Putative tubulin-specific chaperone

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin-specific chaperone, putative

Species:

Leishmania mexicana

UniProt:

E9ARI3_LEIMU

TriTrypDb:

LmxM.18.0460

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9ARI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARI3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	111	113	PF00082	0.428
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.428
CLV_PCSK_SKI1_1	176	180	PF00082	0.245
CLV_PCSK_SKI1_1	202	206	PF00082	0.348
DOC_CKS1_1	39	44	PF01111	0.336
DOC_CYCLIN_RxL_1	117	130	PF00134	0.455
DOC_MAPK_gen_1	117	126	PF00069	0.452
DOC_MAPK_MEF2A_6	181	190	PF00069	0.243
DOC_PP1_RVXF_1	64	71	PF00149	0.501
DOC_PP4_FxxP_1	190	193	PF00568	0.243
DOC_PP4_FxxP_1	39	42	PF00568	0.413
DOC_WW_Pin1_4	38	43	PF00397	0.404
LIG_14-3-3_CanoR_1	176	181	PF00244	0.245
LIG_BIR_II_1	1	5	PF00653	0.261
LIG_FHA_1	151	157	PF00498	0.293
LIG_FHA_2	103	109	PF00498	0.463
LIG_FHA_2	203	209	PF00498	0.354
LIG_FHA_2	39	45	PF00498	0.336
LIG_LIR_Apic_2	189	193	PF02991	0.243
LIG_LIR_Apic_2	37	42	PF02991	0.413
LIG_LIR_Gen_1	205	213	PF02991	0.314
LIG_LIR_Gen_1	33	43	PF02991	0.452
LIG_LIR_Gen_1	91	99	PF02991	0.454
LIG_LIR_Nem_3	33	39	PF02991	0.452
LIG_LIR_Nem_3	91	96	PF02991	0.453
LIG_SH2_CRK	213	217	PF00017	0.375
LIG_SH2_NCK_1	93	97	PF00017	0.575
LIG_SH2_SRC	93	96	PF00017	0.543
LIG_SH2_STAT5	173	176	PF00017	0.307
LIG_SH3_3	136	142	PF00018	0.620
LIG_SH3_3	213	219	PF00018	0.375
LIG_TRAF2_1	105	108	PF00917	0.527
LIG_TRAF2_1	228	231	PF00917	0.461
MOD_CK2_1	102	108	PF00069	0.414
MOD_CK2_1	202	208	PF00069	0.315
MOD_CK2_1	27	33	PF00069	0.466
MOD_CK2_1	38	44	PF00069	0.417
MOD_CK2_1	94	100	PF00069	0.427
MOD_GlcNHglycan	10	13	PF01048	0.240
MOD_GSK3_1	34	41	PF00069	0.355
MOD_GSK3_1	6	13	PF00069	0.433
MOD_NEK2_1	24	29	PF00069	0.476
MOD_NEK2_2	197	202	PF00069	0.152
MOD_PIKK_1	10	16	PF00454	0.469
MOD_Plk_1	143	149	PF00069	0.475
MOD_Plk_4	202	208	PF00069	0.315
MOD_ProDKin_1	38	44	PF00069	0.404
MOD_SUMO_for_1	62	65	PF00179	0.473
MOD_SUMO_rev_2	49	58	PF00179	0.449
MOD_SUMO_rev_2	59	68	PF00179	0.389
TRG_ENDOCYTIC_2	213	216	PF00928	0.243
TRG_ENDOCYTIC_2	36	39	PF00928	0.478
TRG_ENDOCYTIC_2	93	96	PF00928	0.479
TRG_Pf-PMV_PEXEL_1	122	127	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJN4	Leptomonas seymouri	82%	100%
A0A0S4JE98	Bodo saltans	60%	100%
A0A1X0P6T3	Trypanosomatidae	64%	100%
A0A3Q8IJN5	Leishmania donovani	94%	100%
A0A422NJ66	Trypanosoma rangeli	58%	100%
A4H9F4	Leishmania braziliensis	88%	100%
A4HXS1	Leishmania infantum	94%	100%
D0A053	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
Q10235	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	99%
Q20728	Caenorhabditis elegans	40%	100%
Q4QDZ6	Leishmania major	93%	100%
Q54Z01	Dictyostelium discoideum	33%	86%
Q5E951	Bos taurus	39%	95%
Q67Z52	Arabidopsis thaliana	37%	95%
Q99426	Homo sapiens	38%	95%
Q9D1E6	Mus musculus	38%	95%