Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paralyzed flagella protein 20

Species:

Leishmania mexicana

UniProt:

E9ARI4_LEIMU

TriTrypDb:

LmxM.18.0470

Length:

624

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9ARI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARI4

Function

Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0003341	cilium movement	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0048870	cell motility	2	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0060294	cilium movement involved in cell motility	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	213	215	PF00675	0.523
CLV_NRD_NRD_1	271	273	PF00675	0.645
CLV_NRD_NRD_1	41	43	PF00675	0.575
CLV_NRD_NRD_1	498	500	PF00675	0.261
CLV_NRD_NRD_1	542	544	PF00675	0.390
CLV_PCSK_KEX2_1	213	215	PF00082	0.538
CLV_PCSK_KEX2_1	271	273	PF00082	0.683
CLV_PCSK_KEX2_1	41	43	PF00082	0.478
CLV_PCSK_KEX2_1	542	544	PF00082	0.390
CLV_PCSK_PC7_1	209	215	PF00082	0.495
CLV_PCSK_SKI1_1	172	176	PF00082	0.421
CLV_PCSK_SKI1_1	202	206	PF00082	0.375
CLV_PCSK_SKI1_1	407	411	PF00082	0.215
CLV_PCSK_SKI1_1	72	76	PF00082	0.458
DOC_ANK_TNKS_1	299	306	PF00023	0.524
DOC_CYCLIN_RxL_1	199	208	PF00134	0.439
DOC_MAPK_gen_1	200	207	PF00069	0.414
DOC_MAPK_gen_1	213	223	PF00069	0.523
DOC_MAPK_gen_1	542	550	PF00069	0.357
DOC_PP2B_LxvP_1	50	53	PF13499	0.615
DOC_PP2B_LxvP_1	61	64	PF13499	0.540
DOC_PP4_FxxP_1	293	296	PF00568	0.616
DOC_USP7_MATH_1	345	349	PF00917	0.468
DOC_USP7_MATH_1	359	363	PF00917	0.379
DOC_USP7_MATH_1	377	381	PF00917	0.313
DOC_USP7_MATH_1	401	405	PF00917	0.415
DOC_USP7_MATH_1	521	525	PF00917	0.394
DOC_USP7_MATH_1	570	574	PF00917	0.363
DOC_USP7_MATH_1	597	601	PF00917	0.535
DOC_USP7_MATH_1	86	90	PF00917	0.442
DOC_WW_Pin1_4	102	107	PF00397	0.540
DOC_WW_Pin1_4	274	279	PF00397	0.638
DOC_WW_Pin1_4	325	330	PF00397	0.690
DOC_WW_Pin1_4	51	56	PF00397	0.409
LIG_14-3-3_CanoR_1	157	164	PF00244	0.529
LIG_14-3-3_CanoR_1	272	278	PF00244	0.647
LIG_14-3-3_CanoR_1	368	373	PF00244	0.545
LIG_14-3-3_CanoR_1	41	45	PF00244	0.527
LIG_14-3-3_CanoR_1	418	424	PF00244	0.450
LIG_14-3-3_CanoR_1	462	466	PF00244	0.446
LIG_BIR_II_1	1	5	PF00653	0.560
LIG_BRCT_BRCA1_1	599	603	PF00533	0.496
LIG_BRCT_BRCA1_1	606	610	PF00533	0.444
LIG_Clathr_ClatBox_1	204	208	PF01394	0.399
LIG_Clathr_ClatBox_1	547	551	PF01394	0.481
LIG_CSL_BTD_1	294	297	PF09270	0.528
LIG_deltaCOP1_diTrp_1	332	339	PF00928	0.516
LIG_deltaCOP1_diTrp_1	428	435	PF00928	0.400
LIG_FHA_1	116	122	PF00498	0.430
LIG_FHA_1	281	287	PF00498	0.637
LIG_FHA_1	341	347	PF00498	0.445
