Uracil-DNA glycosylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

uracil-DNA-glycosylase, putative

Species:

Leishmania mexicana

UniProt:

E9ARI5_LEIMU

TriTrypDb:

LmxM.18.0480

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0005739	mitochondrion	5	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9ARI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARI5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006284	base-excision repair	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004844	uracil DNA N-glycosylase activity	6	7
GO:0016787	hydrolase activity	2	7
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	7
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4	7
GO:0019104	DNA N-glycosylase activity	4	7
GO:0097506	deaminated base DNA N-glycosylase activity	5	7
GO:0140097	catalytic activity, acting on DNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	9	11	PF00675	0.592
CLV_PCSK_SKI1_1	146	150	PF00082	0.326
CLV_PCSK_SKI1_1	177	181	PF00082	0.370
CLV_PCSK_SKI1_1	196	200	PF00082	0.149
CLV_PCSK_SKI1_1	236	240	PF00082	0.224
CLV_PCSK_SKI1_1	3	7	PF00082	0.548
CLV_PCSK_SKI1_1	302	306	PF00082	0.247
CLV_PCSK_SKI1_1	56	60	PF00082	0.664
DEG_APCC_DBOX_1	145	153	PF00400	0.375
DEG_Kelch_Keap1_1	39	44	PF01344	0.618
DEG_Nend_UBRbox_3	1	3	PF02207	0.608
DOC_CYCLIN_yClb1_LxF_4	300	305	PF00134	0.473
DOC_PP1_RVXF_1	300	306	PF00149	0.425
DOC_PP4_FxxP_1	148	151	PF00568	0.346
DOC_PP4_FxxP_1	245	248	PF00568	0.424
DOC_USP7_MATH_1	130	134	PF00917	0.430
DOC_USP7_MATH_1	189	193	PF00917	0.310
DOC_USP7_MATH_1	353	357	PF00917	0.331
DOC_USP7_MATH_1	38	42	PF00917	0.532
DOC_USP7_MATH_1	92	96	PF00917	0.577
DOC_USP7_UBL2_3	55	59	PF12436	0.613
DOC_WW_Pin1_4	330	335	PF00397	0.424
DOC_WW_Pin1_4	44	49	PF00397	0.780
LIG_14-3-3_CanoR_1	10	18	PF00244	0.465
LIG_BRCT_BRCA1_1	191	195	PF00533	0.352
LIG_CtBP_PxDLS_1	228	232	PF00389	0.473
LIG_deltaCOP1_diTrp_1	144	148	PF00928	0.324
LIG_deltaCOP1_diTrp_1	155	162	PF00928	0.388
LIG_FHA_1	237	243	PF00498	0.424
LIG_FHA_1	265	271	PF00498	0.424
LIG_FHA_1	286	292	PF00498	0.424
LIG_FHA_2	139	145	PF00498	0.391
LIG_FHA_2	2	8	PF00498	0.552
LIG_FHA_2	58	64	PF00498	0.626
LIG_LIR_Apic_2	147	151	PF02991	0.387
LIG_LIR_Gen_1	184	195	PF02991	0.315
LIG_LIR_Gen_1	206	214	PF02991	0.453
LIG_LIR_Gen_1	281	292	PF02991	0.465
LIG_LIR_Nem_3	144	148	PF02991	0.365
LIG_LIR_Nem_3	184	190	PF02991	0.324
LIG_LIR_Nem_3	192	198	PF02991	0.305
LIG_LIR_Nem_3	206	211	PF02991	0.453
LIG_LIR_Nem_3	281	287	PF02991	0.496
LIG_MAD2	199	207	PF02301	0.424
