLV_PCSK_KEX2_1	242	244	PF00082	0.602
CLV_PCSK_KEX2_1	36	38	PF00082	0.411
CLV_PCSK_SKI1_1	112	116	PF00082	0.346
CLV_PCSK_SKI1_1	151	155	PF00082	0.562
CLV_PCSK_SKI1_1	184	188	PF00082	0.746
CLV_PCSK_SKI1_1	243	247	PF00082	0.583
CLV_PCSK_SKI1_1	279	283	PF00082	0.491
CLV_PCSK_SKI1_1	41	45	PF00082	0.513
DEG_APCC_DBOX_1	36	44	PF00400	0.411
DOC_CYCLIN_RxL_1	276	283	PF00134	0.508
DOC_CYCLIN_yClb3_PxF_3	162	168	PF00134	0.465
DOC_MAPK_DCC_7	226	236	PF00069	0.538
DOC_MAPK_gen_1	277	284	PF00069	0.541
DOC_MAPK_MEF2A_6	277	284	PF00069	0.600
DOC_PP1_RVXF_1	240	247	PF00149	0.636
DOC_PP2B_LxvP_1	282	285	PF13499	0.508
DOC_PP2B_LxvP_1	86	89	PF13499	0.411
DOC_PP4_FxxP_1	169	172	PF00568	0.599
DOC_USP7_MATH_1	206	210	PF00917	0.708
DOC_USP7_MATH_1	216	220	PF00917	0.557
LIG_14-3-3_CanoR_1	157	162	PF00244	0.545
LIG_14-3-3_CanoR_1	208	216	PF00244	0.725
LIG_14-3-3_CanoR_1	279	285	PF00244	0.503
LIG_14-3-3_CanoR_1	36	41	PF00244	0.513
LIG_14-3-3_CanoR_1	85	89	PF00244	0.436
LIG_APCC_ABBAyCdc20_2	242	248	PF00400	0.640
LIG_BIR_II_1	1	5	PF00653	0.514
LIG_BRCT_BRCA1_1	116	120	PF00533	0.366
LIG_CSL_BTD_1	135	138	PF09270	0.471
LIG_EVH1_2	164	168	PF00568	0.471
LIG_FHA_1	189	195	PF00498	0.812
LIG_FHA_1	247	253	PF00498	0.516
LIG_FHA_1	258	264	PF00498	0.375
LIG_FHA_2	37	43	PF00498	0.513
LIG_LIR_Gen_1	94	102	PF02991	0.513
LIG_LIR_Nem_3	101	107	PF02991	0.418
LIG_LIR_Nem_3	72	77	PF02991	0.357
LIG_LIR_Nem_3	94	98	PF02991	0.416
LIG_SH2_NCK_1	105	109	PF00017	0.513
LIG_SH2_SRC	76	79	PF00017	0.494
LIG_SH2_STAT5	134	137	PF00017	0.479
LIG_SH2_STAT5	33	36	PF00017	0.411
LIG_SH2_STAT5	38	41	PF00017	0.411
LIG_SH2_STAT5	76	79	PF00017	0.411
LIG_SH2_STAT5	80	83	PF00017	0.411
LIG_SH3_1	226	232	PF00018	0.540
LIG_SH3_3	132	138	PF00018	0.478
LIG_SH3_3	159	165	PF00018	0.728
LIG_SH3_3	226	232	PF00018	0.643
LIG_SUMO_SIM_par_1	259	264	PF11976	0.585
LIG_TYR_ITIM	102	107	PF00017	0.513
LIG_WRC_WIRS_1	115	120	PF05994	0.323
LIG_WW_2	229	232	PF00397	0.541
MOD_CK1_1	217	223	PF00069	0.654
MOD_CK2_1	36	42	PF00069	0.513
MOD_Cter_Amidation	240	243	PF01082	0.623
MOD_GlcNHglycan	1	4	PF01048	0.578
MOD_GlcNHglycan	159	162	PF01048	0.606
MOD_GlcNHglycan	175	178	PF01048	0.649
MOD_GlcNHglycan	209	212	PF01048	0.817
MOD_GlcNHglycan	219	222	PF01048	0.585
MOD_GlcNHglycan	239	242	PF01048	0.677
MOD_GSK3_1	110	117	PF00069	0.294
MOD_GSK3_1	167	174	PF00069	0.691
MOD_GSK3_1	184	191	PF00069	0.604
MOD_GSK3_1	257	264	PF00069	0.569
MOD_GSK3_1	28	35	PF00069	0.513
MOD_NEK2_1	110	115	PF00069	0.572
MOD_NEK2_1	120	125	PF00069	0.573
MOD_NEK2_1	167	172	PF00069	0.596
MOD_NEK2_1	246	251	PF00069	0.500
MOD_NEK2_1	32	37	PF00069	0.411
MOD_NEK2_1	8	13	PF00069	0.525
MOD_PIKK_1	246	252	PF00454	0.535
MOD_PKA_1	36	42	PF00069	0.513
MOD_PKA_2	207	213	PF00069	0.731
MOD_PKA_2	246	252	PF00069	0.535
MOD_PKA_2	36	42	PF00069	0.513
MOD_PKA_2	84	90	PF00069	0.436
MOD_Plk_1	110	116	PF00069	0.580
MOD_Plk_4	110	116	PF00069	0.587
MOD_Plk_4	120	126	PF00069	0.454
MOD_Plk_4	257	263	PF00069	0.474
MOD_Plk_4	28	34	PF00069	0.513
MOD_Plk_4	3	9	PF00069	0.562
MOD_Plk_4	61	67	PF00069	0.355
MOD_Plk_4	69	75	PF00069	0.349
TRG_DiLeu_BaEn_1	94	99	PF01217	0.411
TRG_DiLeu_BaEn_2	60	66	PF01217	0.411
TRG_ENDOCYTIC_2	104	107	PF00928	0.513
TRG_ER_diArg_1	125	127	PF00400	0.640
TRG_ER_diArg_1	242	244	PF00400	0.602
TRG_ER_diArg_1	277	280	PF00400	0.603
TRG_ER_diArg_1	36	38	PF00400	0.513
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Z1	Leptomonas seymouri	57%	100%
A0A3S5H729	Leishmania donovani	89%	100%
A4H9F7	Leishmania braziliensis	77%	100%
A4HXS4	Leishmania infantum	89%	100%
Q4QDZ3	Leishmania major	90%	100%