Putative phosphatidic acid phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidic acid phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9ARI1_LEIMU

TriTrypDb:

LmxM.18.0440

Length:

393

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9ARI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARI1

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	8
GO:0006644	phospholipid metabolic process	4	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0019637	organophosphate metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044255	cellular lipid metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0008195	phosphatidate phosphatase activity	6	8
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0016791	phosphatase activity	5	8
GO:0042578	phosphoric ester hydrolase activity	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.594
CLV_NRD_NRD_1	269	271	PF00675	0.408
CLV_NRD_NRD_1	321	323	PF00675	0.378
CLV_PCSK_KEX2_1	321	323	PF00082	0.378
CLV_PCSK_SKI1_1	228	232	PF00082	0.433
DEG_ODPH_VHL_1	334	345	PF01847	0.217
DEG_SPOP_SBC_1	174	178	PF00917	0.695
DOC_CYCLIN_yCln2_LP_2	337	343	PF00134	0.507
DOC_MAPK_DCC_7	329	339	PF00069	0.455
DOC_MAPK_gen_1	321	327	PF00069	0.547
DOC_MAPK_MEF2A_6	150	158	PF00069	0.659
DOC_PP1_RVXF_1	289	295	PF00149	0.294
DOC_PP2B_LxvP_1	337	340	PF13499	0.507
DOC_PP4_FxxP_1	137	140	PF00568	0.639
DOC_USP7_MATH_1	181	185	PF00917	0.676
DOC_USP7_MATH_1	190	194	PF00917	0.648
DOC_USP7_MATH_1	207	211	PF00917	0.728
DOC_USP7_MATH_1	245	249	PF00917	0.217
DOC_USP7_MATH_1	359	363	PF00917	0.217
DOC_WW_Pin1_4	130	135	PF00397	0.685
DOC_WW_Pin1_4	136	141	PF00397	0.646
DOC_WW_Pin1_4	186	191	PF00397	0.744
DOC_WW_Pin1_4	208	213	PF00397	0.677
DOC_WW_Pin1_4	272	277	PF00397	0.333
LIG_14-3-3_CanoR_1	160	167	PF00244	0.624
LIG_14-3-3_CanoR_1	218	223	PF00244	0.623
LIG_14-3-3_CanoR_1	291	295	PF00244	0.294
LIG_14-3-3_CanoR_1	322	328	PF00244	0.521
LIG_14-3-3_CanoR_1	42	47	PF00244	0.340
LIG_BRCT_BRCA1_1	242	246	PF00533	0.334
LIG_BRCT_BRCA1_1	299	303	PF00533	0.294
LIG_BRCT_BRCA1_1	49	53	PF00533	0.357
LIG_BRCT_BRCA1_1	57	61	PF00533	0.347
LIG_EH1_1	310	318	PF00400	0.217
LIG_FHA_1	217	223	PF00498	0.702
LIG_FHA_1	251	257	PF00498	0.208
LIG_FHA_1	340	346	PF00498	0.438
LIG_FHA_1	381	387	PF00498	0.612
LIG_FHA_1	63	69	PF00498	0.449
LIG_FHA_2	277	283	PF00498	0.333
LIG_FHA_2	54	60	PF00498	0.277
LIG_IRF3_LxIS_1	29	35	PF10401	0.217
LIG_LIR_Apic_2	136	140	PF02991	0.636
LIG_LIR_Apic_2	45	49	PF02991	0.394
LIG_LIR_Gen_1	103	113	PF02991	0.581
LIG_LIR_Gen_1	282	287	PF02991	0.395
LIG_LIR_Gen_1	300	311	PF02991	0.270
LIG_LIR_Gen_1	63	72	PF02991	0.217
LIG_LIR_Nem_3	243	249	PF02991	0.340
LIG_LIR_Nem_3	282	286	PF02991	0.395
LIG_LIR_Nem_3	300	306	PF02991	0.270
LIG_LIR_Nem_3	326	331	PF02991	0.584
LIG_LIR_Nem_3	63	67	PF02991	0.217