LIG_NRBOX	302	308	PF00104	0.473
LIG_PCNA_yPIPBox_3	2	11	PF02747	0.618
LIG_SH2_STAT3	311	314	PF00017	0.557
LIG_SH2_STAT5	252	255	PF00017	0.424
LIG_SH3_3	220	226	PF00018	0.424
LIG_SUMO_SIM_anti_2	95	102	PF11976	0.596
LIG_SUMO_SIM_par_1	266	271	PF11976	0.424
MOD_CDC14_SPxK_1	52	55	PF00782	0.641
MOD_CDK_SPK_2	44	49	PF00069	0.611
MOD_CDK_SPxK_1	49	55	PF00069	0.652
MOD_CDK_SPxxK_3	49	56	PF00069	0.653
MOD_CK1_1	119	125	PF00069	0.615
MOD_CK1_1	279	285	PF00069	0.489
MOD_CK1_1	333	339	PF00069	0.424
MOD_CK2_1	138	144	PF00069	0.404
MOD_CK2_1	252	258	PF00069	0.466
MOD_CK2_1	38	44	PF00069	0.617
MOD_CK2_1	57	63	PF00069	0.531
MOD_GlcNHglycan	119	122	PF01048	0.592
MOD_GlcNHglycan	281	284	PF01048	0.266
MOD_GlcNHglycan	335	338	PF01048	0.247
MOD_GlcNHglycan	347	350	PF01048	0.271
MOD_GlcNHglycan	38	41	PF01048	0.740
MOD_GSK3_1	116	123	PF00069	0.683
MOD_GSK3_1	274	281	PF00069	0.455
MOD_GSK3_1	326	333	PF00069	0.479
MOD_GSK3_1	43	50	PF00069	0.798
MOD_GSK3_1	62	69	PF00069	0.604
MOD_GSK3_1	99	106	PF00069	0.629
MOD_N-GLC_1	264	269	PF02516	0.224
MOD_N-GLC_1	368	373	PF02516	0.503
MOD_N-GLC_1	66	71	PF02516	0.487
MOD_N-GLC_2	191	193	PF02516	0.348
MOD_NEK2_1	1	6	PF00069	0.586
MOD_NEK2_1	217	222	PF00069	0.424
MOD_NEK2_1	264	269	PF00069	0.450
MOD_NEK2_1	335	340	PF00069	0.554
MOD_NEK2_1	368	373	PF00069	0.503
MOD_NEK2_1	90	95	PF00069	0.587
MOD_NEK2_1	98	103	PF00069	0.607
MOD_PIKK_1	293	299	PF00454	0.466
MOD_PKA_1	10	16	PF00069	0.585
MOD_PKA_2	75	81	PF00069	0.513
MOD_PKB_1	66	74	PF00069	0.525
MOD_Plk_1	264	270	PF00069	0.424
MOD_Plk_1	90	96	PF00069	0.588
MOD_Plk_1	99	105	PF00069	0.610
MOD_Plk_4	1	7	PF00069	0.618
MOD_ProDKin_1	330	336	PF00069	0.424
MOD_ProDKin_1	44	50	PF00069	0.780
TRG_DiLeu_BaEn_1	258	263	PF01217	0.424
TRG_DiLeu_BaEn_2	143	149	PF01217	0.378
TRG_ENDOCYTIC_2	208	211	PF00928	0.455
TRG_ENDOCYTIC_2	235	238	PF00928	0.497
TRG_NES_CRM1_1	259	271	PF08389	0.466
TRG_NES_CRM1_1	352	365	PF08389	0.325
TRG_NLS_MonoExtC_3	314	320	PF00514	0.466
TRG_Pf-PMV_PEXEL_1	167	172	PF00026	0.317
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK50	Leptomonas seymouri	55%	89%
A0A3R7L167	Trypanosoma rangeli	53%	100%
A0A3S7WUW8	Leishmania donovani	86%	95%
A4H9F6	Leishmania braziliensis	78%	99%
A4HXS3	Leishmania infantum	86%	95%
P09307	Varicella-zoster virus (strain Dumas)	33%	100%
P10186	Human herpesvirus 1 (strain 17)	36%	100%
P28275	Human herpesvirus 2 (strain HG52)	37%	100%
Q5UPT2	Acanthamoeba polyphaga mimivirus	32%	100%
Q9J3N2	Varicella-zoster virus (strain Oka vaccine)	33%	100%