LIG_FHA_1	406	412	PF00498	0.415
LIG_FHA_1	425	431	PF00498	0.415
LIG_FHA_1	436	442	PF00498	0.387
LIG_FHA_1	448	454	PF00498	0.415
LIG_FHA_1	479	485	PF00498	0.415
LIG_FHA_1	55	61	PF00498	0.634
LIG_FHA_1	575	581	PF00498	0.323
LIG_FHA_1	587	593	PF00498	0.230
LIG_FHA_1	79	85	PF00498	0.478
LIG_FHA_1	97	103	PF00498	0.509
LIG_FHA_2	185	191	PF00498	0.399
LIG_FHA_2	535	541	PF00498	0.394
LIG_LIR_Apic_2	2	6	PF02991	0.409
LIG_LIR_Apic_2	291	296	PF02991	0.615
LIG_NRBOX	169	175	PF00104	0.472
LIG_PCNA_yPIPBox_3	162	174	PF02747	0.525
LIG_PDZ_Class_2	619	624	PF00595	0.446
LIG_PDZ_Wminus1_1	622	624	PF00595	0.446
LIG_Pex14_1	431	435	PF04695	0.415
LIG_Pex14_2	70	74	PF04695	0.417
LIG_Pex14_2	87	91	PF04695	0.426
LIG_SH2_CRK	3	7	PF00017	0.409
LIG_SH2_NCK_1	3	7	PF00017	0.541
LIG_SH2_STAT5	3	6	PF00017	0.410
LIG_SH3_3	103	109	PF00018	0.597
LIG_SH3_3	242	248	PF00018	0.737
LIG_SH3_3	291	297	PF00018	0.563
LIG_SH3_3	298	304	PF00018	0.545
LIG_SH3_3	350	356	PF00018	0.477
LIG_SH3_3	49	55	PF00018	0.526
LIG_SUMO_SIM_par_1	203	208	PF11976	0.397
LIG_SUMO_SIM_par_1	579	585	PF11976	0.344
LIG_SUMO_SIM_par_1	99	105	PF11976	0.719
LIG_UBA3_1	204	211	PF00899	0.382
MOD_CK1_1	240	246	PF00069	0.565
MOD_CK1_1	260	266	PF00069	0.696
MOD_CK1_1	276	282	PF00069	0.535
MOD_CK1_1	322	328	PF00069	0.582
MOD_CK1_1	424	430	PF00069	0.526
MOD_CK1_1	529	535	PF00069	0.405
MOD_CK1_1	54	60	PF00069	0.416
MOD_CK1_1	613	619	PF00069	0.428
MOD_CK2_1	184	190	PF00069	0.408
MOD_GlcNHglycan	237	240	PF01048	0.717
MOD_GlcNHglycan	262	265	PF01048	0.666
MOD_GlcNHglycan	312	315	PF01048	0.670
MOD_GlcNHglycan	359	362	PF01048	0.271
MOD_GlcNHglycan	379	382	PF01048	0.241
MOD_GlcNHglycan	403	406	PF01048	0.215
MOD_GlcNHglycan	423	426	PF01048	0.128
MOD_GlcNHglycan	443	446	PF01048	0.128
MOD_GlcNHglycan	487	490	PF01048	0.215
MOD_GlcNHglycan	612	615	PF01048	0.246
MOD_GSK3_1	140	147	PF00069	0.414
MOD_GSK3_1	184	191	PF00069	0.532
MOD_GSK3_1	253	260	PF00069	0.685
MOD_GSK3_1	276	283	PF00069	0.650
MOD_GSK3_1	319	326	PF00069	0.689
MOD_GSK3_1	340	347	PF00069	0.479
MOD_GSK3_1	359	366	PF00069	0.415
MOD_GSK3_1	36	43	PF00069	0.509
MOD_GSK3_1	367	374	PF00069	0.488
MOD_GSK3_1	382	389	PF00069	0.403
MOD_GSK3_1	395	402	PF00069	0.385
MOD_GSK3_1	499	506	PF00069	0.467
MOD_GSK3_1	522	529	PF00069	0.452
MOD_GSK3_1	570	577	PF00069	0.317
MOD_GSK3_1	612	619	PF00069	0.526
MOD_GSK3_1	96	103	PF00069	0.573
MOD_NEK2_1	1	6	PF00069	0.600
MOD_NEK2_1	188	193	PF00069	0.526
MOD_NEK2_1	344	349	PF00069	0.471
MOD_NEK2_1	399	404	PF00069	0.415
MOD_NEK2_1	40	45	PF00069	0.504