LIG_Pex14_2	12	16	PF04695	0.578
LIG_Pex14_2	242	246	PF04695	0.315
LIG_PTB_Apo_2	348	355	PF02174	0.208
LIG_PTB_Phospho_1	348	354	PF10480	0.208
LIG_SH2_STAP1	92	96	PF00017	0.530
LIG_SH2_STAT5	21	24	PF00017	0.416
LIG_SH2_STAT5	312	315	PF00017	0.337
LIG_SH2_STAT5	354	357	PF00017	0.372
LIG_SH2_STAT5	55	58	PF00017	0.343
LIG_SH2_STAT5	77	80	PF00017	0.455
LIG_SH3_3	184	190	PF00018	0.645
LIG_SH3_3	289	295	PF00018	0.333
LIG_SUMO_SIM_anti_2	153	158	PF11976	0.656
LIG_SUMO_SIM_anti_2	65	70	PF11976	0.214
LIG_SUMO_SIM_par_1	155	161	PF11976	0.584
LIG_SUMO_SIM_par_1	341	346	PF11976	0.440
LIG_SUMO_SIM_par_1	368	374	PF11976	0.312
LIG_SUMO_SIM_par_1	63	70	PF11976	0.217
LIG_UBA3_1	250	255	PF00899	0.217
LIG_WRC_WIRS_1	13	18	PF05994	0.408
MOD_CDC14_SPxK_1	211	214	PF00782	0.670
MOD_CDK_SPxK_1	208	214	PF00069	0.676
MOD_CK1_1	133	139	PF00069	0.718
MOD_CK1_1	144	150	PF00069	0.672
MOD_CK1_1	193	199	PF00069	0.712
MOD_CK1_1	293	299	PF00069	0.246
MOD_CK1_1	323	329	PF00069	0.578
MOD_CK2_1	180	186	PF00069	0.658
MOD_CK2_1	53	59	PF00069	0.274
MOD_GlcNHglycan	143	146	PF01048	0.486
MOD_GlcNHglycan	163	166	PF01048	0.451
MOD_GlcNHglycan	256	259	PF01048	0.442
MOD_GlcNHglycan	295	298	PF01048	0.494
MOD_GlcNHglycan	303	306	PF01048	0.337
MOD_GlcNHglycan	322	325	PF01048	0.195
MOD_GlcNHglycan	361	364	PF01048	0.508
MOD_GlcNHglycan	367	370	PF01048	0.375
MOD_GlcNHglycan	373	376	PF01048	0.278
MOD_GSK3_1	186	193	PF00069	0.668
MOD_GSK3_1	236	243	PF00069	0.443
MOD_GSK3_1	245	252	PF00069	0.347
MOD_GSK3_1	272	279	PF00069	0.333
MOD_GSK3_1	293	300	PF00069	0.294
MOD_GSK3_1	339	346	PF00069	0.344
MOD_GSK3_1	49	56	PF00069	0.296
MOD_NEK2_1	12	17	PF00069	0.452
MOD_NEK2_1	141	146	PF00069	0.627
MOD_NEK2_1	250	255	PF00069	0.281
MOD_NEK2_1	32	37	PF00069	0.354
MOD_NEK2_1	320	325	PF00069	0.516
MOD_NEK2_1	67	72	PF00069	0.441
MOD_NMyristoyl	1	7	PF02799	0.526
MOD_PIKK_1	236	242	PF00454	0.392
MOD_PKA_2	290	296	PF00069	0.294
MOD_PKA_2	320	326	PF00069	0.578
MOD_PKA_2	37	43	PF00069	0.266
MOD_PKB_1	216	224	PF00069	0.576
MOD_Plk_4	245	251	PF00069	0.299
MOD_Plk_4	323	329	PF00069	0.584
MOD_Plk_4	373	379	PF00069	0.398
MOD_ProDKin_1	130	136	PF00069	0.683
MOD_ProDKin_1	186	192	PF00069	0.747
MOD_ProDKin_1	208	214	PF00069	0.676
MOD_ProDKin_1	272	278	PF00069	0.333
MOD_SUMO_rev_2	99	107	PF00179	0.622
TRG_DiLeu_BaEn_1	103	108	PF01217	0.576
TRG_DiLeu_BaEn_1	153	158	PF01217	0.681
TRG_DiLeu_BaLyEn_6	333	338	PF01217	0.424
TRG_ENDOCYTIC_2	92	95	PF00928	0.535
TRG_ER_diArg_1	260	263	PF00400	0.294
TRG_ER_diArg_1	320	322	PF00400	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WUU8	Leishmania donovani	68%	94%
A4H9E7	Leishmania braziliensis	50%	97%
A4H9F0	Leishmania braziliensis	49%	97%
A4HXR9	Leishmania infantum	69%	94%
D0A051	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4QDZ8	Leishmania major	66%	100%