Tubulin--tyrosine ligase-like protein 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin tyrosine ligase protein, putative

Species:

Leishmania mexicana

UniProt:

E9ARH4_LEIMU

TriTrypDb:

LmxM.18.0370

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9ARH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARH4

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0018095	protein polyglutamylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018200	peptidyl-glutamic acid modification	6	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016874	ligase activity	2	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	1
GO:0016881	acid-amino acid ligase activity	4	1
GO:0070739	protein-glutamic acid ligase activity	3	1
GO:0070740	tubulin-glutamic acid ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.523
CLV_C14_Caspase3-7	419	423	PF00656	0.569
CLV_NRD_NRD_1	124	126	PF00675	0.236
CLV_NRD_NRD_1	157	159	PF00675	0.238
CLV_NRD_NRD_1	396	398	PF00675	0.416
CLV_NRD_NRD_1	4	6	PF00675	0.516
CLV_NRD_NRD_1	74	76	PF00675	0.238
CLV_PCSK_KEX2_1	124	126	PF00082	0.224
CLV_PCSK_KEX2_1	157	159	PF00082	0.291
CLV_PCSK_KEX2_1	396	398	PF00082	0.419
CLV_PCSK_KEX2_1	4	6	PF00082	0.509
CLV_PCSK_SKI1_1	14	18	PF00082	0.351
CLV_PCSK_SKI1_1	142	146	PF00082	0.224
CLV_PCSK_SKI1_1	158	162	PF00082	0.224
CLV_PCSK_SKI1_1	302	306	PF00082	0.298
CLV_PCSK_SKI1_1	327	331	PF00082	0.331
CLV_PCSK_SKI1_1	334	338	PF00082	0.339
CLV_PCSK_SKI1_1	385	389	PF00082	0.256
CLV_PCSK_SKI1_1	425	429	PF00082	0.427
CLV_PCSK_SKI1_1	81	85	PF00082	0.238
DEG_APCC_DBOX_1	262	270	PF00400	0.436
DEG_Nend_UBRbox_2	1	3	PF02207	0.689
DEG_SPOP_SBC_1	426	430	PF00917	0.499
DOC_CYCLIN_RxL_1	324	331	PF00134	0.456
DOC_CYCLIN_yClb5_NLxxxL_5	296	305	PF00134	0.529
DOC_MAPK_gen_1	124	132	PF00069	0.424
DOC_MAPK_gen_1	231	239	PF00069	0.424
DOC_MAPK_gen_1	4	13	PF00069	0.421
DOC_MAPK_MEF2A_6	231	239	PF00069	0.424
DOC_PP2B_LxvP_1	438	441	PF13499	0.544
DOC_PP2B_LxvP_1	445	448	PF13499	0.518
DOC_PP4_FxxP_1	110	113	PF00568	0.450
DOC_PP4_MxPP_1	133	136	PF00568	0.424
DOC_USP7_MATH_1	365	369	PF00917	0.436
DOC_USP7_MATH_1	416	420	PF00917	0.502
DOC_USP7_MATH_1	426	430	PF00917	0.507
DOC_USP7_MATH_1	44	48	PF00917	0.469
DOC_USP7_UBL2_3	134	138	PF12436	0.436
DOC_USP7_UBL2_3	283	287	PF12436	0.424
DOC_USP7_UBL2_3	84	88	PF12436	0.424
DOC_WW_Pin1_4	363	368	PF00397	0.436
DOC_WW_Pin1_4	370	375	PF00397	0.436
LIG_14-3-3_CanoR_1	263	267	PF00244	0.424
LIG_14-3-3_CanoR_1	327	333	PF00244	0.456
LIG_deltaCOP1_diTrp_1	155	160	PF00928	0.523
LIG_deltaCOP1_diTrp_1	36	43	PF00928	0.316
LIG_EH1_1	329	337	PF00400	0.491
LIG_FHA_1	107	113	PF00498	0.439
LIG_FHA_1	127	133	PF00498	0.326
LIG_FHA_1	246	252	PF00498	0.450
LIG_FHA_1	312	318	PF00498	0.476
LIG_FHA_1	6	12	PF00498	0.534
LIG_FHA_2	18	24	PF00498	0.301
LIG_FHA_2	31	37	PF00498	0.350
LIG_FHA_2	371	377	PF00498	0.436
LIG_FHA_2	72	78	PF00498	0.424
LIG_LIR_Apic_2	109	113	PF02991	0.425
