Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARH8_LEIMU

TriTrypDb:

LmxM.18.0410

Length:

200

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9ARH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARH8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	170	172	PF00675	0.625
CLV_NRD_NRD_1	3	5	PF00675	0.641
CLV_NRD_NRD_1	32	34	PF00675	0.435
CLV_PCSK_KEX2_1	140	142	PF00082	0.673
CLV_PCSK_KEX2_1	145	147	PF00082	0.690
CLV_PCSK_KEX2_1	3	5	PF00082	0.641
CLV_PCSK_KEX2_1	86	88	PF00082	0.632
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.673
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.690
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.650
CLV_PCSK_PC7_1	141	147	PF00082	0.655
CLV_PCSK_SKI1_1	101	105	PF00082	0.600
CLV_PCSK_SKI1_1	4	8	PF00082	0.679
DEG_Nend_Nbox_1	1	3	PF02207	0.652
DEG_SCF_FBW7_1	187	194	PF00400	0.718
DOC_CKS1_1	188	193	PF01111	0.716
DOC_CKS1_1	48	53	PF01111	0.615
DOC_CYCLIN_RxL_1	1	10	PF00134	0.650
DOC_PP4_FxxP_1	48	51	PF00568	0.555
DOC_USP7_UBL2_3	145	149	PF12436	0.616
DOC_WW_Pin1_4	111	116	PF00397	0.672
DOC_WW_Pin1_4	187	192	PF00397	0.664
DOC_WW_Pin1_4	23	28	PF00397	0.621
DOC_WW_Pin1_4	47	52	PF00397	0.569
LIG_BRCT_BRCA1_1	157	161	PF00533	0.632
LIG_FHA_1	62	68	PF00498	0.613
LIG_FHA_2	47	53	PF00498	0.613
LIG_GSK3_LRP6_1	191	196	PF00069	0.551
LIG_HCF-1_HBM_1	147	150	PF13415	0.438
LIG_LIR_Apic_2	47	51	PF02991	0.564
LIG_LIR_Gen_1	55	62	PF02991	0.596
LIG_LIR_Nem_3	55	60	PF02991	0.600
LIG_SH2_STAT5	150	153	PF00017	0.636
LIG_SH2_STAT5	162	165	PF00017	0.572
LIG_SH2_STAT5	181	184	PF00017	0.421
LIG_SH3_1	33	39	PF00018	0.531
LIG_SH3_2	195	200	PF14604	0.693
LIG_SH3_2	36	41	PF14604	0.546
LIG_SH3_3	151	157	PF00018	0.704
LIG_SH3_3	189	195	PF00018	0.607
LIG_SH3_3	33	39	PF00018	0.509
LIG_SH3_5	152	156	PF00018	0.643
MOD_CDK_SPxxK_3	111	118	PF00069	0.661
MOD_CK1_1	89	95	PF00069	0.633
MOD_CK2_1	46	52	PF00069	0.603
MOD_CK2_1	73	79	PF00069	0.691
MOD_GlcNHglycan	101	104	PF01048	0.493
MOD_GlcNHglycan	76	79	PF01048	0.628
MOD_GlcNHglycan	88	91	PF01048	0.579
MOD_GlcNHglycan	9	12	PF01048	0.662
MOD_GSK3_1	187	194	PF00069	0.737
MOD_GSK3_1	69	76	PF00069	0.600
MOD_GSK3_1	82	89	PF00069	0.471
MOD_GSK3_1	99	106	PF00069	0.415
MOD_N-GLC_1	111	116	PF02516	0.646
MOD_NEK2_1	7	12	PF00069	0.651
MOD_PIKK_1	156	162	PF00454	0.656
MOD_PKA_1	86	92	PF00069	0.671
MOD_PKA_2	86	92	PF00069	0.530
MOD_ProDKin_1	111	117	PF00069	0.664
MOD_ProDKin_1	187	193	PF00069	0.667
MOD_ProDKin_1	23	29	PF00069	0.624
MOD_ProDKin_1	47	53	PF00069	0.576
MOD_SUMO_rev_2	63	70	PF00179	0.550
TRG_ENDOCYTIC_2	45	48	PF00928	0.525
TRG_ER_diArg_1	2	4	PF00400	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC40	Leptomonas seymouri	65%	100%
A0A0S4JE60	Bodo saltans	31%	100%
A0A1X0P7T6	Trypanosomatidae	39%	100%
A0A3Q8I9X5	Leishmania donovani	94%	100%
A4H9E5	Leishmania braziliensis	83%	100%
A4HXR6	Leishmania infantum	94%	100%
D0A048	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	70%
Q4QE01	Leishmania major	92%	100%