MOD_NEK2_1	414	419	PF00069	0.369
MOD_NEK2_1	435	440	PF00069	0.419
MOD_NEK2_1	441	446	PF00069	0.410
MOD_NEK2_1	447	452	PF00069	0.407
MOD_NEK2_1	483	488	PF00069	0.449
MOD_NEK2_1	610	615	PF00069	0.419
MOD_NEK2_1	80	85	PF00069	0.574
MOD_NEK2_2	405	410	PF00069	0.415
MOD_NEK2_2	461	466	PF00069	0.428
MOD_PIKK_1	140	146	PF00454	0.530
MOD_PIKK_1	248	254	PF00454	0.797
MOD_PIKK_1	529	535	PF00454	0.437
MOD_PKA_1	499	505	PF00069	0.266
MOD_PKA_2	115	121	PF00069	0.544
MOD_PKA_2	140	146	PF00069	0.517
MOD_PKA_2	156	162	PF00069	0.406
MOD_PKA_2	168	174	PF00069	0.375
MOD_PKA_2	367	373	PF00069	0.499
MOD_PKA_2	395	401	PF00069	0.510
MOD_PKA_2	40	46	PF00069	0.527
MOD_PKA_2	461	467	PF00069	0.446
MOD_Plk_1	334	340	PF00069	0.314
MOD_Plk_1	405	411	PF00069	0.415
MOD_Plk_1	616	622	PF00069	0.471
MOD_Plk_4	200	206	PF00069	0.417
MOD_Plk_4	334	340	PF00069	0.285
MOD_Plk_4	395	401	PF00069	0.431
MOD_Plk_4	473	479	PF00069	0.546
MOD_Plk_4	522	528	PF00069	0.498
MOD_Plk_4	534	540	PF00069	0.324
MOD_ProDKin_1	102	108	PF00069	0.539
MOD_ProDKin_1	274	280	PF00069	0.636
MOD_ProDKin_1	325	331	PF00069	0.679
MOD_ProDKin_1	51	57	PF00069	0.408
TRG_DiLeu_BaEn_2	288	294	PF01217	0.629
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.524
TRG_ER_diArg_1	212	214	PF00400	0.503
TRG_ER_diArg_1	40	42	PF00400	0.480
TRG_ER_diArg_1	541	543	PF00400	0.375
TRG_NES_CRM1_1	36	49	PF08389	0.535
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCN2	Leptomonas seymouri	69%	98%
A0A0S4JA64	Bodo saltans	44%	100%
A0A1X0P716	Trypanosomatidae	50%	100%
A0A3R7NP23	Trypanosoma rangeli	50%	100%
A0A3S7WR72	Leishmania donovani	30%	100%
A0A3S7WUV4	Leishmania donovani	93%	100%
A1DDL6	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	23%	95%
A4H666	Leishmania braziliensis	29%	100%
A4H9F5	Leishmania braziliensis	83%	100%
A4HUJ0	Leishmania infantum	30%	100%
A4HXS2	Leishmania infantum	93%	100%
A4RJV3	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	21%	94%
A6ZQL5	Saccharomyces cerevisiae (strain YJM789)	22%	87%
D0A054	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AN88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
P47025	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	87%
P93107	Chlamydomonas reinhardtii	34%	100%
Q4QDZ5	Leishmania major	92%	100%
Q4QHD6	Leishmania major	30%	100%
Q4WVS4	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	23%	95%
Q8K450	Mus musculus	33%	98%
Q8N0X2	Homo sapiens	33%	99%
Q9P7I3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	96%
Q9UTC7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%