LIG_LIR_Apic_2	205	210	PF02991	0.456
LIG_LIR_Gen_1	254	264	PF02991	0.424
LIG_LIR_Gen_1	270	281	PF02991	0.424
LIG_LIR_Gen_1	386	393	PF02991	0.436
LIG_LIR_Gen_1	40	49	PF02991	0.321
LIG_LIR_Nem_3	104	108	PF02991	0.428
LIG_LIR_Nem_3	115	119	PF02991	0.439
LIG_LIR_Nem_3	243	247	PF02991	0.427
LIG_LIR_Nem_3	254	259	PF02991	0.430
LIG_LIR_Nem_3	270	276	PF02991	0.424
LIG_LIR_Nem_3	284	288	PF02991	0.424
LIG_LIR_Nem_3	36	42	PF02991	0.320
LIG_LIR_Nem_3	386	391	PF02991	0.436
LIG_LIR_Nem_3	51	56	PF02991	0.362
LIG_OCRL_FandH_1	159	171	PF00620	0.498
LIG_PCNA_PIPBox_1	323	332	PF02747	0.498
LIG_PCNA_yPIPBox_3	323	334	PF02747	0.498
LIG_Pex14_1	156	160	PF04695	0.424
LIG_Pex14_2	106	110	PF04695	0.444
LIG_Pex14_2	119	123	PF04695	0.416
LIG_Pex14_2	407	411	PF04695	0.348
LIG_Rb_pABgroove_1	382	390	PF01858	0.512
LIG_SH2_CRK	244	248	PF00017	0.424
LIG_SH2_CRK	53	57	PF00017	0.511
LIG_SH2_NCK_1	288	292	PF00017	0.491
LIG_SH2_PTP2	238	241	PF00017	0.424
LIG_SH2_PTP2	273	276	PF00017	0.523
LIG_SH2_SRC	273	276	PF00017	0.523
LIG_SH2_STAP1	233	237	PF00017	0.436
LIG_SH2_STAP1	348	352	PF00017	0.436
LIG_SH2_STAT3	216	219	PF00017	0.424
LIG_SH2_STAT5	166	169	PF00017	0.523
LIG_SH2_STAT5	216	219	PF00017	0.424
LIG_SH2_STAT5	221	224	PF00017	0.424
LIG_SH2_STAT5	238	241	PF00017	0.424
LIG_SH2_STAT5	273	276	PF00017	0.523
LIG_SH2_STAT5	288	291	PF00017	0.436
LIG_SH2_STAT5	431	434	PF00017	0.441
LIG_SH3_3	206	212	PF00018	0.485
LIG_SH3_4	134	141	PF00018	0.436
LIG_SUMO_SIM_anti_2	20	26	PF11976	0.297
LIG_TRAF2_1	398	401	PF00917	0.547
LIG_UBA3_1	325	334	PF00899	0.426
LIG_WW_3	447	451	PF00397	0.443
MOD_CK1_1	148	154	PF00069	0.436
MOD_CK1_1	196	202	PF00069	0.546
MOD_CK2_1	30	36	PF00069	0.399
MOD_CK2_1	395	401	PF00069	0.440
MOD_Cter_Amidation	229	232	PF01082	0.224
MOD_Cter_Amidation	394	397	PF01082	0.531
MOD_GlcNHglycan	169	172	PF01048	0.298
MOD_GlcNHglycan	186	189	PF01048	0.368
MOD_GlcNHglycan	195	198	PF01048	0.304
MOD_GlcNHglycan	200	203	PF01048	0.291
MOD_GlcNHglycan	291	294	PF01048	0.227
MOD_GlcNHglycan	397	400	PF01048	0.546
MOD_GSK3_1	198	205	PF00069	0.434
MOD_GSK3_1	30	37	PF00069	0.419
MOD_GSK3_1	363	370	PF00069	0.436
MOD_GSK3_1	416	423	PF00069	0.564
MOD_GSK3_1	71	78	PF00069	0.498
MOD_LATS_1	3	9	PF00433	0.608
MOD_N-GLC_1	363	368	PF02516	0.236
MOD_N-GLC_1	420	425	PF02516	0.537
MOD_N-GLC_1	454	459	PF02516	0.619
MOD_NEK2_1	145	150	PF00069	0.424
MOD_NEK2_1	167	172	PF00069	0.498
MOD_NEK2_1	17	22	PF00069	0.311
MOD_NEK2_1	240	245	PF00069	0.437
MOD_NEK2_1	251	256	PF00069	0.404
MOD_NEK2_1	305	310	PF00069	0.491
MOD_NEK2_1	360	365	PF00069	0.436
MOD_NEK2_1	427	432	PF00069	0.525
MOD_NEK2_2	202	207	PF00069	0.456
MOD_PIKK_1	148	154	PF00454	0.426
MOD_PIKK_1	420	426	PF00454	0.647
MOD_PIKK_1	440	446	PF00454	0.539
MOD_PKA_1	75	81	PF00069	0.498
MOD_PKA_2	17	23	PF00069	0.248
MOD_PKA_2	262	268	PF00069	0.424
MOD_PKA_2	395	401	PF00069	0.440
MOD_Plk_1	269	275	PF00069	0.424
MOD_Plk_1	352	358	PF00069	0.498
