acidPPc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ARI0_LEIMU

TriTrypDb:

LmxM.18.0430

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9ARI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARI0

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	4
GO:0006644	phospholipid metabolic process	4	4
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0008152	metabolic process	1	4
GO:0009987	cellular process	1	4
GO:0019637	organophosphate metabolic process	3	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044255	cellular lipid metabolic process	3	4
GO:0071704	organic substance metabolic process	2	4

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	160	162	PF00675	0.587
CLV_NRD_NRD_1	246	248	PF00675	0.537
CLV_PCSK_FUR_1	158	162	PF00082	0.525
CLV_PCSK_KEX2_1	160	162	PF00082	0.628
CLV_PCSK_KEX2_1	246	248	PF00082	0.533
CLV_PCSK_SKI1_1	161	165	PF00082	0.589
CLV_PCSK_SKI1_1	41	45	PF00082	0.248
DEG_APCC_DBOX_1	159	167	PF00400	0.829
DEG_APCC_DBOX_1	46	54	PF00400	0.545
DEG_ODPH_VHL_1	193	204	PF01847	0.649
DOC_ANK_TNKS_1	190	197	PF00023	0.646
DOC_CKS1_1	116	121	PF01111	0.739
DOC_CKS1_1	145	150	PF01111	0.641
DOC_CYCLIN_yCln2_LP_2	54	60	PF00134	0.520
DOC_MAPK_gen_1	41	50	PF00069	0.498
DOC_MAPK_gen_1	8	17	PF00069	0.545
DOC_MAPK_MEF2A_6	47	55	PF00069	0.404
DOC_PP1_RVXF_1	12	18	PF00149	0.545
DOC_PP2B_LxvP_1	54	57	PF13499	0.520
DOC_PP2B_LxvP_1	58	61	PF13499	0.456
DOC_USP7_MATH_1	112	116	PF00917	0.616
DOC_USP7_MATH_1	151	155	PF00917	0.836
DOC_USP7_MATH_1	167	171	PF00917	0.653
DOC_WW_Pin1_4	115	120	PF00397	0.738
DOC_WW_Pin1_4	144	149	PF00397	0.811
DOC_WW_Pin1_4	222	227	PF00397	0.706
DOC_WW_Pin1_4	257	262	PF00397	0.647
LIG_14-3-3_CanoR_1	207	214	PF00244	0.666
LIG_14-3-3_CanoR_1	6	15	PF00244	0.612
LIG_14-3-3_CanoR_1	68	76	PF00244	0.436
LIG_Actin_WH2_2	30	46	PF00022	0.545
LIG_BRCT_BRCA1_1	22	26	PF00533	0.545
LIG_FHA_1	116	122	PF00498	0.813
LIG_FHA_1	145	151	PF00498	0.640
LIG_FHA_1	50	56	PF00498	0.404
LIG_FHA_1	61	67	PF00498	0.316
LIG_FHA_2	100	106	PF00498	0.670
LIG_FHA_2	7	13	PF00498	0.553
LIG_LIR_Nem_3	23	29	PF02991	0.556
LIG_NRBOX	49	55	PF00104	0.404
LIG_SH2_PTP2	29	32	PF00017	0.586
LIG_SH2_SRC	29	32	PF00017	0.545
LIG_SH2_STAT5	29	32	PF00017	0.586
LIG_SH2_STAT5	35	38	PF00017	0.443
LIG_SH3_3	113	119	PF00018	0.679
LIG_SH3_3	142	148	PF00018	0.833
LIG_SH3_3	199	205	PF00018	0.843
LIG_SUMO_SIM_anti_2	254	260	PF11976	0.642
LIG_SUMO_SIM_anti_2	52	57	PF11976	0.404
LIG_SUMO_SIM_par_1	254	260	PF11976	0.642
LIG_SUMO_SIM_par_1	62	67	PF11976	0.520
LIG_UBA3_1	36	44	PF00899	0.441
LIG_WW_2	148	151	PF00397	0.638
MOD_CDK_SPK_2	257	262	PF00069	0.639
MOD_CK1_1	115	121	PF00069	0.623
MOD_CK1_1	154	160	PF00069	0.648
MOD_CK1_1	16	22	PF00069	0.545
MOD_CK1_1	177	183	PF00069	0.838
MOD_CK1_1	209	215	PF00069	0.657
MOD_CK1_1	222	228	PF00069	0.666
MOD_CK1_1	67	73	PF00069	0.380
MOD_CK2_1	180	186	PF00069	0.748
MOD_CK2_1	246	252	PF00069	0.734
MOD_CK2_1	6	12	PF00069	0.554
MOD_CK2_1	99	105	PF00069	0.575
MOD_GlcNHglycan	179	182	PF01048	0.614
MOD_GlcNHglycan	18	21	PF01048	0.345
MOD_GlcNHglycan	208	211	PF01048	0.513
MOD_GlcNHglycan	233	237	PF01048	0.486
MOD_GlcNHglycan	241	244	PF01048	0.495
MOD_GSK3_1	16	23	PF00069	0.540
MOD_GSK3_1	175	182	PF00069	0.717
MOD_GSK3_1	205	212	PF00069	0.847
MOD_GSK3_1	60	67	PF00069	0.520
MOD_GSK3_1	80	87	PF00069	0.199
MOD_NEK2_1	39	44	PF00069	0.548
MOD_NEK2_1	80	85	PF00069	0.520
MOD_PK_1	246	252	PF00069	0.650
MOD_PKA_1	246	252	PF00069	0.734
MOD_PKA_2	13	19	PF00069	0.545
MOD_PKA_2	206	212	PF00069	0.668
MOD_PKA_2	239	245	PF00069	0.681
MOD_PKA_2	246	252	PF00069	0.719
MOD_PKA_2	67	73	PF00069	0.436
MOD_PKA_2	98	104	PF00069	0.736
MOD_Plk_1	104	110	PF00069	0.780
MOD_Plk_1	112	118	PF00069	0.715
MOD_Plk_1	251	257	PF00069	0.645
MOD_Plk_4	209	215	PF00069	0.690
MOD_Plk_4	251	257	PF00069	0.645
MOD_Plk_4	49	55	PF00069	0.498
MOD_Plk_4	84	90	PF00069	0.371
MOD_ProDKin_1	115	121	PF00069	0.738
MOD_ProDKin_1	144	150	PF00069	0.813
MOD_ProDKin_1	222	228	PF00069	0.706
MOD_ProDKin_1	257	263	PF00069	0.648
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID01	Leishmania donovani	74%	74%
A4HXR8	Leishmania infantum	74%	74%
Q4QDZ9	Leishmania major	66%	100%