MOD_Plk_1	44	50	PF00069	0.468
MOD_Plk_2-3	32	38	PF00069	0.446
MOD_Plk_4	126	132	PF00069	0.528
MOD_Plk_4	17	23	PF00069	0.314
MOD_Plk_4	202	208	PF00069	0.456
MOD_Plk_4	245	251	PF00069	0.467
MOD_Plk_4	269	275	PF00069	0.424
MOD_Plk_4	427	433	PF00069	0.387
MOD_Plk_4	44	50	PF00069	0.465
MOD_Plk_4	75	81	PF00069	0.498
MOD_ProDKin_1	363	369	PF00069	0.436
MOD_ProDKin_1	370	376	PF00069	0.436
MOD_SUMO_rev_2	155	162	PF00179	0.514
TRG_ENDOCYTIC_2	116	119	PF00928	0.424
TRG_ENDOCYTIC_2	238	241	PF00928	0.424
TRG_ENDOCYTIC_2	244	247	PF00928	0.424
TRG_ENDOCYTIC_2	273	276	PF00928	0.509
TRG_ENDOCYTIC_2	348	351	PF00928	0.437
TRG_ENDOCYTIC_2	53	56	PF00928	0.399
TRG_ER_diArg_1	123	125	PF00400	0.436
TRG_ER_diArg_1	156	158	PF00400	0.491
TRG_ER_diArg_1	25	28	PF00400	0.334
TRG_ER_diArg_1	4	7	PF00400	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P402	Leptomonas seymouri	84%	100%
A0A0N1I1A1	Leptomonas seymouri	22%	100%
A0A0N1IH77	Leptomonas seymouri	23%	83%
A0A0S4ISF0	Bodo saltans	25%	81%
A0A0S4JEF0	Bodo saltans	39%	100%
A0A0S4KQK8	Bodo saltans	25%	70%
A0A1X0NFL2	Trypanosomatidae	21%	100%
A0A1X0NFU6	Trypanosomatidae	36%	87%
A0A1X0NZP1	Trypanosomatidae	36%	89%
A0A1X0P705	Trypanosomatidae	66%	100%
A0A3Q8IDP1	Leishmania donovani	21%	86%
A0A3R7MY56	Trypanosoma rangeli	65%	100%
A0A3S5IS28	Trypanosoma rangeli	25%	72%
A0A3S7WUU3	Leishmania donovani	93%	99%
A0A422N932	Trypanosoma rangeli	34%	100%
A0A422NE52	Trypanosoma rangeli	23%	100%
A0A422P136	Trypanosoma rangeli	25%	70%
A2APC3	Mus musculus	46%	100%
A4H9E1	Leishmania braziliensis	92%	100%
A4HG29	Leishmania braziliensis	20%	91%
A4HH59	Leishmania braziliensis	22%	100%
A4HXR2	Leishmania infantum	94%	100%
A4I351	Leishmania infantum	22%	97%
A4Q9E4	Mus musculus	26%	86%
B6DTF7	Bodo saltans	63%	100%
C9ZI96	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	68%
C9ZJM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
C9ZPR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	88%
C9ZR25	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	73%
C9ZYH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	70%
D0A044	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9ACW9	Leishmania major	22%	96%
E9AZF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	97%
O95922	Homo sapiens	40%	100%
P38160	Sus scrofa	24%	100%
P38584	Bos taurus	24%	100%
P38585	Mus musculus	24%	100%
Q0VC71	Bos taurus	40%	100%
Q23SI8	Tetrahymena thermophila (strain SB210)	38%	100%
Q3SXZ7	Homo sapiens	42%	100%
Q3SZH6	Bos taurus	46%	100%
Q4QE05	Leishmania major	94%	100%
Q564U4	Caenorhabditis elegans	42%	100%
Q5PPI9	Rattus norvegicus	40%	100%
Q641W7	Rattus norvegicus	45%	100%
Q8NG68	Homo sapiens	24%	100%
Q91V51	Mus musculus	40%	100%
Q9BWV7	Homo sapiens	26%	78%
Q9QXJ0	Rattus norvegicus	25%	100%
V5ARK1	Trypanosoma cruzi	24%	99%
V5BLZ7	Trypanosoma cruzi	64%	100%
V5BVF5	Trypanosoma cruzi	24%	72%
V5D711	Trypanosoma cruzi	24%	100%